JP2001288493A - Perfume composition for improving memory and composition containing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a foolproof means for improving memory and, more particularly, a means for improving memory when a person has a failure of his memory due to lack of sleep. SOLUTION: A perfume or cosmetic product (e.g. cosmetic) is compounded with a memory improving perfume composition containing one or more members selected from nerolidol, hedione, mayol, lilial, helional, phenylethyl alcohol, and α-hexylcinnamaldehyde.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fragrance composition suitable for cosmetics and fragrances, and a fragrance containing the same.

[0002]

2. Description of the Related Art With the progress of modern medicine, the average life expectancy has been getting longer and longer in recent years, and society can now be said to be on the aging path. Under these circumstances, even if physical measures to prolong life are taken, there is no means to prevent the aging of functions such as the brain, so there is an increase in memory impairment from severe symptoms such as dumbness to mild forgetfulness. Is becoming a social problem. In addition, in recent years it has been a stressed society, and modern people living there live more or less under some stress load, and such stress has a great effect on the decline of memory. For this reason, memory disorders caused by stress also occur.
It can be said that it is increasing in modern times. However,
For such memory disorders, modern medicine has not provided as many countermeasures as various diseases such as infectious diseases and cancer, and it has been desired to develop countermeasures for such memory disorders.

[0003] On the other hand, it has long been said that fragrance components help to alleviate stress, but it has not been specified what fragrance components have such an effect, and such fragrance components have not been specified. Was not observed with good reproducibility. Also, there was no discussion as to whether there is a causal relationship between such stress relief and memory enhancement. Further, nerolidol, hedion, mayol, liaryl, helional, phenylethyl alcohol and α-hexylcinnamic aldehyde were widely known as fragrance components and were used as fragrances. It was not known at all that it had a memory-enhancing effect due to load.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide means for enhancing memory ability against memory impairment such as a decrease in memory ability under a high stress load. .

[0005]

In view of such a situation, the present inventors have conducted intensive research efforts for a means for enhancing memory ability against memory impairment such as a decrease in memory ability under high stress load, and as a result, nerolidol Hedion, Mayol, Lilyal, Helional, phenylethyl alcohol and α-hexylcinnamic aldehyde were found to have an excellent memory-enhancing effect, and also an excellent memory-enhancing effect under high stress load. After further study,
When these components were combined and included in the fragrance composition, and flavor was imparted in an aquafloral tone, it was found that a more specific effect could be obtained, and the invention was completed. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) Fragrance composition for enhancing memory of the present invention The fragrance composition for enhancing memory of the present invention is nerolidol (3,7,11-trimethyl-, 6,10-dodecatriene-). 3-ol), hedion (methyldihydrojasmonate), mayol (cis-p-isopropylcyclohexylmethanol), lilial (p-tert-butylhydrocinnamic aldehyde), helional (α-methyl-3,4-methylenediamine) (Oxyhydrocinnamic aldehyde) 1 selected from phenylethyl alcohol and α-hexylcinnamic aldehyde
It is characterized by containing at least two species. All of these components are widely known as fragrance components, and are already used in cosmetics and fragrances. These have an effect of alleviating memory impairment by themselves, and exhibit such effects when used alone or in combination with other fragrances. Such action is remarkable when two or more kinds selected from these are combined, and in particular, a composition containing 5 to 15% by weight of each of these components is particularly remarkable. It is particularly preferable to use the product as the fragrance composition for enhancing memory of the present invention. Further, it is particularly preferable that the scent of the scent be adjusted to a so-called aqua-floral scent reminiscent of a fresh flower. In order to produce an aqua-floral scent by combining these, an equal mixture of nerolidol, hedion, mayol, lilial and helional, phenylethyl alcohol and α-hexylcinnamic aldehyde are mixed at a composition ratio close to the equivalent. You should do it. Here, the fragrance composition referred to in the present invention is a composition containing a fragrance used for flavoring cosmetics and fragrance products, and in addition to the fragrance component, contains a diluting medium such as ethanol or water. be able to. In the fragrance composition of the present invention, the content of the fragrance component for enhancing memory ability of the present invention is preferably from 40 to 80% by weight, more preferably from 50 to 70% by weight.

(2) Cosmetic product of the present invention The cosmetic product of the present invention is characterized by containing the above-mentioned perfume for enhancing memory of the present invention as a composition. The cosmetic according to the present invention is a product containing a fragrance composition and means a composition used in a use form similar to cosmetics and fragrances. For example, basic cosmetics, make-up cosmetics ,
Preference is given to fragrances, skin external medicines and the like.
Here, fragrances include not only eau de cologne, eau de toilette, and perfumes, but also room fragrances and dough,
Examples include incense and incense. As the cosmetics of the present invention, basic cosmetics are particularly preferred, and among them, basic cosmetics having an element which embodies the feeling of use or comfort as a component thereof and exerts an action of relaxing. This is because such a cosmetic can exert an effect of further enhancing the memory-enhancing effect derived from the flavor component. A particularly preferred coexisting component is an extract of bougainvillea. This is because this component has a function of adjusting the environment of the living body so as not to lose the load of the stress, and also has a function of promoting the elimination of the adverse effect of the stress on the memory. The preferred content of this component in the cosmetic of the present invention is 0.01 to 0.1% by weight. In the cosmetics of the present invention, the content of the flavor composition of the present invention is preferably from 0.01 to 20% by weight, more preferably from 0.1 to 10% by weight. By using these cosmetics, it is possible to reduce memory impairment such as memory loss or frequent forgetfulness. The cosmetics of the present invention may contain, in addition to such essential and preferred components, optional components usually used in cosmetics. Such optional components include, for example, hydrocarbons such as squalane, petrolatum, and microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, triglycerides such as olive oil, tallow, and coconut oil; Fatty acids such as stearic acid, oleic acid and ritinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol and octyldodecanol, anionic surfactants such as sulfosuccinates and sodium polyoxyethylene alkyl sulfate, and amphoteric salts such as alkyl betaine salts Surfactants, cationic surfactants such as dialkylammonium salts, sorbitan fatty acid esters, fatty acid monoglycerides, their polyoxyethylene adducts, polyoxyethylene alkyl ethers, polyoxyethylene Nonionic surfactants such as alkylene fatty acid esters, polyethylene glycol, glycerine, 1,3
Preferred examples include polyhydric alcohols such as butanediol, thickening / gelling agents, antioxidants, ultraviolet absorbers, coloring agents, preservatives, and powders. The cosmetics of the present invention can be produced by treating these components according to a conventional method.

[0008]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it is needless to say that the present invention is not limited to only these Examples.

<Example 1> Regarding nerolidol, hedion, mayol, liliar, helional, phenylethyl alcohol and α-hexylcinnamic aldehyde, which constitute the fragrance composition of the present invention, the memory-enhancing effect was evaluated by a human lack of sleep model. It was confirmed by a memory test of a four-digit number using. That is, in a human sleep deprivation model produced by forcibly preventing sleep for 24 hours, a four-digit number is presented for 10 seconds when a fragrance component is present and when it is not present, and 30 seconds later They were asked to give the numbers presented, and the correct answer rate in 10 repetitions was determined. As a negative control, one in which no fragrance component was present was used, and as a positive control, a case in which sufficient sleep was performed was used. In Comparative Example 1, linalool was used, and in Comparative Example 2, α-pinene was used. The amount of the fragrance component used was determined by preparing a 60% by weight ethanol solution of these components and spraying 0.01 g of the solution into a room of 3 cubic meters. The number of human cases was 10. Table 1 shows the results. This indicates that the fragrance component of the fragrance composition of the present invention has an excellent memory enhancing effect.

[0010]

[Table 1]

Example 2 A fragrance composition of the present invention was prepared according to the following formulation. That is, the prescription components were mixed well, and a fragrance composition 1 was obtained. The incense tone of this was aqua floral. When the effect was observed in the above human sleep deprivation model, the correct answer rate was 72%. As the fragrance composition of the present invention, nerolidol, hedion, mayol, lilial, helional, phenylethyl alcohol, and α-hexylsine It turns out that it is appropriate to mix a plurality of namic aldehydes, and more preferably to include all seven types. Further, it can be seen that aqua floral tone is preferable as the tone of the incense. Nerolidol 10 parts by weight Hedion 10 parts by weight Mayol 10 parts by weight Lilyal 5 parts by weight Helional 5 parts by weight Phenylethyl alcohol 10 parts by weight α-hexylcinnamic aldehyde 10 parts by weight Ethanol 40 parts by weight

Example 3 An cologne was prepared according to the following formulation. That is, the ingredients are mixed well,
Aged at 5 ° C. for 1 month and filtered to obtain cologne. By using this, in the sleep shortage model,
The correct answer rate was 69%. Ethanol 40 parts by weight Fragrance composition 1 10 parts by weight Water 49.9 parts by weight Polyoxyethylene (60) hydrogenated castor oil 0.1 part by weight

Example 4 A water-in-oil cream was prepared according to the following formulation. That is, the components (a) and (b) were each heated to 80 ° C., (b) was gradually added to (a), emulsified, and the particles were homogenized with a homogenizer. Here, as an essence of rosemary, 1 l of 1,3-butanediol was added to the above-ground part of 100 g of rosemary, extracted, filtered and used.
The essence of Astragalus was added to 100 g of the whole plant of Aspergillus, and 1 l of 1,3-butanediol was extracted and filtered. The essence of Astragalus was extracted by adding 1 L of ethanol to 100 g of mycelia of Astragalus. After filtration, the solvent was distilled off.
The evaluation result was 81% correct answer rate. It can be seen that the fragrance composition of the present invention is preferably used in the presence of an extract of bougainvillea. A Sucrose fatty acid ester 0.5 parts by weight Vaseline 1 part by weight Lanolin 3 parts by weight Liquid paraffin 8 parts by weight Low viscosity silicone 30 parts by weight Stearyl alcohol 0.5 parts by weight Stearic acid 0.55 parts by weight Undecylenic acid monoglyceride 2 parts by weight Organic modification Bentonite 2 parts by weight Fragrance composition 1 part by weight b 1,3-butanediol 5 parts by weight Glycerin 20 parts by weight Rosemary essence 1 part by weight Tubula essence 0.5 part by weight Bulky essence 0.1 part by weight Potassium hydroxide 0.05 parts by weight water 24.8 parts by weight

Example 5 A room fragrance was prepared according to the following recipe. That is, the prescription component is 90 ° C.
Heat, stir and homogenize, pack in a metal pan and cool,
Got room fragrance. In these, a memory-enhancing effect was observed. Fragrance composition 1 10 parts by weight Polyethylene 20 parts by weight Microcrystalline wax 20 parts by weight Dimethicone 30 parts by weight Squalane 20 parts by weight

[0015]

According to the present invention, it is possible to provide a memory enhancing means which can be easily made by anyone, especially a memory enhancing means for lack of sleep.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 7/46 A61K 7/46 A 315 315A 315Z 345 345Z 385 385E 411 411 A61P 25/28 A61P 25/28 ( 72) Inventor Takehiro Okuda 27-1 Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa F-term in the POLA Yokohama Research Laboratory 4H059 BA12 BA14 BA20 BA35 BB04 BB06 BB13 BB14 BB15 BB18 BB23 BB44 BB45 DA09 EA33

Claims (8)

[Claims] 1. A fragrance composition for enhancing memory ability, comprising one or more selected from nerolidol, hedion, mayol, liaryl, helional, phenylethyl alcohol and α-hexylcinnamic aldehyde. object. 2. The fragrance composition for enhancing memory according to claim 1, wherein the base color of the scent is aqua floral. 3. The content of one or more selected from nerolidol, hedion, mayol, lilial, helional, phenylethyl alcohol and α-hexylcinnamic aldehyde is 60% or more based on the total amount of the fragrance component. The fragrance composition for enhancing memory ability according to claim 1 or 2, characterized in that: 4. The method according to claim 1, which is designed to cope with a decline in memory ability under a high stress load.
3. The fragrance composition for enhancing memory ability according to any one of 3. 5. A cosmetic comprising the fragrance composition for enhancing memory according to any one of claims 1 to 4. 6. The cosmetic according to claim 5, which is a cosmetic or a fragrance. 7. It is for memory enhancement,
The cosmetic according to claim 5. 8. A cosmetic or fragrance for enhancing memory, which comprises one or more selected from nerolidol, hedion, mayol, liaryl, helional, phenylethyl alcohol and α-hexylcinnamic aldehyde.