JP2001261580A - Medicine of dissolution type in time of use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a medicine of dissolution type in time of use having an improved feeling of administration such as flavor, body, aftertaste, etc., when dissolved in warm water or water and taken in administration. SOLUTION: This medicine for dissolution type in time of use is characterized by formulating the medicine with a starch.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to a time-dissolved drug,
In particular, the present invention relates to a cold medicine for use at the time of use, that is, a so-called cold medicine for drinking. More specifically, the present invention relates to a cold medicine having an improved flavor, richness, and aftertaste when taken after being dissolved in hot water or water when taken.

[0002]

2. Description of the Related Art In today's world in which the needs of consumers are diversifying, it is desired to develop products corresponding to this. From such a viewpoint, in recent years, cold medicines are also different from conventional medicines, granules, tablets, capsules and the like which are taken in the form of solid preparations. Formulations that can be taken in water or in water have been developed and are already on the market. Cold-acting cold medicines are cold medicines that are suitable for people who are not good at taking solid preparations such as tablets.If they are dissolved in hot water and taken, they will not only have the cold medicine's original effect, but also have the effect of warming the body. It is excellent in that the effect of replenishing water lost due to heat generation is obtained. Since the cold medicine for use is a cold medicine that is taken in a liquid state, it is natural that the original effect of the cold medicine must be obtained.
The feeling of taking such as body and aftertaste is an important factor. Many of the active ingredients contained in cold medicines have strong bitterness.Currently available cold-melting cold medicines are prepared by adding sweet and sour ingredients to make them lemon-like. Has been formulated to be easy to take.

[0003]

However, even if the flavor is good, it is not easy for anyone to take it unless the overall feeling of taking, including the richness and aftertaste, is excellent. As for, the currently available cold-dissolving cold medicines still have room for improvement.
Therefore, an object of the present invention is to provide a time-dissolved medicine such as a cold-dissolved cold medicine with an improved feeling of taking such as flavor, body, aftertaste when dissolved and taken in hot water or water when taken. And

[0004]

Means for Solving the Problems In view of the above points, the present inventors have studied to improve the feeling of ingestion by adding an additive to a cold medicine for use at the time of use. It has been found that when starch is blended, the overall feeling of taking, including flavor, richness, aftertaste, etc., is improved, and the formulation is easier to take than a formulation without starch.

[0005] The present invention has been made based on the above findings, and the time-dissolved drug of the present invention is characterized by incorporating starch as described in claim 1. Also,
According to a second aspect of the present invention, there is provided a freshly-dissolved medicine according to the first aspect, wherein the medicine is a cold medicine. In addition, the freshly-dissolved medicine according to claim 3 is characterized in that, in the freshly-dissolved medicine according to claim 1 or 2, the starch is corn starch and / or potato starch. In addition, the ready-to-use medicine according to claim 4 is the same as in any of claims 1 to 3, except that the starch is 0.0001% by weight based on 1 part by weight of hot water or water used for dissolution. Parts to 0.1 parts by weight. Further, the method for improving the feeling of taking a ready-to-use drug of the present invention is characterized in that starch is blended as described in claim 5.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, corn starch, corn starch,
Potato starch, rice starch, wheat starch, and the like, as well as assimilable starch of plants, these processed products such as hydroxypropyl starch, pregelatinized starch, edible processed starch such as partially pregelatinized starch, and the like. In order to further improve the flavor, it is desirable to add corn starch and / or potato starch.

[0007] The amount of starch to be added to the dissolving drug at the time of use is appropriately adjusted in accordance with the components and content contained in the drug. Generally, the amount of starch is 1 part by weight of hot water or water used for dissolution. On the other hand, the amount of starch is 0.0001 parts by weight to 0.
1 part by weight, desirably 0.0003 parts by weight to 0.01
It is desirable to mix them in parts by weight. When the amount of the starch is less than 0.0001 part by weight, the effect may not be sufficiently exhibited. On the other hand, when the amount is more than 0.1 part by weight, the thickening becomes too strong, and a moderate feeling of taking is obtained. This is because they may not be able to do so.

[0008] The time-dissolved drug to which the present invention can be applied is not particularly limited as long as it is a drug which is dissolved in hot water or water when taken, and examples thereof include a cold-dissolved cold drug. Can be

[0009] The cold medicine for use is a cold medicine which is taken by dissolving it in hot water or water at the time of taking it, and having various symptoms of a cold (throat pain, cough, chills, fever, headache, runny nose, stuffy nose,
It means a preparation that claims to relieve sneezing, sputum, joint pain and muscle pain). The amount of hot water or water used for dissolution is generally 11 mL or more. The terms “dissolve” and “dissolve” used in the present invention are defined as
In addition to those that result in a complete solution, those that disperse or suspend some of the components without dissolving are also included.

[0010] As an active ingredient of the cold-dissolving cold medicine, an antipyretic analgesic ingredient such as acetaminophen is an essential ingredient,
Along with antipyretic analgesic components, antihistamine components such as chlorpheniramine maleate, antitussive components such as dihydrocodeine phosphate and dextromethorphan hydrobromide, bronchodilator components such as methylephedrine hydrochloride, expectorant components such as potassium guaiacol sulfonate, In addition to caffeine, vitamins such as vitamin C, antacids such as synthetic aluminum silicate, crude drug components such as licorice, a Chinese herbal prescription and the like are appropriately blended.

In order to improve the flavor, a sweet component such as sucrose, aspartame and stevia, and an acid component such as citric acid are appropriately added.

Examples of the dosage form of the ready-to-use drug in the present invention include powders, granules, effervescent tablets and the like. These include additives such as a binder such as povidone and a dispersant such as light silicic anhydride. And then formulated by a method known per se. The amount of starch in the preparation is preferably 0.1% by mass to 30% by mass, more preferably 0.5% by mass to 5% by mass.

[0013]

EXAMPLES The in-use medicine of the present invention will be described in detail below with reference to an in-use cold medicine, but the invention is not limited to the following description. Example 1: Corn starch was used as a starch, and the following components were weighed and uniformly mixed. Then, wet granulation was performed using purified water, followed by drying to obtain a powder. The obtained powder was packaged to obtain 3 packets of a packaged medicine which is a cold solution for use according to the present invention (5 g per package). Acetaminophen 900.0 mg dl-chlorpheniramine maleate 7.5 mg dihydrocodeine phosphate 24.0 mg dl-methylephedrine hydrochloride 60.0 mg anhydrous caffeine 75.0 mg ascorbic acid 500.0 mg white sugar 11638.5 mg aspartame 90.0 mg stevia 15.0 mg citric acid 750.0 mg povidone (K30) 600.0 mg corn starch 300.0 mg light silicic anhydride 40.0 mg

Comparative Example 1: After weighing and uniformly mixing the following components, wet granulation was performed using purified water, and dried to form a powder, which was packaged to obtain three packages. (5 g per packet). Acetaminophen 900.0 mg dl-chlorpheniramine maleate 7.5 mg dihydrocodeine phosphate 24.0 mg dl-methylephedrine hydrochloride 60.0 mg caffeine anhydrous 75.0 mg ascorbic acid 500.0 mg sucrose 11938.5 mg aspartame 90.0 mg stevia 15.0mg Citric acid 750.0mg Povidone (K30) 600.0mg Light silicic anhydride 40.0mg

Test Example 1: (Test Materials) As the test materials, the formulation of Example 1 containing the starch (Sample A) and the formulation of Comparative Example 1 containing no starch (Sample B) were used. (Test method) Total of 3 healthy adult men and women in their 20s to 50s
A questionnaire survey regarding the feeling of taking was conducted with 0 panelists. In the questionnaire survey, a method in which a paneler dissolves sample A and sample B, one packet each in 100 mL of hot water, and takes them, and then responds to a questionnaire sheet was used. The evaluation items were seven items of comprehensive evaluation of sweetness, sourness, bitterness, aftertaste and taste, and evaluated on a seven-point scale of very good, good, relatively good, neither, relatively bad, bad, and very bad. The judgment was made. In addition, the panelists were asked to take the sample in a crossover without revealing the contents of the sample. (Test Results) The questionnaire results for each evaluation item of each panel were scored, and the average score of all panelists was obtained. Table 1 shows the results. FIG. 1 shows the result of graphing the average points. As is clear from Table 1 and FIG. 1, for all the evaluation items, the sample A containing the starch of Example 1 was the same as the sample B not containing the starch of Comparative Example 1.
The value was higher than that of the sample, and the evaluation was good. Among them, the evaluation of the body was excellent.

[0016]

[Table 1]

[0017]

According to the present invention, it is possible to improve the feeling of taking, such as the flavor, richness, and aftertaste, when the medicine is taken by dissolving in hot water or water at the time of taking by taking starch into the cold medicine at the time of use. Can be.

[Brief description of the drawings]

FIG. 1 is a graph showing the evaluation results regarding the feeling of taking a sample A of Example 1 and a sample B of Comparative Example 1.

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Shinji Ando 3-24-1, Takada, Toshima-ku, Tokyo Taisho Seiyaku Co., Ltd. F-term (reference) 4C076 AA30 BB01 CC04 DD29 DD38 DD43 DD59 DD60 DD69 EE16 EE38 EE41 FF06 FF15 4C084 AA17 MA52 NA04 NA09 NA10 ZA071 ZA072 ZA081 ZA082 4C206 AA01 GA31 KA01 MA02 MA05 MA72 NA04 NA09 NA10 ZA07 ZA08

Claims (5)

[Claims] (1) A pre-dissolution type medicine characterized by blending starch. 2. The pharmacologically soluble medicine according to claim 1, wherein the medicine is a cold medicine. 3. The pharmaceutical composition according to claim 1, wherein the starch is corn starch and / or potato starch. 4. The method according to claim 1, wherein the starch is blended in an amount of 0.0001 to 0.1 parts by weight with respect to 1 part by weight of hot water or water used for dissolution. The pharmacologically soluble drug according to the above. 5. A method for improving the feeling of taking a ready-to-dissolve drug, which comprises mixing starch.