JP2001261567A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation capable of providing sufficient moisture retention even by a small amount of components, and hardly causing problems such as cutaneous sensitization. SOLUTION: This skin care preparation contains an emu oil, or a combination of the emu oil with other functional components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. The present invention particularly relates to an external preparation for skin that can be applied to pharmaceuticals, quasi-drugs, cosmetics, and the like for humans and other animals.

[0002]

2. Description of the Related Art The skin plays an important role in protecting the body from various external stimuli. Moreover, the skin is naturally soft and not fragile. However, low humidity environment caused by recent changes in living environment, use of chemical products,
External factors such as air pollution and internal factors such as stress and aging often cause the skin to lose its moisturizing power. As a result, it is necessary to take care and care according to the condition of the skin (skin).

Heretofore, for the purpose of such treatment and care, development of various functional components such as humectants, emollients, cell activators, antioxidants and the like, and use of various skin external preparations using them have been made. ing.

[0004]

However, since the various functional components have independent functions, the number of compounds in the external preparation for skin is inevitably increased, which causes problems such as skin sensitization. ing. In addition, various oil components have been developed as emollients, and they have been applied to many pharmaceutical products.However, sufficient effects cannot be obtained by themselves, and eventually the number of ingredients is increasing. It is.

The present invention has been made in view of these problems of the prior art, and has been made to provide an external preparation for skin which can provide sufficient moisture retention with a small amount of components and does not cause problems such as skin sensitization. It is.

[0006]

Means for Solving the Problems As a result of intensive studies on the above problems, the present inventors have found that emu oil is a functional component excellent in functionality and safety, and based on this finding, The present invention has been completed.
That is, the present invention provides an external preparation for skin containing emu oil and an external preparation for skin containing emu oil and other functional components.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The emu oil used in the present invention is an animal oil obtained from an ostrich emu widely edible in the Australian region. Emu oil is generally obtained as it is from adipose tissue of emu, or purified and extracted by using an organic solvent in the same manner as a conventional method of collecting an animal oil. it can. In the case of extraction with an organic solvent, for example, an organic solvent such as methanol, ethanol, and glycols, water, a mixture of water and an organic solvent, and the like can be freely selected as the extraction solvent. Also,
The purification method is not particularly limited, and a conventionally known method including a filtration operation and a fractionation operation can be employed.

[0008] The emu oil thus obtained has a lighter touch to the skin and is more excellent in skin conditioning action than oils derived from other animals. Due to this effect, when skin external preparations containing it are applied to the skin, various factors such as low humidity environment, use of chemical products, air pollution, stress and aging impair the skin's inherent moisturizing power. The abnormal condition is improved and the skin can be brought to a healthy state and maintained.

The external preparation for skin of the present invention contains various functional ingredients having dermatological activity, which are used as conventionally known moisturizers, emollients, cell activators, antioxidants and the like. can do. These functional components are not particularly limited. For example, emollient components such as squalane, macadamia nut oil, jojoba oil, moisturizing components such as glycerin, butylene glycol, urea, amino acids, vitamin Es, and pepper. Peripheral vasodilator components such as tincture, refreshing components such as menthol and camphor, antibacterial components such as hinokitiol and benzalkonium chloride, anti-inflammatory components such as glycyrrhizin and allantoin, whitening components such as ascorbic acid, arbutin and kojic acid, dibutylhydroxytoluene (BHT),
Antioxidant components such as butylhydroxyanisole (BHA), tocopherol acetate, and ascorbic acid; cell activating components such as nucleic acids; and superoxide dismutase (S
OD) and the like, extractables derived from animals and plants or microorganisms, such as a gougon extract, an aloe extract, a ginkgo extract, a placenta extract, and a lactic acid bacteria culture extract, are preferably used.

The external preparation for skin of the present invention is prepared by mixing the above-mentioned emu oil in a known dosage form which is acceptable for skin application, and the amount of the external preparation is usually based on the whole external preparation for skin. It may be 0.01 to 100.0% by weight, preferably about 0.1 to 20.0% by weight. Emu oil content of 0.01% by weight based on the total amount of skin external preparation
If less, the effect may not be sufficiently expected.

The dosage form of the external preparation for skin of the present invention is not particularly limited, and examples thereof include external preparations such as pastes, creams, ointments, lotions, emulsions, packs, powders, and poultices. Further, in addition to the above-mentioned functional components, the skin external preparation of the present invention further comprises a surfactant, base components such as oils and fats, and if necessary, a known thickener, a preservative, an antioxidant, and an ultraviolet ray. Various additives such as an absorbent and a chelating agent can be used in combination.

There is no particular limitation on the surfactant, and general nonionic surfactants, anionic surfactants, cationic surfactants and amphoteric surfactants can be used. For example, non-alkylene oxide adducts such as alkylene oxide adducts of higher alkyl amines, alkylene oxide adducts of higher fatty acid amides, sucrose monofatty acid esters, alkylene oxide adducts of hydrogenated castor oil, polyethylene glycol sorbitan alkyl esters, and sterols. Anionic surfactants, anionic surfactants such as alkyl sulfates, alkylloylmethyl taurine salts, α-olefin sulfonates, polyoxyalkylene alkyl ether sulfates, and cationic surfactants such as alkylpyridinium chloride and distearyldimethylammonium chloride And amphoteric surfactants such as sodium alkylaminopropionate and alkylpolyaminoethylglycine. These can be used alone or in combination of two or more.

The base component is not particularly limited, and generally known fats and oils can be used. For example,
Olive oil, camellia oil, jojoba oil, avocado oil, macadamia nut oil, squalane, squalene, horse oil and the like. The thickener is not particularly limited, for example,
Polyvinyl alcohol, polyacrylamide, polyethylene glycol, and various derivatives thereof, celluloses or derivatives thereof such as hydroxyalkyl cellulose, dextran, gelatin, gums such as gum arabic, gum tragacanth, and water-soluble polymers such as carboxyvinyl polymers. Can be

The preservative is not particularly restricted but includes, for example, parahydroxybenzoate, alkylpyridinium chloride, benzalkonium chloride, hinokitiol and the like. The ultraviolet absorber is not particularly limited, and examples thereof include para-aminobenzoic acid, benzophenone-based compounds, and benzotriazole-based compounds.

The chelating agent is not particularly limited, and includes, for example, ethylenediaminetetraacetic acid, phytic acid, citric acid, and water-soluble salts thereof.

[0016]

EXAMPLES The present invention will be further described below with reference to examples, but the present invention is not limited to these examples. Skin external preparations containing the emu oil of the present invention were prepared according to the procedures of Examples 1 to 6 by using the formulations shown in Table 1. Similarly, skin external preparations of Comparative Examples 1 and 2 containing no emu oil were prepared. The numerical values in the table represent parts by weight, and the whole was made up to 100 parts by weight with the remaining water.

[0017]

[Table 1]

Example 1 Emu oil is stirred at 70 to 80 ° C. to obtain a uniform preparation. Example 2 (a) Emu oil, polyoxyethylene (10 mol) hydrogenated castor oil and polyoxyethylene (20 mol)
Homogenize the sorbitan monooleate at 70-80 ° C.

(B) In a separate vessel, homogenize methylparaben, carboxyvinyl polymer and water at 70-80 ° C.
While stirring (a), (b) is gradually added to make a uniform preparation. Example 3 (a) Emu oil, polyoxyethylene (10 mol) hardened castor oil and polyoxyethylene (20 mol)
Homogenize the sorbitan monooleate at 70-80 ° C.

(B) In a separate container, urea, methyl paraben, carboxyvinyl polymer and water are homogenized at 70 to 80 ° C. While stirring (a), (b) is gradually added to make a uniform preparation. Example 4 (a) Emu oil, squalane, polyoxyethylene (10 mol) hydrogenated castor oil and polyoxyethylene (20 mol) sorbitan monooleate are homogenized at 70 to 80 ° C.

(B) In a separate vessel, homogenize methylparaben, carboxyvinyl polymer and water at 70-80 ° C.
While stirring (a), (b) is gradually added to make a uniform preparation. Example 5 (a) Emu oil, squalane, polyoxyethylene (10 mol) hydrogenated castor oil, polyoxyethylene (2
0 mol) Sorbitan monooleate and tocopherol acetate are homogenized at 70-80 ° C.

(B) In a separate container, add allantoin, methylparaben, carboxyvinyl polymer and water at 70 to 80 ° C.
And make it uniform. While stirring (a), (b) is gradually added to make a uniform preparation. Example 6 (a) Emu oil, squalane, polyoxyethylene (10 mol) hydrogenated castor oil, polyoxyethylene (2
0 mol) Sorbitan monooleate and tocopherol acetate are homogenized at 70-80 ° C.

(B) In a separate container, urea, allantoin, methylparaben, carboxyvinyl polymer and water
Make uniform at 80 ° C. While stirring (a), (b) is gradually added to make a uniform preparation. Comparative Example 1 (a) Polyoxyethylene (10 mol) hydrogenated castor oil,
The polyoxyethylene (20 mol) sorbitan monooleate and urea are homogenized at 70-80 ° C.

(B) In a separate container, homogenize methylparaben, carboxyvinyl polymer and water at 70 to 80 ° C.
While stirring (a), (b) is gradually added to make a uniform preparation. Comparative Example 2 (a) Olive oil, polyoxyethylene (10 mol) hardened castor oil, polyoxyethylene (20 mol) sorbitan monooleate and urea were homogenized at 70 to 80 ° C.

(B) In a separate vessel, homogenize methylparaben, carboxyvinyl polymer and water at 70-80 ° C.
While stirring (a), (b) is gradually added to make a uniform preparation. Use effect test A use effect test was performed using the skin external preparations of Examples 1 to 6 and the skin external preparations of Comparative Examples 1 and 2. The study was conducted on 20 healthy women, with three samples for each sample.
It was applied to hands and arms for days, morning, noon and before bedtime. The judgment is
Each item was determined according to the following criteria.

Table 2 shows the results. The numbers in the table represent the number of people.

[0027]

[Table 2]

As a result, the skin external preparations of Examples 1 to 6
It can be seen that, compared to the skin external preparations of Comparative Examples 1 and 2, a very light tactile sensation was given and the feel was also refreshing.
In addition, it can be seen that the skin external preparations of Examples 1 to 6 are excellent in skin conditioning effect, and the effect is enhanced by using emu oil and a functional component in combination.

[0029]

The external preparation for skin of the present invention has excellent tactile sensation, feeling of use, and skin conditioning effect. Therefore, the skin external preparation is affected by various factors such as low humidity environment, use of chemical products, air pollution, stress and aging. Is effective in improving abnormal skin conditions, in which the moisturizing power of the skin is impaired, and has the effect of leading and maintaining the skin in a healthy state.

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Claims (3)

[Claims] 1. An external preparation for skin containing emu oil. 2. The external preparation for skin according to claim 1, comprising emu oil and other functional ingredients. 3. The method according to claim 1, wherein the other functional component is an emollient component,
At least one selected from the group consisting of a moisturizing component, a peripheral vasodilator component, a cooling component, an antibacterial component, an anti-inflammatory component, a whitening component, an antioxidant component, a cell activating component, a peroxide suppressing component, and an extract derived from animals, plants and microorganisms. The external preparation for skin according to claim 1 or 2, which is: