JP2001245629A - Material for medicament or health food and method for producing the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a material for medicaments or health foods capable of effectively exerting active oxygen scavenging ability, immunopotentiative action and antiallergic action as biological activities, and to provide a method for producing the material. SOLUTION: This material for medicaments or health foods comprises a solvent extract from a plant belonging to the genus Compositae/Baccharis: wherein the plant is desirable to be Baccharis dracuncurifolia, and its new leaves of buds are more desirable to be used; a caffeic acid, coumaric acid, cinnamic acid, chlorogenic acid and derivative thereof are desirable to be contained; in addition, flavonoids or terpenoids are more desirable to be contained. This material for medicaments or health foods comprising the solvent extract from the above plant is produced by extraction from the plant using water and/or ethanol, or suppercritical carbon dioxide as solvent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pharmaceutical or health food material comprising a plant extract having a useful physiological activity and a method for producing the same.

[0002]

2. Description of the Related Art Plants have been actively studied because they contain many useful components. In particular, pharmacological actions and applications of many plant components have been studied.

[0003] In recent years, diseases such as cancer, AIDS and allergies have been increasing, and a method of treating these diseases is a major problem. All of these diseases are related to immunity, which is a natural defense mechanism of animals, and are caused by reduced or abnormal immune function. Among these diseases, cancer is of great interest to people. Cancer is considered to be caused by reduced immune function.

[0004] Therefore, there is an increasing expectation for substances that enhance immune function, particularly plant components that are natural products. In recent years, the relationship between aging and active oxygen, and the relationship between allergy and active oxygen have been elucidated, and there have been reports that active oxygen promotes aging and allergy, and it is thought that removing active oxygen can improve and maintain health. Have been. Since many components for removing active oxygen are contained in plants, their effects are expected for plant components.

[0005] For this reason, as mentioned above, the pharmacological action of its components has been studied in many plants.

[0006]

However, among many plants, there are reports suggesting that antibacterial and antibacterial activities of the components of the plant belonging to the genus Baccharis and the use of this effect have been suggested. No mention is made of effects, in particular immunostimulation, antiallergy and elimination of active oxygen. In particular, Baccharis dracunculiforia reports antibacterial activity in its report, but does not describe its application and use, especially its physiological activity when taken. Baccharis dracunculifo
For ria, exudates have been reported, but no usefulness for extracts with solvents has been reported.

[0007] Also, in the thinking of Western medicine so far,
A single component has been extracted and separated from plants, and research has been focused on only the pharmacological action of the single component. However, in recent years, there is a problem of side effects, and there is a tendency to use the whole herb like a herbal medicine in oriental medicine. The use of whole plants and all components in extracts has not been reported in the aforementioned report.

The present invention has been made by paying attention to the problems existing in the prior art as described above. It is an object of the present invention to provide a drug or health food material capable of effectively exhibiting, as physiological activities, active oxygen removing ability, immunostimulatory action and antiallergic action, and a method for producing the same.

[0009]

In order to achieve the above object, the material for pharmaceuticals or health foods according to the first aspect of the present invention comprises a solvent extract of a plant belonging to the genus Baccharis of the family Asteraceae.

[0010] In a second aspect of the present invention, the plant according to the first aspect is characterized in that the plant is Baccaris dracunculifolia (Bacci).
haris dracuncurifolia).

[0011] In a third aspect of the present invention, there is provided a material for pharmaceuticals or health food according to the first or second aspect, wherein the plant is a part of a bud or a new leaf. The material for pharmaceuticals or health foods of the invention according to claim 4 contains at least one of caffeic acid, coumaric acid, cinnamic acid and chlorogenic acid in the invention according to any one of claims 1 to 3. It is characterized by the following.

According to a fifth aspect of the present invention, there is provided a pharmaceutical or health food material according to any one of the first to fourth aspects, wherein the material contains flavonoids.

According to a sixth aspect of the present invention, there is provided a pharmaceutical or health food material according to any one of the first to fifth aspects, further comprising a terpenoid.

According to a seventh aspect of the present invention, there is provided a method for producing a material for pharmaceuticals or health foods, comprising extracting a plant of the genus Baccharis of Asteraceae with at least one solvent selected from water and ethanol to obtain a solvent extract thereof. It is characterized by the following.

[0015] The method for producing a pharmaceutical or health food material of the invention according to claim 8 is characterized in that a solvent extract is obtained by extracting a plant of the genus Baccharis of the Compositae family with supercritical carbon dioxide. Is what you do.

[0016]

Embodiments of the present invention will be described below in detail. The pharmaceutical or health food material comprises a solvent extract obtained by extracting a plant of the genus Bactari in the Asteraceae family with a solvent. Asteraceae Baccharis is a plant commonly found in South America. Among the genus Baccharis in the Asteraceae family, those that grow in South America are preferable, and Baccharis druculifolia (Baccharis dr.)
acuncurifolia) is more preferred. Active oxygen removal from extracts containing caffeic acid (3,4-dioxycinnamic acid), coumaric acid (oxycinnamic acid), cinnamic acid, chlorogenic acid and their derivatives, flavonoids and terpenoids of the buds or new leaves It has physiological activities such as potency, antiallergic action, and immunostimulatory action, and has few side effects on the living body. Since the aromatic organic acids are significantly increased by the treatment of hydrolyzing the extract, it is presumed that these aromatic organic acids are also contained in the form of derivatives.
In the present invention, the flavonoid is a generic term for plant components having a peak in the same region as the peak retention time (retention time) of the flavonoid compound on the high performance liquid chromatogram of the extract component, and includes the flavonoid compound and its structure and chromatography. Organic compounds having similar behaviors are also included. The plant body may be used for food as it is, or it may be boiled like tea and consumed.
Uses an extract extracted with a suitable solvent such as water or ethanol because it contains impurities and garbage, and is difficult to use as it is as a form of pharmaceuticals such as drinks and tablets and health foods. Is preferred.

Next, a method for producing a pharmaceutical or health food material comprising a solvent extract of a plant will be described. The plant is desirably crushed to increase its surface area in order to increase the extraction efficiency. It is also desirable to dry the active ingredient in order to concentrate it. Subsequently, at least one solvent of water and ethanol is added to the plant, immersed, and stirred or left. Here, ethanol refers to ethanol having an ethanol content of 95% by weight or more. Since the components to be extracted differ depending on the ratio of water and ethanol used, the ratio is changed according to the target extracted component. That is, if it is desired to include a large amount of caffeic acid, coumaric acid, cinnamic acid, chlorogenic acid and their derivatives, only water or the ratio of water is increased, and if it is desired to include a large amount of flavonoids, the blending amount of ethanol is More. If the amount of water is increased, the solvent extract is often hydrophilic,
Easy to handle and drink. Further, since the ethanol content is small, it is easy to use when used as it is. When the ethanol content is increased, the extraction of the active ingredient becomes easier. Extraction conditions such as immersion temperature and time are arbitrarily set according to the desired concentration of the solvent extract. By filtering the plant after immersion, a pharmaceutical or health food material comprising a solvent extract of the plant can be obtained. Further, this material may be concentrated if necessary, or may be made into a dry powder using an appropriate excipient.
In addition, in addition to extraction with water and ethanol, when it is desired to further increase the above-mentioned physiological activity containing a large amount of terpenoids, extraction with a hydrophobic organic solvent or carbon dioxide in a supercritical state can be carried out to extract the solvent of the plant body. A pharmaceutical or health food material comprising the extract is obtained. As the solvent, a hydrophobic organic solvent such as n-hexane may be used.However, when a material composed of a solvent extract is used for a drug or a health food, the remaining hydrophobic organic solvent becomes a problem. It is desirable to obtain a material consisting of a solvent extract of a plant by extracting with carbon dioxide. Here, carbon dioxide in a supercritical state is
It refers to carbon dioxide that has exceeded the critical temperature and critical pressure of carbon dioxide, and has intermediate physical properties between gas and liquid. When extracted with carbon dioxide in a supercritical state, a solvent extract having a higher hydrophobicity than a plant body is obtained, and particularly contains a large amount of terpenoids. A drug or health food material comprising a solvent extract of a plant obtained by extraction with carbon dioxide in a supercritical state may be used as it is, or may be used after emulsified and dispersed in water. . Alternatively, it may be dried with an appropriate excipient and used as a powder. Pharmaceutical or health food materials comprising the solvent extract of the plant obtained in this manner include various components contained in the extract extracted from the plant with the extraction solvent, for example, caffeic acid, coumaric acid, silica Based on components such as cinnamate, chlorogenic acid and their derivatives, flavonoids and terpenoids, immunostimulatory activity, active oxygen removal ability and antiallergic activity can be significantly exhibited. Therefore, it is useful as a material to be used as a medicine, health food, or the like.

The effects exerted by the above embodiment will be described below. According to the pharmaceutical or health food material described in the embodiment, based on the function of the solvent extract from a plant of the genus Bactari in the Asteraceae family, the active oxygen removal ability as a biological activity, immunostimulatory action and antiallergic action. It can be used effectively.

Also, among the plants belonging to the genus Baccharis of the Compositae family, Baccharis
Since dracuncurifolia) has a high content of the active ingredient, it can more reliably obtain an active oxygen removing ability, an immunostimulatory action and an antiallergic action.

Further, since the content of the active ingredient is high in the buds or new leaves of the plant, the ability to remove active oxygen,
An immunostimulatory action and an anti-allergic action can be obtained more reliably.

The extraction of only water or a large proportion of water as a solvent makes it possible to increase the content of caffeic acid, coumaric acid, cinnamic acid, chlorogenic acid and derivatives thereof, There is little irritation at the time and the water solubility is high, so that the handling becomes easy.

By increasing the amount of ethanol as a solvent for extraction, the content of flavonoids can be increased, and a smaller amount of solvent extract can remove active oxygen, immunostimulatory action and anti-allergy. Action can be obtained.

By extracting with carbon dioxide in a supercritical state, a solvent extract containing a large amount of terpenoids can be obtained, and a smaller amount of the solvent extract can remove active oxygen, immunostimulatory action and antiallergic action. Can be obtained.

The active ingredient can be more efficiently extracted by a simple method of performing extraction using at least one solvent of water and ethanol, or performing extraction using carbon dioxide in a supercritical state. In addition, a desired drug or health food material can be obtained at low cost.

[0025]

The above embodiment will be described more specifically with reference to examples and test examples. (Example 1) New leaves with buds of Baccharis dracuncurifolia were dried and then powdered using a small crusher. To 50 g of this powder was added 450 ml of ethanol and 50 ml of water.
After the mixture was left to stand at room temperature for 24 hours, the mixture was subjected to gravity filtration using a filter paper for chemistry (5c), and the obtained filtrate was dried under reduced pressure to obtain 22 g of a resinous dry solid. The obtained dry solid was soluble in ethanol, but was poorly soluble in water, and only a part thereof (3% by weight or less of the dry solid) was soluble.

After 1 g of the dried solid was dissolved in ethanol to make the total amount 10 ml, a part thereof was used as a sample to measure an ultraviolet absorption spectrum and subjected to high performance liquid chromatography. The results are shown in FIG. 1 (ultraviolet absorption spectrum) and FIG. 2 (high-performance liquid chromatogram).

According to the ultraviolet absorption spectrum of FIG.
UV absorption in the range from 60 nm to about 400 nm,
It has two broad peaks at 328 nm and 301 nm, indicating that the sample solution contains many compounds.

In addition, the high performance liquid chromatogram of FIG. 2 also showed a number of peaks representing a number of compounds.
These peaks confirmed the presence of aromatic organic acids such as flavonoids, cinnamic acid, chlorogenic acid, coumaric acid, and caffeic acid by matching the retention time (retention time) with the standard substance. Further, in an analytical method in which aluminum nitrate is added to form a chelate color and the absorbance at 415 nm is measured, the amount of the organic compound having chelating ability in the above sample is converted to the amount of quercetin as a standard substance.
It was measured at a concentration of 40% (w / v). This analytical method is a quantitative method applied to the determination of flavonoids, and is an effective analytical method for comparing the amounts of compounds having a plurality of hydroxyl groups that form a color by chelating with aluminum. (Example 2) Baccharis dracuncurifolia budded new leaves and adult leaves (about 10 kg) were dried and then pulverized using a pulverizer to obtain 955 g of powder. After adding 400 ml of ethanol and 10 ml of water to 100 g of the powder and leaving the mixture at room temperature for 24 hours, the mixture is suction-filtered using a filter paper for chemistry (5c), and the obtained filtrate is dried at 50 ° C. under reduced pressure to obtain a resinous dry solid. 36 g of the product were obtained. The obtained dry solid was soluble in ethanol, but was poorly soluble in water and only a part thereof (5% by weight or less of the dry solid) was soluble.

After 1 g of the dried solid was dissolved in ethanol to make the total amount 10 ml, a part of the dried solid was used as a sample to measure an ultraviolet absorption spectrum and subjected to high performance liquid chromatography. The results are shown in FIG. 3 (ultraviolet absorption spectrum) and FIG. 4 (high-performance liquid chromatogram).

According to the ultraviolet absorption spectrum of FIG.
UV absorption in the range from 60 nm to about 450 nm,
It has two broad peaks at 328 nm and 300.5 nm, indicating that the sample solution contains many compounds.

Also, the high performance liquid chromatogram of FIG. 4 showed many peaks representing many compounds.
The presence of aromatic organic acids such as flavonoids, cinnamic acid, coumaric acid, caffeic acid, and chlorogenic acid was confirmed by the coincidence of the retention time with the standard substance among those peaks. Further, in an analytical method in which aluminum nitrate is added to form a chelate color and absorbance at 415 nm is measured, the amount of the organic compound having chelating ability in the sample is 0.38% (w) in terms of the amount of quercetin as a standard substance.
/ V). (Example 3) Baccharis dracuncuri obtained in Example 2
5000 ml of water was added to 250 g of folia whole leaf dry powder, and the mixture was stirred at 50 ° C. for 48 hours, and then 3800 ml of a filtrate was obtained by suction filtration. The obtained filtrate was dried under reduced pressure to obtain 30 g of a dry solid.

The obtained dry solid was soluble in 80% ethanol, but was hardly soluble in ethanol. One gram of the dried solid was dissolved in water to make the total amount 10 ml, and a portion of the sample was subjected to high performance liquid chromatography as a sample.
The results are shown in FIG. 5 (high-performance liquid chromatogram).
As a result, the presence of aromatic organic acids such as coumaric acid, cinnamic acid, caffeic acid, and chlorogenic acid was mainly confirmed. (Example 4) New leaves with buds of Baccharis articulata were dried and then powdered using a small crusher. To 100 g of this powder, 450 ml of ethanol and 50 ml of water
And left at room temperature for 24 hours.
Natural filtration was performed using c), and the obtained filtrate was dried under reduced pressure to obtain 40 g of a resinous dry solid. This dry solid was soluble in ethanol, but was poorly soluble in water, and only a part thereof (5% by weight or less of the dry solid) was soluble.

One gram of the obtained dried solid was dissolved in ethanol to make a total volume of 10 ml, and a part thereof was used as a sample to measure an ultraviolet absorption spectrum and subjected to high performance liquid chromatography. The results are shown in FIG. 6 (ultraviolet absorption spectrum) and FIG. 7 (high-performance liquid chromatogram).

According to the ultraviolet absorption spectrum of FIG.
UV absorption in the range of 50 nm to about 400 nm,
It had one broad peak at 311.5 nm. The high performance liquid chromatogram of FIG. 7 also shows a number of peaks representing a number of compounds, and among these peaks, several flavonoids, chlorogenic acid, coumaric acid, and cinnamon were identified due to coincidence of the retention time with the standard substance. The presence of aromatic organic acids such as acid and caffeic acid was confirmed.

Further, in an analytical method of measuring the absorbance at 415 nm by adding aluminum nitrate to form a chelate color and measuring the absorbance at 415 nm, the amount of the organic compound having chelating ability in the sample is 0.1% in terms of the amount of quercetin as a standard substance.
It was measured at a concentration of 5% (w / v). (Example 5) New leaves with buds of Baccharis dracuncurifolia were dried and then powdered using a small crusher. 500 g of this powder was extracted with a supercritical carbon dioxide extractor under the conditions of an extraction temperature of 35 ° C., an extraction pressure of 85 kg / cm ² , and a separation pressure of 50 kg / cm ² to obtain 5 g of a yellow-green waxy substance.

The resulting solvent extract was sparingly soluble in polar solvents such as water and ethanol, but was readily soluble in nonpolar solvents such as hexane. This solvent extract was confirmed by liquid chromatography to be rich in diterpenes and triterpenes. In addition, flavonoids were also confirmed, but were not clear peaks due to a small amount. (Test Example 1) A sample prepared by dissolving 1 g of the dried solid matter of Examples 1 to 4 in ethanol to make the total amount 10 ml was examined for its ability to remove active oxygen by the following DPPH radical scavenging activity measurement method. The DPPH radical scavenging activity measurement method was as follows: 0.5 ml of a 60 μM MDPPH ethanol solution and a dilution ratio of 1000
The absorbance at a wavelength of 520 nm was measured for a mixture of 0.5 ml of the sample solution at several dilution ratios determined between 1 and 20000 times, and the IC50 was calculated. Here, the IC50 is a concentration at which 50% of DPPH radicals are eliminated. The value of IC50 was taken as the active oxygen removing ability.
Table 1 shows the results.

[0037]

[Table 1] As shown in Table 1, the active oxygen scavenging ability was confirmed for all of Examples 1 to 4.

(Test Example 2) To examine the immunostimulating activity of a health food or pharmaceutical material comprising a solvent extract of the plant obtained in Examples 1 to 5, as described below, Hand et al. According to the method, the effect of increasing the ratio of lymphocytes to polymorphonuclear leukocytes (L / P activity) was measured.

Sw within 6 to 12 hours after birth, when immature is immature
Litters of iss-Webster mice were divided into two groups, one of which was a physiological saline suspension (2
0 μg / 0.02 ml / mouse) was administered intraperitoneally. The other side contains physiological saline (0.02 ml / mouse)
e) was intraperitoneally administered as a control group. Before administration,
On days 6, 10, and 14 after administration, blood was collected from the tail vein, a thin blood smear was prepared, and the number of lymphocytes and polymorphonuclear leukocytes was determined to be 1
L / P ratio was determined by counting 00 pieces.

The results are shown in Table 2. Determination of efficacy,
A case in which a significance level was 5% or less by the t-test was considered to be valid. In addition, a) in the table indicates that the significant difference with respect to the control is 1% or less, and b) indicates that the significant difference with respect to the control is 5% or less.

[0041]

[Table 2] As shown in Table 2, in each of the administration groups of Examples 1 to 5, significant enhancement of L / P activity was observed from the sixth day or the tenth day. From this, it was found that the samples of Examples 1 to 5 had an immunostimulating effect. Example 5 had the highest activity. (Test Example 3) With respect to the antiallergic effect of the product of the present invention, a hyaluronidase activity inhibitory effect was measured as an index indicating the effect according to the test method described below.

As a sample, a dry powder of a health food or pharmaceutical material comprising a solvent extract of the plant of Examples 1 to 5 was dispersed or dissolved in water, and then dispersed in a 0.1 M acetate buffer (pH
3.5) to prepare four types of sample solutions having different concentrations. 390 units of hyaluronidase (derived from bovine testes, type IV-S, manufactured by Sigma) was added to these four types of aqueous solutions to prepare reaction solutions. The final concentration of the sample in the reaction solution was 0.1, 0.3, 1.0 mg /
ml. Further, a reaction solution to which these dry powders were not added was prepared in the same manner as above, and was used as a control.

In order to sufficiently inhibit the hyaluronidase activity by these samples, the above five reaction solutions were heated at 37 ° C.
For 20 minutes. Thereafter, a concentrated solution of the compound 48/80 (formaldehyde condensate of N-methyl-p-methoxyphenethylamine manufactured by Sigma), which is an activator of hyaluronidase, was added to a final concentration of 0.1 mg.
/ Ml and further incubated at 37 ° C for 20 minutes to activate hyaluronidase. To this pre-incubated solution, a concentrated solution of potassium hyaluronate derived from human umbilicus (manufactured by Wako Pure Chemical Industries, Ltd.) as a substrate was added to a final concentration of 0.6 mg / ml.
The enzyme reaction was performed by incubating for 0 minutes.

Thereafter, the N-acetylglucosamine released by the decomposition of the substrate was colored by an improved method of Morgan-Elson, and 585 n was measured using a spectrophotometer.
m was measured. From this measurement result, the hyaluronidase inhibitory activity rate (%) in the sample solution was calculated according to the following formula.

Inhibition rate (%) = [(absorbance of control−absorbance of sample) / absorbance of control] × 100 The results are shown in Table 3. In addition, the result which did not obtain an accurate numerical value in the measurement of the inhibition rate was not entered.

[0046]

[Table 3] As shown in Table 3, the health food or pharmaceutical material comprising the solvent extract of the plant of Examples 1 to 5 was confirmed to inhibit the hyaluronidase activity, and thus was confirmed to have an antiallergic effect.

The technical idea grasped from the embodiment will be described below. The drug or health food material according to any one of claims 1 to 6, wherein the solvent extract is extracted using at least one of water and ethanol or carbon dioxide in a supercritical state as a solvent. . According to this configuration,
An extract that is easy to handle and suitable as a material for pharmaceuticals or health foods can be obtained.

The method according to claim 7, wherein the plant is dried and pulverized. According to this method, the active ingredient can be concentrated, and the surface area of the powder particles can be increased, so that the effective ingredient can be extracted more efficiently.

[0049]

As described above, according to the present invention, the following effects can be obtained. According to the material for pharmaceuticals or health foods of the invention according to claim 1, based on the function of a solvent extract from a plant of the genus Bactari in the family Asteraceae, the ability to remove active oxygen as a physiological activity, an immunostimulatory effect and an antiallergic effect. Can be effectively exhibited.

According to the material for pharmaceuticals or health foods of the second aspect of the present invention, Baccharis dracuncurifolia has a high active ingredient content, and the effect of the first aspect of the present invention can be more reliably achieved. Obtainable.

According to the third aspect of the present invention, the content of the active ingredient is high in the buds or new leaves of the plant, so that the content of the active ingredient is high. The effects of the invention can be more reliably obtained.

According to the pharmaceutical or health food material of the invention described in claim 4, in addition to the effects of any one of claims 1 to 3, there is little irritation during drinking and water solubility is low. It is easy to handle because it is expensive.

According to the pharmaceutical or health food material of the invention described in claim 5, the effects of any of claims 1 to 4 can be obtained with a smaller amount of solvent extract. According to the material for pharmaceuticals or health food of the invention described in claim 6, the effect of any one of claims 1 to 5 can be surely obtained in a smaller amount.

According to the method for producing a drug or health food material according to claim 7, the desired material can be obtained by a simple method of extracting with at least one solvent of water and ethanol. .

According to the method for producing a pharmaceutical or health food material according to claim 8, the desired material can be obtained by a simple method of performing extraction using carbon dioxide in a supercritical state. The active ingredient can be extracted more efficiently.

[Brief description of the drawings]

FIG. 1 is an ultraviolet absorption spectrum for Example 1.

FIG. 2 is a high performance liquid chromatogram for Example 1.

FIG. 3 is an ultraviolet absorption spectrum of Example 2.

FIG. 4 is a high performance liquid chromatogram for Example 2.

FIG. 5 is a high performance liquid chromatogram for Example 3.

FIG. 6 is an ultraviolet absorption spectrum of Example 4.

FIG. 7 is a high performance liquid chromatogram for Example 4.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 37/02 A61P 37/02 37/08 37/08 39/06 39/06 (72) Inventor Masaki Kawai 1-1-1, Kano-Sakurada-cho, Gifu-shi Api Co., Ltd. (72) Inventor Kazunori Yoshimura 1-1-1, Kano-Sakurada-cho, Gifu-shi Api Co., Ltd. F-term (reference) 4B018 MD61 ME06 ME07 MF01 MF06 MF07 4C086 AA01 AA02 BA08 MA01 MA02 MA03 MA04 MA52 NA14 ZB07 ZB13 ZC21 4C088 AB26 AC05 BA09 BA10 BA14 BA32 CA05 CA06 CA10 MA52 NA14 ZB07 ZB13 ZC21 4C206 AA01 AA02 BA01 BA03 CA17 CA19 DA21 DB11 MA01 MA02 MA03 MA04 MA72 NA14 ZB07 ZB13

Claims (8)

[Claims] 1. A pharmaceutical or health food material comprising a solvent extract of a plant of the genus Baccharis of the family Asteraceae. 2. The pharmaceutical or health food material according to claim 1, wherein the plant is Baccharis dracuncurifolia. 3. The pharmaceutical or health food material according to claim 1, wherein the plant is a bud or a new leaf portion thereof. 4. The pharmaceutical or health food material according to claim 1, further comprising at least one of caffeic acid, coumaric acid, cinnamic acid, and chlorogenic acid. 5. The pharmaceutical or health food material according to claim 1, further comprising flavonoids. 6. The pharmaceutical or health food material according to claim 1, further comprising a terpenoid. 7. The medicament or health according to claim 4 or 5, wherein a solvent extract is obtained by extracting a plant of the genus Baccharis of the Compositae family with at least one solvent selected from water and ethanol. Manufacturing method of food material. 8. The method for producing a drug or health food material according to claim 6, wherein a solvent extract is obtained by extracting carbon dioxide in a supercritical state from a plant of the genus Baccharis of the Compositae family.