JP2001243325A - Quality guaranteeing method for bio-product and distributing method for bio-information - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve a problem that there is no method for distributing or transmitting bio-product information corresponding to the update of information up to this time although it is estimated that the information is to be frequently updated because of the progress of a genome research and a user uses a bio- product on the basis of non-updated information sometimes although the information is updated. SOLUTION: The product code of the bio-product, information on the bio- product or bio-information on a product user is recorded and held by an information center or acquired from a database as needed and information on the bio-product including the quality guarantee of the bio-product is provided. Thus the information is processed and distributed to a terminal by the information center so that the bio-product user can efficiently and easily acquire the updated information.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a method of providing product information of a bioproduct and information on quality assurance of the bioproduct to a user of the bioproduct.

[0002]

2. Description of the Related Art Conventionally, when a bioproduct including a pharmaceutical product or a reagent is provided to a user, product information and quality assurance information attached in the form of paper or a recording medium have been produced. It was information at the time. That is, for example, when designing, producing and providing a drug that is expected to be effective in patients with a specific disease at a certain point in time, information on the effects and side effects brought by the drug is -Information at the time of production was otherwise current at the time the drug was provided to the user.

[0003]

In an environment where biological information represented by, for example, genomic information and information on biological substances such as proteins (biological information) are increasing rapidly, Biological information (including biological information and biological information) has been added or changed, and existing information has been updated. When providing a user with a bio product designed and produced based on the bio-related information, not only the completed bio product but also the bio-related information referred at the time of designing is provided. However, at present, the information is provided at the time of reference as the base biological information, and the purchaser who has obtained the bioproduct and the information could not know the new information that was elucidated thereafter.

[0004] For example, in the case of a drug, even if the drug is designed using the latest information as much as possible at the time of development, as the subsequent research progresses, the drug is effective in other diseases. This is because it may become apparent that the effect cannot be expected for a patient of a specific constitution.

[0005] Therefore, an object of the present invention is to provide a bio-related information which is added to or changed over time even after the bio-product is provided as information provided to the user together with the bio-related product, and the effect and the efficacy are provided. To provide users with the latest information on bio-products, such as safety. In addition to providing the latest information when information is updated, it also informs the extent of the safety of the bioproduct that has been confirmed in light of past research standards and past information. We must provide a means of tightening. In an environment where information is updated every moment, such as when designing, producing, providing, or using a bioproduct, a means to know the degree of quality assurance of the bioproduct or a bioproduct at any stage It is necessary to provide information that serves as an index to evaluate as a user.

[0006] An object of the present invention is to realize a means for providing information on bioproducts and information on quality assurance as described above.

[0007] In addition to the bioproduct provider,
It is necessary for users to obtain various information on bioproducts. Nowadays, large-scale research projects such as the genome analysis project are underway, and the base sequence information of DNA from various species including humans is constantly increasing in large quantities, and the base sequence information of DNA is being decoded. Stored in the database. As a result, research based on nucleotide sequence information, such as genomic science and molecular biology, has also progressed, and various biological-related information, including information on genes, information on proteins, and information on single nucleotide polymorphisms, has increased. I will do it. The degree of the increase in the bio-related information is only increasing year by year. Not only information about bioproducts but also information about users, animals to be used, and objects to be used are updated.For example, if a person takes a medicine under certain conditions, Even if it was not known a few days ago that taking pills would cause side effects, a search of the database may now indicate that the likelihood of having side effects is increased. In particular, individual single nucleotide polymorphism SNP
When performing personalized medical treatment according to the individual's constitution, in other words, the prescribed medicine differs for each individual, and information such as safety, effect, efficacy, dosage conditions, safety etc. is individually managed Is required. It is another object of the present invention to provide a means and a method for acquiring information based on information about a user or a use object when the user uses the bioproduct.

[0008] More specifically, for example, when a primer is sold as a bioproduct, the primer is used in the same manner as before.
When only the sequence of the primer is provided to the user, the user can obtain information on the primer and exons (subsequences) amplified by the primer by himself / herself using a commercially available gene analysis tool or NCBI. Use tools published on the Web, such as site tools,
It was necessary to compare with various public databases such as Genbank and PubMed. In addition to using a single tool or database, if the information cannot be obtained with a single tool or database, such as "Search for homologous genes and search for literature information", the user Needed to find the right combination of tools and databases and tweak to achieve the connection between tools and database. Accordingly, it is an object of the present invention to provide an information distribution system that can easily access data related to primers originally recorded in different places in different formats and can easily distribute the data to a data requester. Of course, the information to be distributed may include not only information on primers but also information on SNIPs.

[0009]

In order to achieve the above-mentioned object, according to the present invention, a recording medium on which information references of bioproducts are recorded is mounted on a terminal, and the terminal reads out the information references,
The information about the bioproduct and the information about the user are acquired from the database as the information reference destination via the network.

A bio product package having a bio product and a recording medium on which the information reference destination of the bio product is recorded, a terminal for reading the information reference destination from the recording medium, an information center connected to the network and receiving access from the terminal, An information providing system for bioproducts having a database connected to a network.

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS As a first embodiment of the present invention, a method for providing information on a bio product and information on quality (including quality assurance) after providing the bio product to a consumer will be described. In addition, the bio-product here means medicines, reagents, various kinds of chemicals, biological substances, artificial skin,
It refers to various products including artificial organs, foods, genetically modified foods, pesticides, bacteria, microorganisms, vectors and primers. Some of these bioproducts are designed based on biological information or biological origin information, as represented by nucleotide sequence information of DNA or amino acid sequence information of protein. Biological information including biological information and biological origin information, in addition to the above information, information on heart beats such as heartbeat or pulse, blood pressure value information, information on organs including liver and kidney, Information on the response to brain waves and brain stimulation, information on urine components, information on the quantity and quality of blood components, information on chemical reactions with chemicals and precipitation reactions, information on opening and closing the pupil, information on skin color and sweating on the skin, light Information on the biological response to stimuli, acoustic stimuli, chemical stimuli, and psychological stimuli, information on the color and soreness of the mucous membranes of the throat and nose, information on cell tissues such as cell proliferation, cell death and cell alteration, in genetically modified foods Information on diagnostics and food, such as information on which gene was modified and how, and information on the safety of genetically modified foods. It refers to the concept, including the annotation of biological origin. Annotation means information that is useful for knowing the nature, quantity, state, or origin of a biological substance, including a biological or part of a living organism, biologically derived substance, or reactions and interactions between multiple types of biological substances. I do.

[0012] Or, in the case of a bioproduct produced from an organism or substance that originally existed in the natural world, or a bioproduct produced as an artificial substance but without using the above-mentioned information of biological origin. However, in some cases, the use effect of the product or the presence or absence and the degree of the use effect can be explained by referring to the biological information. For example, crude drugs such as herbal medicines are substances that exist in nature and are not artificially designed and generated based on information on human DNA. However, there are cases where it is possible to explain that there are individual differences in medicinal effects, such as the ineffectiveness of the herbal medicine when taking the herbal medicine, from the difference in the information on the DNA of the user.
In this sense, the bioproduct is generated based on the biological information, or the effect of using the bioproduct can be explained by referring to the biological information to be used or the biological information. Therefore, when a bioproduct is used, biological information or biological information related to the bioproduct is essential or useful.

[0013] In providing bioproducts, providing biological information, or information derived from biological information or providing information related to biological information is considered to become increasingly important in the future. Have been. Because DN
This is because, as the research on the decoding of the A base sequence information and the research on the gene progress, bioproducts are also generated in association with biological information and biological information obtained as a result of the research.

FIG. 5 shows a form of providing a primer product, which is a reagent used in a PCR amplification method, as an example of a bioproduct. The primer set 500 includes n containers 502 (1) to which a plurality of types of primers are provided on one plate 501.
It is a bio product put in 502 (n). A primer set is a bioproduct used for PCR amplification when performing a large-scale automated analysis of a gene, and is a form of providing primers suitable for mechanization processing. Since primers are reagents used to amplify DNA,
Must be indicated to the user as to whether it is a primer for amplification of That is, it is necessary to present information on the DNA to be amplified. Therefore, a recording medium provided with the primer set is required, and a paper surface 503 on which information is described, a recording medium 504 on which information is recorded, and a card on which an ID code used for collation of information is recorded or described.
505 etc. are provided with the primer set. That is, in the example of FIG. 5, the product is provided to the user in the form of a bioproduct package such as (1) primer set + recording medium and (2) primer set + ID code. Paper 503 with primer set and information
In the case of a combination package of, a method of describing an information reference destination such as a URL on the page 503 can be considered, but the information is provided only by the information on the page 503 without referring to other information other than the page description information It is extremely difficult.

In order for a user to obtain information using the recording medium 504 or the ID code 505, the user must use the recording medium 504 or the ID code 505.
The code 505 is input to the terminal 101a or the terminal 101b or the card reader / writer 102a or the card reader / writer 102b in FIG. Alternatively, the ID information described in the ID code 505 may be input to the terminal 101a or the terminal 101b. The terminal 101a reads out the reference destination of the information recorded on the recording medium 504, and
Network 106 or network 1 connected via
Access the database group 105 connected to 06 and make an inquiry. For example, when trying to obtain information on a primer for amplifying a disease-related gene, a biomedical database 107 that records information such as gene loci, expression, and mutation information on the disease-related gene, Clinical database 111 that records important information
The terminal refers to a medicine database 115 or the like in which information of medicines for treating a disease is recorded, and displays and outputs the information to the terminal 101a for use by the user. These pieces of information may be information held by the information center or information held by the database group 105 connected to the network 106. The terminal 101b is configured to access the database group 105 via the network 106 without passing through the information center 104. In this case, information necessary for making an inquiry to the database group is recorded in the recording medium 504 or the ID code 505. In addition, the recording medium 504 includes information processing software for integrating various information from the database group and providing useful information to the user at the terminal 101a or the terminal 101b regardless of whether or not the information passes through the information center 104. You may go out. Further, information transmitted from the database group 105 to the terminal 101a or the terminal 101b is a magnetic recording unit, a semiconductor recording unit, by a card reading and writing device 102a and a card reading and writing device 102b.
Recording may be performed on the card 103 including some recording means such as an optical recording means and a phase change recording means. Of course, the information obtained from the database group 105 is not limited to being recorded on the card 103, but may be recorded and stored in a recording means provided in the terminal 101a or the terminal 101b.

The database group 105 in FIG. 1 includes, for example, a biomedical database 107, a genome sequence database 108, a protein database 109, a signal transmission system database 110, a clinical database 111, an electronic medical record database 112, and a genome database of other species. 113, food database 114, drug database 115, family lineage database 116, family register database 117,
In practicing the present invention, the database is not limited to these. The database to be referred to is determined according to the characteristics of the bioproduct and the purpose of use of the product user.

When a user who holds a medicine, which is a bio product, wants to know the safety of the product, the following database can be used. First, to refer to the drug database 115 to know the components of the drug, the effect and treatment results of the drug on the patient, the occurrence of side effects,
An electronic medical record database 112 is referred to the clinical database 111 to know whether or not the medicine can be taken in combination with another medicine, and to see if the medicine is appropriate by referring to the medical history of the person who took the medicine.
, And refer to the individual pedigree database 116 to see if the drug is effective against familial genetic diseases, and to other databases if necessary. The information thus obtained is temporarily stored in the terminal 101a or the terminal 101b, and is provided for use by the user.

Each database in the database group 105 is usually managed by each database provider, such as updating and maintaining information, so that the latest information is provided when an inquiry access is received. It has become. Therefore, the user who has obtained the information from these databases can receive the information on the bio product and the quality assurance information of the bio product as the newest information at that time.

As described above, in the first embodiment, the paper 503, the information medium 504, or the ID code 505 is used together with the bio product.
To provide the destination information of the reference database recorded in the database, and the database group that is the reference database
The method of providing the latest bioproduct information to the user by the system in which the terminal 105 is connected to the terminal 101a or the terminal 101b via the network 106 and, if necessary, the information center is shown.

In addition to the method of updating information in response to a request from a user of a bio product, there is also a method of transmitting update information by automatically transmitting update information from an information manager to a user. is there. In the information center, a bio product code is stored in order to manage information on the bio product. Also, if necessary, storing information of a purchaser or a user of the bioproduct is useful in transmitting update information.

If the single nucleotide polymorphism SNPs are stored as the user information, the constitution of the user can be known, so that the information on the bioproduct can be notified more efficiently. The information center stores information related to bioproducts and checks whether this information has been updated.
If the database is referred to at intervals of time, the information center can obtain the latest information and manage the information. Then, if the updated information is delivered to the user of the bio product, the user can use the bio product by referring to the latest information. In addition to simply distributing the updated information as it is, more useful information can be distributed by combining it with other information. For example, if the user's single nucleotide polymorphism information is combined with the information on the active ingredient of the drug, it is estimated whether or not the drug exhibits effective drug efficacy in light of the user's single nucleotide polymorphism information. It is possible to do. In addition, by performing such information processing by the information center, the capacity of the storage unit can be reduced or the processing performance of the information processing unit can be reduced, so that the terminal device can have a simpler configuration. If the transmission of update information from the information center to the terminal device is made wireless,
It is also possible to reduce the thickness or size of a chip or a film having a wireless reception function provided with a display means.

In addition, by managing the information on the bioproduct by the information center, it is possible to perform an automatic distribution service of update information of the bioproduct from the information manager to the user.

FIG. 2 is described below as a second embodiment. As described in the first embodiment, the product information and quality assurance information of the bioproduct must always be provided to the user by updating the information. However, on the other hand, there may be a case where the user wants to know what kind of quality assurance has been provided for the bio product in the past, such as when designing or manufacturing the bio product or when the user obtains the product. Therefore, the history archive 206 is prepared.
The history archive 206 contains the database group 1 of FIG.
It is configured to include a plurality of databases that hold the same information as the types of databases included in 05. That is, for example, the gene database history 207 includes from the latest database in which information on genes is stored to past databases. The gene database history 207 may be a database including a plurality of databases, or may be a single database holding updated contents. Not only Gene Database History 207 but also Clinical Database History 2
08, the drug database history 209, the SNPs database history 210, and the drug efficacy database history 211 are the same. The history archive 206 includes not only the above-mentioned database but also the database group 10 shown in FIG.
A database holding other types of information, such as the database included in 5, may be included. Further, the history archive 206 may be included in the database group 105 shown in FIG. 1 or may be held by the information center 104, in addition to the configuration shown in FIG. The information held by the history archive 206 may include the entire old database in the history archive 206 every time the information is updated, or may include only the update information in the history archive 206 each time the information is updated.
If the amount of information to be updated is far greater than the amount of information held by the database, it is easier to include the entire old database in the history archive 206.

As described above, the history archive 206
Is provided, it is possible to obtain not only the latest information from the database group 105 but also information on bioproducts at a past time. History Archive
By referring to 206, it is possible to obtain information on bioproducts as information at any time.

In FIG. 1, the transmission line 118 connecting the information center 104 and the terminal 101a may be wired or wireless. When the transmission path 118 is wireless, the information center 104 and the terminal 101a are provided with a wireless interface for wireless transmission and reception. The terminal 101a or the terminal 101b may be a versatile information device such as a personal computer, or may be a dedicated terminal for acquiring bioproduct information. Further, the terminal may be a terminal incorporated in a device for using or handling a bioproduct such as a PCR device or an X-ray analyzer.

In the first embodiment or the second embodiment,
The reference destination of the information may be not only a database that only stores the data, but also a service site that performs information processing such as performing a homology search with the stored data. Usually, the homology search means a search for examining similarity or homology with data such as DNA base sequence information and protein amino acid sequence information. Therefore, if the collation with the information held in the database is not limited to the search for the identity of whether or not it matches the data, but also includes the search for similarity and homology, more advanced search such as homology search The present invention can be implemented in a form including
In the future, if the number of sites providing the bioinformatics service increases, the present invention can provide a new information acquisition method including information processing and processing. The bioinformatics service may be configured to be combined with a database, may be a service site that exclusively performs information processing, or may be an information center.
You may make it perform in 104.

FIG. 8 shows a third embodiment in which the terminal 101a is a small terminal that acquires information by wireless transmission and reception.
This will be described with reference to FIG. The wireless small terminal 800 includes at least an information acquisition request receiving unit 801, a wireless interface 804 for wirelessly transmitting and receiving an information acquisition request or information, a display unit 805 for displaying an information acquisition request or information, and control for controlling these. Means 803 and storage means 802.

The information acquisition request may be made using the user's personal information. If information on bioproducts is acquired based on individual SNPs information, efficient individual information can be provided according to the individual's constitution. The personal information may be stored in the terminal 101a by providing a storage means, or the card 103 read and written by the card reader / writer 102a.
May be provided with storage means and held.

If the wireless small terminal 800 can be formed in a thin card shape, it can be conveniently attached directly to a bioproduct container. The user can also obtain the product information and the quality assurance information by looking at the display means 805 of the small wireless terminal 800 without using a PC or another device.

Although not shown in FIG. 8, the small wireless terminal also includes power supply means. The power supply means may be a battery, or may be provided with another power generation mechanism that generates electric power by receiving radio waves.

The display means 805 includes, for example, information on the efficacy and taking of the medicine, SNPs of the user who needs to be careful in use.
Various biological information or biological information such as information can be displayed. The information displayed by the display means 805 is the information stored in the database included in the database group 105, the information stored in the history archive 206, the information processed in the information center 104, the small wireless terminal 8
These information processed by the control means 803 in 00,
Any information such as information held in the card 103 may be used.

FIG. 3 shows that when the bioproduct is a drug,
4 shows an example of a procedure for acquiring information using a D number. The ID number assigned to the medicine is input to the terminal, and the date of manufacture is determined from the input ID number (302). The production date may be determined (302) by searching the information center 104 from the ID number to find the production date. Next, I
The chemical formula or molecular structure of the substance contained in the drug is determined from the D number (303). Procedure 303 may refer to history archive 206. In step 304, information on the ligand or protein is obtained. In step 305, information about the exon structure is obtained.

In step 306, information on the gene product is obtained. In step 307, information on the DNA sequence is obtained.
In step 308, the accession number of the relevant DNA is obtained. Steps 304 to 308 are history archives at any time
See also 206. Further, the procedure 308 may refer to the latest database, for example, a database included in the database group 105. Cross-check the information of the manufacture date 199Y and the use date 200X in step 313, check if the updated information needs to be changed to the drug safety information, and output the check result I do. In step 309, the latest information on drug safety derived from the information obtained in steps 303 to 308 and 313 is obtained. In step 310, information related to security is output.

In this way, when the drug manufactured in 199Y is used in 200X, the drug can be used based on the latest information of 200X.

FIG. 7 shows an example of a procedure for acquiring information using an ID code when the bioproduct is a primer.

The ID code assigned to the primer is input to the terminal, and the year of manufacture 199Y is determined from the input ID code (702). Next, the oligonucleotide sequence information of the primer is determined from the ID code (703). In step 704, exon information is obtained (704). Steps 702-704 are ID
Code to Information Center or History Archive 311
And may be obtained by referring to. In step 705, annotation information on the oligonucleotide sequence of the primer is obtained (705). In step 707, the acquired information is 199Y and 200X
Checks for information updates between the years and outputs the results. Steps 704 to 705 may be obtained by referring to a database included in the information center or the database group 105 from the ID code. In step 706, the update or transition of the information is specified between 199Y, when the primer was manufactured, and as of 200X.

FIG. 4 is an example showing in what data format biological information or biological information is provided to a user. In FIG. 4, ID number 401, species information 402, organ 40
3. Gene 404, sequence information 405, and other information 406 on annotation or protein are shown. The present invention is not limited to these items 401 to 406, and items may be added or deleted as necessary. It is important that the information to be provided or the information to be obtained satisfy the information required by the user. In addition, since the contents or information may change over time even if the items are the same, time information may be added to the items to indicate that the information changes over time.
If necessary, graphic data may be added in addition to character or symbol data such as a diagram showing the molecular structure.

FIG. 6 shows an example of how to connect the databases. The center 603 may be considered to have the same configuration as the information center 104 in FIG. Although the terminal 601 is connected to the network 602 in FIG. 6, the terminal 601 may be connected to the network 602 via the center 603. Databases 604-606 may be databases included in database group 105 or databases such as history archive 206. The in house database 607 is a database connected to the center 603, and access or search requests from the network 602 are restricted by the center 603. The database 608 and the database 609 of each user are databases to which access restrictions are imposed by the center 603.

A bio product seller or manufacturer, a bio product information provider manages and operates the center 603,
Obtain or store user's personal information in database 607
You may make it manage by ~ 609. In this way, the center 603 blocks unauthorized access performed via the network 602, and
You can deposit important personal information in 09.

As a third embodiment, an information distribution form when a primer set is sold as a bioproduct will be described in more detail. A conventional gene analysis method using the PCR method is as follows.

FIG. 9 shows an example of a conventional gene analysis method.

Conventionally, for each gene or protein of interest, the nucleotide sequence of the gene or the amino acid sequence of the protein is cloned by subtraction or DD method and identified (step 900). A method of checking whether or not it has such a function was generally used. That is, an exon that is considered to match the purpose of the research is selected in advance from the identified base sequence (step 902), and the corresponding primer is designed (step 903). Then, the target exon was amplified by PCR (Polymerase Chain Reaction) using the primer (Step 604), and the exon was analyzed (Step 905). PC
R is a method in which primers are designed at both ends of a region to be amplified and a gene is logarithmically amplified by a temperature cycle using a heat-resistant DNA enzyme such as Taq DNA polymerase. Primers are oligonucleotides having -OH at the 3 termini necessary for the initiation of DNA synthesis.

In such a conventional gene analysis method, if the exon selected by the analysis in step 905 does not meet the purpose, the process is repeated in step 902.
It is necessary to repeat the process from the selection of exons (step 906), and it is very important to correctly select exons that match the purpose of the study. However, when analyzing, for example, genetic differences between a patient suffering from a disease (eg, cancer) and a normal individual, the exon to be studied is the exon that causes the disease. However, it was extremely difficult to determine which exon that exon was, and the only way to determine that exon was to analyze candidate exons by trial and error as described above.

On the other hand, when a plurality of types of primers for amplifying a large number of exons predicted to have some function by the PCR method are provided as a set, a purchaser of the primer set is provided with information on individual primers, For example, information such as what DNA each primer is derived from, what part of the DNA is related to the gene, what kind of function it has, or the possibility that it has some kind of function is described on the paper 503. , Recording medium 504, or I
It is provided by a card 505 or the like on which a D code is recorded. Here, as another embodiment, an example will be described with reference to FIG. 10 in which a purchaser who has purchased a primer set is provided with an access right to an information center having information on the primer set and the related information is distributed.

The primer set 950 is a plate 951
A plurality of primers 952 are arranged two-dimensionally on the top. If the plate has a well called a well beforehand, a primer is placed on the well 952 so that the solution can be easily placed. Product number 9 on each plate
Reference numeral 54 is attached, and the primers arranged on the plate are also numbered. In this embodiment, the primer well number 955 is represented by a combination of column numbers 1 to 5 and row numbers a to e (a1, b3, etc.) assigned to the wells on the plate 951.

The purchaser can use such a primer set 95
By purchasing No. 1, an access right to an information center 957 that holds information on primers is obtained. The access right is an access ID number 953 to data held by the information center when accessing the information center. The primer set seller informs the information center 957 of the sales destination (purchaser) of the primer set sold and the name of the sold product (product number). To obtain information, the user can connect to the terminal
With 56, the information center 957 is accessed. The information center 957 receives the access ID from the dealer.
A table (961) in which the numbers are associated with information on the primer sets purchased by the purchaser and the user is created and managed. The information center 957 includes an interface 959 for inputting / outputting information to / from the outside, a memory 960 for holding primer set information, and a CPU 962 for controlling information processing in the information center 957. When the user accesses the information center 957 from the user terminal 956, the information center 957 requests the user for an access number. In response to this request, the user has access ID number 9
Enter 53. The information center 957 checks whether the access ID number 953 obtained under the control of the CPU 963 is registered in the table 961 in the memory. Only users (registered users) registered in the user table 961 are allowed to access the primer information in the memory. The information center 957 notifies the registered user that access has been permitted, and subsequently waits for an input from the user. The user confirms permission to access the information center 957, and inputs the product number 954 of the purchased primer set. The information center 957 receives the product number 95 from the user.
When the input of 4 is received, the product information table 962 of the product specified by the product number is referred to. When the user inputs the well primer number 955, the information center 9
57 returns the information corresponding to the well primer number 955 from the product information table 962 to the user terminal.

The table 961 in the memory 960 includes a purchaser name 9612 corresponding to the access ID number 9611,
Product number 9613, product number 9613 purchased by buyer
961 and a flag indicating the presence of undelivered new information
4. A data address 9615 indicating a recording location of information on the purchased product 9613 is included. The product information table 962 is created for each product number 9613, and its recording location is the location indicated by the data address 9615. In this example, the product information for each product number includes, for each product, the well primer number 9621, the position, sequence, function, primer structure, and the position of the exon that the primers located in the well primer number 9621 amplify. , An update record 9623 of such information, and a record 9624 of distribution to the user. When the function of the exon to be amplified has been analyzed, the determined function information is retained in 9622. When the function of the exon to be amplified has not been analyzed yet, the predicted function or the predicted function The situation is kept. Although not shown, the information 9622 includes, in addition to the above, positional information on the chromosome of the exon to be amplified, information on a gene family having a similar sequence, information on a gene group of another species having a similar sequence, and a similar sequence. There are expression information such as EST and SAGE, information on gene functions deduced from genes having similar sequences, and latest literature information.

When the update record 9623 is newer than the distribution record 9624, the CPU 963 sets a flag 9614 in the table 961 and separately sets a flag (not shown) that the user desires automatic distribution of update information by setting.
When the information in the product information table 962 is updated according to the flag 9614, the update information is automatically delivered to the user. Even if the update information is not automatically distributed, if the user having the registered access ID number receives an inquiry about the product, the flag 9614 is checked, and the updated product number information is transmitted to the user. Send. Only the information on the updated well primer number may be transmitted according to a request or setting. For the setting, the user appropriately applies for a desired service when accessing the information center.

When the information is requested from the user irrespective of the update, the information about the primer set purchased by the user is transmitted without checking the flag 9614.

The update information includes, for example, the function information of the exon to be amplified. The analysis of DNA is progressing rapidly, and new findings and analysis results can be obtained every day. Therefore, when the function of the exon to be amplified is unknown for the primers included in the sold primer set at the time of sale and the function is revealed by a subsequent experiment, the function information is updated.

The method of distributing primer information shown in the above embodiment is shown by the following configuration.

A primer set comprising a plate and a plurality of types of primers arranged on the plate;
When there is an information center that holds primer information on the primer set, the seller of the primer set sells the access right to the primer set and the information center to a purchaser, and the primer set is sent to the information center. And the purchaser information that is the selling destination of the access right is notified, and the information center holds the stored primer information, the purchaser information, and the access right in association with each other, and transmits the access right from an external terminal to the access right. A method of distributing primer information associated with the access right when the information center is accessed based on the information.

Further, there is also the following configuration.

A primer set consisting of a plate and a plurality of types of primers arranged on the plate and an access right to an information center holding primer information on the primer set are purchased, and information is obtained via a network. A method for distributing information, wherein when the terminal accesses the information center, the primer information is distributed to the information terminal on condition of access by the access right.

In the above information distribution method, the primer information is functional information of exons that the primer amplifies.

The following configuration is also available.

A method of distributing information on primers used for amplifying exons of DNA, comprising: user data holding primers, function information of exons amplified by the primers, and an update indicating whether or not the function information is updated When the update information indicates that there is an update to the memory holding the information, the memory is controlled so that the update is notified to the destination indicated by the user data or the function information is distributed. Information delivery method.

[0058]

According to the present invention, it is possible to support biological-related information added over time even after the provision of a bioproduct, and to provide the user with the latest information. When using a bio product, the user can refer to the updated information on the effect, efficacy and safety, so that the user himself can check the quality of the bio product and use it properly.

When a bio product is provided, an access right to an information center having product information on the bio product is automatically given, so that it is possible to easily obtain information arranged in advance on the product. Even when the information on the bioproduct is updated, the updated information is automatically transmitted from the information center, so that the latest information on the product can always be grasped. The latest information is distributed so that the results of gene functions can be quickly grasped, so that functional information can be obtained without analyzing exons that were to be amplified and analyzed. Can be eliminated, and the user's R & D efficiency can be improved. In addition, it is possible to start new research and analysis by referring to the already analyzed results, which can lead to a leap in the entire industry such as genetic research and business.

[Brief description of the drawings]

FIG. 1 is a system for transmitting information on bioproducts.

FIG. 2 shows a system having a database including a history archive.

FIG. 3 shows a procedure for obtaining the latest information on drug safety.

FIG. 4 is an example of a data array.

FIG. 5 shows a primer set.

FIG. 6 is a system including a database managed by a center.

FIG. 7 shows a procedure for acquiring the latest information on a primer set.

FIG. 8 is an example of a terminal device.

FIG. 9 is a diagram showing an example of a conventional gene analysis method.

FIG. 10 is a view for explaining a method of acquiring information of a primer set purchaser.

[Explanation of symbols]

101 is a terminal 102 is a card reader / writer 103 is a card 104 is an information center 105 is a database group 106 is a network 107 is a biomedical database 108 is a genome sequence database 109 is a protein database 110 is a signal transduction database 111 is a clinical database 112 is an electronic medical record Database 113 is a genome database of other species 114 is a food database 115 is a drug database 116 is an individual family database 117 is a family register database 118 is a transmission line 201 is a terminal 202 is a network 203 is a literature database 204 is a firewall 205 is a network 206 is History archive 207: Gene database 208: Clinical database 209: Drug database 210: SNPs database 211: Statistical database of drug efficacy 301: Acquisition of drug ID number 302: Acquisition of date of manufacture 303: Acquisition of chemical formula / molecular structure Acquisition 304: Acquisition of ligand / protein information 305: Acquisition of exon structure information 306: Acquisition of gene product information 307: Acquisition of DNA sequence information 308: Acquisition of accession number information of related DNA 309: Acquisition of the latest information on drug safety 310: Safety 311 is the database environment of 199Y 312 is the database environment of 200X 313 is the cross check under the database environment of 199Y and 200X 401 is the ID of the bio product 402 is the species information 403 is the organ information 404 is genetic information 405 is sequence information 406 is other annotations (for example, proteins) 501 is a plate 502 is a container 503 is paper information 504 is a recording medium 505 is an ID code 601 is a terminal 602 is a network 603 is a center 604 is a database 605 is a database 606 Database 607 has restricted access to the center Database 608 has restricted access to the center Database 609 is a database whose access to the center is restricted (database holding information on each user) 701 is the primer ID code 702 is the date of manufacture 703 is the primer sequence information 704 is the exon information 705 is the latest primer sequence Annotation information acquisition 706 outputs past transitions 707 cross-check under database environment of 199Y and 200X 800 is a wireless portable terminal device 801 is an information acquisition request receiving means 802 is a storage means 803 is a control means 804 is a wireless interface 805 is a display means.

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 5B075 KK03 KK07 KK13 KK33 KK37 ND03 ND20 ND23 NK54 PP06 PP12 PP30 PQ02 PQ05 UU18 UU26 UU27

Claims (1)

[Claims] 1. A bio product code, first information on the bio product, second information on the bio product, correspondence between the bio product code and the first information, and the bio product And a reference destination of a database that holds information belonging to the same category as the first information, and records and holds a correspondence between the code and the second information. Acquiring the third information, recording and holding the third information, generating the fourth information by combining the second information and the third information, and generating the code of the bio product and the fourth information. A method for distributing bioproduct information, comprising transmitting a pair with information to a transmission path, wherein the third information is changed, updated, deleted, or added to the first information. Information that has been The method of delivery bio-product information and said.