JP2001181211A - Water-soluble vitamin powder preparation - Google Patents
Water-soluble vitamin powder preparationInfo
- Publication number
- JP2001181211A JP2001181211A JP36697799A JP36697799A JP2001181211A JP 2001181211 A JP2001181211 A JP 2001181211A JP 36697799 A JP36697799 A JP 36697799A JP 36697799 A JP36697799 A JP 36697799A JP 2001181211 A JP2001181211 A JP 2001181211A
- Authority
- JP
- Japan
- Prior art keywords
- water
- soluble
- soluble vitamin
- salt
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、水溶性ビタミン粉
剤及びその製造法に関する。TECHNICAL FIELD The present invention relates to a water-soluble vitamin powder and a method for producing the same.
【0002】[0002]
【従来の技術及び発明が解決しようとする課題】水溶性
ビタミン類は人や動物にとって必須の栄養素であり、そ
の欠乏は成長、健康に重大な影響を及ぼすことから、こ
れを補充するために水溶性ビタミン類を含有する種々の
食品、飼料等が知られている。また、該水溶性ビタミン
類を効率よく体内に吸収させるために、該水溶性ビタミ
ン類を含有する清涼飲料水や、家畜、ペット用の飲料水
が実用されている。しかしながら、水溶性ビタミン類と
いう分類はされているものの、ビオチン、葉酸、ニコチ
ン酸等水溶性に乏しいものが多く、実質的に飲料水等の
水性液に溶解し難いため、実用上は一旦塩の形態に変換
して水溶性を向上させた形態で目的とする水性液に溶解
しているのが現状であり、煩雑であるばかりか、水性液
の目的によっては塩の形態ではなくフリー体とすること
が必要とされる等、飲料水等の水性液に水溶性ビタミン
類をフリーの状態で容易に溶解させ得る工業的にも優れ
た水溶性ビタミン製剤の開発が望まれていた。2. Description of the Related Art Water-soluble vitamins are essential nutrients for humans and animals, and their deficiency has a serious effect on growth and health. Various foods, feeds, and the like containing sex vitamins are known. Further, in order to efficiently absorb the water-soluble vitamins into the body, soft drinks containing the water-soluble vitamins and drinking water for livestock and pets have been put to practical use. However, although they are classified as water-soluble vitamins, biotin, folic acid, nicotinic acid, etc. are often poorly water-soluble, and are practically difficult to dissolve in aqueous liquids such as drinking water. At present, it is dissolved in the target aqueous liquid in the form of improved water solubility by conversion into a form, and it is not only complicated, but depending on the purpose of the aqueous liquid, it is not a salt form but a free form. Thus, there has been a demand for the development of an industrially excellent water-soluble vitamin preparation which can easily dissolve water-soluble vitamins in an aqueous liquid such as drinking water in a free state.
【0003】[0003]
【課題を解決するための手段】かかる状況下、本発明者
は、水溶性ビタミン製剤について鋭意検討した結果、水
溶性ビタミン類、糖類及び水溶性塩を含有し、該成分の
含有量を特定した粉剤が、これを水中に投入したとき
に、対応する塩への変換を行わなくとも水溶性ビタミン
類が固体として浮遊、沈殿することなく速やかに溶解し
得る製剤であることを見出し本発明に至った。即ち本発
明は、０．１〜４０重量％の水溶性ビタミン類、６０〜
９９．８重量％の糖類及び０．１〜４０重量％の水溶性
塩を含有する水溶性ビタミン粉剤（以下、本製剤と記
す）及びその製造方法に関するものである。Under these circumstances, the present inventors have made intensive studies on water-soluble vitamin preparations, and as a result, have identified water-soluble vitamins, sugars and water-soluble salts, and determined the content of the components. The present invention was found to be a powder, which, when put into water, was a preparation in which the water-soluble vitamins could be rapidly dissolved without being suspended and precipitated as a solid without conversion to the corresponding salt. Was. That is, the present invention provides 0.1 to 40% by weight of water-soluble vitamins,
The present invention relates to a water-soluble vitamin powder containing 99.8% by weight of a saccharide and 0.1 to 40% by weight of a water-soluble salt (hereinafter referred to as the present preparation) and a method for producing the same.
【0004】[0004]
【発明の実施の形態】本製剤において用いられる水溶性
ビタミン類としては、通常は水に溶け難く、かつその化
学構造にカルボキシル基あるいはカルバモイル基を有す
る水溶性ビタミン類をあげることができる。具体的に
は、ニコチン酸、ニコチン酸アミド、葉酸、ビオチン、
パントテン酸、Ｌ−アスコルビン酸等があげられる。上
記の水溶性ビタミン類は、単独で用いてもよく、２種類
以上を組み合わせて用いてもよい。本製剤中の水溶性ビ
タミン類の含有量は、全重量に対して０．１〜４０重量
％であり、好ましくは２〜４０重量％である。BEST MODE FOR CARRYING OUT THE INVENTION The water-soluble vitamins used in the present preparation include water-soluble vitamins which are usually hardly soluble in water and have a carboxyl group or a carbamoyl group in the chemical structure. Specifically, nicotinic acid, nicotinamide, folic acid, biotin,
Pantothenic acid, L-ascorbic acid and the like. The above water-soluble vitamins may be used alone or in combination of two or more. The content of the water-soluble vitamins in the present preparation is 0.1 to 40% by weight, preferably 2 to 40% by weight based on the total weight.
【0005】糖類としては、医薬、食品、飼料分野において
利用でき、かつ水溶性のものを用いることができ、具体
的には、グルコース、ラクトース、ガラクトース、フラ
クトース、キシロース等の単糖類、トレハロース、蔗
糖、マルトース等の２糖類、デキストリン等の水溶性多
糖類等を挙げることができる。糖類は、単独で用いても
よく、２種類以上を組み合わせて用いてもよい。本製剤
中の糖類の含有量は、全重量に対して６０〜９９．８重
量％であり、好ましくは６０〜９８重量％である。[0005] As the saccharides, those usable in the fields of medicine, food and feed and soluble in water can be used. Specifically, monosaccharides such as glucose, lactose, galactose, fructose and xylose, trehalose and sucrose And disaccharides such as maltose, and water-soluble polysaccharides such as dextrin. The saccharides may be used alone or in combination of two or more. The content of the saccharide in the present preparation is 60 to 99.8% by weight, preferably 60 to 98% by weight based on the total weight.
【0006】水溶性塩としては、医薬、食品、飼料分野にお
いて利用でき、かつ水に溶解性の、好ましくは水に対す
る２０−３０℃における溶解度が１％以上の塩を用いる
ことができ、アンモニウム塩、アルカリ金属塩またはア
ルカリ土類金属塩を挙げることができる。具体的には、
燐酸２水素ナトリウム、燐酸水素２ナトリウム、燐酸３
ナトリウム、燐酸２水素カリウム、燐酸水素２カリウ
ム、燐酸３カリウム、燐酸２水素アンモニウム、燐酸水
素２アンモニウム、燐酸３アンモニウム等の燐酸塩、炭
酸ナトリウム、炭酸カルシウム、炭酸水素ナトリウム等
の炭酸塩などの無機酸のアンモニウム塩、無機酸のアル
カリ金属塩、無機酸のアルカリ土類金属塩や、蟻酸アン
モニウム、蟻酸ナトリウム等の蟻酸塩、酢酸ナトリウ
ム、酢酸カリウム、酢酸アンモニウム等の酢酸塩、乳酸
ナトリウム、乳酸カリウム、乳酸カルシウム等の乳酸
塩、リンゴ酸カリウム、リンゴ酸カルシウム、リンゴ酸
ナトリウム等のリンゴ酸塩などの有機酸のアンモニウム
塩、有機酸のアルカリ金属塩、有機酸のアルカリ土類金
属塩等があげられる。水溶性塩は、単独で用いてもよ
く、２種類以上を組み合わせて用いてもよい。本製剤中
の水溶性塩の含有量は、全重量に対して０．１〜４０重
量％であり、好ましくは２〜４０重量％である。As the water-soluble salt, a salt which can be used in the fields of medicine, food and feed, and which is soluble in water, preferably having a solubility in water of 20% to 30 ° C. of 1% or more can be used. , Alkali metal salts or alkaline earth metal salts. In particular,
Sodium dihydrogen phosphate, disodium hydrogen phosphate, phosphoric acid 3
Inorganic substances such as sodium, phosphates such as potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, ammonium dihydrogen phosphate, diammonium hydrogen phosphate, and triammonium phosphate; and carbonates such as sodium carbonate, calcium carbonate, and sodium bicarbonate. Ammonium acid salt, alkali metal salt of inorganic acid, alkaline earth metal salt of inorganic acid, formate such as ammonium formate, sodium formate, acetate such as sodium acetate, potassium acetate, ammonium acetate, sodium lactate, potassium lactate Ammonium salts of organic acids such as lactates such as calcium lactate; malates such as potassium malate, calcium malate and sodium malate; alkali metal salts of organic acids; alkaline earth metal salts of organic acids. Can be The water-soluble salts may be used alone or in combination of two or more. The content of the water-soluble salt in the present preparation is 0.1 to 40% by weight, preferably 2 to 40% by weight based on the total weight.
【0007】本製剤には、前記した水溶性ビタミン類、糖類
及び水溶性塩のほか、例えば防黴目的で安定剤や、流動
性向上目的で静電気防止剤等を含有していてもよい。安
定剤としては、食品、飼料分野において利用でき、水溶
性のものを用いることができ、具体的には、ソルビン
酸、ソルビン酸ナトリウム、ソルビン酸カリウム、プロ
ピオン酸、プロピオン酸ナトリウム、プロピオン酸カル
シウム、クエン酸、クエン酸ナトリウム、クエン酸カリ
ウム等があげられる。静電気防止剤としては、食品、飼
料分野において利用でき、水溶性のものを用いることが
でき具体的には、焼成シリカ等があげられる。安定剤や
静電気防止剤は、単独で用いてもよく、２種類以上を組
み合わせて用いてもよい。本製剤中の安定剤の含有量
は、全重量に対して好ましくは０．１〜２重量％であ
り、静電気防止剤の含有量も同様である。[0007] In addition to the above-mentioned water-soluble vitamins, saccharides and water-soluble salts, the present preparation may contain, for example, a stabilizer for the purpose of preventing fungi, an antistatic agent for the purpose of improving fluidity, and the like. As the stabilizer, it can be used in the food and feed fields, and water-soluble ones can be used.Specifically, sorbic acid, sodium sorbate, potassium sorbate, propionic acid, sodium propionate, calcium propionate, Citric acid, sodium citrate, potassium citrate and the like. As the antistatic agent, a water-soluble one can be used in the food and feed fields, and specific examples thereof include calcined silica. The stabilizer and the antistatic agent may be used alone or in combination of two or more. The content of the stabilizer in the present preparation is preferably 0.1 to 2% by weight based on the total weight, and the content of the antistatic agent is also the same.
【0008】本製剤は例えば、水溶性ビタミン類、水溶性塩
及び糖類を、混合、微細粉砕することにより得られる。
具体的には、所定量の糖類、水溶性ビタミン類及び水溶
性塩、さらに必要により安定剤、静電防止剤等をヘンシ
ェル化学ミキサー等のミキサーに加え、室温もしくは水
冷下に、１５００〜３０００ｒｐｍにて、５〜３０分程
度攪拌混合することにより得られる。得られる粉剤は、
通常はその９５％を超える量が１５０メッシュ篩いを通
過する程度の大きさであり、水分含量は通常１５％以
下、好ましくは１０％以下である。[0008] This preparation can be obtained, for example, by mixing and finely pulverizing water-soluble vitamins, water-soluble salts and sugars.
Specifically, a predetermined amount of saccharides, water-soluble vitamins and water-soluble salts, and if necessary, stabilizers, antistatic agents, etc. are added to a mixer such as a Henschel chemical mixer, and at room temperature or under water cooling, at 1500 to 3000 rpm. For about 5 to 30 minutes. The resulting powder is
Usually, the amount exceeding 95% is large enough to pass through a 150 mesh sieve, and the water content is usually 15% or less, preferably 10% or less.
【0009】本製剤は通常、飲料水等の水性液に添加、溶解
され、人や、家畜、ペット等の動物の使用に供される。
飲料水等への本製剤の希釈倍率は、本製剤中の水溶性ビ
タミン類の種類や含有量、施用対象や場面等により変わ
るが、通常は１０〜１００００倍程度、好ましくは５０
〜８０００倍程度である。本製剤を用いて調製される水
性液は、含有される水溶性ビタミン類の安定性において
も優れる。もちろん、本製剤を飼料等に添加、混合し、
使用に供することもでき、この場合の本製剤の量も水溶
性ビタミン類の種類や含有量、施用対象等により変わる
が、飼料１トンあたり、通常１ｇ〜１ｋｇ程度である。[0009] This preparation is usually added and dissolved in an aqueous liquid such as drinking water and used for animals such as humans, livestock and pets.
The dilution ratio of the present formulation to drinking water or the like varies depending on the type and content of the water-soluble vitamins in the present formulation, the application target, the scene, and the like, but is usually about 10 to 10,000 times, preferably 50 to 50 times.
It is about 8000 times. The aqueous liquid prepared using this preparation is excellent also in the stability of the contained water-soluble vitamins. Of course, this formulation is added to feed, etc., mixed,
The preparation can be used. In this case, the amount of the present preparation also varies depending on the type and content of the water-soluble vitamins, the application target, and the like, but is usually about 1 g to 1 kg per ton of feed.
【0010】本製剤の容器としては、例えば、アルミ袋、紙
袋、紙パック等通常の粒剤や水和剤で使用可能な容器を
挙げることができる。保存時の吸湿を避けるためには、
アルミ袋や内装がアルミコーティングされた紙袋、ポリ
袋等が好ましい。[0010] Containers of the present preparation include, for example, containers usable with ordinary granules and wettable powders, such as aluminum bags, paper bags, and paper packs. To avoid moisture absorption during storage,
Aluminum bags, paper bags or plastic bags whose interior is coated with aluminum are preferred.
【0011】[0011]
【実施例】以下、実施例により本発明をさらに詳細に説
明するが、本発明はこれらに限定されるものではない。 実施例１ 葉酸１０重量部、デキストリン（日澱化学株式会社製の
可溶性デンプン、商品名：アミコール６Ｌ）７８重量部
及び燐酸水素２アンモニウム１２重量部をジューサーミ
キサーで混合し、解砕して微粉末とし、黄色粉剤（粒
径：＜１００μｍ）を得た。EXAMPLES The present invention will be described in more detail with reference to the following Examples, but it should not be construed that the present invention is limited thereto. Example 1 10 parts by weight of folic acid, 78 parts by weight of dextrin (soluble starch manufactured by Nichien Chemical Co., Ltd., trade name: AMICOL 6L) and 12 parts by weight of diammonium hydrogen phosphate were mixed with a juicer mixer, crushed and finely powdered. To obtain a yellow powder (particle size: <100 μm).
【0012】実施例２ ビオチン２重量部、デキストリン（日澱化学株式会社製
の可溶性デンプン、商品名：アミコール６Ｌ）９６重量
部、燐酸水素２ナトリウム２重量部及びソルビン酸０．
０１重量部をジューサーミキサーで混合し、解砕して微
粉末とし、白色粉剤（粒径：＜１００μｍ）を得た。Example 2 2 parts by weight of biotin, 96 parts by weight of dextrin (soluble starch manufactured by Nisseki Chemical Co., Ltd., trade name: Amicol 6L), 2 parts by weight of disodium hydrogen phosphate and 0.1 part of sorbic acid.
01 parts by weight were mixed with a juicer mixer, crushed to a fine powder, and a white powder (particle size: <100 μm) was obtained.
【0013】実施例３ ニコチン酸４０重量部、ラクトース（関東化学株式会社
製の乳糖）３７重量部及び燐酸水素２ナトリウム２２重
量部をジューサーミキサーで混合し、解砕して微粉末と
し、白色粉剤（粒径：＜１００μｍ）を得た。Example 3 40 parts by weight of nicotinic acid, 37 parts by weight of lactose (lactose manufactured by Kanto Chemical Co., Ltd.) and 22 parts by weight of disodium hydrogen phosphate are mixed with a juicer mixer, crushed to a fine powder, and a white powder. (Particle size: <100 μm).
【0014】比較例１ 燐酸水素２ナトリウムに代えてカゼインナトリウムを用
いる以外は実施例２と同様の操作を行い、乳白色粉剤
（粒径：＜１００μｍ）を得た。Comparative Example 1 The same operation as in Example 2 was carried out except that sodium caseinate was used instead of disodium hydrogen phosphate, to obtain a milky white powder (particle size: <100 μm).
【0015】実施例４〜１３ 表１に示す各成分及びその量を用いる以外は実施例１と
同様の操作を行い、各粉剤を得た。Examples 4 to 13 The same operation as in Example 1 was carried out except that the components and amounts shown in Table 1 were used to obtain each powder.
【0016】[0016]
【表1】 【table 1】
【0017】試験例１ 実施例１〜３及び比較例１で得られた粉剤を用い、下記
の要領に従って水溶解性試験を行った。また対照例とし
て、水１リットルにビオチン１ｇを添加して調製した液
についても水溶解性試験を行った。その評価が◎であっ
た試料についてさらに下記の要領に従って虐待保存試験
を行い、虐待保存試験後のサンプルについて水溶解性試
験を行った。結果を表２に示す。 ・水溶解性試験 試料を１グラムを秤量して、水１０ｍｌを加え、水への
溶解性を以下に従い評価する。 表示方法 溶解に要する時間が≦５分 ◎ 溶解に要する時間が＞５分 × ・虐待保存試験 １０〜３０ｇの各粉剤をアルミニウム袋中に密閉し、５
４℃の恒温器中で２週間保存する。Test Example 1 Using the powders obtained in Examples 1 to 3 and Comparative Example 1, a water solubility test was performed according to the following procedure. As a control, a water solubility test was also performed on a liquid prepared by adding 1 g of biotin to 1 liter of water. The sample with the evaluation of ◎ was further subjected to an abuse preservation test according to the following procedure, and a sample after the abuse preservation test was subjected to a water solubility test. Table 2 shows the results. -Water solubility test 1 g of a sample is weighed, 10 ml of water is added, and the solubility in water is evaluated as follows. Labeling method Time required for dissolution ≤ 5 minutes ◎ Time required for dissolution> 5 minutes × · Abuse preservation test 10 to 30 g of each powder was sealed in an aluminum bag, and
Store in a 4 ° C. incubator for 2 weeks.
【0018】[0018]
【表2】 [Table 2]
【0019】試験例２ 実施例２、３、４、１２及び１３で得られた粉剤を用
い、前記と同様の虐待保存試験を行い、試験前後におけ
る水溶性ビタミン類の含有量を測定し、虐待保存試験後
の含有量の保持率（％）（試験後の含有量／試験前の含
有量×１００）を求めた。結果を表３に示す。Test Example 2 Using the powders obtained in Examples 2, 3, 4, 12, and 13, an abuse preservation test similar to that described above was conducted, and the contents of water-soluble vitamins before and after the test were measured. The retention rate (%) of the content after the storage test (content after the test / content before the test × 100) was determined. Table 3 shows the results.
【0020】[0020]
【表3】 [Table 3]
【0021】試験例３ 虐待保存試験前後における実施例２及び実施例４で得ら
れた各粉剤の２０％の水溶液を調製し、分光光度計で７
００ｎｍ及び４２０ｎｍでの水溶液の各吸光度を測定
し、７００ｎｍ及び４２０ｎｍの吸光度差を求めること
により、ビオチンの分解度を、着色度として測定、比較
した。対照例として、ビオチン２重量部及びデキストリ
ン９８重量部をアルカリ存在下に水に溶解後、公知のス
プレイドライ法により製造された粉剤（対照粉剤）につ
いても同様に虐待保存試験前後における着色度を測定
し、比較した。結果を表４に示す。Test Example 3 A 20% aqueous solution of each of the powders obtained in Examples 2 and 4 before and after the abuse preservation test was prepared.
The respective absorbances of the aqueous solution at 00 nm and 420 nm were measured, and the difference in absorbance at 700 nm and 420 nm was determined. As a control, 2 parts by weight of biotin and 98 parts by weight of dextrin were dissolved in water in the presence of an alkali, and then the degree of coloring before and after the abuse preservation test was measured for a powder (control powder) manufactured by a known spray-drying method. And compared. Table 4 shows the results.
【0022】[0022]
【表4】 [Table 4]
【0023】[0023]
【発明の効果】本発明によれば、通常は水に溶解し難い
水溶性ビタミン類を容易にそして速やかに溶解すること
が可能となる。According to the present invention, water-soluble vitamins which are usually hardly soluble in water can be easily and quickly dissolved.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ２３Ｋ 1/16 ３０３ Ａ２３Ｋ 1/16 ３０３Ｄ 1/175 1/175 Ａ６１Ｋ 9/14 Ａ６１Ｋ 9/14 31/197 31/197 31/4188 31/4188 31/455 31/455 31/525 31/525 47/26 47/26 47/36 47/36 Ａ６１Ｐ 3/02 １０１ Ａ６１Ｐ 3/02 １０１ Ｆターム(参考） 2B150 AB03 BC10 BE01 DA23 DC14 DC15 DE06 DE08 DE09 DE11 DH02 DH03 DH04 DH05 DH32 DH37 DJ24 4C076 AA29 AA32 BB01 CC24 DD67 EE30 FF32 FF33 GG46 4C084 AA17 BA34 BA44 MA01 MA43 MA52 NA02 NA11 ZC221 ZC222 4C086 AA01 AA04 BC19 CB09 CB28 NA02 NA11 ZC22 4C206 AA01 AA04 GA36 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme coat ゛ (Reference) A23K 1/16 303 A23K 1/16 303D 1/175 1/175 A61K 9/14 A61K 9/14 31/197 31/197 31/4188 31/4188 31/455 31/455 31/525 31/525 47/26 47/26 47/36 47/36 A61P 3/02 101 A61P 3/02 101 F term (reference) 2B150 AB03 BC10 BE01 DA23 DC14 DC15 DE06 DE08 DE09 DE11 DH02 DH03 DH04 DH05 DH32 DH37 DJ24 4C076 AA29 AA32.
Claims (9)
６０〜９９．８重量％の糖類及び０．１〜４０重量％の
水溶性塩を含有する水溶性ビタミン粉剤。1. A water-soluble vitamin of 0.1 to 40% by weight,
A water-soluble vitamin powder containing 60 to 99.8% by weight of a saccharide and 0.1 to 40% by weight of a water-soluble salt.
はカルバモイル基を有する化合物である請求項１に記載
の水溶性ビタミン粉剤。2. The water-soluble vitamin powder according to claim 1, wherein the water-soluble vitamin is a compound having a carboxyl group or a carbamoyl group.
ン酸アミド、葉酸、ビオチンまたはパントテン酸である
請求項１または２に記載の水溶性ビタミン粉剤。3. The water-soluble vitamin powder according to claim 1, wherein the water-soluble vitamin is nicotinic acid, nicotinamide, folic acid, biotin, or pantothenic acid.
属塩またはアルカリ土類金属塩である請求項１〜３のい
ずれかに記載の水溶性ビタミン粉剤。4. The water-soluble vitamin powder according to claim 1, wherein the water-soluble salt is an ammonium salt, an alkali metal salt or an alkaline earth metal salt.
類である請求項１〜４のいずれかに記載の水溶性ビタミ
ン粉剤。5. The water-soluble vitamin powder according to claim 1, wherein the saccharide is a monosaccharide, a disaccharide, or a water-soluble polysaccharide.
ずれかに記載の水溶性ビタミン粉剤6. The water-soluble vitamin powder according to claim 1, further comprising a stabilizer.
混合、微細粉砕することにより得られたものである請求
項１〜６のいずれかに記載の水溶性ビタミン粉剤。7. A water-soluble vitamin, water-soluble salt and saccharide,
The water-soluble vitamin powder according to any one of claims 1 to 6, which is obtained by mixing and finely pulverizing.
有量が１５重量％以下である請求項１〜７のいずれかに
記載の水溶性ビタミン粉剤。8. The water-soluble vitamin powder according to claim 1, which has an average particle size of 100 microns or less and a water content of 15% by weight or less.
混合、微細粉砕することを特徴とする水溶性ビタミン粉
剤の製造方法。9. A water-soluble vitamin, water-soluble salt and saccharide,
A method for producing a water-soluble vitamin powder, which comprises mixing and finely pulverizing.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36697799A JP2001181211A (en) | 1999-12-24 | 1999-12-24 | Water-soluble vitamin powder preparation |
| PCT/JP2000/008758 WO2001047519A1 (en) | 1999-12-24 | 2000-12-11 | Powdery biotin preparations |
| AU17363/01A AU1736301A (en) | 1999-12-24 | 2000-12-11 | Powdery biotin preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP36697799A JP2001181211A (en) | 1999-12-24 | 1999-12-24 | Water-soluble vitamin powder preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2001181211A true JP2001181211A (en) | 2001-07-03 |
Family
ID=18488170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP36697799A Pending JP2001181211A (en) | 1999-12-24 | 1999-12-24 | Water-soluble vitamin powder preparation |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2001181211A (en) |
| AU (1) | AU1736301A (en) |
| WO (1) | WO2001047519A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10206415B2 (en) * | 2016-08-02 | 2019-02-19 | Zinpro Corporation | Folic acid rumen by-pass method and composition |
| US10219528B2 (en) * | 2016-08-02 | 2019-03-05 | Zinpro Corporation | Folic acid, metal complexes for rumen by-pass nutritional supplementation of ruminants |
| JP2019526638A (en) * | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | Magnesium biotinate composition and method of use |
| US11622571B2 (en) | 2019-12-16 | 2023-04-11 | Nutrition21, LLC | Methods of production of arginine-silicate complexes |
| US11850219B2 (en) | 2015-11-12 | 2023-12-26 | Nutrition21, LLC | Inositol-stabilized arginine-silicate for hair growth and thickening |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5555112A (en) * | 1978-10-19 | 1980-04-22 | Sumitomo Chem Co Ltd | Preparation of biotin preparation rapidly soluble in water |
| EP0036902B1 (en) * | 1980-04-01 | 1983-04-27 | Sumitomo Chemical Company, Limited | Process for the production of water-soluble biotin-containing preparations and their use as additives to feed supplements |
| US4725427A (en) * | 1984-03-13 | 1988-02-16 | Albion International, Inc. | Effervescent vitamin-mineral granule preparation |
| JP2575008B2 (en) * | 1986-03-31 | 1997-01-22 | 日本農薬株式会社 | Veterinary pharmaceutical composition |
| JPH04169528A (en) * | 1990-11-01 | 1992-06-17 | Tanabe Seiyaku Co Ltd | Spray-dried biotin medicine and preparation thereof |
| US5397576A (en) * | 1992-09-23 | 1995-03-14 | Hoffmann-La Roche Inc. | Spray triturated micronutrient compositions |
| JP4367723B2 (en) * | 1997-08-25 | 2009-11-18 | 大正製薬株式会社 | Solid preparation containing poorly water-soluble ingredients |
-
1999
- 1999-12-24 JP JP36697799A patent/JP2001181211A/en active Pending
-
2000
- 2000-12-11 WO PCT/JP2000/008758 patent/WO2001047519A1/en active Application Filing
- 2000-12-11 AU AU17363/01A patent/AU1736301A/en not_active Abandoned
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11850219B2 (en) | 2015-11-12 | 2023-12-26 | Nutrition21, LLC | Inositol-stabilized arginine-silicate for hair growth and thickening |
| US10206415B2 (en) * | 2016-08-02 | 2019-02-19 | Zinpro Corporation | Folic acid rumen by-pass method and composition |
| US10219528B2 (en) * | 2016-08-02 | 2019-03-05 | Zinpro Corporation | Folic acid, metal complexes for rumen by-pass nutritional supplementation of ruminants |
| KR20190034319A (en) * | 2016-08-02 | 2019-04-01 | 진프로 코포레이션 | Methods and compositions for folate rumen bypassing |
| JP2019527556A (en) * | 2016-08-02 | 2019-10-03 | ジンプロ コーポレーション | Methods and compositions for bypassing the rumen of folic acid |
| KR102304967B1 (en) | 2016-08-02 | 2021-09-23 | 진프로 코포레이션 | Folic acid rumen bypass method and composition |
| JP2019526638A (en) * | 2016-09-01 | 2019-09-19 | ジェイディーエス・セラピューティクス、エルエルシー | Magnesium biotinate composition and method of use |
| US11931342B2 (en) | 2016-09-01 | 2024-03-19 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
| US11938117B2 (en) | 2016-09-01 | 2024-03-26 | Nutrition21, LLC | Magnesium biotinate compositions and methods of use |
| US11622571B2 (en) | 2019-12-16 | 2023-04-11 | Nutrition21, LLC | Methods of production of arginine-silicate complexes |
Also Published As
| Publication number | Publication date |
|---|---|
| AU1736301A (en) | 2001-07-09 |
| WO2001047519A1 (en) | 2001-07-05 |
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