JP2001161314A - Motor ability enhancer based on ferulic acid salt - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a motor ability enhancer capable of inhibiting central fatigue and muscular fatigue based on a ferulic acid salt which is the main ingredient of γ-orizanol obtained from rice embryo buds/seed membrane extracts and having been administered to neuropathic patients in the medical field, and capable of improving the muscular endurance of sportsmen and making sportsmen maximally exert their muscle-nervous system motor ability. SOLUTION: This enhancer is such as to have been realized, for sportsmen regardless of whether they are professional or amateur sportsmen, as a product by combining γ-orizanol consisting mainly of a ferulic acid salt with octacosanol so as to exhibit excellent effects for maintaining and/or improving their motor ability. This enhancer is to be commercially manufactured in a triangular form with a weight of 300 mg, to be taken through oral administration, and designed so as to fully satisfy the necessary daily intake.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a pharmaceutical composition which is administered to a patient suffering from a neurological disorder in the medical field, and comprises a combination of ferulate and octacosanol, which are the main components of γ-oryzanol composed of rice germ / seed membrane extract. The purpose is to prevent central fatigue and muscle fatigue, improve muscle endurance, and maximize muscle-nervous system motor skills.

[0002]

2. Description of the Related Art Gamma-oryzanol, which is mainly composed of ferulate, activates the hypothalamus and the limbic system which are the centers of the autonomic nervous system.
It has been used as a therapeutic drug for improving various symptoms based on neuropsychiatric modulation, promoting microcirculatory blood flow, antioxidant properties, promoting growth, gonad stimulating action, and vitamin E-like action. Γ-, which is mostly converted to ferulate during the digestion process
Oryzanol is considered to be a drawback of formulation because it hardly dissolves in water.It dissolves under heating, but may precipitate over time after cooling, and is limited in terms of solubility, dispersibility, etc. in commercialization. Therefore, it was mainly used as pharmaceuticals.

[0003]

Octacosanol, extracted from the same rice germ / seed membrane as γ-oryzanol, is 4%.
0 years ago, T.A. of the University of Illinois Physical Fitness Laboratory. K. The function of octacosanol has been reported by Cureton et al. The scale is 894 people.
People have been around for 20 years. The contents are also 4
It is evaluated by a training program targeting two items. To summarize the research content, endurance, energy,
Increasing physical strength, improving reflex / sensitivity, improving stress resistance, stimulating sex hormones / reducing muscle spasm, improving muscle function including myocardium, lowering systolic blood pressure, improving basal metabolism, etc. . In 1956, Ezra Levin (University of Illinois) et al. Filed a patent for "stamina enhancer" using octacosanol. Since then, there have been few reports on the function of octacosanol. 19
Between 1984 and 1989, only a few experimental examples appeared. In addition, only a few processed foods using octacosanol have been put on the market to date. The reason is that octacosanol has a high melting point, so that it hardly dissolves in water, making it difficult to use in many foods. It is an object of the present invention to commercialize an athletic ability enhancer by combining octacosanol and ferulate, which is a main component of γ-oryzanol, by utilizing various physiological and pharmacological actions.

[0004]

SUMMARY OF THE INVENTION Ferulates are phenolic acids commonly found in almost all plants. As the experimental sample, γ-oryzanol, which is a ferulate ester of sterols contained in rice germ / seed membrane, is used. γ-Oryzanol is mostly converted to ferulic acid during the digestion process. Literature: Powe
rs, S.R. , Byrd, R .; Tulley, R .; , A
nd Callender, T.W. , Effects o
f caffineine ingestion on m
etabolism and performance
During graded exercise, Eu
r. J. Appl Physiol. , 40, 301,
1983. Ferulic acid is the first metabolite of norepinephrine, which closely resembles the structure of nometanephrine. Literature: Bruni, O .; j. , GammaOry
zanol-The Facts, Claudell
Publishing, Houston, TX, 198
9. Administration of ferulate caused similar effects as increasing hypothalamic norepinephrine, such as promoting somatotropin synthesis in the pituitary gland. Literature:
Ishihama, A .; , Hamatsu, Y .; , An
d Ito, T .; , On the effects o
f gamma oryzanol up ant
erior love rat pituitary,
Yokohama Med. Bull. , 17 (5),
183, 1966. Yamauchi, J .; , Taka
hashi, J .; Uneki, T .; , Yakushi
ji, W .; , Nakashima, Y .; , Miyoshi
i, M. , And Ofuji, T .; , The eff
ects of gamma oryzanolonr
at pituitary hormone secr
etion. FoliaEndocrinol. Jp
n. , 56 (8), 1130, 1980. Ieiri,
T. Kase, N .; , Hashigami, Y .; , K
obori, H .; , Nakamura, T .; , And
Shimoda, S .; , The effects of
gamma oryzanol on the hy
pothalamo-pituitary axis
in the rat, Folia Endocrin
ol. Jpn. , 58 (10), 1350, 1982.
Bruni, O .; J. , Gamma Oryzanol
-The Facts, Claudell Public
shing, Houston, TX, 1989.100.
mg or 500 mg of ferulate (0.3 mg / k
Injection of g) into young cows resulted in a significant increase in serum somatotropin levels. Reference: Gorewit, R .; C. ,
Pituitary and thyroid hor
monesponses of heifers
after ferulicacid admins
transition, J.A. Diary Sci. , 66,6
24, 1983. Other pituitary hormones were not affected. In addition, ferulate showed an activity similar to vitamin E in both in vitro and in vivo studies, and as a result of ingesting 300 mg of γ-oryzanol orally for 40 to 4 women for 4 to 8 weeks. Serum lipid peroxide levels were significantly reduced and returned to normal levels. Therefore, it was confirmed that ferulate was an antioxidant. Literature: Yagi K. and O
hishi, N .; , Action of feruli
c acid and it's derivatives
s as antioxidants, J. et al. Nutr.
Sci. Vitaminol. , 25, 127, 197
9. Tajima, K .; , Sakamoto, M .; , O
kada, K .; Mukai, K .; , Ishizu,
K. , Mori, H .; , And Sakurai,
H. , Reaction of biological
phenolic antioxidants wi
the superoxide generated b
y cytochrome P450 model s
ystem, Biology. Biophys. Re
s. Commun. , 115 (3), 1002, 198
3. Bors, W.C. Michael, C .; , Erben
Russ, M .; Kreilder, B .; , Tai
t, D. , And Saran, M .; , Rate co
nstants of sparingly water
r-soluble pheolic antioxi
dants with hydroxyradical
als, in Oxygen Radicals in
Chemistry and Biology, Bo
rs, W.S. , Saran, M .; , And Tait,
D. , Eds. , Walter deGruyter,
Berlin, 1984, 95. Yin, Z .; Z. , W
ang, J .; P. , And Xu, L .; N. , Effe
ct of sodium ferulate on
malondialdehyde productio
n from the platesets of ra
ts, Acta Pharmacol. Sin. , 7
(4), 336, 1986. Ohta, S, Furuk
awa, M .; , And SHINODA, M .; , Che
medical protectors against
radiation. 23. Radioprotec
active activities of feruli
c acidand it's related com
pounds, YakugakuZasshi, 104
(7), 793, 1984. Ishida, M .; , Ef
facts of gamma oryzanolon
serm lipid peroxide level
l and clinical symptoms ofs
patents with climacteri
c disturbances, Asia-Ocean
ia J.J. Obset. Gynaecol. , 10
(3), 317, 1984. Since it affects somatotropin and can be expected to have an antioxidant effect, a weight-lifting athlete who has been trained was examined for a motor-enhancing effect by orally ingesting ferulate every day for 8 weeks. As a result, a significant increase in lean body mass, a significant decrease in body fat, a significant increase in muscle strength, an improvement in exercise recovery ability, and a decrease in muscle pain after exercise were confirmed. In addition, endorphins were significantly increased after strenuous exercise, supporting the hypothalamic effect on catecholamine neurotransmitters suggested in animal studies. Therefore, supplementation with ferulate improves multiple resistance training effects. Reference: Bucc
i, L. R. , A natural magic bu
llet. Flex, April, 25, 1989. B
ucci, L .; R. , Blackman, G .; , Def
ord, W.C. Kaufmann, R .; , Mandel
-Tayes, C.I. , Sparks, W.C. S. , J. et al.
C. , And Hickson, J. et al. F. Effect
of ferulate on strength
and body composition of w
Eightlighters, J. et al. Appl. SportS
ci. Res. 4 (3), 104, 1990. Bon
ner, B .; , Warren, B .; , And Bucc
i, L. , Influenceof ferulate
supplementation on postex
ercise stress hormore lev
els afterrepeats exercise
stress, J.M. Appl. SportSci. R
es. , 4 (3), 110, 1990. It is a general plant ingredient and ferulate, which is just a nutrient ingredient, confirmed that endorphin, which has an inhibitory effect on fatigue perception, and somatotropin of the pituitary gland were confirmed to be antioxidants, We found the ability to enhance athletic ability.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Ferulate is a material extracted from rice germ / seed membrane, which can be maintained as natural and natural as possible and can maintain its freshness. In the process, it is necessary to consider a product form in which additives and quality deterioration factors such as heat, water, pressure, and air oxidation are small. In addition, daily intake, body absorption, ease of eating,
Factors such as ease of handling, cost, and related laws and regulations must also be considered. The ferulate-based product can be combined with a known food or a food ingredient, an excipient, or a pharmaceutical carrier by a known method to obtain a processed food aimed at enhancing exercise performance. Food ingredients or foods using ferulate, which is the main component of γ-oryzanol, and octacosanol extracted from the same rice germ / seed membrane are not particularly limited, and those skilled in the art may use the food ingredients or foods according to the specific intended use. Can be appropriately selected. Also, the form is not particularly limited, and various forms and shapes can be used according to specific applications.

[0006]

[Example] Male long-distance runner 6 with trehenning
As a result of giving 50 mg / day of ferulate for 3 weeks to the subjects, cortisol, testosterone, and endorphin significantly increased as compared with those at rest. In particular, endorphin increased significantly. Oral ingestion of ferulate by weightlifting athletes for more than 8 weeks resulted in one increase in maximum output for leg press and chest press.

[0007] As a result of giving octacosanol of 1000 µg / day to 16 general students for 8 weeks, the reaction time to the visual stimulus and the grip strength significantly increased.

[0008]

As described above, γ-oryzanol, which is converted into ferulate during the digestion process, has been reported many times for its physiological action and clinical application effect, and has already been used as a drug. In octacosanol, Dr. Cureton concludes that octacosanol's function is "catalytically diverse in the energy production of muscle and human body." From the above, ferulate, which is an extract of rice germ / seed membrane, can be expected to have a sufficient exercise ability enhancing effect.

Claims (1)

[Claims] 1. An agent for enhancing athletic performance of a processed food, which is mainly composed of ferulate having a structure similar to that of normetanephrine.