JP2001131073A5 - - Google Patents
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- Publication number
- JP2001131073A5 JP2001131073A5 JP1999318857A JP31885799A JP2001131073A5 JP 2001131073 A5 JP2001131073 A5 JP 2001131073A5 JP 1999318857 A JP1999318857 A JP 1999318857A JP 31885799 A JP31885799 A JP 31885799A JP 2001131073 A5 JP2001131073 A5 JP 2001131073A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- diphosphonic acid
- hydroxyethylidene
- dysesthesia
- dichloromethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000003839 salts Chemical class 0.000 description 3
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 2
- 208000004454 Hyperalgesia Diseases 0.000 description 2
- 206010013886 Dysaesthesia Diseases 0.000 description 1
- 208000035154 Hyperesthesia Diseases 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 206010053552 allodynia Diseases 0.000 description 1
- ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 （１−ヒドロキシエチリデン）ジホスホン酸もしくはその塩、または（ジクロロメチレン）ジホスホン酸もしくはその塩を有効成分として含有する外科的手術、外傷および／または神経損傷に伴う疼痛、痛覚過敏（hyperalgesia）、異常感覚症（dysesthesia）または異痛症（allodynia）の治療剤。
【請求項２】投与量が約１００〜１０００ｍｇ（１−ヒドロキシエチリデン）ジホスホン酸またはその塩／日／ヒトの経口製剤であることを特徴とする請求項１の治療剤。
[Claims]
(1) (1-hydroxyethylidene) diphosphonic acid or a salt thereof, or (dichloromethylene) diphosphonic acid or a salt thereofFor the treatment of pain, hyperalgesia, dysesthesia or allodynia associated with surgical operation, trauma and / or nerve damage, which contains as an active ingredient.
2. A dosage of about 100 to 1000 mg.(1-hydroxyethylidene) diphosphonic acid or a salt thereof2. The therapeutic agent according to claim 1, which is an oral preparation per day.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31885799A JP2001131073A (en) | 1999-11-09 | 1999-11-09 | Ache-treating agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP31885799A JP2001131073A (en) | 1999-11-09 | 1999-11-09 | Ache-treating agent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001131073A JP2001131073A (en) | 2001-05-15 |
| JP2001131073A5 true JP2001131073A5 (en) | 2006-12-21 |
Family
ID=18103737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP31885799A Abandoned JP2001131073A (en) | 1999-11-09 | 1999-11-09 | Ache-treating agent |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2001131073A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017126700A1 (en) * | 2016-01-20 | 2017-07-27 | 芳則 森山 | Inhibitor of activity of vesicular nucleotide transporter |
| JP2019014684A (en) * | 2017-07-07 | 2019-01-31 | 国立大学法人大阪大学 | Host response inhibitor in fungal infection |
-
1999
- 1999-11-09 JP JP31885799A patent/JP2001131073A/en not_active Abandoned
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