RU2001118854A - OPTICALLY ACTIVE DERIVATIVE OF Pyridyl-4H-1,2,4-Oxadiazine AND ITS APPLICATION FOR TREATMENT OF VASCULAR DISEASES - Google Patents
OPTICALLY ACTIVE DERIVATIVE OF Pyridyl-4H-1,2,4-Oxadiazine AND ITS APPLICATION FOR TREATMENT OF VASCULAR DISEASESInfo
- Publication number
- RU2001118854A RU2001118854A RU2001118854/04A RU2001118854A RU2001118854A RU 2001118854 A RU2001118854 A RU 2001118854A RU 2001118854/04 A RU2001118854/04 A RU 2001118854/04A RU 2001118854 A RU2001118854 A RU 2001118854A RU 2001118854 A RU2001118854 A RU 2001118854A
- Authority
- RU
- Russia
- Prior art keywords
- oxadiazine
- pyridyl
- treatment
- piperidinyl
- dihydro
- Prior art date
Links
- 201000011528 vascular disease Diseases 0.000 title claims 4
- QWVRTSZDKPRPDF-UHFFFAOYSA-N 5-(piperidin-1-ylmethyl)-3-pyridin-3-yl-5,6-dihydro-2H-1,2,4-oxadiazine Chemical compound C1CCCCN1CC(N=1)CONC=1C1=CC=CN=C1 QWVRTSZDKPRPDF-UHFFFAOYSA-N 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 206010007554 Cardiac failure Diseases 0.000 claims 2
- 206010019280 Heart failure Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
Claims (6)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUP9802897 | 1998-12-14 | ||
| HU9802897A HU226617B1 (en) | 1998-12-14 | 1998-12-14 | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001118854A true RU2001118854A (en) | 2003-11-20 |
| RU2222538C2 RU2222538C2 (en) | 2004-01-27 |
Family
ID=10991166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001118854/04A RU2222538C2 (en) | 1998-12-14 | 1999-12-07 | Optically active derivative of pyridyl-4h-1,2,4-oxadiazine and pharmaceutical composition |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6384029B1 (en) |
| EP (1) | EP1147105B1 (en) |
| JP (2) | JP2002532498A (en) |
| KR (1) | KR100661774B1 (en) |
| AT (1) | ATE266027T1 (en) |
| AU (1) | AU765336B2 (en) |
| BG (1) | BG65179B1 (en) |
| BR (1) | BR9913982A (en) |
| CA (1) | CA2340734C (en) |
| CZ (1) | CZ300764B6 (en) |
| DE (1) | DE69917074T2 (en) |
| DK (1) | DK1147105T3 (en) |
| EE (1) | EE04551B1 (en) |
| ES (1) | ES2219091T3 (en) |
| HR (1) | HRP20010133B1 (en) |
| HU (1) | HU226617B1 (en) |
| IL (1) | IL141515A (en) |
| NO (1) | NO317649B1 (en) |
| PL (1) | PL196584B1 (en) |
| PT (1) | PT1147105E (en) |
| RS (1) | RS50129B (en) |
| RU (1) | RU2222538C2 (en) |
| SI (1) | SI1147105T1 (en) |
| SK (1) | SK285582B6 (en) |
| UA (1) | UA70340C2 (en) |
| WO (1) | WO2000035914A1 (en) |
| ZA (1) | ZA200101182B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2471752A1 (en) | 2002-01-11 | 2003-07-17 | Biorex Kutato Es Fejlesztoe Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| KR100678577B1 (en) * | 2006-09-11 | 2007-02-06 | 조만규 | Distribution box for home use |
| EP2484371B1 (en) | 2008-06-26 | 2014-12-17 | Orphazyme APS | Use of Hsp70 as a regulator of enzymatic activity |
| JP2010150243A (en) | 2008-11-18 | 2010-07-08 | Santen Pharmaceut Co Ltd | Treating agent of retinochoroidal degeneration disorder containing pyridine-3-carbaldehyde o-(piperidin-1-yl-propyl)-oxime derivative as active ingredient |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| KR102487452B1 (en) | 2014-09-15 | 2023-01-10 | 오르파짐 에이/에스 | Arimoclomol formulation |
| WO2017178029A1 (en) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Heat shock proteins and cholesterol homeostasis |
| RS61291B1 (en) | 2016-04-29 | 2021-02-26 | Orphazyme As | Arimoclomol for treating glucocerebrosidase associated disorders |
| CA3063974A1 (en) | 2017-05-24 | 2018-11-29 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
| BR112020024182A2 (en) | 2018-05-28 | 2021-03-30 | Orphazyme A/S | METHODS FOR DETECTING HEAT SHOCK PROTEIN 70, TO DIAGNOSE A DISEASE WITH A REDUCED LEVEL OF HEAT SHOCK PROTEIN 70, TO SELECT A PATIENT HAVING A REDUCED LEVEL OF HSP70, TO MONITOR A MONITOR TO MONITOR A MONITOR OF MONITORING EFFECTIVENESS OF A THERAPY TO TREAT A DISEASE, AND TO ADJUST THE DOSAGE OF A SMALL MOLECULE HYDROXYLAMINE DERIVATIVE. |
| WO2022106614A1 (en) | 2020-11-19 | 2022-05-27 | Orphazyme A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU222994B1 (en) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hydroxylamine derivatives and use thereof in the preparation of a pharmaceutical compositions for enhancing of molecular chaperon production of cells |
| AU7324196A (en) * | 1995-11-03 | 1997-05-22 | Global Trading Uk Limited | Apparatus for dispensing and filling bags at a checkout counter of a supermarket |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells |
-
1998
- 1998-12-14 HU HU9802897A patent/HU226617B1/en not_active IP Right Cessation
-
1999
- 1999-07-12 UA UA2001063850A patent/UA70340C2/en unknown
- 1999-12-07 WO PCT/HU1999/000095 patent/WO2000035914A1/en active IP Right Grant
- 1999-12-07 DK DK99961225T patent/DK1147105T3/en active
- 1999-12-07 CZ CZ20011550A patent/CZ300764B6/en not_active IP Right Cessation
- 1999-12-07 EP EP99961225A patent/EP1147105B1/en not_active Expired - Lifetime
- 1999-12-07 SI SI9930566T patent/SI1147105T1/en unknown
- 1999-12-07 DE DE69917074T patent/DE69917074T2/en not_active Expired - Lifetime
- 1999-12-07 KR KR1020017002870A patent/KR100661774B1/en not_active IP Right Cessation
- 1999-12-07 AT AT99961225T patent/ATE266027T1/en active
- 1999-12-07 EE EEP200100188A patent/EE04551B1/en not_active IP Right Cessation
- 1999-12-07 PL PL346767A patent/PL196584B1/en not_active IP Right Cessation
- 1999-12-07 US US09/762,949 patent/US6384029B1/en not_active Expired - Lifetime
- 1999-12-07 ES ES99961225T patent/ES2219091T3/en not_active Expired - Lifetime
- 1999-12-07 JP JP2000588174A patent/JP2002532498A/en not_active Withdrawn
- 1999-12-07 BR BR9913982-0A patent/BR9913982A/en not_active Application Discontinuation
- 1999-12-07 RS YUP-250/01A patent/RS50129B/en unknown
- 1999-12-07 RU RU2001118854/04A patent/RU2222538C2/en not_active IP Right Cessation
- 1999-12-07 SK SK234-2001A patent/SK285582B6/en not_active IP Right Cessation
- 1999-12-07 AU AU17906/00A patent/AU765336B2/en not_active Expired
- 1999-12-07 PT PT99961225T patent/PT1147105E/en unknown
- 1999-12-07 IL IL14151599A patent/IL141515A/en not_active IP Right Cessation
- 1999-12-07 CA CA002340734A patent/CA2340734C/en not_active Expired - Lifetime
-
2001
- 2001-02-12 ZA ZA200101182A patent/ZA200101182B/en unknown
- 2001-02-23 HR HR20010133A patent/HRP20010133B1/en not_active IP Right Cessation
- 2001-03-14 BG BG105342A patent/BG65179B1/en unknown
- 2001-05-10 NO NO20012310A patent/NO317649B1/en not_active IP Right Cessation
-
2011
- 2011-06-08 JP JP2011128516A patent/JP5620340B2/en not_active Expired - Lifetime
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