JP2001120530A - Standard sample and method of manufacturing the sample - Google Patents
Standard sample and method of manufacturing the sampleInfo
- Publication number
- JP2001120530A JP2001120530A JP30207999A JP30207999A JP2001120530A JP 2001120530 A JP2001120530 A JP 2001120530A JP 30207999 A JP30207999 A JP 30207999A JP 30207999 A JP30207999 A JP 30207999A JP 2001120530 A JP2001120530 A JP 2001120530A
- Authority
- JP
- Japan
- Prior art keywords
- standard sample
- measured
- hydroxyapatite
- density
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 31
- 239000000203 mixture Substances 0.000 claims abstract description 29
- 239000008188 pellet Substances 0.000 claims abstract description 26
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 23
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 23
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 17
- 229910052586 apatite Inorganic materials 0.000 claims abstract description 12
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims description 8
- 238000000465 moulding Methods 0.000 claims 1
- 239000012535 impurity Substances 0.000 abstract description 7
- 229910017053 inorganic salt Inorganic materials 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 42
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 10
- 229910000019 calcium carbonate Inorganic materials 0.000 description 5
- 229910052500 inorganic mineral Inorganic materials 0.000 description 5
- 239000011707 mineral Substances 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- 239000000463 material Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000013170 computed tomography imaging Methods 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 230000001066 destructive effect Effects 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004453 electron probe microanalysis Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 239000010421 standard material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は標準試料及びその製
造方法に関し、詳細には人体の歯や骨等の被測定対象物
のＣＴ値を非破壊測定器によって測定し、測定した被測
定対象物のＣＴ値と相対的に比較して被測定対象物の密
度、そして無機塩量を定量的に算出するための、予め組
成成分が既知である標準試料及びその製造方法に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a standard sample and a method for manufacturing the same, and more particularly, to a non-destructive measuring device for measuring a CT value of a measured object such as a human tooth or bone, and measuring the measured CT value. The present invention relates to a standard sample whose composition is known in advance for quantitatively calculating the density of an object to be measured and the amount of an inorganic salt in comparison with a CT value of the sample, and a method for producing the same.
【０００２】[0002]
【従来の技術】従来より、人体の歯と骨の無機成分量
（又は骨塩量）を定量的に測定する方法として、単一Ｘ
−線撮影及びＸ−線ＣＴ（ｃｏｍｐｕｔｅｄ ｔｏｍｏ
ｇｒａｐｈｙ）撮影による非破壊定量測定方法を用い、
そしてアルミニウム板や炭酸カルシウム（ＣａＣＯ3 ）
などからなる標準試料（ファントム）と、被測定対象と
なる生体の歯や骨とを同時に上記非破壊定量測定方法に
よって被測定対象となる生体の歯や骨の無機成分量を定
量的に測定していた。2. Description of the Related Art Conventionally, as a method for quantitatively measuring the amount of inorganic components (or the amount of bone mineral) of teeth and bones of a human body, a single X method has been used.
-Radiography and X-ray CT (computed tomo)
graphy) using a nondestructive quantitative measurement method
And aluminum plate or calcium carbonate (CaCO 3 )
The non-destructive quantitative measurement method is used to simultaneously quantitatively measure the amount of inorganic components in the teeth and bones of the living body to be measured by simultaneously measuring the standard sample (phantom) composed of, for example, the teeth and bones of the living body to be measured. I was
【０００３】[0003]
【発明が解決しようとする課題】しかしながら、生体の
歯や骨の無機質はハイドロキシアパタイトというＣａと
Ｐからなる結晶でできており、上記従来のようなアルミ
ニウム板や炭酸カルシウムなどからなる標準試料では、
直接に、しかも正確に歯や骨に含まれる無機質の量を算
出することはできなかった。また、従来のように、アル
ミニウム板や炭酸カルシウムを用いた場合では、骨の海
綿質における無機質の量を推定することにとどまり、か
つその推定にも限界があった。即ち、アルミニウム板や
炭酸カルシウムを用いた標準試料では、骨の海綿質より
も高いＸ−線不透過性を有する骨の緻密質や歯の象牙質
に対して標準試料の最大値を超えた値を示すため、測定
不能もしくは予測値でしかなかった。更に、従来用いら
れている標準試料のように、炭酸カルシウムを標準試料
とする場合には、結合剤又は賦型材として高分子樹脂等
が用いられているため、これらのＸ−線透過性に及ぼす
影響をゼロにすることは不可能であった。従って、ある
一つの標準試料に対して骨塩量が高いとか、低いという
表現に止まらざるを得なかった。However, the minerals of the teeth and bones of a living body are made of hydroxyapatite, which is a crystal composed of Ca and P. In the above-mentioned standard sample composed of an aluminum plate or calcium carbonate,
It was not possible to directly and accurately calculate the amount of minerals contained in teeth and bones. In addition, when an aluminum plate or calcium carbonate is used as in the related art, only the amount of minerals in the spongy bone is estimated, and the estimation is limited. That is, in the case of a standard sample using an aluminum plate or calcium carbonate, the value exceeding the maximum value of the standard sample for the denseness of bone and the dentin of teeth having higher X-ray opacity than the spongy bone of bone In order to show, it was impossible to measure or was only a predicted value. Furthermore, when calcium carbonate is used as a standard sample, as in the case of a conventionally used standard sample, a polymer resin or the like is used as a binder or a shaping material. It was impossible to eliminate the effect. Therefore, it was inevitable that the bone mineral content was high or low with respect to a certain standard sample.
【０００４】本発明はこれらの問題点に鑑みなされたも
のであり、人体の歯や骨等の被測定対象物の密度、そし
て無機塩量を定量的に算出できるための、人体の歯や骨
等の被測定対象物に非常に近い組成及び緻密度を有する
と共に不純物を含まない標準試料、及びその製造方法を
提供することを目的とする。The present invention has been made in view of these problems, and has been made in consideration of the above problems, and has been made in view of the fact that the density of an object to be measured such as teeth and bones of a human body and the amount of inorganic salts can be quantitatively calculated. It is an object of the present invention to provide a standard sample having a composition and a density very close to an object to be measured and containing no impurities, and a method for manufacturing the same.
【０００５】[0005]
【課題を解決するための手段】前記問題点を解決するた
めに、人体の歯や骨等の被測定対象物の画像濃度と比較
し、被測定対象物の密度を定量的に算出するための、複
数のペレットから構成する、本発明の標準試料の各ペレ
ットは、ハイドロキシアパタイト又は当該ハイドロキシ
アパタイトの一部の組成を他の元素に置換したアパタイ
トと炭素を、複数の所定の混和比で混和して構成するこ
とに特徴がある。また、アパタイトと炭素の混和比を、
１００：０、８０：２０、６０：４０、４０：６０、２
０：８０とした。また、炭素の純度を９９．９９９９％
とした。よって、人体の歯や骨等の被測定対象部に非常
に近い組成及び緻密度を有すると共に不純物を含まない
標準試料を提供できる。In order to solve the above-mentioned problems, the density of an object to be measured is quantitatively calculated by comparing the image density of the object to be measured such as teeth and bones of a human body. Each pellet of the standard sample of the present invention, composed of a plurality of pellets, is prepared by mixing hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element with carbon at a plurality of predetermined mixing ratios. There is a feature in the configuration. Also, the mixing ratio of apatite and carbon,
100: 0, 80:20, 60:40, 40:60, 2
0:80. Further, the purity of carbon is 99.9999%.
And Therefore, it is possible to provide a standard sample which has a composition and a density very close to a portion to be measured, such as teeth and bones of a human body, and does not contain impurities.
【０００６】また、別の発明として、人体の歯や骨等の
被測定対象物の画像濃度と比較し、被測定対象物の密度
を定量的に算出するための、複数のペレットから構成す
る標準試料を製造する製造方法において、ハイドロキシ
アパタイト又は当該ハイドロキシアパタイトの一部の組
成を他の元素に置換したアパタイトと炭素を、混和比１
００：０、８０：２０、６０：４０、４０：６０、２
０：８０で混和した混和物を作成し、各混和物を減圧し
ながら４．４１×１０7 Ｐａの圧力で複数のペレットに
成型する。よって、人体の歯や骨等の被測定対象物に非
常に近い組成及び緻密度を有すると共に不純物を含まな
い標準試料を製造できる。In another aspect of the present invention, a standard comprising a plurality of pellets for quantitatively calculating the density of an object to be measured by comparing the image density of the object to be measured such as teeth and bones of a human body. In the production method for producing a sample, hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element and carbon are mixed at a mixing ratio of 1
00: 0, 80:20, 60:40, 40:60, 2
At 0:80, a mixture is prepared, and each mixture is molded into a plurality of pellets at a pressure of 4.41 × 10 7 Pa while reducing the pressure. Therefore, it is possible to manufacture a standard sample having a composition and a density very close to the object to be measured such as human teeth and bones and containing no impurities.
【０００７】[0007]
【発明の実施の形態】本発明の標準試料の各ペレット
を、ハイドロキシアパタイト又は当該ハイドロキシアパ
タイトの一部の組成を他の元素に置換したアパタイトと
炭素を、複数の所定の混和比で混和して構成した。。BEST MODE FOR CARRYING OUT THE INVENTION Each pellet of the standard sample of the present invention is prepared by mixing hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element with carbon at a plurality of predetermined mixing ratios. Configured. .
【０００８】[0008]
【実施例】はじめに、本発明の一実施例に係る標準試料
の組成について説明する。EXAMPLES First, the composition of a standard sample according to an example of the present invention will be described.
【０００９】本実施例の標準試料を構成するペレットの
組成は、 ハイドロキシアパタイト（Ｈｙｄｒｏｘｙａｐａｔｉ
ｔｅ）《化学式；Ｃａ 10（ＰＯ4）6（ＯＨ）2，分子
量；１００５》 炭素（Ｃ，原子量；１２，純度；９９．９９９９％）
である。The pellets constituting the standard sample of this embodiment
The composition is hydroxyapatite (Hydroxyapati)
te) << Chemical formula; Ca Ten(POFour)6(OH)Two,molecule
Amount; 1005 >> Carbon (C, atomic weight; 12, purity; 99.9999%)
It is.
【００１０】次に、本実施例の標準試料を製造する工程
について説明する。 工業的に生産されたもの、あるいは自家製のものであ
って、詳細な組成が既知であるハイドロキシアパタイト
（以下ＨＡと表す）と、炭素（以下Ｃと表す）とを以下
のような例えば６種類の混和比になるようにそれぞれの
重量を計量しておく。Next, a process of manufacturing the standard sample of the present embodiment will be described. For example, six types of hydroxyapatite (hereinafter, referred to as HA) and carbon (hereinafter, referred to as C), which are industrially produced or home-made, and whose detailed composition is known, are as follows. Weigh each weight so that the mixing ratio is obtained.
【００１１】サンプル１ ＨＡ：Ｃ＝１００：０ サンプル２ ＨＡ：Ｃ＝ ８０：２０ サンプル３ ＨＡ：Ｃ＝ ６０：４０ サンプル４ ＨＡ：Ｃ＝ ４０：６０ サンプル５ ＨＡ：Ｃ＝ ２０：８０Sample 1 HA: C = 100: 0 Sample 2 HA: C = 80: 20 Sample 3 HA: C = 60: 40 Sample 4 HA: C = 40: 60 Sample 5 HA: C = 20: 80
【００１２】そして、上記割合となる５種類のサンプ
ル毎に各々乳鉢を用いてＨＡとＣが均一に混和させて、
５個の混和物を作成する。Then, HA and C are uniformly mixed using a mortar for each of the five types of samples having the above ratio,
Make 5 blends.
【００１３】金型に各混和物を入れてプレスして５個
のペレット１〜５に成型する。その際４．４１×１０7
Ｐａの圧力で圧縮し、真空ポンプを用いて同時に減圧す
る減圧状態とし、人体の歯や骨の緻密度に近い材料を作
成する。Each mixture is put into a mold and pressed to form five pellets 1-5. At that time, 4.41 × 10 7
The material is compressed under a pressure of Pa, and is decompressed at the same time using a vacuum pump to produce a material having a density close to the densities of human teeth and bones.
【００１４】次に、このような製造工程によって作成さ
れた５個のペレット１〜５からなる標準試料を用いた実
際の測定方法について説明する。Next, an actual measuring method using a standard sample composed of five pellets 1 to 5 prepared by such a manufacturing process will be described.
【００１５】完成した各ペレットの直径と厚さをマイ
クロメータを用いて計測して体積を算出する。 完成した各ペレットの正確な重量を測定する。 完成した各ペレットの密度を、上記で計測した体積
と、で測定した重量に基づいて算出する。当該密度は
ＨＡｍｇ／ｍｍ3 という単位で表すと、各ペレットの密
度は下記の表に示す数値となる。 完成した各ペレットを有する標準材料として、実際に
Ｘ−線ＣＴ撮影による分析を行う。その結果、表及び図
１に示すような特性が得られた。 図２に示すように、実際に被測定対象物１１である人
体の歯や骨と、完成した各ペレット１〜５を有する標準
試料１２とをＸ−線ＣＴ撮影によって各々のＣＴ値を測
定する。 得られた被測定対象物１１、特に測定対象領域１１ａ
のＣＴ値と標準試料のＣＴ値を比較することにより、又
は図１の特性に照らし合わせることにより、直接歯や骨
の密度、そして歯や骨に含まれる無機塩量を定量的に算
出できる。The diameter and thickness of each completed pellet are measured using a micrometer to calculate the volume. Measure the exact weight of each completed pellet. The density of each completed pellet is calculated based on the volume measured above and the weight measured above. When the density is expressed in units of HAmg / mm 3 , the density of each pellet is a numerical value shown in the following table. As a standard material having each completed pellet, analysis is actually performed by X-ray CT imaging. As a result, characteristics as shown in the table and FIG. 1 were obtained. As shown in FIG. 2, each CT value is measured by X-ray CT imaging of the tooth or bone of the human body, which is the object 11 to be measured, and the standard sample 12 having the completed pellets 1 to 5. . Obtained object 11 to be measured, especially area 11a to be measured
By comparing the CT value of the standard sample with the CT value of the standard sample, or by comparing with the characteristics of FIG. 1, the density of teeth and bones and the amount of inorganic salts contained in teeth and bones can be directly calculated quantitatively.
【００１６】[0016]
【表１】 [Table 1]
【００１７】以上説明したように、本実施例によれば、
標準試料は４．４１×１０7 Ｐａの圧力で圧縮し、同時
に真空ポンプを用いて減圧するため、非常に人体の骨の
緻密質や歯の象牙質に近い密度の標準試料が完成する。
また、本実施例の標準試料はハイドロキシアパタイトと
炭素以外の不純物をほとんど含まないため、Ｘ−線透過
性に及ぼす影響をほぼゼロにすることができる。理想的
にも、また実際のＣＴ値の測定においても、本実施例に
よれば、そのＣＴ値とハイドロキシアパタイトの密度の
間での相関係数ｒ＝０．９９９９以上の値を示す標準試
料が得られる。As described above, according to this embodiment,
Since the standard sample is compressed at a pressure of 4.41 × 10 7 Pa and simultaneously depressurized by using a vacuum pump, a standard sample having a density very close to the denseness of human bone and the dentin of teeth is completed.
Further, since the standard sample of this example contains almost no impurities other than hydroxyapatite and carbon, the influence on the X-ray permeability can be made almost zero. According to this embodiment, ideally and in actual measurement of CT value, according to the present embodiment, a standard sample exhibiting a correlation coefficient r = 0.9999 or more between the CT value and the density of hydroxyapatite is obtained. can get.
【００１８】なお、上記実施例における標準試を構成す
るペレットの組成の１つをハイドロキシアパタイトであ
ったがこれに限定するものではなく、ハイドロキシアパ
タイトの一部の組成を他の元素に置換したアパタイトの
同族であればよい。また、各ペレットの混和比は上記数
値に限定するものではなく、上記実施例における標準試
料はＸ−線撮影装置及びＥＰＭＡ（ｅｌｅｃｔｒｏｎ
ｐｒｏｂｅ ｍｉｃｒｏ ａｎａｌｙｚｅｒ）にも応用
可能であることは言うまでもない。更に、本発明は上記
実施例に限定されるものではなく、特許請求の範囲内の
記載であれば多種の変形や置換可能であることは言うま
でもない。In the above embodiment, one of the compositions of the pellets constituting the standard sample was hydroxyapatite, but the present invention is not limited to this. The apatite obtained by substituting a part of the composition of hydroxyapatite with another element is used. Any family members are acceptable. The mixing ratio of each pellet is not limited to the above value, and the standard sample in the above example is an X-ray photographing apparatus and an EPMA (electron).
Needless to say, the present invention can also be applied to a probe micro analyzer. Further, it is needless to say that the present invention is not limited to the above-described embodiment, and various modifications and substitutions can be made within the scope of the claims.
【００１９】[0019]
【発明の効果】以上説明したように、本発明によれば、
人体の歯や骨等の被測定対象物の画像濃度と比較し、被
測定対象物の密度を定量的に算出するための、複数のペ
レットから構成する、本発明の標準試料の各ペレット
は、ハイドロキシアパタイト又は当該ハイドロキシアパ
タイトの一部の組成を他の元素に置換したアパタイトと
炭素を、複数の所定の混和比で混和して構成することに
特徴がある。また、アパタイトと炭素の混和比を、１０
０：０、８０：２０、６０：４０、４０：６０、２０：
８０とした。また、炭素の純度を９９．９９９９％とし
た。よって、人体の歯や骨等の被測定対象部に非常に近
い組成及び緻密度を有すると共に不純物を含まない標準
試料を提供できる。As described above, according to the present invention,
Compared with the image density of the object to be measured such as teeth and bones of the human body, for quantitatively calculating the density of the object to be measured, each pellet of the standard sample of the present invention, comprising a plurality of pellets, It is characterized in that hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element and carbon are mixed at a plurality of predetermined mixing ratios. Further, the mixing ratio of apatite and carbon is set to 10
0: 0, 80:20, 60:40, 40:60, 20:
80. The carbon purity was 99.9999%. Therefore, it is possible to provide a standard sample which has a composition and a density very close to a portion to be measured, such as teeth and bones of a human body, and does not contain impurities.
【００２０】また、別の発明として、人体の歯や骨等の
被測定対象物の画像濃度と比較し、被測定対象物の密度
を定量的に算出するための、複数のペレットから構成す
る標準試料を製造する製造方法において、ハイドロキシ
アパタイト又は当該ハイドロキシアパタイトの一部の組
成を他の元素に置換したアパタイトと炭素を、混和比１
００：０、８０：２０、６０：４０、４０：６０、２
０：８０で混和した混和物を作成し、各混和物を減圧し
ながら４．４１×１０7 Ｐａの圧力で複数のペレットに
成型する。よって、人体の歯や骨等の被測定対象部に非
常に近い組成及び緻密度を有すると共に不純物を含まな
い標準試料を製造できる。According to another aspect of the present invention, there is provided a standard comprising a plurality of pellets for quantitatively calculating the density of an object to be measured by comparing the image density of the object to be measured such as teeth and bones of a human body. In the production method for producing a sample, hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element and carbon are mixed at a mixing ratio of 1
00: 0, 80:20, 60:40, 40:60, 2
At 0:80, a mixture is prepared, and each mixture is molded into a plurality of pellets at a pressure of 4.41 × 10 7 Pa while reducing the pressure. Therefore, it is possible to manufacture a standard sample which has a composition and a density very close to a measurement target portion such as a human tooth or a bone and does not contain impurities.
【図１】本発明の一実施例に係る標準試料を用いた密度
とＣＴ値の関係を示す特性図である。FIG. 1 is a characteristic diagram showing a relationship between a density and a CT value using a standard sample according to one embodiment of the present invention.
【図２】本発明の一実施例に係る標準試料を用いたＣＴ
値測定の様子を示す図である。FIG. 2 shows a CT using a standard sample according to one embodiment of the present invention.
It is a figure showing a situation of a value measurement.
１１；被測定対象物、１２；標準試料。 11: object to be measured, 12: standard sample.
Claims (4)
度と比較し、被測定対象物の密度を定量的に算出するた
めの、複数のペレットから構成する標準試料において、 前記各ペレットは、ハイドロキシアパタイト又は当該ハ
イドロキシアパタイトの一部の組成を他の元素に置換し
たアパタイトと炭素を、複数の所定の混和比で混和して
構成することを特徴とする標準試料。1. A standard sample composed of a plurality of pellets for quantitatively calculating the density of an object to be measured by comparing the image density of the object to be measured such as teeth and bones of a human body, A standard sample, wherein the pellet is formed by mixing hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element and carbon at a plurality of predetermined mixing ratios.
０、８０：２０、６０：４０、４０：６０、２０：８０
とする請求項１記載の標準試料。2. The mixing ratio of apatite and carbon is 100:
0, 80:20, 60:40, 40:60, 20:80
The standard sample according to claim 1, wherein
た請求項１又は２に記載の標準試料。3. The standard sample according to claim 1, wherein the purity of the carbon is 99.9999%.
度と比較し、被測定対象物の密度を定量的に算出するた
めの、複数のペレットから構成する標準試料を製造する
製造方法において、 ハイドロキシアパタイト又は当該ハイドロキシアパタイ
トの一部の組成を他の元素に置換したアパタイトと炭素
を、混和比１００：０、８０：２０、６０：４０、４
０：６０、２０：８０で混和した混和物を作成し、各混
和物を減圧しながら４．４１×１０7 Ｐａの圧力で複数
のペレットに成型することを特徴とする標準試料の製造
方法。4. A method for manufacturing a standard sample composed of a plurality of pellets for quantitatively calculating the density of an object to be measured by comparing the image density of the object to be measured such as teeth and bones of a human body. In the method, hydroxyapatite or apatite obtained by substituting a part of the composition of the hydroxyapatite with another element and carbon are mixed at a mixing ratio of 100: 0, 80:20, 60: 40,4.
A method for producing a standard sample, comprising preparing a mixture at 0:60 and 20:80 and molding each mixture into a plurality of pellets at a pressure of 4.41 × 10 7 Pa while reducing the pressure of each mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30207999A JP3300690B2 (en) | 1999-10-25 | 1999-10-25 | Standard sample and its manufacturing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP30207999A JP3300690B2 (en) | 1999-10-25 | 1999-10-25 | Standard sample and its manufacturing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001120530A true JP2001120530A (en) | 2001-05-08 |
| JP3300690B2 JP3300690B2 (en) | 2002-07-08 |
Family
ID=17904679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP30207999A Expired - Fee Related JP3300690B2 (en) | 1999-10-25 | 1999-10-25 | Standard sample and its manufacturing method |
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| Country | Link |
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| JP (1) | JP3300690B2 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005312945A (en) * | 2004-03-30 | 2005-11-10 | National Institute Of Advanced Industrial & Technology | Nanoapatite phantom and its application |
| JP2009000205A (en) * | 2007-06-20 | 2009-01-08 | Univ Of Tsukuba | Conversion apparatus and method for ct number-water equivalent thickness, storage medium used therefor, and radiation therapy apparatus and method |
| JP2009233294A (en) * | 2008-03-28 | 2009-10-15 | Bionic Co Ltd | Ct marker and generation method of three-dimensional tomographic image |
| JP2020008391A (en) * | 2018-07-06 | 2020-01-16 | 国立研究開発法人海洋研究開発機構 | Density measurement method, calibration reference material, and fabrication method therefor |
| EP3569149A4 (en) * | 2017-01-10 | 2020-11-04 | Media Co., Ltd. | Bone density measurement device, bone density measurement system, and imaging assisting tool |
-
1999
- 1999-10-25 JP JP30207999A patent/JP3300690B2/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005312945A (en) * | 2004-03-30 | 2005-11-10 | National Institute Of Advanced Industrial & Technology | Nanoapatite phantom and its application |
| JP2009000205A (en) * | 2007-06-20 | 2009-01-08 | Univ Of Tsukuba | Conversion apparatus and method for ct number-water equivalent thickness, storage medium used therefor, and radiation therapy apparatus and method |
| JP2009233294A (en) * | 2008-03-28 | 2009-10-15 | Bionic Co Ltd | Ct marker and generation method of three-dimensional tomographic image |
| EP3569149A4 (en) * | 2017-01-10 | 2020-11-04 | Media Co., Ltd. | Bone density measurement device, bone density measurement system, and imaging assisting tool |
| JP2020008391A (en) * | 2018-07-06 | 2020-01-16 | 国立研究開発法人海洋研究開発機構 | Density measurement method, calibration reference material, and fabrication method therefor |
| JP7175462B2 (en) | 2018-07-06 | 2022-11-21 | 国立研究開発法人海洋研究開発機構 | Density measurement method and calibration standard sample and method for preparing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP3300690B2 (en) | 2002-07-08 |
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