JP2001114671A - Cataplasm - Google Patents

Abstract

PROBLEM TO BE SOLVED: To solve a problem that the effects of a cataplasm are not sustained for a long time and a problem that the cataplasm causes rash and inflammation at a cataplasm-applied site as adverse effects against the effects of the cataplasm, because the cataplasm must be brought into contact with skin for a long period and must supply a medicinally active ingredient into a body through the skin originally having a role for preventing the invasion of substances into the body. SOLUTION: This cataplasm is an epoch-making cataplasm which can maintain the antiphlogistic sedative effect of a main ingredient and improve the flow of blood at the contact side of the cataplasm usually saturated with water to keep the medicinal effect, whose cell-activating action and active oxygen- resistant effect improve the irritating property of the cataplasm to protect the skin at the cataplasm-applied site, and which thus solve the adverse effects.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an anti-inflammatory analgesic patch.

[0002]

2. Description of the Related Art Patches conventionally used are generally referred to as molded cataplasms, and include stiff shoulders, muscular fatigue, bruises and other bruises.
It is widely used for pain associated with inflammation. Its usage is simple, just sticking it to the affected area.

[0003] However, the patch must be in contact with the skin for a long time because of its form, and it is necessary to put a medicinal ingredient into the body through the skin, which originally has a function of preventing invasion into the body from the outside. For these reasons, in addition to the effect not being maintained for a long time, irritation to the skin such as the base of the patch or the medicinal component always poses a problem. That is, rash and inflammation at the site of application are present as side effects on the effect.

[0004] Of these, the base itself has been studied considerably, and a base having low irritation has come to be used. However, in the form of a patch, there are also effects of medicinal ingredients, various stabilizers, transdermal absorption enhancers, and the like, and the problem of irritation, which is the reverse of the effect, has not been solved. In particular, those containing hot pepper type pepper extract or nonylate vanillylamide have the effect of stimulating the hot spot of the skin and improving blood flow, but at the same time, it is the effect of irritation to the skin, which has a long effect. The use of time has the potential to worsen the condition of the skin. The inventors of the present invention have conducted intensive studies from the viewpoint of safe and less irritating as a whole patch without reducing the effect of the patch, and as a result, the blood flow improvement of the patch site and the anti-reactive oxygen effect on the skin surface and The present invention has been completed by a combination of cell activation effects.

[0005]

DISCLOSURE OF THE INVENTION The present invention relates to a commonly used analgesic and anti-inflammatory component and a component that generates far-infrared rays that have a positive effect on blood flow improvement, and also has an effect on antioxidant and cell activating effects on the skin. Consists of a colloid of a platinum group element. As the anti-inflammatory analgesic component, not only menthol, camphor, salicylic acid and the like, which are said to be the first generation, and their derivatives and combinations thereof, but also indomethacin, which is said to be the second generation, can be used. These show the medicinal effects of anti-inflammatory analgesia.

As a component for generating far-infrared rays, for example, barley stone, tourmaline, peridotite, serpentine, kyanite, sericite, or ceramics prepared using them are used. This fine powder is usually 0.1% to 10%, preferably 0.5% to 5%.
Use at a% concentration. Increasing the amount further does not change the effect. Further, if it is lower than this, the effect cannot be expected.
The far-infrared ray-generating component expands the blood vessel at the site by the far-infrared ray, improves blood flow, and stably maintains the patch application site.

As a colloidal product of a platinum group element, a colloid of platinum and palladium is particularly preferably used. The colloid of platinum and palladium has a particle diameter of 75 μm or less, and the ratio of platinum and palladium is 1: 3 to 3: 1,
In particular, it is desirable to use a colloid such as about 2: 3 or a solution containing it. The colloid of platinum and palladium used in the present invention can be prepared by a method known in the art, for example, by placing distilled water in an evaporating dish, and cooling the mixture between two platinum electrodes immersed therein.
It is possible to use one manufactured by a Bragg method or the like in which an arc is blown by a direct current of about 100 V or a high-frequency high current of about 10 ⁵ to 10 ⁷ . A palladium colloid can be similarly produced by a Bragg method or the like in which a platinum electrode is replaced with a palladium electrode. The content of these colloids in the product is 20 to 3000 ppm, preferably 100 to 1000 ppm. If the amount is less than this, the effect is not obtained. If the amount is more than this, only the cost increases and the effect is not improved.

[0008] Since such colloids of platinum and palladium have a strong anti-reactive oxygen effect and a cell activating effect, when used as a patch, the moisture generated from the base material on the skin surface is saturated and the drug permeates from the skin. Promotes and simultaneously protects the sensitized skin surface and protects the skin from irritation.

As the base of the patch, commonly used substances such as gelatin, carmellose sodium, methylcellulose and sodium polyacrylate can be used. An appropriate amount of medicinal component, far-infrared ray generating component and platinum and palladium colloid are mixed with this base and kneaded to form a plaster,
A patch can be produced by a standard method for producing a molded cataplasm.

[0010]

Embodiments or Examples Indomethacin 1%, 3
3% barley rice stone and platinum colloid 2 crushed to less than 00 mesh
00 ppm and 300 ppm of palladium colloid were kneaded with a base of sodium polyacrylate together with a transdermal absorption enhancer d-limonene under a nitrogen stream to prepare a plaster according to a standard method as a plaster.

[0011]

Industrial Applicability The present invention improves the blood flow at the contact site of a patch which is usually saturated with water, maintains the efficacy, and has a cell activating effect and an anti-reactive oxygen effect. It is an epoch-making solution that improves the irritancy of the patch and protects the skin at the patch site, eliminating the side effects of the patch.

Claims (4)

[Claims] 1. An anti-inflammatory analgesic patch characterized by using a colloidal substance of a platinum group element, a drug having a medicinal component for anti-inflammatory analgesia, and a component generating far-infrared rays. 2. An anti-inflammatory analgesic patch, wherein at least one of platinum, palladium and other platinum group elements is used as the colloidal product of the platinum group element according to claim 1. 3. The anti-inflammatory analgesic component used in claim 1 is one or more of menthol, salicylic acid, camphor, borneol, glycyrrhizic acid and derivatives thereof, peppermint oil, eucalyptus oil and indomethacin. Anti-inflammatory analgesic patch 4. The component that generates far-infrared rays used in claim 1 is malted stone, tourmaline, peridotite,
An anti-inflammatory analgesic patch characterized by using one or more of serpentine, kyanite, sericite or ceramics prepared using them at a concentration of 0.1% to 10%.