JP2001089337A - Composition for oral use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral use free from the generation of carbonic acid gas during preparation, capable of keeping foaming performance even after a long storage at high temperatures and having good taste on use. SOLUTION: This composition for oral use comprises (A) an alkaline aqueous solution containing one or more materials selected from alkali metal hydrogen carbonates, basic amino acids, alkali metal salts of an organic acid and tri alkali metal salts of phosphoric acid, and (B) an aqueous solution containing an acidic substance. The composition foams by mixing the aqueous solution (A) and the aqueous solution (B).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an effervescent oral composition.

[0002]

2. Description of the Related Art Oral compositions in which a carbonate aqueous solution and an acidic aqueous solution are mixed and foamed at the time of use are already known, but have problems in taste and high-temperature stability. As a technique for improving the high-temperature stability, a foamable oral composition which is foamed by mixing one liquid containing an alkali metal bicarbonate and an alkali metal carbonate and two liquids containing an acidic substance (Japanese Patent Laid-Open No. No. 9-175969), and one or more pH-lowering agents selected from alkali metal carbonate, alkali metal dihydrogen phosphate, alkali metal dihydrogen phosphate, and alkali metal hydrogen sulfate. There is known a foamable oral composition (Japanese Patent Application Laid-Open No. 9-235214) in which foaming is performed by mixing one liquid containing an acidic substance and two liquids containing an acidic substance.

[0003]

However, the system in which the alkali metal bicarbonate and the alkali metal carbonate are used in combination has a problem that the taste after mixing the acidic liquid becomes salty.
In addition, a combination of an alkali metal carbonate and an alkali metal dihydrogen phosphate, an alkali metal hydrogen phosphate, or an alkali metal hydrogen sulfate causes foaming at the time of preparation, wastes a large amount of raw material, and reduces the amount of residual carbon dioxide. Is also not constant. In addition, there is a problem such as necessity of handling equipment at a manufacturing site.

[0004]

Accordingly, the present inventor has proposed an aqueous carbonate solution using an alkali metal bicarbonate and a basic amino acid, an organic acid alkali metal salt or a tri-alkali metal phosphate as an aqueous alkali solution. By adopting,
It has been found that the salty taste after mixing the acidic liquid is remarkably improved, and that unnecessary foaming during preparation can be effectively prevented.

That is, the present invention relates to an alkaline aqueous solution containing (A) an alkali metal bicarbonate and at least one substance selected from a basic amino acid, an organic acid alkali metal salt and a trialkali metal phosphate. , (B) an aqueous solution containing an acidic substance, and an oral composition which foams by mixing the aqueous solution (A) and the aqueous solution (B).

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The oral composition of the present invention comprises the above aqueous solution (A) and aqueous solution (B), wherein the alkali metal bicarbonate used in the aqueous solution (A) is sodium or potassium. And bicarbonates such as lithium, with sodium bicarbonate being particularly preferred. The concentration of the alkali metal bicarbonate in the aqueous solution (A) is from 0.1 to 10% by weight (hereinafter simply referred to as%), further from 0.5 to 5%, particularly from 0.5 to 3% from the viewpoint of foaming property. Is preferred.

The basic amino acids used in the aqueous solution (A) include arginine, lysine, histidine and the like. Examples of the alkali metal salts of organic acids include alkali metal salts of organic acids such as citric acid and malic acid. Further, examples of the trialkali metal phosphate include trisodium phosphate and tripotassium phosphate. Among these, basic amino acids are more preferable from the viewpoint of taste when mixed with the aqueous solution (B). These substances are used alone or in combination of two or more. The amount of these substances in the aqueous solution (A) is not particularly limited as long as the amount of the aqueous solution (A) is alkalified, but the pH is particularly preferably 8.3 or more from the viewpoint of prevention of foaming during preparation and taste. 8.3-1
An amount of 0, particularly 8.3 to 9.5 is preferred.

The acidic substance used in the aqueous solution (B) may be an organic acid or an inorganic acid, for example, malic acid, citric acid,
Examples thereof include organic acids such as tartaric acid, glycolic acid, adipic acid, succinic acid, and lactic acid, and inorganic acids such as boric acid, hydrochloric acid, pyrophosphoric acid, and phosphoric acid. The pH of the aqueous solution (B) varies depending on the amount used, and the pH of the mixed solution when mixed with the aqueous solution (A) can be adjusted to 2.0 to 7.0, preferably 5.5 to 6.5. Usually, it is acidic, that is, it is in the range of 1.0 to 7.0, and preferably in the range of 2.0 to 5.0.

The oral composition of the present invention is prepared by mixing the aqueous solution (A) and the aqueous solution (B) and foaming them when used, and includes mouthwashes, liquid dentifrices, mouthwashes, mouth fresheners and the like. Used as Therefore, components according to these uses can be blended with the aqueous solution (A) and / or the aqueous solution (B) as long as the liquid properties are not impaired. Examples of such components include abrasives such as silica, hydroxyapatite, calcium phosphate, and hydrated alumina; glycerin, sorbite, propylene glycol, polyethylene glycol,
Wetting agents such as xylitol; binding agents such as sodium carboxymethylcellulose, xanthan gum, gum arabic, guar gum, polyacrylate, carboxyvinyl polymer; peppermint oil, spearmint oil, l
-Fragrances such as menthol, carvone, anethole and the like; sweeteners such as saccharin sodium, bactericides such as triclosan, cetylpyridinium chloride, benzethonium chloride and sodium fluoride, and other medicinal ingredients.

Since the aqueous composition (A) and the aqueous solution (B) are not brought into contact with the oral composition of the present invention until use, they are usually supplied in separate containers.

[0011]

EXAMPLES Examples 1 to 7 and Comparative Examples 1 to 3 An aqueous solution (A) and an aqueous solution (B) were prepared according to the formulations shown in Tables 1 and 2. The presence or absence of foaming (visual observation) during the preparation of the aqueous solution (A) and the residual ratio of carbonate groups after storing the aqueous solution (A) at 50 ° C. for one month were measured. In addition, equal amounts of the aqueous solution (A) and the aqueous solution (B) were mixed and foamed, and then the taste when gargle was evaluated. The results are shown in Tables 1 and 2.

(1) Method for measuring the residual ratio of carbonate radicals: Measured by a neutralization titration method. Excess acid was mixed with the sample, and carbonic acid radicals in the sample were carbonized. The generated carbon dioxide gas was absorbed into an aqueous barium hydroxide solution, and the excess barium hydroxide was back-titrated with dilute hydrochloric acid.

(2) Taste evaluation method Sensory evaluation was performed by 10 panelists. The evaluation criteria were the following three levels. ：: good △: slightly salty ×: salty

[0014]

[Table 1]

[0015]

[Table 2]

As is clear from Tables 1 and 2, the composition of the present invention did not foam at the time of preparing the aqueous solution (A), and retained the foaming performance even when stored at a high temperature for a long period of time. Also,
Good taste when used.

[0017]

[0018]

[0019]

[0020]

The oral composition of the present invention does not generate carbon dioxide at the time of preparation, and maintains its foaming performance even when stored at a high temperature for a long time. The taste at the time of use is also good.

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Claims (1)

[Claims] 1. An alkaline aqueous solution containing (A) an alkali metal bicarbonate and one or more substances selected from a basic amino acid, an organic acid alkali metal salt and a trialkali metal phosphate, and (B) An oral composition comprising an aqueous solution containing an acidic substance and foaming by mixing the aqueous solution (A) and the aqueous solution (B).