JP2001081036A - Prophylactic and ameliorating composition for nasty aftereffect and hangover - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of imparting a new method for utilizing fish testes and excellent in effect and safety by including a constituent obtained by a specific method from fish testes. SOLUTION: This composition comprises a filtrate component obtained after the centrifugal separation of ground fish testes mixed with water or its extraction separation using alcohols or water-containing alcohols. The filtrate may be used as it is but can be utilized for preparations as a concentrate by being concentrated or a dried product by being dried. The composition is preferably produced by conducting the above centrifugal separation or extraction separation, separating the mixture into a filtrate part and a precipitation part, and then recovering the filtrate part. The mixture of the fish testes with water is made easy to be separated into the filtrate part and the precipitation part in the centrifugal separation by being heated up to a liquid temperature of about 70 deg.C. The testes can be obtained as a by-product in processing fishes such salmon, trout, herring and Alaska pollack.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for preventing and improving sickness and hangover during drinking, comprising an extract from fish testis as an active ingredient, and a method for producing the same.

[0002]

2. Description of the Related Art Drinking has been a widely used habit since ancient times, but unpleasant symptoms such as headache, nausea, nausea, palpitations, tachycardia, and skin flushing caused by drinking are called sickness and hangover.

[0003] Such a symptom is attributed to the fact that alcohol absorbed into the body and acetaldehyde generated during alcohol metabolism in the liver remain in the blood without being sufficiently metabolized. As a technique using a naturally-derived component to suppress or alleviate these symptoms, a technique using a silk protein hydrolyzate as an active ingredient (Japanese Patent Laid-Open No. 01-2)
No. 56352), a technique using caffeine and catechin as active ingredients (JP-A-08-169831), and a technique using a hydrolyzate of eggshell membrane as an active ingredient (JP-A-09-40564).
No.) etc. are known. However, these have not been sufficiently satisfactory in terms of absorption into the body, effectiveness, taste, and the like, and have not been able to sufficiently exhibit the intended effects.

[0004] On the other hand, fish testis is a food material that has been eaten for a long time. However, its use is low for edible purposes due to the timing of catch and the speed of freshness reduction. Most of them had been discarded. However, in recent years, research and development have been advanced, and protamine obtained from fish testes has begun to be used as an antibacterial agent and the like, and deoxyribonucleic acid has been used as a material for health foods.

[0005]

However, the consumption of fish testes is still insufficient, and a large amount of testes are still being discarded, and the development of a new use method has been an issue. Also, research and development of novel useful components other than protamine and deoxyribonucleic acid, which are components obtained from fish testes, have been an issue.

Accordingly, the present inventors have conducted intensive studies, and as a result,
It has been newly discovered that a component obtained by adding water to a fish testis and centrifuging or extracting it with alcohol has an effect of preventing or improving symptoms of sickness and hangover. The present invention relates to a novel method for utilizing an extract component from fish testes, and an object of the present invention is to provide a composition for preventing and improving sickness and hangover excellent in its effect and safety, and a method for producing the same. I do.

[0007]

According to a first aspect of the present invention, a patent is obtained by adding water to a ground fish testis and subjecting it to centrifugation or extraction separation with alcohols and hydrous alcohols. A composition for preventing and improving sickness and hangovers, comprising a cleaning component.

[0008] The fish testes used in the first invention are easily available because they are generated in large quantities as by-products when processing fish such as salmon, trout, herring, and pollock. In the present invention, the supernatant obtained as an active ingredient is obtained by adding water to the ground fish testis and centrifuging the extract, or extracting and separating with alcohols and hydrous alcohols. The supernatant can be used as it is, but can be used as a concentrate by concentrating it as a concentrated solution or by drying it as a dried product.

In the second invention, which is to be patented, water is added to the ground fish testis and centrifuged or extracted and separated with alcohols and hydrous alcohols, and this mixture is separated into a supernatant and a sediment. A method for producing a composition for preventing and improving sickness and hangover, wherein the supernatant is recovered after the treatment.

[0010] The method for producing a composition for preventing and improving sickness and hangover according to the second invention is characterized in that, first, water is added to ground fish testes and centrifuged, or alcohol and hydrous alcohol are used. To separate into a supernatant and a precipitate by alcohol extraction. Next, the precipitate is removed to obtain a supernatant. The mixture of fish testis and water is heated to have a liquid temperature of about 70 ° C. or more, so that it is easy to separate into a supernatant portion and a sedimentation portion during centrifugation.

[0011] The components used as the raw materials for protamine and deoxyribonucleic acid have migrated to the sedimentation part by centrifugation, so that the sedimentation part generated as a by-product can be used effectively.

In the present invention, the detailed mechanism of the effect of the fish testis extract on the prevention and amelioration of sickness and hangover is unknown, but as a result of analysis of the free amino acid of the extract, as shown in Table 1, The ratio of amino acids conventionally known to be effective in improving liver function and promoting alcohol metabolism, such as taurine, glycine, arginine, glutamic acid and alanine, was high. However, the amino acid content of this extract was not particularly large compared to the previous reported examples, and it is presumed that some components other than these amino acids are involved in the expression of the effect. I do.

[0013]

[Table 1]

[0014]

The present invention will be described below with reference to examples. [Production Example] An equal amount of water was added to 1 kg of ground testis of chum salmon, mixed, and heated to 90 ° C. Then
After centrifuging at 4000 × g for 20 minutes to collect the supernatant, the obtained supernatant was freeze-dried to obtain a fish testis extract composition having an effect of preventing and improving sickness and hangover. The recovered amount was 20 g.

Example 1 (Hangover Prevention Effect) Using testicular fish extract obtained by the above-mentioned production method, 12 adult men and women who had experience of drinking and who had experienced hangover were drunk. One hour before, one gram of the test substance was drunk, and each person was drunk according to the amount of alcohol when the person experienced a hangover in the past, and the symptoms of the hangover on the next day were examined. A similar test was performed using lactose as a placebo control. In addition, at the time of the control and the test, they were asked not to eat or drink anything other than alcohol such as snacks.

The hangover symptoms were indicated in five stages: ：: none, ：: none, Δ: slight, ×: considerable, XX: severe. As shown in Table 2, the fish testis extract of the present invention showed good results in preventing hangover symptoms, and a clear difference was observed as compared with the case where the test article was not taken.

[0017]

[Table 2]

[Example 2] (Effectiveness of hangover) [0018] Using the fish testis extract of the present invention, a test article was prepared for nine adult men who complain of symptoms such as headache and nausea due to hangover caused by drinking the previous day. 1g was taken and the effect of improving hangover after 2 hours was examined. The symptoms of the hangover are ◎: none, ○: none, △: slight, ×: fair, ×
X: It was shown in five levels of severe. As shown in Table 3, the fish testis extract of the present invention showed good results in improving hangover symptoms.

[0019]

[Table 3]

[Example 3] (Effect of preventing sickness) The effect of the test article on sickness symptoms such as palpitations, flushing of the skin, nausea, etc. during human drinking was evaluated using the rise in surface temperature of the face as an index of the degree of sickness. went. The surface temperature of the face is determined by thermography (TH310, manufactured by NEC Sanei Co., Ltd.).
0MR). Five healthy male subjects (25 to 28 years old) were allowed to drink 1 g of the test substance on an empty stomach, and after forty-five minutes after drinking 350 ml of beer in a short time, forehead, cheek, nose, chin and neck surface Temperature was measured over time. As a control, the same test was performed when the test article was not taken before drinking. Table 4 shows the average values of the degree of increase in the surface temperature of the forehead, cheek, nose, chin, and neck at that time. As shown in the table, it was clarified that the test article suppressed the temperature rise of the face, which is a symptom of sickness.

[0021]

[Table 4]

[0022]

As described above, the extract from the testes of fish according to the present invention is of high safety because it is derived from a natural product, and has the effect of preventing and improving the symptoms of sickness and hangover when drinking.

Claims (2)

[Claims] 1. Prevention of sickness and hangover characterized by containing a supernatant component obtained by adding water to the ground fish testis and centrifuging or extracting and separating with alcohols and hydroalcoholics. And improving compositions. 2. Addition of water to the ground fish testis and centrifugation or extraction and separation with alcohols and hydrous alcohols. After separating this mixture into a supernatant and a precipitate, the supernatant is recovered. A method for producing a composition for preventing and improving sickness and hangovers, characterized in that: