JP2001064154A - Humectant composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a humectant composition, high in safety, low in effect on morphological stability of product, excellent in water absorption and humectant capacity, and accelerating formation of a lamellar liquid-crystal structure and stabilizing the structure excellent in water-holding effect. SOLUTION: This humectant composition is incorporated with a collagen tripeptide, 2-pyrrolidone-5-carboxylic acid and/or butyric acid, or salt thereof. The collagen tripeptide is an enzymatically hydrolyzable collagen tripeptide produced by the advanced bio-technology. It is highly pure collagen tripeptide with glycin as the N-terminal, and produced from collagen coming from fresh pig skin or highly pure gelatin as the stock material.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a collagen tripeptide and 2-pyrrolidone-5-carboxylic acid (hereinafter referred to as PCA).
Abbreviated as) and / or a humectant composition comprising lactic acid or a salt thereof, the purpose of which is to have high safety and a low effect on form stability to the product,
Moreover, it is an object of the present invention to provide a wetting agent composition which has excellent hygroscopicity and moisturizing properties, and which promotes and stabilizes the formation of a lamellar liquid crystal structure which is excellent in a moisture retaining effect. In general, products that lose quality when products lose moisture, such as cosmetics and ointments, or products that are used for imparting wettability, such as skin lotions, emulsions, and creams, have a highly hygroscopic substance. Is used as There are quite a few types of substances that have a high moisture absorption capacity, including organic and inorganic substances.However, the types of wetting agents actually used are limited due to the necessity of safety or low impact on morphological stability in products. It has been. Furthermore, the properties that the wetting agent should have are hygroscopicity, that is, the ability to absorb moisture, and at the same time, moisturizing, that is, the ability to prevent the evaporation of moisture. Necessary for considering wetness in low temperature and low humidity environment.

[0002]

2. Description of the Related Art Generally, however, substances having high hygroscopicity are not always high in moisturizing properties. Therefore, as a wetting agent for emulsions, creams, ointments and the like, PCA salt, which is a substance having high hygroscopicity as a hygroscopic agent, Lactate, mineral, glycerin, etc. are used in combination with mucopolysaccharides, polypeptides, amino acids, proteins, etc., which have high moisturizing properties. As described above, although the natural moisturizing factor (NMF) of the stratum corneum cells has been studied, at present, sufficient scalpels have not been inserted into the complex of intercellular lipids which plays a leading role in water retention of the stratum corneum. .

[0003]

[Problems to be Solved by the Invention] To study the humectant composition which is suitable for skin physiology, studying the homeostasis maintenance mechanism of the living body, and conduct intensive research in a biological system model in order to study the humectant composition suitable for skin physiology. Excellent wettability with high safety, low influence on the form stability of the product, combined with hygroscopicity and moisture retention, and with the ability to promote and stabilize the formation of lamella liquid crystal structure with excellent moisture retention effect The agent composition was completed.

[0004]

According to the present invention, a wetting agent composition can be provided by blending collagen tripeptide with PCA and / or lactic acid or a salt thereof.

[0005]

DESCRIPTION OF THE PREFERRED EMBODIMENTS In order to supplement the moisturizing function of keratinocytes,
As a result of various studies, such as NMF in keratinocytes and sufficient intercalation of the intercellular lipid complex of the stratum corneum (moisturizing ability at low humidity), excess mixture of collagen tripeptide with PCA or lactic acid and their salts was found to be excessive. Thus, the present invention was found to have an effect of suppressing moisture and improving hygroscopicity, such as increasing the persistence. In order to obtain the composition of the present invention, it is only necessary to mix the constituents of collagen tripeptide with PCA and / or lactic acid or a salt thereof in an arbitrary ratio, but each component itself is hygroscopic. Therefore, a stable composition can be obtained by using an aqueous solution. Further, by adding a predetermined amount of collagen tripeptide corresponding to the present composition and PCA and / or lactic acid or a salt thereof to a face wash, a pack, an emulsion, a cream, a lotion, or the like, the desired wettability of these products is obtained. Can be granted. Collagen tripeptide is an enzymatically degraded collagen tripeptide born of advanced biotechnology. It is made of fresh pig skin collagen or high-purity gelatin as raw material, and N-terminal is glycine, high-purity collagen tripeptide. is there. This high-purity collagen tripeptide has an amino acid sequence of [Glycine-XY] in which the N-terminal is glycine, which has been difficult so far. The main amino acids are glycine, proline,
Hydroxyproline, alanine, etc. The average molecular weight is about 280, about 500-600, depending on the tripeptide content.
It is about 3000, and the smaller the molecular weight, the stronger the moisture retention.
Superior in water retention compared to conventional peptides. It is also expected to have a cell activating effect by penetrating into the skin. Easy to dissolve in water. The compositions of the present invention can provide the expected moisturizing effect depending on the ratio of collagen tripeptide and PCA and / or lactic acid or salts thereof in any composition as shown in the examples. Collagen tripeptide, which is an essential component of the present invention, exerts its effect even when added in a small amount. As described above, the composition of the present invention is an excellent humectant composition having both a moisture absorbing property and a moisture retaining property and having an ability to promote and stabilize the formation of a lamellar liquid crystal structure having an excellent moisture retaining effect. As described above, the composition of the present invention is effective as a humectant in any product, but all of its components have a mild effect on the skin and eyes and are non-toxic, so that they can be used in cosmetics and foods. Can be added to In particular, since each component of the composition of the present invention is a component of the skin's natural moisturizing factor (NMF), use as a cosmetic humectant not only maintains the product form but also makes it suitable for the skin after use. It has the effect of giving moisture and smoothness and preventing rough skin. Such cosmetics include soaps, packs, serums, lotions, emulsions, creams, foundations, lipsticks, nail varnishes, shampoos, rinses, and the like. When the composition of the present invention is added to each product, wettability according to the added amount can be imparted, but usually 0.00001
The intended purpose can be achieved by using at least 0.001% by weight, preferably 0.0001 to 10% by weight. Furthermore, the composition of the present invention can be used in combination with other humectants, such as glycerin, urea, amino acids, saccharides, minerals, mucopolysaccharides, collagen, elastin, other proteins, polypeptides, keratin, and other components. Example 1 Swelling / color development test method An intercellular lipid model (diameter 1c) was added to the aqueous solution containing the wetting agent composition.
m), and observe the swelling, lamellar liquid crystal and coloring state. Wetting agent composition comprising collagen peptide and PCA or lactic acid and their salts can be used to color the intercellular lipid model, color swelling, color continuity, shape retention, interface beauty, shape retention, etc. It turns out that the item has excellent ability. Example 2 Fresh pack 1) Polyvinyl alcohol 12.5 Production method 2) Collagen tripeptide 0.2 3) Lactic acid-Na 0.10 (1) 2) to 12), weighing, mixing 4) Lactic acid 0.02, Stir. 5) Sodium hyaluronate solution 0.2 (2) Add 1) little by little to (1) 6) Dipotassium glycyrrhizinate 0.1 Add, mix and stir. 7) Preservatives 0.1 (3) Warm (2) to 80 ° C, mix 8) Glycerin 4.0, mix and cool after stirring 9) 1.3 Butylene glycol 6.0 Good fit to skin After spreading and peeling. 10) The skin with 5.0 denatured alcohol specified by the government becomes firm and elastic skin 11) Purified water 71.78. Example 3 Milk lotion production method 1) Squalane 10.0 2) Palmitic acid 1.5 (1) 1) to 4) 5) to 11) 3) Glycerin monostearate 2.0 was heated at 72 ° C, respectively. 4) While stirring the oil phase 4) Behenyl alcohol 0.5, gradually add the aqueous phase and 305) Stir and cool to 0.1 ° C collagen tripeptide. 6) PCA-Na 0.2 7) Arginine 0.15 Feeling of use and feeling of skin after use 8) Caustic potassium 0.16 Moist and smooth, 9) Glycerin 8.0 effect is maintained. 10) Preservative 0.1 11) Purified water 87.29

[0006]

EFFECTS OF THE INVENTION By mixing collagen tripeptide with 2-pyrrolidone-5-carboxylic acid and / or lactic acid or a salt thereof, the safety is high, the effect on the form stability to the product is low, and moisture is absorbed. Provided is a wetting agent composition that promotes and stabilizes the formation of a lamellar liquid crystal structure that is excellent in water resistance and moisturizing properties and excellent in water retention.

Claims (1)

[Claims] A wetting agent composition comprising a collagen tripeptide and 2-pyrrolidone-5-carboxylic acid and / or lactic acid or a salt thereof.