JP2001017551A - Tube assembly for medical treatment, medical tube used for the same, and guide wire - Google Patents

Abstract

PROBLEM TO BE SOLVED: To insert a tube assembly for a medical treatment surely and in a short time to a desired site in the body by providing a medical tube having magnetism at least at one section on the internal surface, and a guide wire having magnetism which repels the magnetism of the medical tube at least at one section on the external surface. SOLUTION: This tube assembly for a medical treatment is equipped with a medical tube 1 having magnetism at least at one section on the internal surface, and a guide wire 4 having magnetism at least at one section on the external surface. In this case, the magnetism on the internal surface of the medical tube 1 and the magnetism on the external surface of the guide wire 4 are magnetism which repel each other. For example, when the internal surface of the medical tube 1 is polarized to S polar, and the external surface of the guide wire 4 is polarized to S polar, a repelling force works between the internal surface of the medical tube 1 and the external surface of the guide wire 4. By this constitution, a friction between the medical tube 1 and the guide wire 4, i.e., a sliding resistance when the medical tube 1 is advanced along the guide wire 4 is reduced.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medical tube assembly including a medical tube such as a medical catheter and an endoscope, and a guide wire for guiding the medical tube into a body cavity. Medical tubes and guidewires to be used. The present invention also relates to a method for guiding the medical tube.

[0002]

2. Description of the Related Art In many cases, diagnosis and treatment using medical tubes such as medical catheters and endoscopes are performed by guiding them to a desired position such as an affected part in a living body with a guide wire. That is, a guidewire smaller in diameter than the medical tube is inserted into the body cavity prior to the medical tube, and after reaching a desired position, the guidewire is inserted through the lumen of the medical tube. Push the tube along the guidewire to reach the desired location.

However, due to variations in the inner diameter of the medical tube and the outer diameter of the guide wire, and the bending of a body tube such as a blood vessel into which the medical tube is inserted, the sliding resistance due to friction increases as the insertion length increases. And it becomes difficult to push the medical tubing. Therefore, the medical tube may not be able to reach a desired position. In addition, even when it is possible to reach a desired position, it often takes too much time, and this is a problem especially when urgency is required. Furthermore, after inserting the catheter along the guide wire, if the guide wire is once pulled out and the guide wire is inserted again, the inner wall of the medical tube may be damaged, or the medical tube itself may be pierced and come out. It can happen.

[0004]

SUMMARY OF THE INVENTION The present invention relates to a medical tube assembly capable of reliably and quickly inserting a medical tube to a desired position in a living body, a medical tube used therefor, and a medical tube assembly. It is intended to provide a guidewire.

[0005]

SUMMARY OF THE INVENTION The present invention provides a medical tube having a medical tube having magnetism on at least a portion of an inner surface thereof, and a guide wire having magnetism repelling the magnetism on at least a portion of an outer surface. Tube assembly.

[0006] In one preferred embodiment, the magnetism of the medical tube and / or the guide wire is obtained by a permanent magnet and / or an electromagnet.

In a preferred embodiment, the magnetism of the medical tube and / or the guide wire is obtained by a material containing permanent magnet particles.

[0008] In one preferred embodiment, the medical tube is a microcatheter.

[0009] In one preferred embodiment, the medical tube is an angiographic catheter.

[0010] The present invention also provides a medical tube having magnetism on at least a part of an inner surface used in the medical tube assembly. That is, the present invention is a medical tube having magnetism on at least a part of an inner surface thereof, wherein the medical tube assembly is combined with a guidewire having magnetism repelling the magnetism on at least a part of an outer surface. Provide a medical tube to be used.

The present invention also provides a guidewire having magnetism on at least a part of an outer surface used for the medical tube assembly. That is, the present invention relates to a guidewire having magnetism on at least a part of an outer surface thereof, and combining with a medical tube having magnetism repelling the magnetism on at least a part of an inner surface to form the medical tube assembly. Provide a guidewire to be used.

Further, according to the present invention, the guide wire is inserted into a body cavity prior to the medical tube, and after reaching the target position, the medical tube is pushed along the guide wire, Provided is a method for guiding a medical tube, which is characterized by reaching a target position.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION A medical tube assembly according to the present invention comprises a medical tube according to the present invention having at least a part of its inner surface magnetic and a guide wire according to the present invention having a magnetic at least part of its outer surface. And the guide tube is inserted through the medical tube. Specifically, the guidewire of the present invention is inserted into the body cavity prior to the medical tube of the present invention, and after reaching the target position, the medical tube is pushed along the guidewire, Make it reach the target position.

The magnetism on the inner surface of the medical tube of the present invention and the magnetism on the outer surface of the guidewire of the present invention have repulsive magnetism. For example,
The inner surface of the medical tube can be magnetized to the south pole, and the outer surface of the guidewire can be magnetized to the south pole. In this case, when the guidewire is inserted through the medical tube, A repulsive force acts between the outer surface of the guidewire. Thereby, the friction between the medical tube and the guide wire, that is, the sliding resistance when pushing the medical tube along the guide wire is reduced.

Hereinafter, the medical tube and guide wire of the present invention used in the medical tube assembly of the present invention will be described.

The medical tube of the present invention has magnetism on at least a part of the inner surface. The magnetism is not particularly limited,
For example, it is obtained by a permanent magnet and / or an electromagnet or other magnetic material. It is preferable that the magnetism of the medical tube of the present invention is obtained from a material containing permanent magnet particles in terms of ease of molding and the like.

Materials containing permanent magnet particles include, for example,
Permanent magnet material particles in which resin, rubber, etc. before molding contain permanent magnet material particles, and permanent magnet material particles are oriented and magnetized during molding of resin, rubber, etc .; permanent magnet particles or pre-magnetized permanent magnets A material in which material particles are contained in a resin, rubber, or the like so as to be oriented may be used. Specific examples include a resin obtained by orienting and magnetizing a ferrite powder on various resins. As a method for producing the resin, a mixture of a resin and a magnetic material described in JP-B-58-8571 is melted. A method of applying a magnetic field during injection molding to orient the magnetic material in a certain direction can be used. Magnetization can be performed, for example, for a tubular object, a columnar object, or a linear object so that the magnetic poles are different on the radially inner and outer sides (radial magnetization). For planar objects,
Magnetization can be performed such that the magnetic poles are different between one surface and the other surface.

The magnetic material used for the material containing permanent magnet particles is a metal such as a platinum-cobalt-based magnet alloy, a samarium-cobalt-based magnet alloy, an iron-chromium-cobalt-based magnet alloy, a neodymium-iron-boron-based magnet alloy, or a strontium-ferrite magnet alloy. A powder is illustrated.

The resin, rubber and the like used for the material containing the permanent magnet particles are not particularly limited. Examples thereof include polyolefins (eg, polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-vinyl acetate copolymer, cross-linked Type ethylene-vinyl acetate copolymer), polyester, polyvinyl chloride, polyurethane, polyamide, polyimide, polyamide elastomer, polyurethane elastomer, polyester elastomer, polyfluoro resin, other thermoplastic resin or thermosetting resin; silicone rubber .

The medical tube of the present invention only needs to have magnetism on at least a part of the inner surface. The entire medical tube may have magnetism, and the entire inner surface may have magnetism. And a portion having magnetism may be scattered and / or localized on a part of the inner surface. In addition, the medical tube of the present invention necessarily has a magnetic portion exposed on the inner surface as long as a repulsive force can be exerted on a guide wire having magnetism on at least a part of the outer surface. No need. That is, as long as the repulsive force can be exerted to such an extent that the friction between the inner surface of the medical tube and the outer surface of the guide wire can be effectively reduced, the magnetic portion is not exposed on the inner surface. It may exist in the vicinity.
For example, a material obtained by molding or coating the inner surface of a medical tube with a material containing permanent magnet particles, and further coating the material with another material can be used.

The strength of the magnetism of the medical tube of the present invention is not particularly limited, and may be used when a guide wire is inserted through the medical tube or when the guide wire is pulled out of the medical tube. It is sufficient that the sliding resistance due to friction can be reduced. JP-A-8-89582
In the publication, a medical catheter characterized in that the distal end portion of the catheter tube body is made of a magnetic material, and by applying a magnetic attraction force from the surface of a living body,
Although a method for facilitating the guidance of the catheter is described, in the present invention, the magnet is not required to be strong enough to guide the catheter in the body from the surface of the living body,
Conversely, if the magnetism is strong, operability when inserting the guide wire through the medical tube may be impaired. That is, the strength of the magnetism of the medical tube of the present invention may be weak, as long as the sliding resistance at the time of inserting and pulling out the guide wire can be reduced, but the operability is impaired. Preferably not strong.

The medical tube of the present invention only needs to have magnetism on at least a part of the inner surface, and may have magnetism over the entire length of the tube. End), especially about 10 to 100 mm from the front end
One that does not have magnetism in the meantime is also a preferred embodiment.
Since the inner surface of the medical tube and the outer surface of the guide wire repel each other, it may be difficult to insert the medical tube. In particular, for example, when the outer surface of the guide wire is magnetized to the south pole and the inner surface of the medical tube is radially magnetized to be the south pole so as to repel it, the outer surface of the medical tube becomes the north pole As in the case, when the outer surface of the medical tube may be pulled against the outer surface of the guide wire, the insertion operation becomes difficult. In such a case, in order to prevent the front end of the medical tube from exerting a magnetic force with the rear end of the guide wire, it is preferable to use a medical tube having no magnetism at the front end. Also, for catheters and the like that are expected to be inserted into the human body in advance, magnetize the place where the curvature is considered to be high, and repel each other when inserting a guide wire having magnetism on the entire outer surface. Thus, friction can be reduced.

In the present invention, if a magnetic material having a function as an X-ray contrast agent is used as the magnetic material of the medical tube, it is not necessary to separately include an X-ray contrast agent, or the use of the X-ray contrast agent is not required. The amount can be reduced. In the present invention, an X-ray contrast agent may be used in combination, and examples thereof include fine powders of tungsten, barium sulfate, bismuth oxycarbonate, sodium iodide and the like.

The medical tube of the present invention is not particularly limited in a portion other than a portion having magnetism, and has the same configuration as a normal medical tube, and has a structure such as elasticity, torque transmission, and pushing characteristics. What is necessary is just to secure required characteristics. The medical tube of the present invention has, for example, an inner diameter of 300 to
The thickness can be 1200 μm and the thickness is 50 to 300 μm.

The medical tube of the present invention has an outer surface formed of, for example,
Lubricated by coating or the like with a low friction material such as a hydrophilic polymer (eg, maleic anhydride copolymer, polyacrylamide, cellulosic polymer, water-soluble nylon) or a fluororesin (eg, polytetrafluoroethylene). May be. Moreover, the inner surface of the medical tube of the present invention may be lubricated. Further, the medical tube of the present invention has an outer surface and / or an inner surface,
Biocompatible treatment, antithrombotic treatment and other surface treatments may be performed.

When the medical tube of the present invention is a microcatheter, it is a preferred embodiment. A microcatheter is a catheter that is used by being inserted into a small blood vessel or the like.However, there is a possibility that the inner diameter of the catheter may vary during manufacturing. Therefore, the friction between the guide wire and the outer surface of the guide wire tends to increase. Since the microcatheter has a small diameter and low strength, when the medical tube of the present invention is used as a microcatheter, the effect of reducing sliding resistance due to friction is particularly remarkable. The inner diameter of the microcatheter is not particularly limited, but may be 300
８００800 μm.

Further, when the medical tube of the present invention is an angiographic catheter, it is a preferable embodiment. An angiographic catheter is a catheter used for X-ray examination by being inserted into a thin blood vessel or the like.
As for a micro-catheter having a small inner diameter of about 4/3 mm), the effect of the present invention is particularly remarkably exhibited, similarly to the microcatheter. Further, according to the present invention, a material having a function as an X-ray contrast agent can be used as the magnetic material of the medical tube, which is preferable.

The method for producing the catheter tube of the present invention comprises:
There is no particular limitation. For example, it can be obtained by a method of radially magnetizing a material containing permanent magnet material particles into a tube shape, and a method of coating the outer surface with a biocompatible material or the like. Here, when radially magnetizing a small-diameter material such as a tube for a microcatheter, radially magnetize a strip of a length as short as the diameter of the catheter as one unit, and place these at a certain distance to form a strand or a wire. A long magnetized tube can be prepared by intermittently arranging it on a resin-coated wire and integrating it by heating or melting or resin coating from above. Also, a material containing permanent magnet material particles formed into a tape shape, a perfect circle or a flat monofilament is magnetized so that one side and the other side have different magnetic poles (front and back). It can also be prepared by winding around an element wire or a resin-coated wire. After this winding step, a tube having different magnetic poles at the inner periphery and the outer periphery can be obtained also by heating and melting or integrating with a resin coating or the like from above.

The guide wire of the present invention has magnetism on at least a part of the outer surface. The magnetism is not particularly limited as in the case of the medical tube of the present invention. For example, the magnetism is obtained by using a permanent magnet and / or an electromagnet or another magnetic substance. The magnetic material used for the guide wire of the present invention is the same as the magnetic material used for the medical tube of the present invention.

The guide wire of the present invention only needs to have magnetism on at least a part of the outer surface. The entire guide wire may have magnetism, or the entire outer surface may have magnetism. The magnetic part may be scattered and / or localized on a part of the outer surface. In addition, the guidewire of the present invention necessarily has a magnetized portion exposed on the outer surface as long as it can exert a repulsive force on a medical tube having magnetism on at least a part of the inner surface. No need. That is, as long as the repulsive force can be exerted to such an extent that the friction between the inner surface of the medical tube and the outer surface of the guide wire can be effectively reduced, the magnetic portion is not exposed on the outer surface. It may exist in the vicinity.

The magnetic strength of the guide wire of the present invention is not particularly limited, as is the case with the magnetic strength of the medical tube of the present invention. It is only necessary that the sliding resistance due to friction when pulling out the guide wire from the state where it is inserted through can be reduced.

The guidewire of the present invention may have magnetism over at least a part of its outer surface, and may have magnetism over the entire length of the guidewire. And the opposite end), especially about 10 to
One having no magnetism up to 1000 mm is also a preferable embodiment. This is for the same reason that it is a preferable embodiment that the medical tube has no magnetism at the front end.

Further, X is used as the magnetic material of the guide wire.
The thing having a function as a line contrast agent can be provided as in the case of a medical tube.

The guide wire according to the present invention is not particularly limited in a portion other than a portion having magnetism. The guide wire has the same structure as a normal guide wire and has required characteristics of the guide wire such as elasticity, torque transmission, and push-in characteristics. You only need to secure it. As the core wire of the guide wire of the present invention, for example, a metal wire can be used. The guide wire of the present invention can have, for example, an outer diameter of 200 to 1000 μm. In addition, the outer surface of the guide wire of the present invention may be subjected to a lubrication treatment, a biocompatibility treatment, an antithrombotic treatment and other surface treatments.

The method for manufacturing a guide wire according to the present invention is not particularly limited. For example, it can be obtained by a method in which a material containing permanent magnet material particles is formed into a linear shape and radially magnetized, and a method in which the outer surface is coated with a biocompatible material or the like. Further, it can also be obtained by magnetizing a material containing permanent magnet material particles into a tape shape so that one surface and the other surface have different magnetic poles, and winding this around a wire or the like. . Further, it can be obtained by a method of embedding a permanent magnet and / or an electromagnet in a usual guide wire.

As described above, the medical tube assembly of the present invention includes the medical tube of the present invention and the guide wire of the present invention, and these are used in combination. In the present invention, the medical tube is a double tube, and the guide wire outer surface and the medical tube inner tube inner surface, and the medical tube inner tube outer surface and the medical tube outer tube inner surface repel each other. The medical tube assembly may have a combination.

The medical tube assembly of the present invention is used for:
It is not particularly limited and can be used for a wide range of applications. For example, catheters, endoscopes, therapeutic probes (eg, diagnostic ultrasonic probes, lasers, ablation),
Used as their guidewire. The medical tubes can be used in combination. Among them, PTCA (Percutaneous Translumina)
lCoronary Angioplasty: Percutaneous Coronary Artery Transvascular Angioplasty)
It is particularly suitably used for a catheter for blood vessel insertion such as a dilatation catheter such as a CA catheter), a guiding catheter, a microcatheter, and a small-diameter contrast catheter.

In the method for guiding a medical tube according to the present invention, the guide wire is inserted into a body cavity prior to the medical tube, and after reaching the target position, the medical tube is connected to the guide wire. It is characterized in that it is pushed along and reaches a target position. In the method for guiding a medical tube of the present invention, after the guide wire reaches the target position, insertion of the medical tube may be started, or before the guide wire reaches the target position, May be inserted. According to the method for guiding a medical tube of the present invention, the medical tube can be reliably and quickly inserted to a desired position in a living body.

Further, according to the medical tube assembly of the present invention, not only when inserting the medical tube along the guide wire, but also when pulling out the guide wire after inserting the medical tube, After inserting the tube, the medical tube can be pulled out, and then the same or another medical tube can be inserted again to reduce the sliding resistance, and these operations can be performed in a short time. be able to.

Note that Japanese Patent Application Laid-Open No. 8-89582 discloses that
A medical catheter characterized in that the distal end of the catheter tube body is made of a magnetic material is described, and a method of facilitating the guidance of the catheter by applying a magnet attraction force from the surface of a living body is described. I have. However, the medical catheter described in the above publication is difficult to be guided by a magnet when the whole is a magnetic material, and therefore only the distal end portion needs to be a magnetic material. This differs from the medical tubing of the present invention, which may be magnetic over the entire length of the tube, or preferably over at least 10 cm. Further, the method of guiding a medical catheter described in the above-mentioned publication facilitates the guidance by applying a magnet attraction force from a surface of a living body to a catheter in the body. It is also completely different in that the medical tube can be reliably and quickly inserted to a desired position in the living body by reducing the friction by the repulsive force with the outer surface of the wire.

In Japanese Patent Publication No. 7-32800,
A medical antithrombotic tubular article using an antithrombotic resin to which ferromagnetic fine particles are added, wherein the medical antithrombotic tubular article in which ferromagnetic fine particles are oriented in a certain direction is described. This aims at improving the mechanical strength by orienting the ferromagnetic fine particles. However, the medical antithrombotic tubular article described in the above publication does not need to have a magnetic property on the inner surface, and is different from the medical tube of the present invention. Further, in the medical antithrombotic tubular article described in the above publication, the ferromagnetic fine particles are used only for improving the mechanical strength by being oriented, and it is not necessary to have magnetism at the time of use. The medical tubes of the invention differ in that they need to be magnetic during use.

[0042]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples. 1. Preparation of Medical Tube Assembly (Medical Tube and Guide Wire) (Example 1) Preparation of Medical Tube Polyethylene containing 10% by weight of ferrite was extruded from a slit die, and a tape having a width of 1 mm and a thickness of 40 μm was prepared. Obtained. Next, the obtained tape was coated with S
And the other surface is magnetized so as to be an N pole. Magnetization was performed by a known method using a commercially available magnetizing device having a magnetizing yoke and an impulse power supply device. The magnetic force was 0.005 millitesla. A portion of 100 mm from one end of a wire (outside diameter: 520 μm) in which a polyamide elastomer resin was coated on a 460 μm metal wire with a thickness of 30 μm on one side was a resin tube, and the other portion was spirally wound with the above tape to adhere. . At this time, it was set so that the surface layer side became the N pole (therefore, the inside was magnetized to the S pole).
Then, after the tape was wound, the same polyamide elastomer resin as the above-mentioned tape was extrusion-molded and coated with a thickness of 30 μm, and then the wire was removed to form a tube.

Example 2 Preparation of Guide Wire A resin consisting of 60% by weight of polyurethane resin, 10% by weight of ferrite and 30% by weight of tungsten was extruded from a slit die to obtain a tape having a width of 1 mm and a thickness of 15 μm. This tape was implemented by a known method using the above magnetizing device. The magnetic force was 0.004 millitesla. This was coated with a nickel-titanium wire (wire diameter 330 μm, resin coating layer thickness 15 μm, length 190 c
m). In addition, in the tape winding process, it set so that a wire surface layer part might be an S pole. The tape was wound so that the tape interval was 3 mm. The tape-wound coated wire thus obtained was integrated by heating and melting.

2. Dynamic Friction Test (FIG. 3) The medical tube obtained in Example 1 was bent into a U-shape to have the shape shown in FIG. 3, and the inside was filled with water. The guide wire obtained in Example 2 was inserted through a U-shaped medical tube. The insertion was performed from the end having both non-magnetized portions. After inserting and removing the guide wire several times, the guide wire was reciprocated at 500 mm / min. Insert the guide wire into the catheter lumen, set the position so that the tip of the guide wire projects about 30 mm from the tip of the catheter to the tip side when it is inserted deepest, and reciprocate with a stroke length of 100 mm, and the dynamic friction The force was measured. Further, the same medical tubing as obtained in Example 1 except that non-magnetized tape was used, and Example 2 except that non-magnetized tape was wound.
Using the same guide wire as obtained in the above, the kinetic friction force was measured in the same manner as above, and used as a control.

The dynamic friction force in the dynamic friction test using the medical tube of the present invention and the guide wire of the present invention was a minimum value of 1.2 gf and a maximum value of 3.1 gf. On the other hand, in the case of the control, the minimum value was 4.2 gf,
The maximum value was 9.4 gf. From these results, in the medical tube assembly of the present invention including the medical tube of the present invention and the guide wire of the present invention, the sliding resistance due to friction when inserting the guide wire into the medical tube was significantly reduced. It turns out to be something.

[0046]

When the medical tube of the present invention is inserted through the guide wire of the present invention, the sliding resistance due to friction is extremely small. Therefore, when pushing the medical tube of the present invention along the guide wire of the present invention, it is useful because it can be reliably and quickly inserted to a desired position in a living body.

[Brief description of the drawings]

FIG. 1 is a view showing an example of a medical tube of the present invention.

FIG. 2 is a view showing an example of a guide wire of the present invention.

FIG. 3 is an explanatory diagram of a dynamic friction test using the medical tube of the present invention and the guide wire of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Medical tube 2 Magnetized part 3 Non-magnetized part 4 Guide wire 5 Tape (magnetized part) 6 Element wire (non-magnetized part)

Claims (8)

[Claims] 1. A medical tube assembly comprising: a medical tube having magnetism on at least a portion of an inner surface; and a guide wire having magnetism repelling the magnetism on at least a portion of an outer surface. 2. The medical tube assembly according to claim 1, wherein the magnetism of the medical tube and / or the guide wire is obtained by a permanent magnet and / or an electromagnet. 3. The medical tube assembly according to claim 1, wherein the magnetism of the medical tube and / or the guide wire is obtained by a material containing permanent magnet particles. 4. The medical tube assembly according to claim 1, wherein said medical tube is a microcatheter. 5. The medical tube assembly according to claim 1, wherein the medical tube is an angiography catheter. 6. A medical tube having magnetism on at least a part of an inner surface used in the medical tube assembly according to claim 1. 7. A guide wire having magnetism on at least a part of an outer surface used in the medical tube assembly according to claim 1. 8. A guide wire according to claim 7, which is inserted into a body cavity prior to the medical tube according to claim 6,
A method for guiding a medical tube, comprising: pushing the medical tube along the guide wire after reaching the target position to reach the target position.