JP2000516207A - Ｐ５３媒介抑制への感受性を増強させるためのｄｎａ修復のダウンレギュレーション - Google Patents

Ｐ５３媒介抑制への感受性を増強させるためのｄｎａ修復のダウンレギュレーション

Info

Publication number
JP2000516207A
JP2000516207A JP10505400A JP50540098A JP2000516207A JP 2000516207 A JP2000516207 A JP 2000516207A JP 10505400 A JP10505400 A JP 10505400A JP 50540098 A JP50540098 A JP 50540098A JP 2000516207 A JP2000516207 A JP 2000516207A
Authority
JP
Japan
Prior art keywords
dna
cells
cell
gene
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10505400A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000516207A5 (cg-RX-API-DMAC7.html
Inventor
エイ． ジェルセット，ルース
Original Assignee
シドニー キメル キャンサー センター
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シドニー キメル キャンサー センター filed Critical シドニー キメル キャンサー センター
Publication of JP2000516207A publication Critical patent/JP2000516207A/ja
Publication of JP2000516207A5 publication Critical patent/JP2000516207A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
JP10505400A 1996-07-05 1997-07-02 Ｐ５３媒介抑制への感受性を増強させるためのｄｎａ修復のダウンレギュレーション Pending JP2000516207A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/675,887 1996-07-05
US08/675,887 US6054467A (en) 1996-07-05 1996-07-05 Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis
PCT/US1997/012542 WO1998001123A1 (en) 1996-07-05 1997-07-02 Down-regulation of dna repair to enhance sensitivity to p53-mediated suppression

Publications (2)

Publication Number Publication Date
JP2000516207A true JP2000516207A (ja) 2000-12-05
JP2000516207A5 JP2000516207A5 (cg-RX-API-DMAC7.html) 2005-02-10

Family

ID=24712371

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10505400A Pending JP2000516207A (ja) 1996-07-05 1997-07-02 Ｐ５３媒介抑制への感受性を増強させるためのｄｎａ修復のダウンレギュレーション

Country Status (8)

Country Link
US (2) US6054467A (cg-RX-API-DMAC7.html)
EP (1) EP0910357B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000516207A (cg-RX-API-DMAC7.html)
AT (1) ATE241973T1 (cg-RX-API-DMAC7.html)
AU (1) AU724212B2 (cg-RX-API-DMAC7.html)
CA (1) CA2259960C (cg-RX-API-DMAC7.html)
DE (1) DE69722621D1 (cg-RX-API-DMAC7.html)
WO (1) WO1998001123A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130121740A (ko) * 2012-04-27 2013-11-06 가톨릭대학교 산학협력단 Ｓｒ11302 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2729295A1 (fr) 1995-01-17 1996-07-19 Rhone Poulenc Rorer Sa Traitement therapeutique combine des pathologies hyperproliferatives
US6054467A (en) * 1996-07-05 2000-04-25 Sidney Kimmel Cancer Center Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis
US20030064949A1 (en) * 1998-02-17 2003-04-03 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US20030060434A1 (en) * 1997-02-18 2003-03-27 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
US6831057B2 (en) * 1997-10-28 2004-12-14 The University Of North Carolina At Chapel Hill Use of NF-κB inhibition in combination therapy for cancer
US6573050B1 (en) 1999-10-29 2003-06-03 Sunnybrook & Women's College Health Sciences Centre Treatment, diagnosis and evaluation of anti-cancer therapy resistance in melanoma
AU2002230775A1 (en) * 2000-12-13 2002-06-24 Georgetown University Gene therapy for prostate cancer: sensibilization of cells to dn a damaging drugs and radiation
EP1348030B1 (en) * 2001-01-04 2009-11-25 Wadell, Göran Viral vector for gene therapy
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
AU2002351241A1 (en) * 2001-12-04 2003-06-17 Nereus Pharmaceuticals, Inc. Methods and apparatus for cell based screening
US20050032728A1 (en) * 2002-12-17 2005-02-10 Sidney Kimmel Cancer Center Tumor suppression through bicistronic co-expression of p53 and p14ARF
WO2005012537A2 (en) * 2003-07-25 2005-02-10 Genvec, Inc. Adenoviral vector-based vaccines
US7649013B2 (en) * 2003-11-26 2010-01-19 Arqule, Inc. Methods of protecting against radiation injury
US20070281041A1 (en) * 2004-03-02 2007-12-06 Introgen Therapeutics, Inc. Compositions and Methods Involving MDA-7 for the Treatment of Cancer
JP2008511336A (ja) * 2004-09-01 2008-04-17 アメリカ合衆国 免疫原性が増加したアデノウイルスベクターをインビボで用いる方法
CA2592699C (en) * 2004-12-31 2023-02-21 Per Sonne Holm Method for reversing multiple resistance in animal cells
JP2007119359A (ja) * 2005-10-25 2007-05-17 Fujifilm Corp 癌抑制剤
US20070280905A1 (en) * 2006-06-01 2007-12-06 Shulin Li Prognosis and Systemic Therapy for Treating Malignancy
WO2017085351A1 (es) * 2015-11-20 2017-05-26 Servicio Andaluz De Salud Derivados del ácido retinoico para el tratamiento de la colestasis
US10722530B2 (en) * 2016-12-23 2020-07-28 Case Western Reserve University Methods of diagnosing and treating cancer
WO2019126816A1 (en) * 2017-12-22 2019-06-27 The Johns Hopkins University Regulation of mutant tert by braf v600e/map kinase pathway through fos/gabp in human cancer
WO2019207167A1 (en) 2018-04-27 2019-10-31 Fondazione Telethon Therapy of sulfatase deficiencies

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5532220A (en) * 1987-08-31 1996-07-02 The Regents Of The University Of California Genetic mechanisms of tumor suppression
ATE161039T1 (de) * 1988-10-31 1997-12-15 Univ California Erzeugnisse und verfahren zur regelung der suppression von neoplastischen phenotypen
US5527676A (en) * 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
IE911115A1 (en) * 1990-04-10 1991-10-23 Canji Inc Gene therapy for cell proliferative diseases
US5747469A (en) * 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5521291A (en) * 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
CA2152941C (en) * 1993-02-16 2003-04-22 Francis Mccormick Cytopathic viruses for therapy and prophylaxis of neoplasia
FR2704234B1 (fr) * 1993-04-22 1995-07-21 Centre Nat Rech Scient Virus recombinants, preparation et utilisation en therapie genique.
FR2712602B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
FR2712603B1 (fr) * 1993-11-18 1996-02-09 Centre Nat Rech Scient Virus recombinants, préparation et utilisation en thérapie génique.
FR2716893B1 (fr) * 1994-03-03 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, leur préparation et leur utilisation thérapeutique.
US6054467A (en) * 1996-07-05 2000-04-25 Sidney Kimmel Cancer Center Down-regulation of DNA repair to enhance sensitivity to P53-mediated apoptosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130121740A (ko) * 2012-04-27 2013-11-06 가톨릭대학교 산학협력단 Ｓｒ11302 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물
KR101587687B1 (ko) 2012-04-27 2016-01-21 가톨릭대학교 산학협력단 Ｓｒ11302 화합물을 유효성분으로 포함하는 면역질환의 예방 또는 치료용 조성물

Also Published As

Publication number Publication date
WO1998001123A1 (en) 1998-01-15
EP0910357A1 (en) 1999-04-28
AU724212B2 (en) 2000-09-14
CA2259960C (en) 2008-04-29
US20050095226A1 (en) 2005-05-05
ATE241973T1 (de) 2003-06-15
DE69722621D1 (de) 2003-07-10
EP0910357B1 (en) 2003-06-04
AU3670597A (en) 1998-02-02
CA2259960A1 (en) 1998-01-15
US6054467A (en) 2000-04-25

Similar Documents

Publication Publication Date Title
JP2000516207A (ja) Ｐ５３媒介抑制への感受性を増強させるためのｄｎａ修復のダウンレギュレーション
EP0921821B1 (en) 2-methoxyestradiol-induced apoptosis in cancer cells
JP3847334B2 (ja) ＤＮＡ損傷剤およびр５３を含有する組成物
US20020048566A1 (en) Modulation of cellular apoptosis and methods for treating cancer
KR100688409B1 (ko) 신생물에 대한 종양 억제 유전자 요법 및 화학 요법의 조합치료 방법
JP2000501394A (ja) ガンの診断および処置のための方法および組成物
JP2000510435A (ja) アデノウイルスｅ１ａを用いて腫瘍細胞を感作する方法
EP1021464B1 (en) Cellular receptor for hiv-1 vpr essential for g2/m phase transition of the cell cycle
JP2001502172A (ja) リポソームアンチセンスオリゴデオキシヌクレオチドによるＢｃｌ―２タンパク質発現の阻害
AU724324B2 (en) p16 expression constructs and their application in cancer therapy
CN101918035B (zh) 针对抗癌药物抗性癌的具有抗癌药物增强作用的癌细胞死亡诱导剂
US7772367B2 (en) C-terminal p53 palindromic peptide that induces apoptosis of cells with aberrant p53 and uses thereof
CA2277880A1 (en) Use of pea3 in tumor suppression
EP1758615A2 (en) Combination treatment of cancer with elicitor of gene product expression and gene-product targeting agent
JP2001505529A (ja) Ｈｅｒ―２／ｎｅｕを過剰発現する癌細胞の化学療法への感作
ES2268731T3 (es) Inhibicion del crecimiento de celulas de leucemia mielogena cronica mediante oligodesoxi-nucleotidos antisentido liposomales dirigidos a grb2.
JP2003501362A (ja) 脈管形成インヒビターとしてのｃ−ｃａｍ
CA2557326A1 (en) Combination of ad-p53 and chemotherapy for the treatment of tumours
WO2000015648A1 (en) Adenoviral vector encoding pro-apoptotic bax gene and uses thereof
JPH11506325A (ja) Δｐ６２、その変異体、核酸配列及びこれらの使用
WO2014034609A1 (ja) ｐ５３ファミリーキメラ分子およびその使用
US20010010814A1 (en) Adenoviral vector encoding pro-apoptotic bax gene and uses thereof
US20070081978A1 (en) Adeno-associated virus-mediated survivin mutants and methods related thereto

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040507

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040507

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080219

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080331

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080520

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20080805