JP2000321284A - Blood coagulation analysis apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To select operation patterns of feeding and discarding cuvettes, dispensing test bodies, dispensing reagents and the like and enhance the efficiency for processing. SOLUTION: A standard mode memory part 52 having a standard mode operation pattern stored therein and a high-speed mode memory part 54 having a high-speed mode operation pattern stored therein are provided. When either a standard mode analysis mode or a high-speed mode analysis mode is selected through an analysis condition screen, an input part 60 sends the selected information to an analysis mode selecting part 56. The analysis mode selecting part 56 reads out the operation pattern from the standard mode memory part 52 or high-sped mode memory part 54 on the basis of the selected information, and ends the operation pattern to a control part 58. The control part 58 forms a measurement program in accordance with the operation pattern, thereby controlling the operation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] 1. Field of the Invention [0002] The present invention relates to an analyzer for automatically analyzing a blood coagulation reaction in the field of clinical examination.

[0002]

2. Description of the Related Art To measure a blood coagulation reaction, a sample is placed in a cuvette, the cuvette is moved to a coagulation reaction measurement site (photometry port), and a reagent is dispensed and measured. In most blood coagulation reaction analyzers, the photometric port is provided with a photometer that irradiates the cuvette with measurement light from a light source and detects light scattered or transmitted by the sample reaction solution with a photodetector.

[0003] In order to increase the processing capacity of the blood coagulation reaction analysis, there is also an analyzer in which a plurality of photometric ports are provided, and the cells are sequentially transferred to the photometric ports in units of the number of photometric ports to perform parallel processing. . Conventional blood coagulation analyzers generally have only one reagent dispensing mechanism, and supply of cells, supply of samples,
The measurement program is created based on an operation pattern including the operations of reagent dispensing and cell discharge for one time.

[0004]

[Problem to be Solved by the Invention] The blood coagulation analysis requires only one reagent dispensing (one-reagent coagulation item)
And twice required (two-reagent coagulation item). For example, PT (prothrombin time), FIB (fibrinogen) and TH (thrombotest hepaplastin test) may be dispensed with one reagent, whereas APTT (activated partial thromboplastin time) dispenses the first reagent in advance, After being activated for a certain period of time, the triggering second reagent must be dispensed.

[0005] Therefore, in the measurement program including the two-reagent coagulation item, in order to avoid the timing of having to dispense the reagent to two cells during one cycle, the second reagent of the two-reagent coagulation item is dispensed. It was created by skipping the sample analysis corresponding to the injection timing, and the processing capacity was reduced. Such a problem can be solved by providing two reagent dispensers, but since most of the measurement items of the blood coagulation analysis are of one reagent type, it is useless to provide two reagent dispensers.

[0006] However, some blood coagulation analyzers are provided with, as photometric ports, a scatter photometer for measuring coagulation items and a colorimeter for measuring colorimetric items of two reagents. Depending on the measurement items, there are cases where there are many one-reagent systems and cases where there are many two-reagent systems. Accordingly, it is an object of the present invention to enable the selection of operation patterns such as supply and disposal of cuvettes, sample dispensing, reagent dispensing, and the like, and to increase processing capacity.

[0007]

FIG. 1A is a block diagram showing the present invention, and FIG. 1B shows an analysis condition screen for selecting an analysis mode. A standard mode storage unit 52 in which an operation pattern of the standard mode is stored and a high speed mode storage unit 54 in which an operation pattern of the high speed mode is stored are provided.
The standard mode storage unit 52 and the high-speed mode storage unit 54 are connected to the analysis mode selection unit 56, respectively. The analysis mode selection unit 56 includes a control unit 58 for controlling the operation of the apparatus.
The input unit 60 for selecting one of the analysis modes is also connected (A).

That is, the present invention provides a blood coagulation analysis comprising a reaction unit for detachably holding a plurality of cells, a cell supply / discharge mechanism, a sample dispenser, a reagent dispenser, and a control unit 58 for controlling operations. A standard mode storage unit 52 in which an operation pattern including cell supply, specimen supply, multiple-time reagent dispensing and cell discharge operations is stored in one cycle of the operation, and one cycle of the operation. , A high-speed mode storage unit 54 in which operation patterns including operations of cell supply, sample supply, one-time reagent dispensing, and cell discharge are stored, and either the standard mode or the high-speed mode is selected. Input unit 60, and an analysis mode selection unit 56 that reads an operation pattern from the standard mode storage unit 52 or the high-speed mode storage unit 54 based on the selection information of the input unit 60, and the control unit 58 Based on the operation pattern information from the analysis mode selection unit 56, create a measurement program, a blood coagulation analyzer which is adapted to control the operation accordingly.

When one of the standard mode and the high-speed mode is selected on the analysis condition screen shown in FIG. 1B, the input unit 60 sends the selected information to the analysis mode selection unit 56. The analysis mode selection unit 56 reads an operation pattern from the standard mode storage unit 52 or the high-speed mode storage unit 54 based on the selection information, and
Send to The control unit 58 creates a measurement program according to the operation pattern and controls the operation.

[0010]

FIG. 2 is a plan view showing a blood coagulation analyzer to which the present invention is applied. In the cuvette reaction unit 1, a plurality of photometric ports 2 are arranged in a fan shape on an arc. The photometry port 2 is kept at, for example, 37 ° C. As the photometric port 2, a scattering port for measuring the amount of scattered light and a colorimetric port for measuring the amount of transmitted light are provided. As shown in FIG. 3, the scattering port holds a cuvette 34 into which a sample and a reagent are dispensed one by one, and detachably holds the cuvette 34. A light source 36 such as an LED that irradiates the sample in the cuvette 34 with measurement light is provided.
And a photodetector 38 such as a photodiode provided on an optical axis in a direction perpendicular to the direction of incidence of the measurement light in order to detect scattered light of the measurement light due to the sample liquid. The colorimetric port is a plurality of colorimetric ports that measure the amount of transmitted light, an optical fiber that guides light of a predetermined wavelength from the common light source to the cuvette, a photodiode provided on the same optical axis as the incident direction of the measurement light, etc. And a photodetector.

Returning to FIG. 2, description will be continued. A cuvette transfer arm 4 and a reagent probe 6 which move along an arc in which the photometric ports 2 are arranged are provided. As shown in FIG. 4, the cuvette transfer arm 4 and the reagent probe 6 are arranged at a distance in the vertical direction, and rotate at different heights on a circular arc on which the photometric ports 2 are arranged with a common rotation center. It is provided as follows.

The cuvette transfer arm 4 mounts a cuvette on each photometric port 2 of the cuvette reaction section 1 or removes a cuvette from the photometric port 2. The cuvette transfer arm 4 includes a cuvette supply position A for receiving the cuvette from the cuvette supply unit 8, a cuvette disposal port 10 for discarding the cuvette,
The cuvette into which the sample and the reagent are dispensed is moved to the stirring port 12 for stirring, and is driven so as to be stopped. The cuvette transfer arm 4 takes out the cuvettes stored in the cuvette supply unit 8 one by one at the cuvette supply position A, transfers the cuvette to one of the photometry ports 2 and mounts the cuvette, or completes the measurement of any one of the photometry ports 2 The subsequent cuvette is taken out and discarded in the cuvette discarding port 10.

FIGS. 5A and 5B are schematic structural views showing a cuvette supply section, wherein FIG. 5A is a partially cutaway side view, FIG. 5B is a top view around a guide rail, and FIG. 5C is arranged in the cuvette supply section. (D) is a cross-sectional view of the cuvette. The cuvette 34 is a transparent plastic molded product, and the flange 34a at the opening of the cuvette 34 is formed to have a size larger than the body 34b. Tsuba 34
A band-like grain (a part having unevenness on the surface and a reduced transparency) 34c is formed around the body part 34b on the a side. The grain 34c is formed at a position that does not affect the measurement of the sample. The cuvette supply unit 8 is provided with a cuvette accommodating unit 40 for accommodating a plurality of such cuvettes 34 at random. The cuvette accommodating portion 40 is wider than the body portion 34b of the cuvette 34 and has a flange 34a.
Two turntables are arranged at a smaller interval. By the rotation of the rotating discs, the cuvettes 34 stored in the cuvette storage unit 40 are sequentially discharged from the cuvette outlet 42 with the opening side upward.

At the cuvette outlet 42, a cuvette 34
2 at an interval wider than the body portion 34b and narrower than the flange 34a.
One end of the guide rail 44 is arranged. The guide rail 44 is arranged so as to be inclined with one end being high and the other end being low, and the cuvette 34 supplied from the cuvette outlet 42 slides from one end to the other end, whereby the guide rail 44 is moved. Are arranged.

At the other end of the guide rail 44, a cuvette slide 46 for receiving the cuvette 34 sliding on the guide rail 44 and supplying the arranged cuvettes 34 one by one to the cuvette supply position A is provided. . One end of the guide rail 44 sandwiches a space in which the cuvettes 34 are arranged, and an L
ED 48 and photodetector 5 for detecting light from LED 48
0 is arranged. The LED 48 and the photodetector 50 are installed such that when the cuvette 34 reaches one end of the guide rail 44, the grain 34c of the cuvette 34 exists between the LED 48 and the photodetector 50.

When the cuvette 34 is accommodated in the cuvette accommodating section 40 and the supply of the cuvette is started, the LED 4
8 lights up. When the cuvette 34 does not exist between the LED 48 and the photodetector 50, the light of the LED 48 is detected by the photodetector 50. The turntable in the cuvette storage unit 40 is rotated in response to the detection signal, and the cuvette 34 is supplied to the cuvette outlet 42. The cuvette 34
Slides from one end to the other end of the guide rail 44 and is received by the cuvette slide 46.

When the light of the LED 48 is detected by the photodetector 50, the cuvette 34 from the cuvette housing 40 is
Is repeated, and the cuvettes 34 are sequentially arranged on the guide rail 44 from the other end side. Guide rail 44
The cuvettes 34 arranged in an
When stopped at a position between 0, the LED 48 detects the light
The light irradiated to the side is blocked by the grain 34c of the cuvette 34, and the light of the LED 48 is not detected by the photodetector 50 or falls below a predetermined threshold level. The cuvette supply from the storage unit 40 is stopped.

Thereafter, the cuvette slide 46
When the cuvette 34 is supplied to the cuvette supply position A, the cuvette 34 arranged on the guide rail 44
Each of them slides toward the cuvette slide 46 by the dimension of the flange 34a. Then, the LED 48 and the photodetector 50
Since the cuvette 34 does not exist in the middle, the light detector 5
When 0, the light of the LED 48 is detected, and the cuvette supply from the cuvette storage unit 40 is restarted. Cuvette 3
Since the crevice 34c is formed at a position corresponding to between the LED 48 and the photodetector 50, the LED 48 and the photodetector 5
The detection output of the photodetector 50 greatly differs between the case where the cuvette 34 exists between 0 and the case where the cuvette 34 does not exist, the threshold value can be easily set, and the malfunction can be eliminated.

Returning to FIG. 2, the description will be continued. A plurality of reagents are arranged on the circumference of the disk-shaped reagent table 14.
The reagent table 14 can be rotated and stopped in a reciprocating direction by a drive mechanism not shown in the figure. On the back side of the reagent table 14, a magnetic stirrer (not shown) for rotating the magnetic bar member by magnetism is arranged at a position corresponding to the bottom surface of the reagent container at a predetermined position. By placing the magnetic bar member in the reagent container, when the reagent container is transferred to the position of the magnetic stirrer, the reagent is stirred and the precipitation of the reagent can be suppressed.

A reagent probe 6 is provided in addition to each photometric port 2,
It is moved to the reagent suction positions B and C on the reagent table 14 and the cleaning port 16 for cleaning the nozzle of the reagent probe 6, respectively, and driven to stop. A disk-shaped sample table 18 is provided on the outer periphery of the reagent table 14,
A plurality of samples are arranged on the circumference of the sample table 18. The sample table 18 is rotated in a reciprocating direction separately from the reagent table 14 by a driving mechanism not shown in the drawing,
It can be stopped. Since the reagent table 14 and the sample table 18 are arranged concentrically with each other,
A compact arrangement can be achieved.

A sample probe 20 is provided near the sample table 18. The sample probe 20 aspirates the sample transferred to the sample suction position D of the sample table 18 and places the sample in the cuvette at the cuvette supply position A. Is dispensed. The sample probe 20 includes a cuvette supply position A, a sample suction position D, a washing port 22 for washing the nozzle of the sample probe 20, an emergency sample port 24, a buffer port 26, a diluent port 28, a detergent port 30, and an external sample port 32. , And are driven so that they can be stopped. The reagent table 14 and the sample table 18 are cooled to a predetermined temperature by a cooling mechanism (not shown) in order to prevent deterioration of the placed sample and the reagent. Since the photometric port is kept at 37 ° C., hot water is circulated through the nozzle of the reagent probe 6 in order to avoid a temperature change when the reagent is dispensed. When dispensing the reagent, the temperature of the reagent is set to a predetermined temperature or higher.

As shown in FIG. 1, a control section 58 is provided to control the operation of each section. As the operation by the control unit 58, the standard mode storage unit 52 stores
A standard mode in which reagent dispensing is performed twice in one cycle and a high-speed mode in which reagent dispensing is performed once in one cycle stored in the high-speed mode storage unit 54 are provided. First, the standard mode will be described. FIG. 6 shows the operation of the cuvette transfer arm 4, the reagent probe 6, the sample probe 20, and the like in the standard mode, and one cycle is composed of 20 seconds. One cycle is assigned to each operation of cuvette supply, specimen dispensing, cuvette discharge, first reagent dispensing, stirring after dispensing the first reagent, second reagent dispensing, and stirring after dispensing the second reagent. Therefore, even if those operations are included, only one operation is included in one cycle.

A new cuvette is placed at the cuvette supply position A by the cuvette supply unit 8. In the sample table 18, the identification information of the sample is attached to the sample container by a barcode or the like, and the identification information of the sample container to be dispensed next is read by a barcode reader or the like, and the measurement item is recognized. Thereafter, the sample is transferred to the sample suction position D. The sample port 20 allows the buffer port 26
After a predetermined amount of physiological saline is aspirated from a predetermined amount of buffer or diluent port 28, a predetermined amount of the sample at the sample suction position D is aspirated, and the sample is caught together with the buffer or the physiological saline at the cuvette supply position A. Dispensed into cuvettes (inspection).

The cuvette into which the sample has been dispensed is transferred from the cuvette supply position A to the vacant photometric port 2 by the cuvette transfer arm 4. The cuvette is transferred to the stirring port 12 by the cuvette transfer arm 4 after two cycles of the heat retention time at the photometry port 2. In the reagent table 14, the first reagent is transferred to the reagent suction position B or C. The reagent probe 6 aspirates a predetermined amount of the first reagent at the reagent suction position B or C, and dispenses the first reagent into the cuvette attached to the stirring port 12 and into which the sample has been dispensed (R1). . And stirring port 1
By 2, the sample and the first reagent are stirred. When the nozzle of the reagent probe 6 is lowered to dispense the first reagent, the operation of the cuvette transfer arm 4 is prohibited to prevent the nozzle from contacting the cuvette transfer arm 4. After the stirring, the cuvette into which the first reagent has been dispensed is transferred from the stirring port 12 to the photometry port 2 by the cuvette transfer arm 4. The cuvette has 9 ports at the photometry port 2 for reacting the sample with the first reagent.
After the first reaction time of the cycle, it is transferred to the stirring port 12 by the cuvette transfer arm 4.

In the reagent table 14, the second reagent is transferred to the reagent suction position B or C. A predetermined amount of the second reagent at the reagent suction position B or C is sucked by the reagent probe 6,
The second reagent is dispensed into the cuvette attached to the stirring port 12 and into which the specimen and the first reagent have been dispensed (R2).
Then, the liquid stored in the cuvette is stirred by the stirring port 12. Even when the nozzle of the reagent probe 6 is lowered to dispense the second reagent, the operation of the cuvette transfer arm 4 is prohibited in order to prevent contact between the nozzle and the cuvette transfer arm 4. After the stirring, the cuvette into which the second reagent has been dispensed is moved from the stirring port 12 to the photometric port (colorimetric port) 2 by the cuvette transfer arm 4.
Is transferred to Then, after a second reaction time of about 14 cycles for reacting the product of the reaction between the sample and the first reagent with the second reagent, the amount of transmitted light is measured.
The cuvette of the sample whose measurement has been completed is discarded by the cuvette transfer arm 4 to the cuvette discarding port 10 (discard).

This operation is an operation for measuring a colorimetric item that requires two types of reagents. For example, APT
In a two-reagent coagulation item that requires two types of reagents, such as T measurement, the second reagent is dispensed with the cuvette attached to the photometry port (scattering port) 2 and coagulated simultaneously with the dispensing of the second reagent. Start the reaction process measurement. Also, for example, PT
For one-reagent coagulation items, such as measurement and Fib measurement, in which only one type of reagent is dispensed, the reagent is dispensed with the cuvette attached to the photometry port (scattering port) 2, and coagulation occurs simultaneously with the dispensing of the reagent. Start the reaction process measurement. As described above, the necessity of the stirring operation differs depending on the measurement item.
When measuring a plurality of items for one sample, FIG.
, There is a cycle in which the cuvette transfer operation and the stirring operation related to the first reagent dispensing and / or the second reagent dispensing are omitted.

FIG. 7 shows a basic pattern (operation pattern) for each item in the standard mode. Here, four colorimetric, APTT, PT, and Fib
Shows the case of measuring an item. The symbol “S” in FIG. 7 indicates cuvette supply and sample dispensing, “R1” indicates first reagent dispensing,
“R2” indicates dispensing of the second reagent, and “discharge” indicates discharge of the cuvette. PT and Fib perform the same operation. PT and F
In the case of ib, the sample is dispensed and the cuvette is supplied in the first cycle, and after keeping the temperature for two cycles, the first reagent (trigger reagent) is dispensed in the fourth cycle. After dispensing the trigger reagent, measurement of the amount of scattered light is started, and when blood coagulation is detected, the measurement is terminated and the cuvette is discharged.

In the APTT, the dispensing of the sample and the supply of the cuvette are performed in the first cycle, and the first reagent is dispensed in the fourth cycle after the same two-cycle keeping time. After the dispensing of the first reagent, after a certain time of 189 seconds for activation, the second reagent (trigger reagent) is dispensed in the thirteenth cycle, and the measurement of the amount of scattered light is started. The cuvette is ejected.

In colorimetry, the dispensing of the sample and the supply of the cuvette are performed in the first cycle, and the first reagent is dispensed in the fourth cycle after the same two-cycle warming time.
After dispensing the first reagent, the reaction between the sample and the first reagent (first reaction)
After a certain period of 189 seconds, the second reagent is dispensed in the thirteenth cycle. By dispensing the second reagent, a reaction between the product of the sample and the first reagent and the second reagent (second reaction) is started, and the amount of transmitted light is measured for 297 seconds up to the 27th cycle. Thus, the measurement is performed by both the rate method and the endpoint method. Thereafter, the cuvette is discharged. In this way, four items of measurement are performed for one sample.

FIG. 8 shows a usage state of the photometry port in the standard mode. Here, for one sample, colorimetry, AP
The case where four items of TT, PT and Fib are measured is shown.
However, Fib is also shown as PT. As shown in FIG. 7, in any of the items, the first reagent is dispensed after a predetermined time from the sample dispensing and cuvette supply (S) (R1). Thereafter, photometry or second reagent dispensing (R2) is performed according to the measurement item. In the case of colorimetry, the cuvette is attached to the colorimetric port after dispensing the second reagent. Here, in the colorimetry, the scattering port is used as the photometric port 2 for keeping the cuvette-containing liquid before dispensing the second reagent, but the colorimetric port may be used. According to this standard mode, 180 tests per hour, that is, four items including colorimetric items can be measured for 45 samples.

Next, the high-speed mode will be described. FIG.
Shows the operation of the cuvette transfer arm 4, the reagent probe 6, the sample probe 20, and the like in the high-speed mode, and one cycle is composed of 12 seconds. 1
Each operation of cuvette supply, sample dispensing, cuvette discharge, and reagent dispensing is assigned to a cycle, and even if these operations are included, only one operation is included in one cycle.

In the same manner as in the standard mode, a new cuvette is placed at the cuvette supply position A, and a sample is dispensed into the cuvette together with a buffer or physiological saline (testing). Transferred to 2. In the reagent table 14, a predetermined reagent is transferred to the reagent suction position B or C. Reagent probe 6
As a result, a predetermined amount of the reagent at the reagent suction position B or C is sucked, and the reagent is dispensed into the cuvette attached to the photometry port 2 (R1). The agitation of the sample and the reagent is performed by the force of the reagent ejected from the reagent probe. When the nozzle of the reagent probe 6 is lowered to dispense the reagent, the operation of the cuvette transfer arm 4 is prohibited to prevent the nozzle from contacting the cuvette transfer arm 4. The coagulation reaction process measurement is started simultaneously with the dispensing of the reagent. The cuvette of the sample whose measurement has been completed is discarded by the cuvette transfer arm 4 to the cuvette discarding port 10 (discard).

This operation is an operation in the case of measuring a one-reagent coagulation item, which is performed by dispensing only one type of reagent, such as PT measurement or Fib measurement. In a two-reagent coagulation item that requires two types of reagents, for example, APTT measurement, the first reagent is dispensed first, and after a certain time has elapsed from the dispensing of the first reagent for activation, the second reagent is dispensed. And the coagulation reaction process measurement is started simultaneously with the dispensing of the second reagent. As described above, depending on the measurement items, two reagent dispensing operations are required for one cuvette. If such items are included, the cuvette supply operation and the sample dispensing operation shown in FIG. There are cycles in which the filling operation, or the cuvette disposal operation, or all of these operations are omitted.

FIG. 10 shows a basic pattern for each item in the high-speed mode. Here, a case where three items of APTT, PT and Fib are measured for one sample is shown. Here, a description will be given on the assumption that the colorimetric items are not analyzed. In FIG. 10, the symbol "S" indicates cuvette supply and sample dispensing, "R1" indicates first reagent dispensing, "R2" indicates second reagent dispensing, and "discharge" indicates cuvette discharge. PT
And Fib perform the same operation. For the PT and Fib, the dispensing of the sample and the supply of the cuvette are performed in the first cycle, and after maintaining the temperature for four cycles, the first reagent (trigger reagent) is dispensed in the sixth cycle. After dispensing the trigger reagent, measurement of the amount of scattered light is started, and when blood coagulation is detected, the measurement is terminated and the cuvette is discharged.

In the APTT, the specimen is dispensed and the cuvette is supplied in the first cycle, and the first reagent is dispensed in the sixth cycle after the same four-cycle warming time. After dispensing the first reagent, after a certain time of 192 seconds for activation, the second reagent (trigger reagent) is dispensed at the 22nd cycle to start measuring the amount of scattered light, and after detecting blood coagulation. The cuvette is ejected. Here, the black-out portion (17th cycle) indicates the timing of the first reagent dispensing of the sample and the timing of the APTT measurement with another sample, if the sample dispensing is performed in that cycle. When the injection timing may overlap in the same cycle, this means that the cuvette supply of the sample and the sample dispensing are shifted by one cycle. Thus, 1
The timing is controlled so that the need for dispensing the reagent twice during the cycle does not occur. In this way, three items are measured for one sample.

FIG. 11 shows a usage state of the photometry port in the standard mode. Here, for one sample, APT
The case where three items of T, PT and Fib are measured is shown. However, Fib is also shown as PT. As shown in FIG. 10, in any of the items, the first reagent is dispensed after a predetermined time from the dispensing of the sample and the supply of the cuvette (S1) (R1). Thereafter, photometry or second reagent dispensing (R2) is performed according to the measurement item. In the high-speed mode, the colorimetric item is not analyzed, so the colorimetric port is not used. According to the high-speed mode, 225 tests can be performed per hour, that is, three items including two reagent coagulation items can be measured for 75 samples. When measuring only one reagent coagulation item, a maximum of 300 tests can be performed.

When one of the analysis modes is selected on the analysis condition screen shown in FIG. 1B, the selection information is sent to the analysis mode selection unit 56 by the input unit 60. The analysis mode selection unit 56 reads an operation pattern from the standard mode storage unit 52 or the high-speed mode storage unit 54 based on the selection information, and sends the operation pattern to the control unit 58. The control unit 8 creates a measurement program as shown in FIG. 8 or FIG. 11 according to the operation pattern and the measurement items, and controls the operation of each mechanism according to the measurement program.

In this embodiment, the cuvette transfer mechanism 4 and the reagent probe 6 are configured to move on the photometric ports 2 arranged in a line in an arc, but the present invention is not limited to this. Even if the arrangement of the photometric ports 2 is linear or matrix, the cuvette transfer mechanism 4 and the reagent probe 6 are located at different heights.
Any configuration that moves up is acceptable. Further, in this embodiment, a turntable type is shown as the sample table 18, but a rack type may be used. Although the reagent table 14 is of a turntable type, a reagent container may be arranged on the trajectory of the reagent probe 6. Further, in this embodiment, the reagent table 14 and the sample table 18 are rotated by different drive mechanisms, but may be simultaneously rotated and rotated by the same drive mechanism.

The reagent probe 4 may be provided with a function of dispensing a sample, and may be configured so that the sample probe 20 is not provided. In this embodiment, the operation pattern in which the reagent dispensing operation is performed twice per cycle is set as the standard mode. However, the present invention is not limited to this, and the reagent pattern is not limited to three or more times per cycle. An operation pattern for performing the dispensing operation may be set. Further, in the high-speed mode of this embodiment, the explanation is limited to the coagulation item, but the present invention can be applied to the colorimetric item which does not require stirring.

[0040]

According to the present invention, in one cycle of operation, a standard mode storage unit storing an operation pattern including an operation of supplying a cell, supplying a sample, dispensing a plurality of reagents and discharging a cell, and Cell supply, sample supply, 1
A high-speed mode storage unit in which an operation pattern including the operation of reagent dispensing and cell discharge of one time is stored, an input unit in which one of the standard mode or the high-speed mode is selected, and a selection of the input unit An analysis mode selection unit that reads an operation pattern from a standard mode storage unit or a high-speed mode storage unit based on information, and a measurement program is created based on the operation pattern information from the analysis mode selection unit, and control is performed based on the measurement program. And a control unit, so that an operation pattern can be selected, and by inputting an appropriate analysis mode to the input unit according to the measurement item, the control unit can store the operation pattern stored in the standard mode storage unit or the high-speed mode storage unit. Since the measurement program is created based on the above, the processing capability can be increased.

[Brief description of the drawings]

FIG. 1A is a block diagram showing the present invention, and FIG. 1B is a diagram showing an analysis condition screen when an analysis mode is selected.

FIG. 2 is a plan view showing a blood coagulation apparatus to which the present invention is applied.

FIG. 3 is a plan view showing a photometry port in the same device.

FIG. 4 is a side view showing a cuvette transfer arm and a reagent probe in the same device.

FIG. 5 is a schematic configuration diagram illustrating a cuvette supply unit;
(A) is a partially cutaway side view, (B) is a top view around a guide rail, (C) is a side view showing a cuvette arranged in a cuvette supply unit, and (D) is a cross-sectional view of the cuvette. .

FIG. 6 is a diagram showing an example of one cycle of an operation in a standard mode.

FIG. 7 is a diagram illustrating an example of a basic pattern of measurement items in a standard mode.

FIG. 8 is a diagram illustrating a usage state of a photometry port in a standard mode.

FIG. 9 is a diagram illustrating an example of one cycle of an operation in a high-speed mode.

FIG. 10 is a diagram illustrating an example of a basic pattern of measurement items in a high-speed mode.

FIG. 11 is a diagram illustrating a usage state of a photometry port in a high-speed mode.

[Explanation of symbols]

 Reference Signs List 1 cuvette reaction section 2 photometry port 4 cuvette transfer arm 6 reagent probe 8 cuvette supply section 10 cuvette disposal port 12 stirring port 14, 22 reagent table 16 washing port 18 sample table 20 sample probe 24 emergency sample port 26 buffer port 28 diluent port Reference Signs List 30 Detergent port 32 External sample port 34 Cuvette 40 Cuvette storage unit 44 Guide rail 46 Cuvette slide 52 Standard mode storage unit 54 High-speed mode storage unit 56 Analysis mode selection unit 58 Control unit 60 Input unit

Claims (1)

[Claims] 1. A blood coagulation analyzer comprising a reaction unit for detachably holding a plurality of cells, a cell supply / discharge mechanism, a sample dispenser, a reagent dispenser, and a control unit for controlling operation. A standard mode storage unit in which an operation pattern including a cell supply, a sample supply, a plurality of times of reagent dispensing and a cell discharge operation is stored in one cycle, and a cell supply, a sample supply, A high-speed mode storage unit in which an operation pattern including one reagent dispensing and cell discharging operation is stored; an input unit for selecting one of a standard mode and a high-speed analysis mode; and the input unit An analysis mode selection unit that reads out an operation pattern from the standard mode storage unit or the high-speed mode storage unit based on the selection information. The control unit controls the operation pattern from the analysis mode selection unit. Based on the distribution, to create a measurement program, a blood coagulation analyzer is for controlling the operation based thereon.