JP2000316973A - Medicine containing injector - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medicine containing injector which can connect receiving chambers for each medicine simply. SOLUTION: An outer cylinder 2 is devided into two chambers and the two chambers are composed of a base chamber 2A having an inserting port 6A of which a gasket 4A of a pressing element 4 is inserted and a point chamber 2B having an exhaust port 8A of which a medicine is exhausted. A freeze drying agent is received in the point chamber. On a medicine containing injector which receives solution in the base chamber, the base chamber is composed of a cylindrical container which can seal solution. An inserting port is formed at one end of the cylindrical chamber and the first connecting port 6B which is connected with the point chamber is formed at the other end, furthermore, the first connecting port is sealed with the first stopper body 14. The point chamber is composed of a cylindrical freeze drying container 8 which dries medicine with freezing. An exhaust port is formed at one end of the freeze drying container and the second connecting port 8B which is engaged with the first connecting port of the base chamber from the outside is formed at the other end of the freeze drying container and a concavoconvex part 24 is formed at an inner wall face of the second connecting port so that the second stopper body 22 can be capped incompletely when medicine is dried with freezing.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a syringe containing a medicine, and more particularly, to an inside of an outer cylinder which is divided into two chambers, and a lyophilized agent or the like is hermetically sealed and housed in one chamber.
The present invention relates to a multi-chamber drug-containing syringe in which a liquid such as a solution thereof is contained in another chamber.

[0002]

2. Description of the Related Art In recent years, there has been provided a syringe in which a drug solution is previously stored in a liquid-tight manner in an outer cylinder of the syringe. There is also provided a syringe in which the inside of an outer cylinder is divided into two parts, and a powder medicine and a solution thereof are separately accommodated in the outer cylinder. By the way, in the medicine-containing syringe, the powder medicine and the liquid medicine in the outer cylinder are stored aseptically. Solid drugs such as powdered drugs in the outer cylinder are usually
The liquid medicine in the outer cylinder is accommodated in the outer cylinder by aseptic filling or sterilized with high pressure steam sterilization together with the outer cylinder. It is desirable that the liquid preparation has been subjected to high-pressure steam sterilization in order to enhance safety in particular. In the case where the solid agent and the liquid agent are aseptically accommodated in a syringe with the outer cylinder divided into two parts,
Preferably, the solid preparation is aseptically filled, and the liquid preparation is subjected to high-pressure steam sterilization. For this purpose, the outer cylinder is divided into two containers, one container is aseptically filled with a solid agent, the second container is subjected to high-pressure steam sterilization, and the individual containers are connected aseptically. A two-chamber container / syringe having an outer cylinder has been proposed (Japanese Utility Model Laid-Open No. 5-152).

[0003]

However, there is room for improvement in such a syringe in which the outer cylinder is divided into two parts. For example, the number of members is increased due to the necessity of connecting pipes and the like in connection between containers constituting an outer cylinder, and labor saving in manufacturing is desired. When the solid agent is a freeze-dried agent or the like, it is necessary to aseptically transfer the freeze-dried container to a container member constituting the outer cylinder. this is,
This is a major inconvenience in increasing sterility and performing transfer work. Therefore, the present invention is a syringe capable of separately containing a lyophilized drug and its dissolved liquid in an outer cylinder and performing high-pressure steam sterilization of the liquid in the outer cylinder. It is an object of the present invention to provide a drug-containing syringe that is simple and can easily and safely contain a lyophilized agent aseptically.

[0004]

According to the present invention, the inside of an outer cylinder is divided into two chambers. The two chambers of the outer cylinder have a base end chamber having an insertion port into which a gasket of a pusher is inserted, and a medicine discharge port. A distal end chamber having a discharge port through which a lyophilized agent is stored in the distal end chamber and a liquid agent is stored in the proximal end chamber, wherein the proximal end chamber is liquid-tight. One end of the cylindrical container is formed with the insertion port, the other end is formed with a first connection port with the tip chamber, and the first connection port is formed with a first stopper. The distal chamber is sealed with a body, and the distal chamber is formed of a cylindrical lyophilization container in which the lyophilization of the drug solution is performed. The outlet is formed at one end of the lyophilization container, and the other end of the proximal chamber is formed at the other end. A second connection port that fits over the first connection port is formed, the second connection port is sealed with a second stopper, and Irregular strips are formed on the inner wall surface of the second connection port so that the second plug can be half-plugged at the time of sintering and drying, and the first plug and the second plug are inside the cylindrical container. A bypass means which can slide in the lyophilization container in a liquid-tight manner, and which allows the liquid agent to flow over the side wall of the lyophilization container over the first plug and the second plug and flow to the tip chamber. The length L of the bypass means on the side wall is a thickness L1 of the gasket, a thickness L2 of the first plug,
And the thickness L3 of the second plug and L2 + L3 <L <L1 + L2 +
The object has been achieved by providing a drug-containing syringe characterized by having the relationship of L3.

[0005] In the medicine-containing syringe according to the present invention, the inside of the outer cylinder is divided into two chambers, a chamber at a base end portion and a chamber at a distal end portion. The outer cylinder may be made of glass or resin. However, the outer cylinder is desirably made of resin in terms of its moldability, dimensional stability, handling safety, disposal method, and the like. Examples of the resin used for the outer cylinder include general-purpose thermoplastic resins. Specific outer cylinder resins include polyolefin resin, vinyl chloride, vinylidene chloride resin,
It is a general-purpose resin such as a polyester resin, a polyvinyl alcohol resin, a polyacrylonitrile resin, a polyacrylic resin, and a polyamide resin. The outer cylinder wall may be formed of a single layer or a multilayer resin layer, and the resin layer may be a single resin or a mixed resin layer. It is desirable that the resin on the innermost surface of the outer cylinder wall, that is, the resin in direct contact with the chemical liquid, be a polyolefin-based resin with relatively low contamination. For example, low-, medium-, and high-density polyethylenes, lower olefin resins such as polypropylene, cyclic polyolefins, and copolymers of two or more of them.

[0006] The two chambers of the outer cylinder include a base chamber having an insertion port into which the gasket of the pusher is inserted, and a distal chamber having a discharge port through which the medicine is discharged. Further, a lyophilized agent is stored in the distal end chamber, and a liquid agent is stored in the proximal end chamber. Usually, an injection needle, a catheter, and the like are attached to the outlet from which the medicine is discharged, and a plug (taper shape), a luer adapter, and the like are formed on the outer wall of the outlet. The freeze-dried agent is a product in which a drug solution is filled in a drying container through a sterilization filter, frozen, and dried in a freeze dryer. A series of these operations are performed in a sterile room or in a sterile atmosphere. The liquid is a solution of the freeze-dried agent at the time of use, and is a liquid such as distilled water or an electrolyte solution. The above liquid preparation may be filled aseptically, but is preferably subjected to high-pressure steam sterilization.

In the drug-containing syringe according to the present invention, the base end chamber is formed of a cylindrical container in which the liquid agent is stored in a liquid-tight manner. One end of the cylindrical container is formed with the insertion port, and the other end is formed with a first connection port with the tip chamber. The insertion port is liquid-tightly sealed with a gasket of a pusher, and the first connection port is sealed with a first stopper. The gasket and the first plug are made of a rubber material. Therefore, the liquid agent is stored in the outer cylinder in a liquid-tight manner by the gasket and the first stopper.

[0008] Generally, an operation flange for stopping the middle finger is provided at the insertion opening of the pusher in the outer cylinder. In the present invention, an operation flange may be provided at the insertion port of the base chamber,
Such an operation flange is desirably provided on a freeze-drying container described later. Since the insertion port and the first connection port of the cylindrical container are substantially the same diameter, the cylindrical container can be a simple straight pipe without the flange,
It is preferable for its molding. In addition, the inside of such a straight cylindrical container is liquid-tightly filled with the liquid agent, and after the high-pressure steam sterilization treatment, can be easily temporarily stored as such a cylindrical container. Can be easily inserted into the second connection port.

The above-mentioned tip chamber is formed of a cylindrical freeze-drying container in which a drug solution is freeze-dried. That is, the container itself constituting the above-mentioned tip chamber is a freeze-drying container. For this reason, the freeze-dried agent is subjected to processing such as liquid filling, freezing, and drying in the freeze-dried container, and it is not necessary to fill the freeze-dried agent by transfer work from another container or the like as before. Absent. The outlet is formed at one end of the freeze-drying container,
At the other end, a second connection port for externally fitting the first connection port of the base chamber is formed. When the second connection port fits over the first connection port,
The first connection port and the second connection port are connected to each other in a state where the cylindrical container serving as the base end chamber is fully or partially inserted from the first connection port to the second connection port. Therefore, the cylindrical container that is the base end chamber can be easily set in the second connection port in manufacturing. In addition, a sealing material or the like can be easily arranged between the outer wall of the first connection port and the inner wall of the second connection port to improve the sealing property of the connection portion. The second connection port of the freeze-drying container can be easily covered with a sterile maintenance film that can be peeled off immediately before docking with the first connection port.

The second connection port is sealed with a second stopper made of rubber. In addition, a concave or convex portion is formed in the second connection port, and the concave and convex portion is such that the second stopper can be half-plugged in order to evaporate moisture from the chemical solution in the freeze-drying container during the freeze-drying. It is provided in order to become. The concave and convex strips may have a structure in which a gap is formed between the second plug and the inner wall surface of the freeze-drying container, and may have a moisture evaporation path formed in the axial direction of the second plug. Further, the first plug and the second plug can slide in the cylindrical container and the freeze-drying container in a liquid-tight manner. Therefore, the inner diameter of the cylindrical container forming the base chamber and the inner diameter of the freeze-drying container forming the distal chamber are substantially the same.

The side wall of the freeze-drying container has a bypass means through which the liquid agent can pass through the first stopper and the second stopper and flow to the distal end chamber when used. The bypass means can adopt a structure known per se, for example,
By forming a concave portion in the axial direction on the inner wall surface of the container in which the stopper slides, the gap can be used as a bypass flow passage through which the liquid agent flows. An axial ridge is formed on the inner wall surface of the container in which the stopper slides, and a bypass flow passage through which the liquid agent flows can be formed by utilizing the deformation caused by the ridge of the elastic stopper. A plurality of holes can be drilled in the wall of the lyophilization container to form a bypass flow passage in the outer wall of the container.

The length L of the axial bypass means formed on the side wall of the freeze-drying container is equal to the thickness L 1 of the gasket.
The thickness L2 of the first plug, the thickness L3 of the second plug, and L2 +
L3 <L <L1 + L2 + L3. When the length L of the bypass means is longer than the sum of the thickness L2 of the first stopper and the thickness L3 of the second stopper, the first stopper and the second stopper are located in the region of the bypass means of the freeze-drying container. Even so, the bypass means can secure the bypass flow passage. Therefore, when the gasket is pushed in, the first plug and the second plug temporarily stop in the area of the bypass means, the liquid agent stored in the base chamber flows into the distal chamber through the bypass means, and only the gasket is moved. Moves. On the other hand, if the length L of the bypass means is shorter than the sum of the gasket L1, the thickness L2 of the first plug, and the thickness L3 of the second plug, the gasket, the first plug, and the second plug are in the lyophilized container. When the bypass means is located in the region of the bypass means, the bypass means cannot secure the bypass flow passage and is closed. Therefore, when the gasket is further pushed in, the gasket, the first plug and the second plug move in the region of the bypass means, and move as a normal pusher.

In the medicine-containing syringe according to the present invention,
When assembling the containers constituting the outer cylinder, the outer fitting type or the insertion type that does not use a connecting ring member or the like facilitates the assembly. Since the tip chamber itself is a freeze-drying container for freeze-drying, no transfer is required,
Improved sterility and operability.

According to a second aspect of the present invention, there is provided a medicine-containing syringe according to the first aspect, wherein an elastic sealing material is provided between an outer wall of the first connection port and an inner wall of the second connection port. It is characterized by being arranged. As described above, in the medicine-containing syringe according to the present invention, the connection portion is an external fitting type or an insertion type of each connection port. For this reason, it is possible to easily dispose a sealing material, for example, an elastic member such as an O-ring between the outer wall of the first connection port and the inner wall of the second connection port. Since the airtightness of the sealing material directly acts in the radial direction of the connection port, a sufficient sealing property can be obtained.

[0015]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of a drug-containing syringe according to the present invention will be described below in detail with reference to the accompanying drawings. FIG. 1 is a longitudinal sectional view of the medicine-containing syringe according to the first embodiment. FIG.
(A) And (B) is a longitudinal cross-sectional view of the freeze-drying container in the syringe of the first embodiment when the drug is freeze-dried. FIG. 3 is a vertical sectional view of the cylindrical container in the syringe of the first embodiment. FIG. 4 is a longitudinal sectional view of the syringe of the first embodiment at the start of use. FIG. 5 is a longitudinal sectional view of the syringe of the first embodiment during use. FIG. 6 is a longitudinal sectional view of the medicine-containing syringe according to the second embodiment.

In the medicine-containing syringe 1 according to the first embodiment, as shown in FIGS. 1 to 5, the inside of the outer cylinder 2 is divided into two chambers 2A and 2B. A base chamber 2A having an insertion opening 6A into which the gasket 4A of the pusher 4 is inserted;
Outlet 8A from which injection medicine 11 mixed at the time of use is discharged
And a tip chamber 2B having A lyophilization agent 10 is stored in the distal chamber 2B, and a lysing solution 12 is stored in the proximal chamber 2A.

The outer cylinder 2 is composed of two containers 6,8. The base end chamber 2A is formed of a cylindrical container 6 made of polypropylene, and the above-described insertion port 6A is formed at one end of the cylindrical container 6. An elliptical flange 6C is formed on the outer surface of the insertion port 6A, which is an operating flange of the outer cylinder 2. At the other end, a first connection port 6B with the front end chamber 2B is formed. The insertion port 6A is sealed with a gasket 4A, and the first connection port 6B is sealed with a first plug 14. The gasket 4A and the first plug 14 are formed of elastic rubber, and the solution 12 is contained in the cylindrical container 6, that is, in the proximal chamber 2A in a liquid-tight manner.

As shown in FIG. 2, the distal end chamber 2B has a chemical 1
1 is formed from a cylindrical freeze-drying container 8 made of polypropylene in which freeze-drying is performed. An outlet 8A is formed at one end of the freeze-drying container 8, and the outlet 8A is sealed with a sealing cap 16. The sealing cap 16 is a stand on which the freeze-drying container 8 during freeze-drying can be set up. A second connection port 8B is formed at the other end of the freeze-drying container 8, and the second connection port 8B is fitted over the first connection port 6B of the cylindrical container 6. The outer fitting portion 18 of the second connection port 8B has a large inner diameter, and the first connection port 6B is fitted into the large diameter portion. Between the outer wall of the first connection port 6B and the inner wall of the second connection port 8B, there are two O-ring members 2 which are elastic sealing members.
0 and 20 are arranged. The first connection port 6B and the second connection port 8B are liquid-tightly connected by the O-ring members 20,20.

The second connection port 8B is sealed with a second stopper 22. As shown in FIG. 2A, a plurality of ridges 24, 24 are formed in the inner wall surface of the second connection port 8 </ b> B in the axial direction, and the second plug 22 is located at the position of the ridge 24. The second plug 22 is in a half-plugged state. Therefore, the second plug 22 is in a half-plug or completely-plugged state depending on the position where the second connection port 8B is pushed. The inner diameters of the cylindrical container 6 and the freeze-drying container 8 are formed to have the same diameter except for the inner diameter of the outer fitting portion 18. The inside of the drying container 8 slides in a liquid-tight manner.

A bypass groove 26 is formed on the inner side wall of the freeze-drying container 8 in the axial direction of the outer cylinder 2, and when the first plug 14 and the second plug 22 are located in the bypass groove 26, the base end is formed. The dissolving solution 12 in the chamber 2A uses the bypass groove 26 as a flow passage,
Overcoming the first plug 14 and the second plug 22, the tip chamber 2B
Can be distributed to As shown in FIG. 4, the length L of the bypass groove 26 on the inner side wall is in a relationship of L2 + L3 <L with the thickness L2 of the first plug 12 and the thickness L3 of the second plug 22,
As shown in FIG. 5, the thickness L1 of the gasket, the thickness L2 of the first plug, the thickness L3 of the second plug, and L <L1 + L2 + L
In a relationship of 3.

Next, the drug-containing syringe 1 according to the first embodiment.
The production of will be briefly described. As shown in FIG. 2 (A), first, each member of the syringe 1 is washed, sterilized by irradiation sterilization of γ-rays or a combination of high-pressure steam sterilization, and carried into a work clean room. The hermetic cap 16 is attached to the outlet 8A of the freeze-drying container 8 as a member, and the drug solution 10 'that has passed through the sterilization filter is filled into the freeze-drying container 8 from the second connection port 8B. Next, the second plug 22 is inserted into the first connection port 8B, and the ridge 24 on the inner wall surface of the second connection port 8B is inserted.
At the formation position of. The freeze-drying container 8 is carried into a freeze-dryer, and the drug solution 10 'is frozen and dried. Thereby, as shown in FIG. 2 (B), the freeze-drying agent 10 is housed in the freeze-drying container 8, and the second plug 22 is further pushed into the second connection port 8 </ b> B to be disengaged from the ridge 24. To seal the second connection port 8B.

On the other hand, as shown in FIG. 3, the first stopper 14 is attached to the connection port 6B of the cylindrical container 6, and the liquid agent 12 is filled through the insertion port 6A. After filling, insert 6A with gasket 4A
Seal. Next, the elastic sealing members 20 are attached to predetermined positions outside the cylindrical container 6. Such a cylindrical container 6 is subjected to high-pressure steam sterilization at a temperature of 110 ° C. The outer cylinder 2 is assembled by inserting the cylindrical container 6 into the outer fitting portion 18 of the second connection port 8B of the freeze-drying container 8 with the first connection port 6B as a tip. Next, the tip of the pusher 4 is screwed onto the gasket 4A, the pusher 4 is attached, and the syringe 1 is manufactured.

Next, the syringe 1 of the first embodiment will be described with reference to FIGS. As shown in FIG.
When using the syringe 1, the sealing cap 16 is removed from the outlet 8A of the outer cylinder 2, and an injection needle and the like are set. Then, when the pusher 4 is slowly inserted into the outer cylinder 2,
First, the gasket 4A, the first plug 14, and the second plug 2
2 move together. When the second plug 22 reaches the position up to the bypass groove 26, the second plug 22 stops, and the air between the first plug 14 and the second plug 22 passes through the bypass groove 26. Flows into the distal end chamber 2B through the end chamber 2B. When the air release is completed, the first plug 14 is located in the bypass groove 26 as shown in FIG. 4, and the first plug 14 and the second plug 22 overlap.

In such a state, that is, the bypass groove 26
Is the thickness L2 + of the first plug 14 and the second plug 22.
When the pusher 4 is further pushed in a state where the flow path is secured because it is longer than L3, the lysing solution 12 in the proximal chamber 2A flows into the distal chamber 2B and dissolves the lyophilized agent 10. When the solution 12 completely flows into the distal end chamber 2B, the gasket 4A overlaps the first plug 14 and the second plug 22 at the position of the bypass groove 26 as shown in FIG. In this case, since the length L of the bypass groove 26 is shorter than the thickness L1 + L2 + L3 of the gasket 4A, the first plug 14, and the second plug 22, a flow passage is not secured, and the mixed chemical 11 flows backward in the front end chamber 2B. And is discharged from the discharge port 8A.

In the medicine-containing syringe 1 of the first embodiment, when assembling the cylindrical container 6 and the freeze-drying container 8 constituting the outer cylinder 2, the first connection port 6B and the second connection port 8B are connected to each other. Since the fitting type or the insertion type is used, the assembling can be extremely easily performed. Further, since the distal end chamber 2B itself is a freeze-drying container 8 for freeze-drying, no transfer is required, and sterility and workability are high. Further, the elastic sealing material 20 can be easily arranged between the outer wall of the first connecting port 6A and the inner wall of the second connecting port 8B. Since it acts directly in the radial direction, sufficient sealing properties can be obtained.

Next, a drug-containing syringe according to a second embodiment will be described in detail with reference to FIG. 6 of the accompanying drawings. The medicine-containing syringe 41 according to the second embodiment uses the same or similar structure and members as the syringe 1 according to the first embodiment. The detailed description of the syringe 41 according to the second embodiment regarding the same or similar structure and members as the syringe 1 according to the first embodiment will be omitted. The difference between the syringe 41 with a medicine according to the second embodiment and the syringe 1 according to the first embodiment lies in the following structure and shape. These are described in detail below.

A syringe 41 containing a drug solution according to the second embodiment comprises:
As shown in FIG. 6, the cylindrical container 46 is formed of a straight pipe, and has no flange portion unlike the cylindrical container 6 of the first embodiment. For this reason, the processing and forming of the cylindrical container 46 is extremely easy. Further, storage of the cylindrical container 46 as a component after the high-pressure steam sterilization treatment is extremely easy. The cylindrical container 46 is completely accommodated in the outer fitting portion 18 at the second connection port 8B of the freeze-drying container 48. A ridge stopper 42 is formed on the inner wall surface of the outer fitting portion 18 in the radial direction, and the cylindrical container 46 is set in the outer fitting portion 18 by the ridge stopper 42 so as not to be removable.

The freeze-drying container 48 is constituted as the entire outer cylinder 2 and the outer fitting portion 18 is formed with a flange portion 8C. In addition, a concave ridge portion 44 is formed in the second connection port 8B, and the concave ridge portion 44 serves as a transpiration path when the second plug 22 takes a half-plugged state. A bypass passage 50 is formed on the outer wall surface of the freeze-drying container 48. The bypass passage 50 is formed by a ring-shaped cover member 52, a groove 54, and two through holes 5.
It becomes 6.

The drug-containing syringe 41 according to the second embodiment having such a configuration has the same operation and effect as the syringe 1 according to the first embodiment. In this case, as described above, the manufacture and assembly of the cylindrical container 46 are extremely simple.

[0030]

As described above, in the medicine-containing syringe according to the present invention, the base end chamber is formed of a cylindrical container in which the liquid agent is stored in a liquid-tight manner, and one end of the cylindrical container is provided with the insertion port. The other end is formed with a first connection port with the tip chamber, the first connection port is sealed with a first stopper, and the tip chamber has a cylindrical shape in which a drug solution is freeze-dried. Wherein the discharge port is formed at one end of the lyophilization container, and a second connection port for externally fitting the first connection port of the base chamber is formed at the other end. Is sealed with a second stopper, and an uneven ridge is formed on the inner wall surface of the second connection port so that the second stopper can be half-plugged during freeze-drying of the drug solution, The stopper and the second stopper are slidable in a liquid-tight manner in the cylindrical container and the lyophilization container, so that the outer cylinder is Lyophilized drug and it is easy connection of the housing chamber and its dissolution solution, also sterile accommodating lyophilization agents can be simple and safe.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view of a medicine-containing syringe according to a first embodiment.

FIGS. 2A and 2B are longitudinal sectional views of a freeze-drying container in the syringe of the first embodiment when a drug is freeze-dried.

FIG. 3 is a longitudinal sectional view of a cylindrical container in the syringe according to the first embodiment.

FIG. 4 is a longitudinal sectional view of the syringe of the first embodiment at the start of use.

FIG. 5 is a longitudinal sectional view of the syringe of the first embodiment during use.

FIG. 6 is a longitudinal sectional view of a medicine-containing syringe according to a second embodiment.

[Explanation of symbols]

 Reference Signs List 1 syringe with medicine 2 outer cylinder 2A proximal chamber 2B distal chamber 4 pusher 4A gasket 6 cylindrical container 6A insertion port 6B first connection port 8 lyophilization container 8A discharge port 8B second connection port 10 lyophilizer 12 lyophilizer Reference Signs List 14 first plug 16 sealing cap 18 outer fitting portion 20 elastic sealing material 22 second plug 24 ridge 26 bypass groove

Claims (2)

[Claims] The interior of an outer cylinder is divided into two chambers. The two chambers of the outer cylinder have a base chamber having an insertion opening into which a gasket of a pusher is inserted, and a distal chamber having an outlet through which a medicine is discharged. In the medicine-containing syringe, in which the freeze-dried agent is stored in the distal chamber and the liquid is stored in the proximal chamber, the proximal chamber is formed from a cylindrical container in which the liquid is stored in a liquid-tight manner. One end of the cylindrical container is formed with the insertion port, the other end is formed with a first connection port with the tip chamber, the first connection port is sealed with a first plug, The distal end chamber is formed of a cylindrical freeze-drying container in which the liquid solution is freeze-dried, the discharge port is formed at one end of the freeze-drying container, and the first connection port of the base chamber is fitted at the other end. A second connection port is formed, the second connection port is sealed with a second stopper, and the second stopper is half-closed during freeze-drying of the drug solution. An uneven strip portion is formed on the inner wall surface of the second connection port so as to be pluggable, and the first plug and the second plug are liquid-tight in the cylindrical container and the lyophilization container. And a bypass means on the side wall of the freeze-drying container, through which the liquid agent can flow over the first stopper and the second stopper and flow to the distal end chamber. The length L of the means is the thickness L1 of the gasket, the thickness L2 of the first plug, and the thickness L3 of the second plug,
A drug-containing container having a relationship of L2 + L3 <L <L1 + L2 + L3. 2. The medicine-containing syringe according to claim 1, wherein an elastic sealing material is provided between an outer wall of the first connection port and an inner wall of the second connection port.