JP2000309526A - Adhesive plaster for treating impetigo - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject adhesive plaster capable of exhibiting excellent effects especially on the treatment of impetigo especially developed on the face and prevention of infection therewith by forming an adhesive mass layer containing a sulfa drug and having a specific ball tack value on one surface of a support. SOLUTION: This plaster is obtained by forming an adhesive mass layer containing a sulfa drug [e.g. sulfisomidin (sodium), sulfamethoxazole sodium or sulfadiazine] and having >=2 value of ball tack (a value of ball No. specified by tilted type ball tack tests in JIS Z 0237) and preferably 0.03-1 mm thickness on one surface of a support. For example, an adhesive mass prepared by adding a styrene-isoprene-styrene block copolymer to an ointment or a cream base comprising a fat, a fatty oil, lanolin, vaseline, a paraffin, a wax, a resin, a plastic, water, an emulsifying agent, a suspension, etc., is preferred as the above adhesive mass. The concentration of the sulfa drug in the adhesive mass is preferably 1-10 wt.%.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a patch for treatment of Tobihi.

[0002]

2. Description of the Related Art Tobihi is a disease that is often seen in children up to 10 years of age. It is caused by the infection of bacteria after the insect bite, etc. The infection spreads to the site and others. In the past, creams and ointments containing sulfa drugs have been commonly used for Tobihi, and in the case of the hands and abdomen, the gauze covers the top to prevent the spread of infection along with treatment. are doing.

[0003] However, when “tobihi” develops on the face that is particularly likely to occur frequently, it is difficult to cover the affected part with gauze due to inconvenience in daily life. As a result, in the case of children, the affected area is often scraped, and the site of infection spreads one after another, requiring a long time to cure.Therefore, the development of a therapeutic agent that can easily cover the affected area has been awaited. Was.

[0004]

SUMMARY OF THE INVENTION In view of the above problems, an object of the present invention is to provide a patch for treating Tobihi, which is particularly effective in treating "Tobihi" which has developed on the face and preventing infection. .

[0005]

The patch for the treatment of tohibiki according to the present invention is a patch for the treatment of tobihibashi having a sulfa-containing adhesive layer formed on one surface of a support, and the ball tack value of the adhesive layer is provided. Is 2 or more (the value of the ball No. specified in the inclined ball tack test in JIS Z 0237)
It is characterized by being.

Hereinafter, the present invention will be described in detail.

[0007] The pressure-sensitive adhesive used in the present invention is not particularly limited as long as the desired pressure-sensitive adhesive strength can be obtained.
A styrene-isoprene-styrene block (hereinafter referred to as SIS) copolymer was added to an ointment or cream base composed of fatty oil, lanolin, petrolatum, paraffin, wax, resin, plastic, water, emulsifier, suspending agent, etc. Are preferred.

[0008] The amount of the SIS copolymer to be added is not particularly limited, and can be appropriately adjusted according to the composition of the ointment or cream base to be used so that the desired adhesive strength is obtained. Commercially available SIS copolymers include, for example, “Califlex TR Series” manufactured by Shell Chemical Company.
And the like.

If necessary, a tackifier resin, an antioxidant and the like may be added to the above-mentioned pressure-sensitive adhesive. The tackifying resin is not particularly limited, for example, rosin-based resin, polyterpene resin, cumarone-indene resin,
Examples include petroleum resins, terpene-phenol resins, alicyclic saturated hydrocarbon resins, and the like. Of these, alicyclic saturated hydrocarbon resins are preferably used because they exhibit a tackifying effect without excessively reducing the cohesive force of the adhesive base.

The sulfa drugs used in the present invention include:
There is no particular limitation as long as it has an effect on tobihi, and examples thereof include sulfisomidine (sodium), sodium sulfamethoxazole, sulfadiazine, and silver sulfadiazine. Usually, the drug concentration in the pressure-sensitive adhesive is preferably 1 to 10% by weight.

If necessary, an astringent such as zinc oxide and an antipruritic such as diphenhydramine hydrochloride may be added to the pressure-sensitive adhesive.

The support used in the present invention is not particularly limited, and includes, for example, a synthetic resin film and a nonwoven fabric. Gauze is suitable for the purpose of absorbing the exudate from the affected area.

The patch of the present invention is prepared by a known method. For example, an SIS copolymer, a drug, etc. are added to an ointment or cream base prepared according to a conventional method, and the mixture is heated and kneaded to obtain a uniform composition. And a method of spreading this adhesive on a gauze. The Tobi remedies prepared in this manner are cut into a predetermined size and used.

The ball tack value of the pressure-sensitive adhesive layer is limited to 2 or more (the value of the ball No. specified in the inclined ball tack test in JIS Z 0237). When the ball tack value is less than 2, the pressure-sensitive adhesive layer has insufficient adhesive strength at the time of application and cannot be held at the affected part.

If the thickness of the pressure-sensitive adhesive layer is too small, the amount of the drug absorbed into the skin and the adhesive strength become insufficient, and if the thickness is too large, the patch becomes insufficient in flexibility, causing an uncomfortable feeling on the skin.
A range of 1 mm is preferred.

In order to protect the surface of the pressure-sensitive adhesive layer until use, the patch for the treatment of tobihi of the present invention usually preferably has a release paper on the surface of the pressure-sensitive adhesive layer. The release paper,
A film obtained by treating a polyethylene terephthalate film with silicon, a film obtained by laminating paper after polyethylene lamination, and the like are suitably used. The thickness of the release paper is preferably 1000 μm or less, more preferably 20 to 200 μm.

[0017]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to only these examples.

Example 1 50 g of purified lanolin and 400 g of white ointment were uniformly kneaded, and SIS copolymer ("Califlex 1107" manufactured by Shell Chemical Co., Ltd.) was added thereto.
g and heated to 200 ° C., 50 g of sulfadiazine and 100 g of zinc oxide were further added and kneaded uniformly to prepare an adhesive. After the adhesive was spread on gauze and cooled to prepare a patch for treatment of Tobii, the adhesive strength was evaluated with a ball tack, and the ball No. 4 stopped.

Comparative Example 1 Purified lanolin 60 g, white ointment 450 g, sulfadiazine 30 g and zinc oxide 60
g was uniformly kneaded to prepare an adhesive. After the adhesive was spread on gauze and cooled to produce a patch, the adhesive strength was evaluated with a ball tack. Ball No. 1 did not stop.

[0020]

EFFECT OF THE INVENTION The patch for treatment of tobihi of the present invention, which is constituted as described above, can easily cover the affected area and prevent the spread of infection with respect to the tobiosis of the face, which has not been able to prevent the scraping of children in the past. Therefore, early treatment can be expected.

Claims (1)

[Claims] Claims: 1. A tobacco treatment patch having a sulfa-containing pressure-sensitive adhesive layer formed on one surface of a support, wherein the pressure-sensitive adhesive layer has a ball tack value of 2 or more (in a tilting ball tack test according to JIS Z0237). Prescribed ball No
).