JPH07215847A - Tape for sleepiness prevention - Google Patents

Abstract

PURPOSE:To obtain a tape for sleepiness prevention by compounding a tacky adhesive coating layer mainly containing a styrene-isoprene-styrene block copolymer with 1-menthol. CONSTITUTION:A tacky adhesive base material is an amount of 100 pts.wt. which is composed of 100 pts.wt. of styrene-isoprene-styrene block copolymer, 80-180 pts.wt. of an alicyclic hydrocarbon resin and 10-200 pts.wt. of isopropyl myristate is compounded with 9-30 pts.wt. of 1-menthol. This mixture is applied on a supporting member to obtain a tacky adhesive layer. The tacky adhesive layer is produced into a sheet-shaped, a tape-shaped, a circular, an oval or a rhombic material, etc., by a solvent coating method or a hot-melt coating method. This tape can be produced without deteriorating tacky adhesivity despite that 1-menthol is compounded. The tape rapidly exhibits sleepiness- preventing effect after plastering and holds it for a long time.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drowsiness prevention tape.

[0002]

2. Description of the Related Art Various methods have been tried to prevent drowsiness, such as chewing gum containing l-menthol or putting candy in the mouth to release l-menthol. The candy has an effect only while it is put in the mouth, and the chewing gum has an effect only for a few minutes from the beginning of chewing.

In addition to the above, there is a method of applying a stick-type external preparation for sleepiness containing l-menthol (“Sleep Non” manufactured by ST Chemical Co., Ltd.) to eyelids and the like. However, this external preparation has a problem that l-menthol is volatilized in a short time and thus lacks in sustainability, and the applied portion has a sticky feeling, which causes discomfort.

Therefore, as a method for preventing drowsiness that is durable and does not cause discomfort during use, a method of applying a tape preparation containing 1-menthol is considered. It is necessary to include a large amount of 1-menthol in the base in order to maintain the suppressing effect.
Furthermore, since immediate effect is required, it is necessary to accelerate the release from the adhesive base of 1-menthol.

[0005] In order to promote the release of the drug in the adhesive base, a transdermal anti-inflammatory analgesic tape preparation containing mint oil as a dissolution aid having absorption promoting ability in the adhesive base has been disclosed ( JP-A-64-40420). However, in order to prevent drowsiness, it is necessary to add a large amount of 1-menthol to this anti-inflammatory analgesic tape.
Menthol acts as a plasticizer for the rubber-based adhesive base, and there is a problem that the cohesive force of the rubber-based adhesive base is reduced and adhesive residue occurs. In addition, in the peppermint oil contained in this anti-inflammatory analgesic tape, 50 to 6 l-menthol was added.
Only 0% by weight can be blended, and there is a problem that cohesive failure of the pressure-sensitive adhesive layer occurs when an amount of mint oil required to prevent drowsiness is blended.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and an object thereof is styrene-
Even if the adhesive layer containing isoprene-styrene block copolymer as the main component contains l-menthol in an amount sufficient to prevent drowsiness, it does not hinder the adhesiveness and the drowsiness prevention effect is immediately effective. The object of the present invention is to provide a tape for preventing drowsiness that is specifically expressed and is sustainable for a long time.

[0007]

The tape for preventing drowsiness of the present invention comprises a support and a pressure-sensitive adhesive layer containing 1-menthol formed on the support.

The support is not particularly limited as long as it has a drug impregnating property, and for example, a resin film,
Woven cloth, non-woven cloth and the like are preferably used.

Examples of the resin film include polyethylene, polypropylene, polyamide, polyurethane, polyvinyl alcohol, polybutadiene, polybutene, polyisoprene, silicone resin, plasticized polyvinyl chloride, polyurene-based plasticized polyvinyl chloride, and plasticized (acetic acid. Vinyl-vinyl chloride copolymer), ethylene-vinyl acetate copolymer, ethylene-vinyl chloride copolymer, ethylene-methyl methacrylate copolymer, (meth) acrylic acid alkyl ester, styrene-isoprene-styrene block copolymer Polymer, styrene-butadiene-styrene block copolymer, styrene-ethylene-butadiene rubber-
Examples thereof include those having a styrene block copolymer, styrene-butadiene rubber, cellulose acetate, ethyl cellulose and the like as a base polymer, and these may be used alone or in combination of two or more kinds. Moreover, the said resin film may be used individually and may use 2 or more types together.

Examples of the woven fabric and the non-woven fabric include, for example,
Natural fibers such as cotton, silk, and hemp; those based on synthetic fibers of the base polymer used for the resin film can be mentioned.

When a woven fabric, a non-woven fabric, or a breathable resin film is used as the above-mentioned support, in addition to the percutaneous absorption of 1-menthol, the refreshing odor of 1-menthol which is volatilized through the support prevents drowsiness. Is further improved.

The pressure-sensitive adhesive layer comprises styrene-isoprene-
It is formed from a pressure-sensitive adhesive composition containing styrene (hereinafter referred to as SIS) block copolymer, an alicyclic hydrocarbon resin and isopropyl myristate, and 1-menthol.

When the styrene content of the SIS block copolymer is low, the cohesive force of the pressure-sensitive adhesive layer is reduced when 1-menthol is contained in a high concentration, and cohesive failure occurs during sticking. 12 to 20% by weight because the aromatic hydrocarbon resin becomes difficult to dissolve and the adhesive strength decreases.
Is preferred.

The average molecular weight of the SIS block copolymer is preferably 80,000 to 180,000.

The above alicyclic hydrocarbon resin has a function of controlling the adhesive force, has an average molecular weight of 600 to 800 and a softening point of 80.
It is preferably about 120 ° C. In the adhesive base, if the amount of the alicyclic hydrocarbon resin is small, there is no sufficient tackifying effect, and if it is too large, the adhesive strength becomes strong and the horny layer may be destroyed, causing skin irritation. Since the cohesive force of the layer is reduced to cause cohesive failure and adhesive residue, the amount is preferably 80 to 180 parts by weight, more preferably 100 to 150 parts by weight, based on 100 parts by weight of the SIS block copolymer.

The isopropyl myristate not only acts as a softening agent for the pressure-sensitive adhesive, but also promotes the release of the drug l-menthol. If the amount of isopropyl myristate in the adhesive base is too small, the drug release is insufficient and sufficient immediate effect cannot be obtained. If it is too large, the cohesive force of the adhesive is reduced and adhesive residue occurs, so SIS block 10 to 200 parts by weight is preferable with respect to 100 parts by weight of the polymer,
It is more preferably 50 to 150 parts by weight.

The above-mentioned pressure-sensitive adhesive base contains organic acids, fatty acid esters (monohydric alcohol esters, polyhydric alcohol esters, cyclic polyhydric alcohol esters, other esters), surface active agents, and the like in order to enhance the immediate effect if necessary. Agents (nonionic surfactants, anionic surfactants), amines,
An amide or the like may be added.

If necessary, the above-mentioned adhesive base may further contain
Other tackifiers, liquid rubbers, softeners, antioxidants, etc. may be added. Examples of the softening agent include liquid paraffin. Liquid paraffin functions as a softening agent, and also has the effect of forming an oily film between the skin and the adhesive layer after application, and preventing peeling of the stratum corneum during peeling. The amount of liquid paraffin in the adhesive base is 10 parts with respect to 100 parts by weight of the SIS block copolymer.
-100 parts by weight is preferred.

The above-mentioned pressure-sensitive adhesive base can be used in either a solvent type or a hot-melt type, but a hot-melt type is more preferable because it suppresses the volatilization of 1-menthol.

The above l-menthol has a refreshing sensation and a local stimulating action as well as awakening action. In the tape for preventing drowsiness of the present invention, when the amount of 1-menthol is small, a sufficient drowsiness preventing effect cannot be obtained, and when it is large, it causes skin irritation such as redness. Is limited to 30 parts by weight, preferably 12 to
25 parts by weight.

As a method for preparing the drowsiness preventive tape, the same method as for the adhesive tape can be adopted, and examples thereof include a solvent coating method and a hot melt coating method. Examples of the solvent coating method include a method in which a pressure-sensitive adhesive composition solution containing a pressure-sensitive adhesive base and 1-menthol is prepared, and the solution is coated on a support and dried. Further, it is also possible to use a method in which the pressure-sensitive adhesive composition solution is applied onto release paper, dried, and then adhered to a support.

Examples of the hot melt coating method include a method in which a pressure-sensitive adhesive composition containing a pressure-sensitive adhesive base and 1-menthol is melted by heating, and this is coated on a support and dried. In the hot-melt coating method, a method in which the pressure-sensitive adhesive composition is melted by heating, coated on release paper, dried, and then adhered to a support can be used.

The above-mentioned release paper is used for the purpose of protecting the pressure-sensitive adhesive layer, and is, for example, polyethylene-coated high-quality paper, polyolefin-coated glassine paper, polyethylene terephthalate (hereinafter referred to as PET) film, polypropylene film, or the like whose one side is treated with silicon. It can be used.

The shape of the drowsiness prevention tape can be freely selected from a sheet shape, a band shape, a circle shape, an elliptical shape, a rhombus shape and the like.

The above drowsiness preventive tape is applied to the forehead and around the eyes,
By sticking to temples and the like, l-menthol in the pressure-sensitive adhesive layer is immediately transdermally absorbed, and l-menthol permeates the support or is gradually evaporated from the edge of the pressure-sensitive adhesive layer, Prevents drowsiness by appropriately stimulating eyes, nasal passages, skin, etc.

[0026]

EXAMPLES Examples of the present invention will be described below. (Examples 1 to 4, Comparative Examples 1 to 8) SI of the amounts shown in Table 1
After adding S block copolymer, alicyclic hydrocarbon resin, liquid paraffin, myristin isopropyl and dibutylhydroxytoluene and heating and mixing at 110 to 130 ° C. for 5 hours to prepare an adhesive base, further adhesive base The amount of 1-menthol shown in Table 1 was added to 100 parts by weight and uniformly mixed to obtain a pressure-sensitive adhesive composition solution. PE obtained by subjecting the adhesive composition solution to a 100 μm-thick silicone release treatment
It was coated on a T film so that the thickness after drying was 70 μm, dried, cooled to room temperature, and then transferred onto a soft vinyl chloride film having a thickness of 100 μm to obtain a drowsiness prevention tape.

[0027]

[Table 1]

The components used in Table 1 are as follows. -SIS block copolymer: "Califlex TR1107" manufactured by Shell Chemical Co., Ltd. Styrene content 14% by weight, average molecular weight 125,000-Alicyclic hydrocarbon resin: "Arcon P9 manufactured by Arakawa Chemical Co., Ltd."
0 ", average molecular weight 630, softening point 90 ° C (indicated by hydrocarbon resin in the table) -Isopropyl myristate: manufactured by NOF Corporation-Dibutylhydroxytoluene: antioxidant (B in the table)
HT) -l-menthol: manufactured by Ogi Pharmaceutical Co., Ltd.

[Evaluation of Drowsiness Prevention Tape] The drowsiness prevention tapes obtained in the above Examples and Comparative Examples were evaluated as follows, and the results are shown in Table 2. (1) 180-degree peel strength The drowsiness prevention tapes obtained in Examples 1 to 4 and Comparative Examples 1 to 8 were measured according to JIS Z0237.

(2) Sensory test A drowsiness prevention tape was attached to the forehead or temple of 5 adults, and 0.5 hours, 1 hour, and 3 hours after the application,
The sleepiness preventive effect was judged according to the following evaluation criteria, and the average score of 5 persons was shown. <Evaluation Criteria> 3 points: There is a menthol odor and an appropriate feeling of irritation to the skin, and drowsiness is prevented. 2 points: Almost no menthol odor, but moderately irritating to the skin. 1 point: There is no menthol odor and no irritation to the skin.

(3) Skin Permeability Test For the drowsiness prevention tapes obtained in Examples 1 to 4 and Comparative Examples 2 and 3, the Franz diffusion cell 1 shown in FIG. 1 was used.
The skin permeation amount (μg) of 1-menthol was measured by In FIG. 1, the diffusion cell 1 is composed of a bottomed cylindrical receptor tank 2 and a bottomed cylindrical donor tank 3 arranged on the receptor tank 2. An opening 4 is provided at the center of the bottom wall of the donor tank 3, and an upper flange 5 and a lower flange 6 are provided at the lower end of the donor tank 3 and the upper end of the receptor tank 2, respectively. Further, a sampling port 7 protruding laterally is attached to the side wall of the receptor tank 2. The above flange 5 and flange 6
Are stacked facing each other, and the receptor tank 2 and the donor tank 3
And are stacked so that they are airtight and concentric. A magnetic stirring bar 9 is placed inside the receptor tank 2.

Hairless mice (7 weeks old, ♂) were sacrificed by cervical dislocation, and immediately the back skin was peeled off to remove subcutaneous fat and muscle layer to obtain a skin piece 8 of about 5 cm × 5 cm.
The obtained skin piece 8 was sandwiched between the flange 5 and the flange 6 of the diffusion cell 1 so that the opening 4 of the donor layer 3 was completely closed by the skin piece 8. A test piece 10 obtained by cutting the obtained drowsiness prevention tape into a circle (radius 1 cm, area 3.14 cm ² ) was used as a skin piece 8 held in the opening 4 of the donor layer 3.
Attached to the central part of.

The receptor layer 2 was filled with the receptor solution, placed in a constant temperature bath maintained at a temperature of 37 ° C., and the magnetic stirrer 9 was rotated and stirred. Test start 1 and 3
After a lapse of time, 1 ml of the receptor liquid was sampled from the sampling port 7, the amount of 1-menthol in the sampled receptor liquid was measured by high performance chromatography, and the permeation amount per 1 cm ^{2 of} the test piece is shown in Table 2. When collecting the receptor liquid, the receptor liquid was replenished after the collection. Also,
The test was performed with n = 3, and the average value was calculated as the transmission amount.

The receptor liquid is NaH ₂ PO ₄ 5 × 10 ^-4.
1N of NaOH in an aqueous solution in which mol, Na ₂ HPO ₄ 2 × 10 ^-4 mol, NaCl 1.5 × 10 ^-1 mol and gentamicin 10 ppm were dissolved.
20 parts by weight of polyethylene glycol 400 was dissolved in 80 parts by weight of an aqueous solution adjusted to pH 7.2 by adding an aqueous solution.

[0035]

[Table 2]

[0036]

EFFECTS OF THE INVENTION The sleepiness-preventing tape of the present invention is as described above, and since it can contain l-menthol in an amount sufficient to prevent drowsiness without impairing its adhesiveness, it has a sleepiness-preventing effect. Can be expressed immediately and can be maintained for a long time.

[Brief description of drawings]

FIG. 1 is a perspective view of a diffusion cell used in a skin permeability test.

[Explanation of Codes] 1 diffusion cell 2 receptor tank 3 donor tank 4 opening 5 upper flange 6 lower flange 7 sampling port 8 skin piece 10 test piece

Claims (1)

[Claims] 1. An adhesive base 100 comprising 100 parts by weight of a styrene-isoprene-styrene block copolymer, 80 to 180 parts by weight of an alicyclic hydrocarbon resin, and 10 to 200 parts by weight of isopropyl myristate on a support. A tape for preventing drowsiness, which comprises an adhesive layer composed of 9 to 30 parts by weight of 1-menthol.