JP2000297037A - Psoriasis-treating agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a psoriasis-treating agent exhibiting no adverse effect, capable of being used with assurance and also having an excellent psoriasis- treating efficacy. SOLUTION: This agent contains 1-(p-chlorobenzoyl)-5-methoxy-2- methylindole-3-acetic acid as an active ingredient. As the psoriasis-treating agent, various administering forms can be adopted and as the forms, e.g. a patch such as a pap agent, an ointment, an emulsion, a gel, a liquid, a cream and a lotion are adopted.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a therapeutic agent for psoriasis.

[0002]

2. Description of the Related Art Psoriasis is a typical disease belonging to the inflammatory keratosis syndrome, and generally produces a rash on the erythema, which is well-defined, irregular, flat and slightly raised, with thick silvery scales. The most common sites are the head and elbows to the forearm extension, and the knees to the front of the lower leg. In severe cases, they frequently occur in other sites. It varies in size from peas and coins to irregularities of more than the size of the palms, and in extreme cases, erythroderma psoriasis, which causes a rash on the entire body. The rash responds temporarily well to various treatments, but recurs immediately, and in many cases it recurs and relapses. The degree of itching varies, and many cases do not. Occasionally, there are pustular psoriasis in which small aseptic pustules frequently appear on the eruption, and arthritic psoriasis in which non-rheumatic arthritis occurs in large and small joints.

[0003]

There are a wide variety of treatments for psoriasis. For example, the following treatment methods are known. 1) Use antihistamines or antiallergic drugs for topical steroid use and itching. Use mouthwash or troche for chronic tonsillitis or periodontitis. Steroids usually start in group 3 and switch to stronger ones in cases where effects are inadequate. However, do not use too strong steroids for a long time. 2) Use PUVA or UVB therapy together. 3) Retinoids or steroids in very small doses should be used in combination with those with insufficient control. 4) A small amount of methotrexate or oral cyclosporine A is rarely used in cases where the above cannot be controlled. However, all of the above treatments have their pros and cons,
It was not definitive.

[0004] In view of such circumstances, the present inventor has conducted intensive studies on the above-mentioned medicament useful for psoriasis, and as a result, found that indomethacin exerts a surprising therapeutic effect on psoriasis. That is, the inventor himself had psoriasis, but when indomethacin was applied topically, itching disappeared in a short period of time, and the scales were regenerated to clean skin. When many people tried this drug, they found that those who had been suffering from psoriasis for many years had surprisingly regenerated normal skin about one to two weeks after application. Was.
The present invention has been completed based on such findings. An object of the present invention is to provide a therapeutic agent for psoriasis which has no side effects, can be used with confidence, and has an excellent therapeutic effect on psoriasis.

[0005]

SUMMARY OF THE INVENTION The present invention relates to a therapeutic agent for psoriasis containing 1- (p-chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid as an active ingredient.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The active ingredient of the present invention, 1- (p
-Chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid is a known compound known under the names of indomethacin, trade name inteban (Sumitomo Pharmaceutical), idomecin (Kowa) and the like. Hereinafter, it is described as indomethacin. The above-mentioned compound of the present invention is generally known as an active ingredient of a nonsteroidal anti-inflammatory external preparation. However, the present inventors have found for the first time that it is effective for the treatment of psoriasis as in the present invention.

[0007] The therapeutic agent for psoriasis according to the present invention can adopt various administration forms depending on the purpose of treatment, such as patches such as cataplasms, ointments, emulsions, gels, liquids and creams. And external preparations such as lotions. The therapeutic agent for psoriasis according to the present invention is prepared and provided for use as a composition in which any conventional pharmaceutical carrier or excipient is compounded by a commonly used method. More specifically, when prepared in the form of an ointment (paste, cream, gel, etc.), commonly used bases, stabilizers, wetting agents, preservatives and the like are added as necessary. You.
Examples of the base include liquid paraffin, white petrolatum, beeswax, octyldodecyl alcohol, paraffin and the like. Sodium bisulfite as a stabilizer,
And sodium edetate. As a humectant,
Examples include propylene glycol, polyethylene glycol, and sodium lactate. Examples of the preservative include methyl paraoxybenzoate, ethyl paraoxybenzoate, and propyl paraoxybenzoate.

In the case of preparation in the form of a patch, the above-mentioned ointment, cream, gel, paste or the like may be applied to a usual support in a conventional manner. As the support, a woven or nonwoven fabric made of cotton, cloth, or synthetic fiber, a film of soft vinyl chloride, polyethylene, polyurethane, or the like, or a foam sheet is suitable. Further, a coloring agent, a preservative, a flavor, a flavoring agent, a sweetening agent and the like and other pharmaceuticals may be added to each of the above-mentioned preparations as needed.

In the present invention, the content of the above active ingredient in the preparation is usually about 0.001 to 5% by weight, preferably about 0.01 to 3% by weight, particularly preferably about 0.1 to 1% by weight. But it is not limited to this. The dose of the active ingredient in the preparation of the present invention can be appropriately selected depending on the usage, the age of the patient, gender and other conditions, the degree of the disease, and the like. Generally, the daily dose of the active ingredient is usually 1 to 120.
mg / 100 cm ² , preferably 20 to 50 mg / 10
0 cm ² , but is not limited to this. These preparations of the present invention can be administered once or twice or four times a day.

The therapeutic agent for psoriasis of the present invention can be applied to various types of psoriasis, and examples thereof include psoriasis vulgaris, pustular psoriasis, guttate psoriasis, erythrodermic psoriasis, psoriatic arthritis and the like.

[0011]

EXAMPLES Examples of the present invention will be described below, but the present invention is not limited thereto. Formulation Example 1 Indomethacin 1000 mg l-menthol 3000 mg Propylene glycol proper amount Benzyl alcohol proper amount diisopropanolamine proper amount sodium bisulfite proper amount
0 g ointment was produced.

Treatment Example 1 Patient ZU. Age, male From around 1995, on the erythema slightly raised on the elbows of both arms, a rash with silvery thick scales was observed, and it was recognized as psoriasis. When the application of the ointment of Formulation Example 1 was continued for one month, psoriasis was almost completely cured.

Treatment Example 2 Patient JU. 54-year-old man Beginning in 1999, he developed rash on his elbows with slightly silvery thin scales on his elbows. Twice a day, the therapeutic agent of the present invention was applied and the state was observed. In about 2 weeks after application, it was relieved. In about 4 weeks, almost the right elbow was cured, but psoriasis was slightly observed in the left elbow. Thereafter, when the application of the therapeutic agent of the present invention was continued, the elbow on the left side healed about 1.5 months after the start of application.

[0014]

According to the present invention, there can be obtained a therapeutic agent for psoriasis which has no side effects, can be used safely, and has an excellent therapeutic effect on psoriasis.

Claims (1)

[Claims] 1. A therapeutic agent for psoriasis comprising 1- (p-chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid as an active ingredient.