JP2000273014A - Cosmetic composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic composition which is used in safety even for patients suffered from atopic or inflammatory dermatosis and inhibits the skin from roughening and drying effectively without increasing the content by percentage of γ-linolenic acid in a cosmetic by including an ingredient, e.g. an anti- inflammatory agent or the like, and a borage oil. SOLUTION: This cosmetic composition is obtained by mixing (A) at least one kind selected from an anti-inflammatory agent, e.g. dipotassium glycyrrhetinate or the like, aluminum magnesium silicate and aluminum silicate with (B) a borage oil preferably in a proportion of the ingredient A0.2-5×104 pts.wt. based on the component B100 pts.wt. The component B, the component A of anti-inflammatory agent and aluminum magnesium silicate or aluminum silicate are preferably blended in proportions of 0.1-20 wt.%, 0.01-1 wt.% and 0.1-20 wt.%, respectively, based on the whole weight of the cosmetic. This composition is useful as a toilet water, a milky lotion, a bathing agent or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention can be incorporated into various cosmetics such as lotions, emulsions, bath salts, detergents, shampoos, rinses, creams, hair restorers, etc. The present invention relates to a cosmetic composition which can be used safely even by a person having a skin disease, and is expected to suppress inflammation such as rash and itching of the skin and suppression of bulkiness of the skin.

[0002]

BACKGROUND OF THE INVENTION Due to allergic or inflammatory diseases,
BACKGROUND ART Percutaneous absorption of γ-linolenic acid has been conventionally known in order to suppress dermatitis such as rough skin and rash, and aging and wrinkles of skin. It is also known to blend γ-linolenic acid or borage oil, evening primrose oil, Mortierella oil, etc. containing γ-linolenic acid into various cosmetics and the like. However, in order to obtain the above-mentioned desired effect by blending in cosmetics or the like, it is necessary to increase the blending ratio of γ-linolenic acid. Ingredients need to be blended, γ in cosmetics
The reality is that the blending ratio of linolenic acid decreases, and it is difficult to obtain the desired effect. Further, when borage oil, evening primrose oil, and Mortierella oil are used as the γ-linolenic acid-containing component, it is inevitable that the mixing ratio of γ-linolenic acid in the cosmetic further decreases. On the other hand, a high concentration of γ-linolenic acid may be blended, but there is a problem in the oxidation stability of the cosmetic itself, and there is a possibility that the management and production method of γ-linolenic acid in the production process and the like become complicated. Yes, the cost is very high.

[0003]

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a cosmetic composition which is safe even in persons with atopic or inflammatory skin diseases without increasing the content of γ-linolenic acid in cosmetics. It is an object of the present invention to provide a cosmetic composition which can effectively suppress rough skin and rough skin, and can be used for various cosmetics.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above problems, and as a result, in persons with atopic or inflammatory skin disease, etc., the problem of eliminating rough skin and rustiness of the skin has been solved. In order to do so, among various oils containing γ-linolenic acid, a borage oil is selected, and the borage oil includes one or two selected from the group consisting of an anti-inflammatory agent, aluminum magnesium silicate and aluminum silicate. It has been found that dermatitis can be suppressed even when the mixing ratio of γ-linolenic acid is not high, and the present invention has been completed. That is, according to the present invention, there is provided a cosmetic composition comprising an anti-inflammatory agent, one or more selected from the group consisting of aluminum magnesium silicate and aluminum silicate, and borage oil. Provided.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in more detail. The cosmetic composition of the present invention comprises an anti-inflammatory agent, one or more selected from the group consisting of aluminum magnesium silicate and aluminum silicate, and borage oil, lotion, emulsion, bath agent, It can be used as a form of various cosmetics such as detergents, shampoos, rinses, creams, and hair restorers.

The borage oil used in the present invention comprises palmitic acid, oleic acid, linoleic acid, γ
-Containing linolenic acid, etc., usually 0 to 1% by weight of myristic acid, 5 to 15% by weight of palmitic acid, 0 to 1% by weight of palmito oleic acid, 0 to 8% by weight of stearic acid, 10 to 20% by weight of oleic acid Linoleic acid 35-45% by weight, γ-
The main component is a triglyceride having a fatty acid composition comprising 15 to 30% by weight of linolenic acid, 0 to 8% by weight of eicosenoic acid, 0 to 5% by weight of behenic acid and 0 to 1% by weight of other components. This borage oil can be obtained by extracting from borage plant seeds, and is commercially available from, for example, Showa Sangyo Co., Ltd., Nippon Oil & Fats Co., Ltd., Nippon Roche Co., Ltd. The standard fatty acid composition of commercially available glycerides is 0.1% by weight myristic acid, 1% palmitic acid.
0.6 wt%, palmitooleic acid 0.3 wt%, stearic acid 3.6 wt%, oleic acid 16 wt%, linoleic acid 40 wt%, γ-linolenic acid 22.8 wt%, eicosenoic acid 4. It consists of 0% by weight, 2.3% by weight of behenic acid and the balance.

[0007] In the cosmetic composition of the present invention, the blending ratio of borage oil can be appropriately determined according to the type and form of the cosmetic.
0.01 to 50% by weight, preferably 0.1 to 20% by weight
It is. If the content is less than 0.01% by weight, it is difficult to obtain a desired effect, which is not preferable.

Examples of the anti-inflammatory agent used in the present invention include glycyrrhizic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, allantoin, hinokitiol, paeoniflorin, cordyceps, lysozyme chloride, plant extracts having an anti-inflammatory effect, and mixtures thereof. Is mentioned. Examples of a plant for obtaining a plant extract having an anti-inflammatory effect include licorice, liquorice, hinoki, hinoki,
Nagikadida (butcher bloom), horse chestnut (Aesculus cinnamon), mukuroji (Mukanshi), loquat, mint (Melissa, Kosuihakka, lemon balm), snowy citrus (Kojisou), lavender, rosemary (Mannenrou), amacha, kawarayomogi, Bodaiju (Northus japonicus), Perilla (Soyo), Guyou,
Great horn, asparagus (shoubakubu, Dutch sword), aloe, ginkgo, age, ononis,
Kingkinka, honeysuckle, peonies, soyakuhaku, tormentilla, tamasakitsurafuji, cock, tencha,
Isaiyoibara (siri, togenashi), oak and the like.

[0009] In the cosmetic composition of the present invention, the mixing ratio of the anti-inflammatory agent can be appropriately selected according to the type and form of the cosmetic. 0.001 to 5% by weight, preferably 0.01
１1% by weight. If the amount is less than 0.001% by weight, the desired effect due to the combination with borage oil is hardly obtained, which is not preferable.

As the aluminum magnesium silicate and / or aluminum silicate used in the present invention, a synthetic product can be used, and a smectite containing a large amount of these can be used. Smectite is a group of montmorillonite group minerals and is a group of typical minerals that constitute clay. Specifically, for example, it is selected from the group consisting of montmorillonite, magnesia montmorillonite, tetum montmorillonite, tetmagnesian montmorillonite, beidellite, aluminian beidellite, sapstone, aluminian sapstone, bentonite. One or more kinds may be mentioned.

[0011] In the cosmetic composition of the present invention, when aluminum magnesium silicate and / or aluminum silicate is used, the mixing ratio is 0.1 to the total amount of the cosmetic.
It is preferably from 0.1 to 50% by weight, particularly preferably from 0.1 to 20% by weight. If it is less than 0.01% by weight, the desired effect due to the combination with borage oil is difficult to obtain, which is not preferable.

[0012] In the cosmetic composition of the present invention, the proportion of the anti-inflammatory agent, one or more kinds of borage oils selected from the group consisting of aluminum magnesium silicate and aluminum silicate is particularly limited. However, 0.002 parts by weight of borage oil
-5 × 10 ⁵ parts by weight, particularly preferably 0.2-5 × 10 ⁴ parts by weight.

[0013] The cosmetic composition of the present invention may be used in accordance with other desired purposes or the like as long as the object of the present invention is not impaired.
Lotion, emulsion, bath salt, detergent, shampoo, rinse,
In order to obtain a form such as a cream or a hair restorer, various safe ingredients which can be usually used can be combined in an appropriate combination according to the kind of the cosmetic. Such other components include, for example, purified water; various surfactants such as anionic surfactants, cationic surfactants, nonionic surfactants, and amphoteric surfactants; antioxidants; chelating agents; humectants;
UV inhibitors; pH adjusters; Disinfectants; Vitamins; Fragrances; Dyes or mixtures thereof, but are not limited thereto, in order to ensure the stability and the like of the incorporated borage oil. , Water, a surfactant, an antioxidant, a chelating agent, an ultraviolet inhibitor, and a mixture thereof. The mixing ratio of these optional components can be appropriately selected and determined according to the purpose.

Examples of the anionic surfactant include alkyl sulfate, polyoxyethylene alkyl ether sulfate, sulfosuccinate, taurine derivative, sarcosine derivative, amide ether sulfate, ether carboxylate, sulfonate, and polyoxyethylene. Examples thereof include alkyl ether phosphates, fatty acid salts, and mixtures thereof. Nonionic surfactants include, for example, lecithin and derivatives thereof, propylene glycol fatty acid ester, glycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxysorbit fatty acid Ester, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, polyoxyethylene sterol, polyoxyethylene hydrogenated sterol, polyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkyl Phenyl ether, polyoxyethylene lanolin, polyoxyethylene lanolin alcohol, polio Shi ethylene beeswax derivatives, polyoxyethylene alkyl amines, polyoxyethylene fatty acid amides, polyoxyethylene alkyl ether phosphoric acid or mixtures thereof. Examples of the cationic surfactant include an alkyltrimethylammonium salt, an alkyldimethylbenzylammonium salt, and a mixture thereof. Examples of the amphoteric surfactant include, for example, an alkyl betaine-based amphoteric surfactant, an alkylamide betaine-based amphoteric surfactant, an imidazoline-based amphoteric surfactant, a glycine-based amphoteric surfactant,
Amine oxide amphoteric surfactant, acylmethyl-β
-Alanine-based amphoteric surfactants or mixtures thereof. The blending ratio when these surfactants are blended is not particularly limited, but usually, based on the total amount of the cosmetic,
0.01 to 60% by weight, preferably 0.1 to 40% by weight
Range.

As antioxidants, for example, vitamin E
And its derivatives, vitamin C and its derivatives, dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate or mixtures thereof. The blending ratio when the antioxidant is blended is not particularly limited, but is usually in the range of 0.001 to 5% by weight, preferably 0.01 to 1% by weight, based on the total amount of the cosmetic.

Examples of the chelating agent include edetate, pyrophosphate, hexane metaphosphate, gluconate, citric anhydride, citrate, hydroxyethanediphosphonate, and mixtures thereof. The blending ratio when the chelating agent is blended is not particularly limited, but is usually in the range of 0.01 to 60% by weight, preferably 0.1 to 40% by weight, based on the total amount of the cosmetic.

Examples of UV inhibitors include, for example, 4-methoxybenzophenone, hydroxymethoxybenzophenonesulfonic acid, sodium dihydroxydimethoxybenzophenonesulfonate, octyldimethyl paraaminobenzoate, ethylhexyl paramethoxycinnamate, fine titanium oxide, fine zinc and mixtures thereof. And the like. The blending ratio when the ultraviolet inhibitor is blended is not particularly limited, but is usually 0.001 to 15% by weight, preferably 0.005 to 5% by weight based on the total amount of the cosmetic.
It is in the range of 10% by weight.

The humectant may be any of a water-soluble humectant and an oil-based humectant. Examples of the water-soluble humectant include polyhydric alcohols such as glycerin, propylene glycol, and 1,3-butylene glycol; glucose, sorbitol,
Saccharides such as dextrin and lactose and derivatives thereof; collagen derivatives, keratin derivatives, sodium glutamate,
Amino acids such as trimethylglycine and derivatives thereof; sodium chondroitin sulfate, sodium lactate, sodium pyrrolidonecarboxylate, sodium hyaluronate,
Water-soluble polymers such as carboxyvinyl polymers and polyethylene glycols; yeast extracts, seaweed extracts, plant extracts having a moisturizing action; and mixtures thereof. As oily humectants, for example, vegetable oils such as castor oil, olive oil, grape seed oil, cacao oil, camellia oil, coconut oil, wood wax, jojoba oil, avocado oil;
Waxes such as whale wax, lanolin, carnauba wax, candelilla wax; hydrocarbons such as liquid paraffin, microcrystalline wax, ceresin wax, paraffin wax, petrolatum; lanolinic acid, myristic acid, palmitic acid, stearic acid, oleic acid Fatty acids such as, isostearic acid, behenic acid; higher alcohols such as cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, cholesteryl oleate And the like; sodium polyacrylate, crystalline cellulose, various plant essential oils, and mixtures thereof.

Examples of the pH adjuster include sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, and disodium hydrogen phosphate. , Dipotassium hydrogen phosphate or a mixture thereof.

Examples of fungicides include benzoate, sorbate, dihydroacetate, p-hydroxybenzoate, benzethonium chloride, phenoxyethanol, chlorhexidine gluconate, isopropylmethylphenol, cetylpyridinium chloride, pyroctonolamine,
Examples include zinc pyrithione, 2,2,4-trichloro-2′-hydroxydiphenyl ether, trichlorocarban, triclosan, benzalkonium chloride, and mixtures thereof.

As the vitamins, for example, vitamin A
And its derivatives, vitamin B ₂ , pantothenic acid and its derivatives, niacin, biotin or a mixture thereof.

Various cosmetics can be prepared using the cosmetic composition of the present invention so as to contain the essential components according to a known method.

[0023]

The cosmetic composition of the present invention is prepared by combining one or more selected from the group consisting of an anti-inflammatory agent, aluminum magnesium silicate and aluminum silicate with borage oil. In addition to the action and effect according to the type of cosmetic, even if the content of γ-linolenic acid is not high, it is safe even in people with atopic or inflammatory skin diseases, and the effect of rough skin, rustiness of skin and the like is effective. Can be suppressed.

[0024]

The present invention will be described in more detail with reference to the following Examples and Comparative Examples, but the present invention is not limited thereto. The borage oil used in the examples shown below contains γ-linolenic acid in the fatty acid of glyceride in about 2%.
Showa Sangyo Co., Ltd. borage oil containing 3% by weight, and evening primrose oil used by Japan Roche Co., Ltd. containing about 9% by weight of γ-linolenic acid. Mortierella oil is
Mortierella oil manufactured by Idemitsu Material Co., Ltd. containing about 35% by weight of γ-linolenic acid was used. Examples 1 to 8 and Comparative Examples 1 to 4 Each component shown in Table 1 was mixed and prepared to produce a lotion. The obtained lotion was applied to the affected area twice in the morning and evening by a panel of 33 persons who had inflammatory dermatitis accompanied by itching, and after 1 week of use, the itch evaluation and the bulk evaluation were made by self-determination. The test was performed according to the following criteria.
A panel of three persons evaluated each lotion, and the average score was used as the evaluation result. Table 1 shows the results. Itching evaluation: 5 points when the itching was reduced, 4 points when the itching was slightly reduced, 3 points when there was no change, 2 points when the itching was slightly worsened, and 1 point when the itching worsened. Looseness rating: 5 points for improved bulkiness, 4 points for slightly improved bulkiness, 3 points for no change, 2 points for slightly increased bulkiness, and 1 point for coarseness increased
Points.

[0025]

[Table 1]

Examples 9 to 15 and Comparative Examples 5 to 7 The components shown in Table 2 were mixed and prepared to produce an emulsion. The obtained emulsion was applied to the affected area twice a day in the morning and evening by 27 panelists who developed allergic dermatitis accompanied by redness and itching. For evaluation, Examples 1 to
Similarly to 8, the redness was evaluated according to the following criteria. We asked each panel to evaluate each emulsion.
The average score was used as the evaluation result. Table 2 shows the results. Redness evaluation: 5 points for improved redness and 4 points for slightly improved redness
3 points, no change, 2 points when redness slightly deteriorated, and 1 point when redness deteriorated.

[0027]

[Table 2]

Examples 16 to 21 and Comparative Examples 8 to 10 The components shown in Table 3 were mixed and prepared to produce a liquid bath agent. About the obtained liquid bath preparation, 24 panelists who have developed inflammatory dermatitis with itching were asked to take a bath. Same as 8. Three panels evaluated each liquid bath emulsion, and the average score was used as the evaluation result. Table 3 shows the results.

[0029]

[Table 3]

Examples 22 to 28 and Comparative Examples 11 to 13 The components shown in Table 4 were mixed and prepared to produce powder bath agents. About the obtained powder bath agent, the same evaluation as Examples 11-21 and Comparative Examples 8-10 was performed. Table 4 shows the results
Shown in

[0031]

[Table 4]

Examples 29 to 37 and Comparative Examples 14 to 16 The components shown in Table 5 were mixed and prepared to produce body soaps. About the obtained body soap, it was used by 36 panels who have developed inflammatory dermatitis with itching, and after 1 week of use, it was evaluated by self-determination, and the itch evaluation and the dryness evaluation were performed according to Examples 1 to 8. It became similar. Three panels evaluated each body soap, and the average score was used as the evaluation result. Table 5 shows the results.

[0033]

[Table 5]

Examples 38 to 44 and Comparative Examples 17 to 20 The components shown in Table 6 were mixed and prepared to produce shampoos. The obtained shampoo was used by 33 panelists who developed dermatitis with allergic itch on the head, and after one week of use, the itch was evaluated by self-determination in the same manner as in Examples 1 to 8. became. Each shampoo was evaluated by three panels, and the average score was used as the evaluation result. Table 6 shows the results.

[0035]

[Table 6]

Examples 45 to 51 and Comparative Examples 21 to 24 The components shown in Table 7 were mixed and prepared to produce a rinse. About the obtained rinse, Examples 38-44 and Comparative Example 1
Each evaluation was performed similarly to 7-20. Table 7 shows the results.

[0037]

[Table 7]

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/08 A61K 7/08 7/50 7/50 31/00 617 31/00 617 637 637 637E C11D 3 / 12 C11D 3/12 3/20 3/20 3/48 3/48 F term (reference) 4C083 AA112 AA121 AA122 AB051 AB242 AB312 AB352 AB381 AB382 AC022 AC072 AC102 AC112 AC122 AC302 AC352 AC422 AC432 AC532 AC642 AC682 AC692 AC712 AC782 AC792 AD092 AD152 AD332 AD532 AD642 AD662 BB01 BB45 BB46 BB47 BB51 CC01 CC04 CC05 EE10 4H003 AB14 AC03 AD04 BA12 DA02 EA24 EA27 EB05 EB08 EB09 EB11 EB16 EB22 ED02 FA07 FA15 FA33

Claims (4)

[Claims] 1. A cosmetic composition comprising one or more selected from the group consisting of an anti-inflammatory agent, magnesium aluminum silicate and aluminum silicate, and borage oil. 2. Magnesium aluminum silicate and / or
The cosmetic composition according to claim 1, further comprising smectite as the aluminum silicate. 3. The fatty acid composition of glyceride in borage oil is 0 to 1% by weight of myristic acid and 5 to 1% of palmitic acid.
5% by weight, palmito oleic acid 0-1% by weight, stearic acid 0-8% by weight, oleic acid 10-20% by weight, linoleic acid 35-45% by weight, γ-linolenic acid 15-30% by weight, eicosenoic acid The cosmetic composition according to claim 1, wherein the composition is 0 to 8% by weight, 0 to 5% by weight of behenic acid, and 0 to 1% by weight of other components. 4. The method according to claim 1, further comprising one or more members selected from the group consisting of water, a surfactant, an antioxidant, a chelating agent, an ultraviolet inhibitor and a mixture thereof. 4. The cosmetic composition according to any one of items 3 to 3.