DE19857491A1 - Cosmetic or dermatological skin-protective compositions, containing UV filter and saturated phosphatidyl choline to give good barrier stabilizing and active agent penetrating effects - Google Patents

Abstract

A formulation (I) for protecting skin against external agents and damage of endogenous origin comprises saturated phosphatidyl choline, medium-chain triglycerides, salts, moisture retainers, ultraviolet (UV) filters, cosmetic or dermatological active agents and water. A formulation (I) for protecting skin against external agents and damage of endogenous origin comprises (in weight % (wt. %)) saturated phosphatidyl choline (0.1-10, preferably 0.5-6), medium-chain triglycerides (1-50, preferably 5-40), salts (0.01-10, preferably 0.1-5), moisture retainers (1-20), ultraviolet (UV) filters (0.5-30, preferably 1-20), cosmetic or dermatological active agents (0.01-20, preferably 1-10) and water (20-95, preferably 30-85).

Description

The present invention relates to skin protection preparations for preventing skin damage with UV filters.

The number of dermatoses and skin allergies is constantly increasing. A common reason are e.g. B. Moist space workplaces where the skin of the working person is particularly watery is exposed. These and other external substances attack the barrier layers of the Skin.

The barrier layers consist, among other components, of ceramides, cholesterol and fatty acids and glycerides (cosmetics, editor W. Umbach, Georg Thieme Verlag, Stuttgart 1995, p. 27); they are localized in the horny layer, the uppermost part of the epidermis. The barrier layers will more or less disturbed by both aqueous and oily substances or mixtures of substances or destroyed. As a result of a barrier disorder, the transepidermal water loss usually increases (TEWL) of the skin. There may be redness. The skin moisture decreases. The skin dries out, becomes rough and cracked. The penetration of irritant, allergic and pathogenic substances or facultatively pathogenic germs is relieved. Eczema, dermatoses and other skin diseases can arise (H. Lautenschläger, Mineralöltechnik 1996, 6).

There are a number of ways the skin can work against agents and other external substances too protect. The simplest protection is e.g. B. gloves for the hands, but they have the disadvantage that the skin sweats and swells from the inside. In addition, gloves are a high standard Lost sensitivity at work. Conventional skin protection products with an occlusive effect on the The basis of mineral oil products, silicones and covering greases and oils have been known Lich the disadvantage that the skin swells from the inside like a glove and the skin's own Synthesis of barrier-reactive substances is reduced (K.R. Feingold, Cosmetics & Toiletries 112 (7), 49-59 (1997)).

Conventional skin protection products are usually oil-in-water (O / W) - or water-in-oil (W / O) - Creams. They are mostly occlusive and usually only take protection against external substances, but not special skin dispositions. So need z. B. people which are predisposed to atopic dermatitis (neurodermatitis), psoriasis (psoriasis), lchthiosis, urticaria (hives) or dyskeratosis, or people who have one Are predisposed to blemishes or acne, preparations that are able to skin at the same time protect against the effects of external (harmful) substances and endogenously caused To prevent skin damage. It is necessary to stabilize the barrier and if necessary also reinforce. Protection also means that the skin in the event of the desired addition a dermatologically active cream component of any present Side effects is protected. Accordingly, an even and tolerable Penetration can be adjustable. Skin protection preparations are therefore necessary with regard to their Composition of both the respective skin, its condition and disposition as well as that from the outside acting substances including dermatological agents can be adapted. Base creams are also desirable, which are added to the skin by adding individual active ingredients individual skin type are adjustable.

The preparations have to supply fatty substances to the skin, but are not allowed after the application fat. I.e. they should be free of substances that remain on the skin surface and in contact with the skin of objects. Substances that have these disadvantages are e.g. B. mineral oil components such as petroleum jelly, paraffin oils and ozokerite (earth wax), but z. Belly polymeric α-olefins and silicones. Such substances are a. completely un in company skin protection suitable. In addition, skin protection preparations should be free from the alkanolamines: triethanolamine, Diethanolamine and ethanolamine and their salts (see restrictions of the German Cosmetics regulation, BGBI. I, No. 67, p. 2410 v. 13.10.97, regarding the nitrosamine problem and the German Technical Rule for Hazardous Substances, TRGS 540, Federal Worksheet 12/1997, regarding the possibility of sensitization). In contrast, small additions can be physiological safe and dermatologically safe amines such as B. trometamol, arginine and lysine, the In addition to the usual alkali hydroxides, the pH of the skin protection preparations are used, be tolerated. The skin protection preparations should be free from conventional emulsifiers such as. B. ethoxylates, the for their irritation and / or comedone formation under normal conditions or under special ones Conditions such as UV radiation are known (G. Dahms, Perfumery and Cosmetics 76, 426-431 (1995)). Preservatives should also be excluded, as these substances are generally sensitive rende and / or irritating properties.

The skin protection preparations must also, despite the lack of typical water-repellent substances such as Vaseline, paraffin oils and silicone oils have sufficient water resistance (water resistance) feature. The water resistance relates primarily to the causal effect of the Skin protection products responsible barrier-stabilizing ingredients. The addition of physiologically compatible moisturizing substances should be part of the skin protection with regard to the prevention of skin roughness and cracking as well as protection from be lipophilic pollutants. An essential component of skin protection products are UV filters, especially for the Skin protection outdoors (leisure and professional activities) and when working under UV exposure, such as. B. Welding work in the metalworking industry.

It has now surprisingly been found that all of the requirements for skin protection preparations mentioned can be met on the basis of hydrogenated (saturated) phosphatidylcholine (PC-H). Hydrogenated phosphatidylcholine is a typical barrier stabilizing substance, which usually originates from soybean phosphatidylcholine, which is concentrated and subsequently hydrogenated. According to formula I, the fatty acid occupancy of such a phosphatidylcholine consists predominantly of stearic acid and palmitic acid (n = 14, 16):

This is completely new in that unsaturated phosphatidylcholine (PC), especially in its lipo somalen form an effective penetration enhancer (K. Egbaria and N. Weiner, Cosmetics & Toiletries 106 (3), 79-93 (1991)) PC can be a lipid-damaged lipid as a bilayer source in skin care products Reconstruct double layers of the horny layer (DE 40 21 082), but it creates due to its low phase transition temperature in an aqueous environment after topical application in the Horny layer of very fluid lipid bilayers. These are naturally for skin protection products contraindicated, d. H. not suitable, as it is extraordinary for externally acting (harmful) substances are well drained. Therefore skin care products and z. B. Treatments for psoriasis (DE 40 21 084) based on PC, where the penetration z. B. of fumaric acid is in the foreground, usually made without preservatives to increase irritation and sensitization to avoid. The penetration enhancement is also associated with liposomal baths medical and cosmetic active ingredients used (DE 40 21 083). Skin protection products on the The basis of PC is therefore not useful since it does not sufficiently counter the skin barrier can stabilize the penetration of external substances.

In contrast, PC-H has a pronounced barrier-stabilizing effect, that of unspecific barriers damage and, moreover, specific barrier damage such as e.g. B. in neurodermatitis and Psoriasis occurs, protects. In addition, it has surprisingly been found that PC-H too preventively protect against acne. As is well known, only PC is due to its essential content Fatty acids recommended for the treatment of acne and blemished skin (WO 94/03 156, DE 44 04 086, DE 44 03 989). This makes it possible to use single emulsifiers and conventional emulsifiers Completely free preparation from both dermatoses and eczema caused by pollutants, in particular also working materials are triggered, as well as with appropriate disposition to endogenous conditions To protect skin damage. In this connection, it should be noted that those described in the patents mentioned Acne remedies not only because of the sole PC base, but also because of the usually in the Preparations containing solvents are unsuitable for use as skin protection agents; also the PC-like bath oils mentioned in DE 40 21 083 are for people who have a disposition too Allergies, psoriasis, neurodermatitis or ichthiosis show, suitable, but can be from the above reasons mentioned also do not use as skin protection products. DE 40 21 084 describes topical drugs for the treatment of psoriasis and related skin diseases, DE 40 21 082 Skin treatment agent with high lipid contents using a bilayer containing Systems, salts of organic acids, alcohol and stabilizer. These two patents are among others also hydrogenated phosphatidylcholines in their known function as a bilayer source, however no skin protection preparations mentioned, DE 40 21 082 also expressly describes soaps as Main components are used. The emulsifying soaps change under the Influence of the alkaline neutralization behavior of the skin only gradually changes into the free acids therefore for everyday business, where immediate protection of the skin is essential, less suitable. The skin barrier is made this way by the PC-H-containing skin protection preparations according to the invention stabilizes that after the application of the skin protection products in a normal range lying TEWL changes only slightly if external substances act on the skin, or one already increased TEWL is normalized. The protection obtained in this way is also characterized by a high water resistance and sweat resistance. PC-H form the with an additional load Skin through sunlight and the UV radiation contained therein no harmful substances; Skin protection agents based on PC-H are therefore characterized by a extremely good tolerance. Another characteristic of the skin protection preparations according to the invention are triglycerides, which with same or comparable structure also occur in natural sebum. Preferably acts medium-chain triglycerides (MCT). Due to their structure, MCT can do the natural thing Some substitute sebum or are extremely compatible with sebum. Have MCT also the advantage of being able to incorporate lipophilic protective and active ingredients and UV filters, and quickly absorbed into the skin and therefore not greasy. MCT forms under the influence of Sunlight is not an irritating substance. Due to the PC-H properties, the preparations need no additional emulsifiers and have no additives of mineral oil products, synthetic Paraffins or silicones have a high water resistance. The amphiphilic structure of the PC-H allows the use of the skin protection preparations according to the invention both compared to the above Barrier and skin damage as well as against aqueous and oily (harmful) substances. At The MCT portion of the skin protection products against special oily pollutants Skin protection products may be reduced. Another advantage of the amphiphilic structure of PC-H and the absence of conventional emulsifiers in skin protection products is the comparatively little swelling of the skin when exposed to aqueous media (cf. corresponding Measurements for body cleansers: U. Zeidler, medical cosmetology 19, 208-219 (1989)); in order to there are also favorable usage properties in the commercial protection of the hands, if working with gloves at times.

The skin protection preparations according to the invention furthermore contain salts which are able to Stabilize or strengthen the mineral salt content that is characteristic of healthy skin. The mineral salt content is known to be an important regulating factor for both the skin moisture and also for normal cell proliferation and cell differentiation and the related Synthesis of epidermal, barrier-reactive lipids (K.R. Feingold, Cosmetics & Toiletries 112 (7), 49-59 (1997)).

The skin protection preparations according to the invention contain physiologically compatible moisturizing substances punch on the basis of polyols and / or urea. These substances bind and have water high effectiveness in preventing skin roughness and cracking and ins special protection against oily (lipophilic) substances.

The skin protection preparations according to the invention contain UV filters, which correspond in particular to one appropriate sun protection outdoors (leisure and professional activities) and when working under UV Load such as B. Ensure welding work in the metalworking industry.

The skin protection preparations according to the invention differ in their composition fundamentally from the previously known conventional O / W and W / O emulsions. During E / W Usually protect emulsions against oily substances and protect W / O against aqueous substances, The skin protection preparations according to the invention can be used against both oily and aqueous Protect substances and their mixtures. The reason is the very low solubility of the hydrogenated Phosphatidylcholins in oily and aqueous media. In this capacity it is very similar to that barrier-reactive ceramides. The skin protection also extends to dusts, high and low air moisture, aerosols and sun protection. The skin protection preparations are characterized by a fine Dispersity and are usually not built up liposomally.

The skin protection preparations according to the invention can be dermatological and cosmetic active ingredients contain. Active ingredients have the sense, the skin-protecting properties according to the invention still to reinforce or supplement. The active ingredients are particularly anti-irritant and anti-inflammatory Nature. With dispositions to neurodermatitis, urticaria, psoriasis or lchthiosis-like skin damage antipruritic and local anesthetic substances are helpful to prevent corresponding to protect manual injuries from scratching from the outset. But also as active ingredients e.g. B. understood substances that reinforce the skin against the penetration of harmful heavy metal ions Protect (nickel, cobalt, copper, etc.). The effect of these active ingredients is usually based on the Binding of the heavy metals by complexation or on an additional reinforcement of the Barrier. Other suitable additional active ingredients are skin-protecting lipids and waxes, vitamins and provitamins, antifungals, anti-inflammatory substances, immunosuppressants, anti-infectives, Antiseptics, antivirals, astringents, plant and yeast extracts, vegetable oils with specific Effects or a high content of highly unsaturated (essential) fatty acids, barrier stabilizing acids, covering substances and pigments as well as single substances with special effects (e.g. with acne).

A particular advantage of skin protection preparations is the fact that in these preparations too sensitive active ingredients, such as vitamins and unsaturated natural products (e.g. evening primrose oil) through the Phosphatidylcholines are protected similarly as in liposomal preparations. These substances are in the skin protection preparations according to the invention are broken down much more slowly or are oxidatively changed. As a result, the dosages of appropriate auxiliaries can be reduced or these substances can be eliminated entirely.

The skin protection preparations can be mixed with conventional mixing tools known to those skilled in the art and subsequently with a guide beam mixer, rotor stator device, high pressure homogenizer, dissolver or other similar devices can be homogenized. The manufacture is in an example explained. The skin protection dispersions stand out due to their specific composition characterized in that dermatological or cosmetic active ingredients either directly or later can be cold worked in without loss of stability by a simple stirring process. It is it does not matter whether it is aqueous or oily active substances or active substance mixtures. This distinguishes them advantageously from conventional emulsions, but also from liposomal ones Formulations that generally do not absorb any additional substances with this procedure or become more or less unstable. The skin protection preparations according to the invention can be therefore easily adapt to the requirements of an individual skin on site.

In summary, the skin protection preparations according to the invention consist of:

• 1. hydrogenated (saturated) phosphatidylcholine (PC-H) with the addition of
• 2. medium chain triglycerides,
• 3. Salting,
• 4. moisturizing substances,
• 5. UV filter,
• 6. active substances,
• 7. Water

For example, in the skin protection preparations according to the invention. B. process the following ingredients be prepared: 1) Hydrogenated (saturated) phosphatidylcholine (PC-H): Among them are phosphatidylcholine plants Licher, animal or synthetic origin to understand their unsaturated esterified acid components were completely hydrogenated. Of course, saturated synthetic Phosphatidylcholines, which are logically identical to hydrogenated phosphatidylcholines, also from synthesize corresponding individual components. Hydrogenated phosphatidylcholines are e.g. More colorful the name Phospholipon 80 H, Phospholipon 90 H or Phospholipon 100 H commercially. The Numbers behind the name are a measure of the phosphatidylcholine content, which includes other commercial products can usually vary between 50 and 100%. The rest most of the products consist of known (soybean oil) typical accompanying phospholipids (Phosphatidylethanolamine, phosphatidylinositol, lysophosphatidylcholine, phosphatidic acid, rest oil content), which are also available in hydrogenated form. Synthetic phosphatidylcholines are e.g. B. Dipalmitoylphosphatidylcholine (DPPC) or Distearoylphosphatidylcholine (DSPC).

2) Medium-chain triglycerides (MCT): In the context of the skin protection according to the invention, these are to be understood as meaning medium-chain triglycerides or triglyceride mixtures in which straight-chain fatty acids with chain lengths of C ₈ to C ₁₆ are esterified with glycerol. Triglycerides with fatty acids C ₈ to C ₁₂ are particularly preferred. Products of this type are traded under different names (e.g. Myritol 312 and 318 or Miglyol, 810 and 812).

3) Salts: These include, within the scope of the skin protection preparations according to the invention, salts of To understand sodium, potassium, magnesium, calcium, zinc and choline. Are preferred Fluorides, chlorides, sulfates, phosphates, 2-aminoethyl phosphates, glycolates, lactates, citrates, Succinate, malate, fumarate, monomethyl fumarate, monoethyl fumarate, tartrate or their Mixtures. The mixtures can e.g. B. also be of natural origin (including sea salt different provenance, e.g. B. from the Dead Sea). Chlorides are particularly preferred, Sulphates and fumarates of potassium, sodium and magnesium.

4) Moisturizing substances: These include within the scope of the skin protection preparations according to the invention understand physiologically compatible polyols, urea or mixtures thereof. Typical representatives are glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, Glycerin, inositol (inositol), sorbitol (sorbitol), mannitol, palatinite, maltodextrin, dextrin, cyclodextrin, Glucose, fructose, lactose, mannose, galactose and other saccharides. Particularly preferred are glycerin, propylene glycol, pentylene glycol and urea, whereby propylene glycol due to its partial penetration-promoting properties are used in the lowest possible dosage.

5) UV filters of the skin protection preparations according to the invention are e.g. E.g .: 1- (4'-isopropylphenyl) -3-phenyl propane-1,3-dione, 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione, 2.4-2'.4'-dihydroxy benzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfone acid, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 4- [bis- (2-hydroxypropyl) amino] benzoic acid ethyl ester, 4-aminobenzoic acid, 2-ethylhexyl 4-dimethylaminobenzoate, 3- (4-methyl benzylidene) -bornan-2-one, 3-benzylidene-bornan-2-one, 3- (4'-trimethylamonium) benzylidene-bornan on-methyl sulfate, 4-methoxycinnamic acid 2-ethylhexyl ester, 4-methoxycinnamic acid propyl ester, 4- Methoxycinnamic acid isamyl ester, 2-cano-3,3-diphenylacrylic acid 2-ethylhexyl ester, (N-cinnamoyl propyl) trimethylammonium chloride, 3.3.5-trimethylcylohexyl salicylate, 4-isopropylbenzyl salicylate, Salicylic acid octyl ester, salicylic acid 2-ethylhexyl ester, 2-phenylbenzimidazole-5-sulfonic acid, 2.4.6- Trianilino-p- (carbo-2'-ethylhexyl-1'-oxi) -1.3.5-triazine, 3-imidazol-4-ylacrylic acid (urocanic acid), 3- Imidazol-4-ylacrylate, zinc oxide, titanium dioxide. If an adjustment of the pH is necessary due to acidic UV filters, this can be done using indifferent bases such as B. sodium hydroxide, potassium hydroxide, trometamol, arginine or lysine. UV and light filters from the group of the dibenzoylmethane are particularly preferred Benzophenone, salicylic acid, cinnamic acid, 4-aminobenzoic acid, triazine, Urocanic acid compounds and from the group of oxides of zinc and titanium, the Filters can be present individually or in a mixture.

6) Dermatological and cosmetic active ingredients of the skin protection preparations according to the invention are skin-protecting lipids and waxes such as. B. mono-, di-, tri- and polyglycerides of ricinoleic, 12-hydroxystearic and 11-hydroxypalmitic acid, castor oil, hydrogenated castor oil, octyl dodecyl ester of ricinoleic acid, octyl 12-hydroxystearic acid, beeswax, Japanese wax, carnauba wax, cetyl palmitate, cocoa butter, cocoa butter, cocoa butter , Squalene, squalane, cholesterol, cholesteryl sulfate, phytosterols, lanolin, lanolin alcohols and their derivatives, ceramides, sphingolipids, sphinganine, sphingosine, sphingosine 1-phosphate, sphingomyelin, C ₁₂ -C ₁₅ alkyl benzoate, linoleic acid methyl and ethyl ester, linoleic acid -mono-, di- and triglycerides, isopropyl myristate, isopropyl palmitate and natural fatty oils, such as. B. avocado oil, wheat germ oil, macadamia nut oil, apricot kernel oil, almond oil, hemp oil, linseed oil, sesame oil, olive oil, sunflower oil, peanut oil in natural and hydrogenated form. Other active ingredients can include vitamins and provitamins (in particular A, B complex, C, E, D and their usual derivatives such as vitamin A acid, vitamin A acetate, vitamin A palmitate, vitamin C palmitate, vitamin E acetate, - palmitate and linoleate, alfacalcidol, calcitriol, colecalciferol, ergocalciferol, transcalcifediol, calciprotriol, calcifediol, vitamin D ₃ , β-carotene, panthenol, pantothenic acid, biotin), itch-relieving surface anesthetics (e.g. 20%, lidocaine, benzocaine, lidocaine, aqueous urea solutions, isoprenaline, crotamiton, quinisocaine), antipruritic H ₁ antihistamines (e.g. meclozin, cetirizine, promethazine, diphenhydramine, chlophenoxamine, doxylamine, pheniramine, bromphenira min. Oxatomide, terfenadine, astemizole), antifungals (e.g. econazole, bifonazole, isoconazole, oxiconazole, tioconazole, fenticonazole, clotrimazole, miconazole, ketoconazole, itraconazole, fluconazole, sertaconazole, terbinazazole n, naftifine, omoconazole, tolnaftate, amorolfine, amphotericin B, nystatin, natamycin, griseofulvin, flucytosine, ciclopirox, tolciclate, undecylenic acid), anti-inflammatory substances (e.g. B. glucocorticoids and their derivatives such as triamcinolone acetonide; Bufexamac, chamomile extract, witch hazel extract, tannins, bisabolol, ammonium bituminosulfonate, acetylsalicylic acid, allantoin), immunosuppressants (e.g. methotrexate, ciclosporin, retinoids (e.g. isotretinoin, acitretinoin, tazarotenindine) , Tetracyclines), cytokines (e.g. interleukins, interferons, tumor necrosis factors), antiseptics (e.g. chlorhexidine, benzalkonium chloride, 8-hydroxyquinolines, ethacridine, hexetidine, acriflavinium chloride, benzoxonium chloride, bibrocathol, dequalinium salts, ethanol, 2, 1-propanol, azelaic acid, resorcinol, triclosan, farnesol, diglycerol monocaprinate, colloidal silver, silver chloride, gentamycin, salicylic acid, ozonized olive oil, benzoyl peroxide), antivirals (e.g. aciclovir, penciclovir, foscarnet sodium, idoxuridine, triflorin, trifin ), Astringents (e.g. tannin, oak bark extract, bismuth gallate), extracts with specific effects (e.g. aloe vera extract, green tea extract, algae extract, Ec hinacea extract, arnica extract, cucumber extract, hop extract, carrot extract, bran extract, witch hazel extract, yeast extract, gingko biloba extract), vegetable oils with specific effects (e.g. B. rosemary oil, chamomile oil, sage oil, calendula oil, lavender oil, St. John's wort oil, lemon balm oil, sea buckthorn oil, tea tree oil, cedarwood oil, cypress oil), oils with a high content of esterified highly unsaturated (essential) fatty acids (e.g. evening primrose oil, currant oil, rosehip oil, borage oil) Soybean oil, fish oil) as well as barrier-stabilizing acids (e.g. linoleic acid, 12-hydroxystearic acid, stearic acid, isostearic acid, palmitic acid, 11-hydroxypalmitic acid, protein hydrolyzate condensates ("lipacides", e.g. palmitoyl wheat protein hydrolyzate, dipalmitoylhydroxy acid), nalogluturylaloylurol), nalogluturylaloylurol), and single substances with special effects (e.g. 1,2-dithiacyclopentane-3-valerian acid, adapalene, ammoidin, tioxolone, minoxidil, fluorouracil). In addition, the active ingredients include substances that are able to prevent heavy metal cations from penetrating the skin (e.g. EDTA, 1-hydroxyethane-1,1-diphosphonic acid, trimethylammonioacetate, cm-glucan, chitosan, polyvinyl alcohol, polyvinylpyrrolidone , Bentonites, kaolin, cyclodextrins, pectins and their derivatives, alginic acid and alginates, polysaccharides and their derivatives (e.g. microcrystalline cellulose, cellulose ethers, methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carmellose, carboxymethyl cellulose, tragacanth, tragacanthine kernel, nutmeg, xanthine, xanthan gum, carraghenane, xanthan gum, xanthan gum, xanthan gum, carraghenane xanthine , Guar gum and its derivatives, arabic gum, polyacrylates and their copolymers). The active ingredients also include covering substances and pigments, such as. As magnesium oxide, magnesium carbonate, magnesium aluminum silicate, magnesium stearate, magnesium isostearate, talc, calcium carbonate, zinc oxide, zinc carbonate, zinc stearate, zinc laurate, titanium dioxide, iron oxide, iron hexacyanoferrate, bismuth oxychloride, aluminum oxide, aluminum silicates, silicon dioxide, aerosil, boron nitride, mica. Pigments, optionally with known compatible dyes or tanning agents, such as. B. dihydroxyacetone, can be mixed, have the sense in the skin protection preparations according to the invention on the one hand to protect against external pollutants, on the other hand to cover localized skin damage or skin anomalies in order to protect the skin from corresponding psychological reactions (scratching, pressing, etc. ). All active ingredients can be contained alone or in a correspondingly meaningful combination in the skin protection preparations according to the invention. If an adjustment of the pH is necessary due to acidic active ingredients, this can be done using indifferent bases such as. B. sodium hydroxide, potassium hydroxide, trometamol, arginine or lysine. The mono-, di- and triglycerides of ricinoleic acid, 12-hydroxystearic acid and linoleic acid, ethyl linoleate, palmitic acid, stearic acid, shea butter, beeswax, jojoba oil, squalane, cholesterol, vitamins A, C, E and D- are particularly preferred. Series and their acetates, palmitates, stearates and linolates, panthenol, biotin, allantoin, lidocaine, salicylic acid, azelaic acid, ethanol, avocado oil, evening primrose oil, currant seed oil, rose hip oil, fish oil, ozonized olive oil, magnesium aluminum silicate, iron oxide, zinc oxide, titanium dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaolin dioxide, kaamin dioxide, ka Polyacrylates and their copolymers, xanthan, witch hazel extract, aloe vera extract and their mixtures with one another.

An essential characteristic of the skin protection preparations according to the invention is that they are alternative either from hydrogenated (saturated) phosphatidylcholine, medium-chain triglycerides, salts, Humectants, UV filters and active ingredients are manufactured or the active ingredients or active ingredient Mixes of substances in whole or in part only later by specialists in already finished preparations the remaining components exist, are incorporated on site. Among specialist staff are e.g. B. Pharmacists, dermatologists, beauticians and appropriately trained laboratory staff understand.

The skin protection preparations according to the invention serve, in addition to protection against exogenous or endogenous related barrier disorders and skin damage especially protecting the skin from watery and oily, externally acting substances or their mixtures, the protection against the action of Sunlight and UV radiation and, depending on the nature of the skin, also protection against stress conditions due to dry and particularly humid climatic conditions. Therefore, the Skin protection products can be used indoors and outdoors. Because a primary goal is the protection of heavily stressed, sensitive and predisposed skin diseases Skin protection preparations according to the invention designed for 24-hour protection. That means, that appropriate applications of skin protection products in both commercial and private area, d. H. in leisure, vacation and household, should take place to the skin at all times preventive protection and promote self-regeneration. The application is not specific Areas of skin such as hands and face are limited, but can also affect the entire body or special other skin areas. The skin protection preparations according to the invention are so set that they can be distributed well and usually move in quickly. You can z. B. Use advantageously in activities where the skin is exposed to water and water for a particularly long time Sunlight is claimed, such as. B. in water sports. With prolonged contact with water it turns out the comparatively low swelling capacity of the skin described above after application the skin protection agent as a great advantage. The skin protection preparations according to the invention can be used as examples against the following Apply substance classes, whereby the composition in individual cases has special properties these substances can be adjusted: water-mixed cooling lubricants, aqueous working materials and water, aqueous rinsing solutions, metal salts, metal dusts, feed and grain dusts, Flour dusts, wood dust, preservatives, disinfectants, permanent waving agents, hair colors, Fragrances, meat, fish, body excrement (faeces, urine), body secretions (sweat, saliva, mucus), Vegetables, bulbs, plant juices, fruits, enzymes, impregnants, surface-active Compounds, photochemicals, water-immiscible cooling lubricants, technical oils, Vegetable oils, fats, waxes, tars, resins, paints and dyes, floor care products, Rubber gloves, latex, vulcanizing agents, glue, dental chemicals. The invention Skin protection products also protect against sunlight and UV radiation.

It goes without saying that the skin protection preparations according to the invention depend on Skin texture even with particularly high and low humidity, with vapors and Aerosols or as cold ointments can be used.

The contents of the main components of the skin protection preparations according to the invention can vary within the following limits:

• 1. phosphatidylcholine (saturated) 0.10-10.00% by weight,
• 2. medium-chain triglycerides 1.00-50.00% by weight,
• 3. salts 0.01-10.00% by weight,
• 4. moisturizing substances 1.00-20.00% by weight,
• 5. UV filter 0.50-30.00% by weight,
• 6. dermatological or cosmetic active substances 0.01-20.00% by weight,
• 7. Water 20.00-95.00% by weight.

The contents of the main components of the skin protection preparations according to the invention are preferably:

• 1. phosphatidylcholine (saturated) 0.50-6.00% by weight,
• 2. medium-chain triglycerides 5.00-40.00% by weight,
• 3. salts 0.10-5.00% by weight,
• 4. moisturizing substances 1.00-20.00% by weight,
• 5. UV filter 1.00-20.00% by weight,
• 6. dermatological or cosmetic active ingredients 1.0-10.00% by weight,
• 7. Water 30.00-85.00 wt%.

Depending on the composition, the skin protection preparations according to the invention have an ointment-like, creamy or milky consistency. The composition and manufacture of the invention Skin protection products and their use when using different components is in the following examples. The numbers from 1) -7) presented to the components correspond to in the description of the classification of the main components of the invention Skin protection products: 1) hydrogenated (saturated) phosphatidylcholine, 2) medium-chain triglycerides, 3) Salts, 4) moisturizing substances, 5) UV filters, 6) dermatological and cosmetic active ingredients, 7) Water. In the examples below, the hydrogenated (saturated) phosphatidylcholine is commercially available Phospholipon 90 H from Nattermann Phospholipid GmbH, Cologne, with a phosphatidyl choline content of approx. 95% used; the phosphatidylcholine comes from the soybean. The one in the Contents of component 1) given in the examples are analogous to the respective phosphate adjust idylcholine content, d. H. with lower phosphatidylcholine contents, one is used accordingly higher amount of component 1) and correspondingly less 7) water calculated. At higher Conversely, the phosphatidylcholine content reduces the amounts of 1) and correspondingly more 7) Water calculated. Since a replacement of z. B. Phospholipon 90 H by Phospholipon 80 H or other available qualities can significantly change the consistency of the products, may also be a 1: 1 exchange or an exchange with a different ratio be made to achieve more ointment-like, creamy or milky consistencies.

example 1 Skin protection preparation for the disposition of the skin to acne

1) phosphatidylcholine (saturated) 1.30% by weight 2) medium chain triglycerides 8.00% by weight 3) sodium chloride 0.10% by weight 4) urea 2%, glycerin 3%, propylene glycol 3% 8.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) ethanol 9%, polyacrylate (as sodium salt) 0.5% 9.50% by weight 7) water 71.10% by weight

Example 2 Skin protection preparation when the skin is predisposed to neurodermatitis

1) phosphatidylcholine (saturated) 3.20% by weight 2) medium chain triglycerides 5.00% by weight 3) sodium chloride 0.10% by weight 4) pentylene glycol 0.8%, glycerin 6%, urea 3% 9.80% by weight 5) 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione 2%, 4-methoxycinnamic acid 2-ethylhexyl ester 10% 12.00% by weight 6) Jojoba oil 1.0% by weight 7) water 68.90% by weight

Example 3 Skin protection preparation when skin is predisposed to psoriasis

1) phosphatidylcholine (saturated) 6.00% by weight 2) medium chain triglycerides 20.00% by weight 3) Sodium chloride 4%, magnesium fumarate 0.5% 4.50% by weight 4) pentylene glycol 5%, glycerin 5% 10.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) Salicylic acid 1.00% by weight 7) water 56.50% by weight

Example 4 Skin protection preparation when the skin is predisposed to impurities

1) phosphatidylcholine (saturated) 1.00% by weight 2) medium chain triglycerides 8.00% by weight 3) sodium chloride 0.10% by weight 4) Glycerin 3%, propylene glycol 2%, pentylene glycol 3% 8.00% by weight 5) 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione 2%, 4-methoxycinnamic acid 2-ethylhexyl ester 10% 12.00% by weight 6) Farnesol 1%, Azelaic acid 2% (as monosodium salt) 3.00% by weight 7) water 67.90% by weight

Example 5 Skin protection preparation when skin is predisposed to ichthiosis

1) phosphatidylcholine (saturated) 2.00% by weight 2) medium chain triglycerides 10.00% by weight 3) sodium chloride 2.00% by weight 4) urea 10%, pentylene glycol 3% 13.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) cholesterol 3.00% by weight 7) water 68.00% by weight

Example 6 Skin protection preparation for irritated, rough and cracked skin

1) phosphatidylcholine (saturated) 6.00% by weight 2) medium chain triglycerides 18.00% by weight 3) sodium chloride 0.10% by weight 4) pentylene glycol 5%, glycerin 3% 8.00% by weight 5) 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione 2%, 4-methoxycinnamic acid 2-ethylhexyl ester 10% 12.00% by weight 6) Shea butter 3%, squalane 1% 4.00% by weight 7) water 51.90% by weight

Example 7 Skin protection preparation for the disposition of the skin to acne

1) phosphatidylcholine (saturated) 1.00% by weight 2) medium chain triglycerides 15.00% by weight 3) sodium chloride 0.20% by weight 4) pentylene glycol 5%, glycerin 3% 8.00% by weight 5) 2-ethylhexyl salicylic acid 5.00% by weight 6) Vitamin E acetate 1%, vitamin C palmitate 0.5% 1.50% by weight 7) water 69.30% by weight

Example 8 Skin protection preparation when skin is predisposed to psoriasis

1) phosphatidylcholine (saturated) 5.00% by weight 2) medium chain triglycerides 35.00% by weight 3) Magnesium chloride 1.00% by weight 4) urea 5%, propylene glycol 5% 10.00% by weight 5) 2-ethylhexyl salicylic acid 5.00% by weight 6) dithranol 0.01%, salicylic acid 1% 1.01% by weight 7) water 42.99% by weight

Example 9 Skin protection preparation when skin is predisposed to psoriasis

1) phosphatidylcholine (saturated) 1,000% by weight 2) medium chain triglycerides 17,000% by weight 3) Sodium chloride 1%, magnesium sulfate 0.5% 1,500% by weight 4) urea 5,000% by weight 5) 2-ethylhexyl salicylic acid 3,000% by weight 6) Vitamin D ₃ 0.002%, shea butter 5% 5.002% by weight 7) water 67.498% by weight

Example 10 Skin protection preparation when skin is predisposed to psoriasis

1) phosphatidylcholine (saturated) 1.00% by weight 2) medium chain triglycerides 20.00% by weight 3) sodium chloride 0.50% by weight 4) urea 5.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) Polidocanol 2.00% by weight 7) water 69.50% by weight

Example 11 Skin protection preparation when the skin is predisposed to neurodermatitis

1) phosphatidylcholine (saturated) 5.00% by weight 2) medium chain triglycerides 30.00% by weight 3) sodium chloride 0.20% by weight 4) urea 5%, pentylene glycol 8% 13.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) Shea butter 5.00% by weight 7) water 44.80% by weight

Example 12 Skin protection preparation for sensitive skin, especially against oily substances

1) phosphatidylcholine (saturated) 3.00% by weight 2) medium chain triglycerides 5.00% by weight 3) sodium chloride 0.30% by weight 4) glycerin 3%, pentylene glycol 7%; Urea 3% 13.00% by weight 5) 4-aminobenzoic acid 4.00% by weight 6) polyacrylate (as sodium salt) 0.2%, xanthan 0.3%, panthenol 1% 1.50% by weight 7) water 73.20% by weight

Example 13 Skin protection preparation for sensitive skin, especially against aqueous agents

1) phosphatidylcholine (saturated) 2.00% by weight 2) medium chain triglycerides 23.00% by weight 3) Magnesium sulfate 0.20% by weight 4) pentylene glycol 6.00% by weight 5) 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione 2%, 4-methoxycinnamic acid 2-ethylhexyl ester 10% 12.00% by weight 6) beeswax 5%, jojoba oil 2%, ethanol 3% 10.00% by weight 7) water 46.80% by weight

Example 14 Skin protection preparation for sensitive skin against oily and watery substances

1) Phosphatidyfcholine (saturated) 5.00% by weight 2) medium chain triglycerides 5.00% by weight 3) Disodium fumarate 0.10% by weight 4) urea 2%, propylene glycol 5% 7.00% by weight 5) 4-aminobenzoic acid 5.00% by weight 6) Stearic acid 2%, 12-hydroxystearic acid 1% and polyacrylate 0.3% (adjusted to pH 7 with sodium hydroxide solution in the aqueous phase), ethanol 6% 9.30% by weight 7) water 68.60% by weight

Example 15 Skin protection preparation when skin is predisposed to psoriasis

1) phosphatidylcholine (saturated) 5.00% by weight 2) medium chain triglycerides 25.00% by weight 3) fumaric acid (as disodium salt) 5%, magnesium chloride 1% 6.00% by weight 4) urea 5%, pentylene glycol 3% 8.00% by weight 5) 2-ethylhexyl salicylic acid 5.00% by weight 6) ethanol 5%, isopropyl myristate 5% 20.00% by weight 7) water 31.00% by weight

Example 16 Skin protection preparation when the skin is predisposed to allergic reactions to heavy metals

1) phosphatidylcholine (saturated) 4.00% by weight 2) medium chain triglycerides 26.00% by weight 3) Magnesium sulfate 0.10% by weight 4) pentylene glycol 5.00% by weight 5) 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione 2%, 4-methoxycinnamic acid 2-ethylhexyl ester 10% 12.00% by weight 6) ethanol 5%, chitosan 1%, xanthan 0.5% 6.50% by weight 7) water 46.40% by weight

Example 17 Skin protection preparation when the skin is predisposed to impurities with a covering pigment additive

1) phosphatidylcholine (saturated) 6.00% by weight 2) medium chain triglycerides 10.00% by weight 3) Magnesium sulfate 0.10% by weight 4) pentylene glycol 5%, glycerin 3% 8.00% by weight 5) zinc oxide 5.00% by weight 6) kaolin 8%, iron oxide 0.5% 8.50% by weight 7) water 62.40% by weight

Example 18 Skin protection preparation for dry skin

1) phosphatidylcholine (saturated) 4.00% by weight 2) medium chain triglycerides 10.00% by weight 3) sodium chloride 0.10% by weight 4) glycerin 5%, pentylene glycol 5%, urea 1% 11.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) Avocado oil 9.5%, xanthan 0.5% 10.00% by weight 7) water 62.90% by weight

Example 19 Skin protection preparation for the disposition of the skin to acne

1) phosphatidylcholine (saturated) 1.00% by weight 2) medium chain triglycerides 20.00% by weight 3) Sodium glycolate 5.00% by weight 4) pentylene glycol 5%, glycerin 3% 8.00% by weight 5) Titanium dioxide 3.00% by weight 6) Salicylic acid 1.00% by weight 7) water 62.00% by weight

Example 20 General production of the skin protection preparations according to the invention

Components 1) to 6) are mixed in a process familiar to the person skilled in the art, to a Temperature of 50-80 ° C warmed and in the water phase 7), the same temperature brought, dispersed, with a jet mixer, rotor stator or high pressure homogenizer homogenized, cooled and homogenized again. Depending on the application or The dispersion process and the consistency of the desired skin protection preparation Homogenization steps carried out over a longer or shorter time. It follows - how is also known to those skilled in the art - firmer or more liquid products.

For gel or film formers or generally water-soluble feedstocks from groups 3) salts, 4) Moisturizing substances and 6) dermatological or cosmetic active ingredients, it may be useful to solve them in the water phase 7) and then the dispersing and homogenizing steps follow to let.

Example 21 General manufacture of the skin protection preparations according to the invention with the subsequent addition of dermatological or cosmetic active ingredients

The dermatological or cosmetic active ingredients 6) can also be subsequently applied Basic creams from 1), 2), 3), 4), 5) and 7) according to the same methods and described Examples are prepared, stir in at a temperature of 15 to 30 ° C. After corresponding The skin protection preparations according to the invention also arise from homogenization. It can It may also be useful to use some of the dermatological or cosmetic base creams Active ingredients 6).

So z. B. the base cream for skin protection preparations when disposing of dry skin (see Example 18):

1) phosphatidylcholine (saturated) 4.00% by weight 2) medium chain triglycerides 10.00% by weight 3) sodium chloride 0.10% by weight 4) glycerin 5%, pentylene glycol 5%, urea 1% 11.00% by weight 5) Urocanic acid sodium salt 2.00% by weight 6) Xanthan 0.50% by weight 7) water 62.90% by weight

be prepared and component 6) avocado oil (9.5%) stirred at a later time will. As an alternative to avocado oil, e.g. B. also jojoba oil, evening primrose oil, wheat germ oil, Macadamia nut oil or e.g. B. cetyl palmitate, dissolved in isopropyl myristate, and other useful Combinations can be added in the same amount. Of course, instead of an oil such. B. also an extract or a water-soluble active ingredient or corresponding mixtures of substances from dermato logical or cosmetic active ingredients are stirred into the base creams.

Claims (6)

1. Formulation for use as skin protection against substances acting externally on the skin and endogenously caused skin damage, characterized in that they

• 1. phosphatidylcholine (saturated) 0.10-10.00% by weight,
• 2. medium-chain triglycerides 1.00-50.00% by weight,
• 3. salts 0.01-10.00% by weight,
• 4. moisturizing substances 1.00-20.00% by weight,
• 5. UV filter 0.50-30.00% by weight
• 6. dermatological or cosmetic active ingredients 0.01-20.00 wt .-% and
• 7. Water contains 20.00-95.00% by weight.

2. Formulation according to claim 1, characterized in that it contains the following components:

• 1. phosphatidylcholine (saturated) 0.50-6.00% by weight,
• 2. medium-chain triglycerides 5.00-40.00% by weight,
• 3. salts 0.10-5.00% by weight,
• 4. moisturizing substances 1.00-20.00% by weight,
• 5. UV filter 1.00-20.00% by weight
• 6. dermatological or cosmetic active ingredients 1.0-10.00% by weight,
• 7. Water contains 30.00-85.00% by weight.

3. Formulation according to claim 1 and 2, characterized in that the medium-chain triglycerides 2) contain fatty acids of chain length C ₈ -C ₁₂ , the salts 3) are selected from the group of chlorides, sulfates and fumarates of potassium, sodium and magnesium or represent a mixture thereof, which are moist substances 4) glycerol, propylene glycol, pentylene glycol or urea or represent a mixture thereof. 4. Formulation according to claim 1 and 3, characterized in that the UV filter 5) is selected are from the group of dibenzoylmethane, benzophenone, salicylic acid, cinnamic acid, the 4-aminobenzoic acid, the triazine, the urocanic acid compounds and from the group the oxides of zinc and titanium, where the filters can be present individually or in a mixture. 5. Formulation according to claim 1 to 4, characterized in that the dermatological and cosmetic active ingredients 6) are selected from the group of skin-protecting lipids and Waxes, the group of vitamins and provitamins, itch-relieving surface anesthetics and antihistamines, antifungals, anti-inflammatory substances, immunosuppressants, anti-infectives, antiseptics, antivirals, astringents, plant and Yeast extracts, the vegetable oils with a high content of highly unsaturated (essential) Fatty acids or with special effects, the group of barrier-stabilizing acids, the covering substances and pigments as well as the group of substances that are able to Prevent heavy metal cations from entering the skin. 6. Formulation according to claim 1 to 5, characterized in that the dermatological Active ingredients 6) in a mixture of saturated phosphatidylcholine 1), medium-chain triglycerides 2), salts 3), moisturizing substances 4), UV filters 5) and water 7) can.