JP2000254111A - Device for measuring body fluid component - Google Patents

Device for measuring body fluid component

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Publication number
JP2000254111A
JP2000254111A JP11063905A JP6390599A JP2000254111A JP 2000254111 A JP2000254111 A JP 2000254111A JP 11063905 A JP11063905 A JP 11063905A JP 6390599 A JP6390599 A JP 6390599A JP 2000254111 A JP2000254111 A JP 2000254111A
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Prior art keywords
body fluid
housing
fluid
measuring apparatus
opening
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JP11063905A
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Japanese (ja)
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JP3659832B2 (en
Inventor
Hisao Nishikawa
Koichi Sonoda
耕一 園田
尚穂 西川
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Terumo Corp
テルモ株式会社
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Priority to JP06390599A priority Critical patent/JP3659832B2/en
Priority claimed from DE69939598A external-priority patent/DE69939598D1/en
Publication of JP2000254111A publication Critical patent/JP2000254111A/en
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Publication of JP3659832B2 publication Critical patent/JP3659832B2/en
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Abstract

PROBLEM TO BE SOLVED: To surely measure the component of a body fluid even when the amount of the body fluid which flows out is the small one by providing a body fluid introducing guide to introduce the body fluid to a suck port in the circumference of the port. SOLUTION: A body fluid component measuring device 1 is constituted of a housing 2, an opening part 7 formed in the housing 2, a suck port 4 arranged in the circumference of the opening part 7, test paper 6 being one of the configuration elements of a measurement detecting part, a flow passage part 3 communicating with the port 4 and the paper 6 and a body fluid introducing guide 5 introducing the body fluid which flows out into the opening part 7 to the suck port 4. Then the fluid is guided by the flow passage part 3 from the suck port 4 to the paper 6. Besides, the guide 5 is provided with a function for introducing the body fluid to the suck port 4 when the fluid is brought into contact with it. The guide 5 can be formed by a material being the same as that in the housing 2 and the flow passage part 3 but it is favorable that the material with high hydrophilicity in the same way as in the part 3 is used or a front surface of the guide 5 is worked to have hydrophilicity.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【発明の属する技術分野】本発明は、体液、特に血液を採取して、その成分を測定する体液成分測定装置に関する。 The present invention relates to the body fluids, especially blood was collected, to the body fluid component measuring apparatus for measuring the components.

【0002】 [0002]

【従来の技術】近年の糖尿病患者の増加に伴い日頃の血糖値の変動を患者自身モニターする自己血糖測定が推奨されてきている。 BACKGROUND OF THE INVENTION a variation of the daily blood sugar values ​​with the increase in recent years of diabetes patients have been recommended blood glucose self-measurement of the patient's own monitor. 従来は,血糖値測定をするための方法は針状や小刀状のランセットを備えた穿刺具を用いて指先の皮膚を切り裂いた後、穿刺部周辺を指等で圧迫して血液を絞り出している。 Conventionally, a method for blood glucose measurement After tearing through fingertip skin using the puncture device provided with a needle or scalpel-like lancets, and squeeze the blood surrounding puncture compresses with a finger or the like . そして、穿刺具と血糖測定装置が別々であるため、穿刺具から血糖測定装置に持ち替え、その血液を血中のグルコースと反応する試薬を含有する試験紙にたどり着かせるための試験片に触れさせ、 Since puncture device and the blood glucose measuring device are separate, dimensional worlds in blood sugar measuring device from the puncture device, exposed to the test strip for Tadoritsuka the test paper containing a reagent which reacts with the blood glucose of the blood,
試験紙部での反応を呈色反応として光学的に測定したり、又は試験紙に設けられた電極により電気的に測定し、血糖値に換算させている。 The reaction of the test paper part or optically measured as color reaction, or electrically measured by electrodes provided on the test paper, thereby converted into blood glucose level. この方法は、操作性が悪く衛生面から見ても不利であった。 This method was also disadvantageous when viewed from the hygiene poor operability.

【0003】そこで、操作性や衛生面の問題を解決するため、特開平6−339473号や特開平9−2762 [0003] Therefore, in order to solve the problem of operability and hygiene, JP-A-6-339473 and JP-A-9-2762
35号などにに開示されている穿刺具と血糖測定装置とを一体とした装置が開示されている。 Apparatus integrated discloses a piercing device disclosed in the like No. 35 and the blood sugar measuring device. しかし、これらの装置は、穿刺具の穿刺針の動作部位と測定系との部材とは同一直線上にはないため、穿刺位置と試験紙との間が離れることになる。 However, these devices, because the member with the operating locality of the puncture needle of the puncture device and the measurement system is not on the same straight line, so that the distance is between the puncture location and the test paper. したがって、表皮の穿刺位置から流出した体液が試験紙にたどり着くには、体液量を多く流出させる必要があり、操作者により多くの負担を与え、 Therefore, the body fluid flowing out from the puncture position of the epidermis reach the test paper, it is necessary to more outflow of body fluid volume, giving a lot of burden by the operator,
かつ測定に必要のない体液が存在することは衛生的に好ましくない。 And the body fluid is present not required for measurement hygienically unfavorable. また、流出させる体液量が少ない場合には、体液が試験紙にたどり着かず測定の確実性が劣ることも考えられる。 Also, if a small fluid volume to flow out, the fluid is also considered inferior that certainty of measurement without Tadoritsuka the test paper.

【0004】 [0004]

【発明が解決しようとする課題】本発明の目的は、表皮を穿刺する機構、体液を採取する採取機構および体液の成分を測定する測定機構を一体化し、かつ流出させた体液が少量であっても、確実に体液の成分を測定することができる体液成分測定装置を提供することにある。 SUMMARY OF THE INVENTION It is an object of the present invention, a mechanism for puncturing the skin, integrated measurement mechanism for measuring a component of the harvesting mechanism and fluid collecting body fluid, and body fluid drained is a minor also, there is provided a body fluid component measuring apparatus capable of reliably measuring components of the body fluid.

【0005】 [0005]

【課題を解決するための手段】上記目的は以下の本発明によって達成される。 SUMMARY OF THE INVENTION The above object is achieved by the following present invention. (1)本発明は、表皮から体液を採取する採取機構と、 (1) The present invention includes a collecting mechanism for collecting body fluid from the skin,
前記体液の成分を測定する測定機構が一体となった装置において、ハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために設けられた吸入口とからなり、前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている体液成分測定装置である。 In the apparatus measuring mechanism for measuring a component of the body fluid are integrated, the housing and the measuring detector for measuring the components of the body fluid provided in said housing, a flow for introducing the fluid to the measuring detector road section, and makes the fluid from the suction port provided to direct the flow path portion, the periphery of the inlet fluid introduction guide portion for guiding said body fluid to said suction port is provided a body fluid component measuring apparatus.

【0006】(2)本発明は、表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構が一体となった装置において、少なくとも一つの開口部を有するハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために前記開口部の周囲に設けられた吸入口とからなり、前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている上記(2)に記載の体液成分測定装置である。 [0006] (2) The present invention includes a collecting mechanism for collecting body fluid from the skin, the measurement mechanism for measuring a component of the body fluid in the device together, a housing having at least one opening, in the housing measuring detector for measuring the components of the body fluid provided in the provided channel part for introducing the body fluid to the measuring detector, and the fluid around the opening to direct the flow path portion and consists of a suction port, the periphery of the inlet is a body fluid component measuring apparatus according to (2) the fluid introduction guide portion for guiding said body fluid to said suction port is provided.

【0007】(3)本発明は、前記体液導入ガイド部が、前記吸入口の周囲に設けられ、前記吸入口から突出、具体的には前記開口部の中心に向かって突出する二以上の突起である上記(1)乃至(2)に記載の体液成分測定装置である。 [0007] (3) The present invention, the body fluid introduction guide portion, the provided around the suction port, protruding from the inlet, the protrusion in particular of two or more projecting toward the center of the opening a body fluid component measuring apparatus according to (1) to (2) is. (4)本発明は、前記流路部が、毛細管現象より体液を測定検出部まで導入する上記(1)乃至(4)に記載の体液成分測定装置である。 (4) The present invention, the flow path unit, a body fluid component measuring apparatus according to (1) to (4) introducing a fluid to the measuring detector than the capillary phenomenon.

【0008】(5)本発明は、前記体液導入ガイド部内の表面張力が、前記流路部内の表面張力よりも小さい上記(1)乃至(4)に記載の体液成分測定装置である。 [0008] (5) The present invention has a surface tension within the fluid introduction guide portion, a body fluid component measuring apparatus according to less the than the surface tension of the channel portion (1) to (4). (6)本発明は、前記体液導入ガイド部内が、前記吸入口から離れるに従い、あるいは前記開口部の中心に向かって裾広がりになっている上記(1)乃至(5)に記載の体液成分測定装置である。 (6) The present invention, in the body fluid introduction guide portion, a body fluid component measurement according the the increasing distance from the suction port, or have become flared toward the center of the opening (1) to (5) it is a device.

【0009】(7)本発明は、穿刺針が突出する穿刺手段を有する上記(1)乃至(6)に記載の体液成分測定装置である。 [0009] (7) The present invention is a body fluid component measuring apparatus according to (1) to (6) having a piercing means piercing needle protrudes. 望ましくは前記開口部から穿刺針が突出する穿刺手段を有する上記(2)乃至(6)に記載の体液成分測定装置である。 Preferably is a body fluid component measuring apparatus according to (2) to (6) having a piercing means piercing needle protrudes from the opening. (8)本発明は、前記ハウジング内を減圧とし、前記開口部から前記表皮の一部または前記体液を吸引する吸引手段を有する上記(2)乃至(7)に記載の体液成分測定装置である。 (8) The present invention, within the housing to a reduced-pressure, is a body fluid component measuring apparatus according to (2) to (7) having a suction means for sucking a part or the body fluid of the skin through the opening .

【0010】(9)本発明は、前記ハウジングの一部が突出しており、その突出した先端に前記開口部を有する上記(2)乃至(8)に記載の体液成分測定装置である。 [0010] (9) The present invention is partially the projection of the housing, a body fluid component measuring apparatus according to (2) to (8) with the opening to the protruding tip. (10)本発明は、前記ハウジングが、前記表皮から前記体液を採取するため前記開口部を前記表皮に押し当てた際に、前記表皮に対して角度を持ったテーパー構造を有する上記(1)乃至(9)に記載の体液成分測定装置である。 (10) The present invention, the housing, the opening for collecting the body fluid from the skin when pressed against the skin, the have a tapered structure in which an angle with respect to the skin (1) or a body fluid component measuring apparatus according to (9).

【0011】(11)本発明は、前記穿刺針が突出する際、前記体液導入ガイドを通過する上記(1)乃至(1 [0011] (11) The present invention, when the puncture needle is projected, the passing through the fluid introduction guide (1) to (1
0)に記載の体液成分測定装置である。 A body fluid component measuring apparatus according to 0). 特に、前記体液導入ガイド部が、前記吸入口の周囲に設けられ、前記吸入口から前記開口の中心に向かって突出する二以上の突起であって、前記二以上の突起の間を通過する上記(1)乃至(10)に記載の体液成分測定装置である。 In particular, the body fluid introduction guide portion, provided around the intake port, wherein a projection of two or more projecting toward the center of the opening from the inlet port, passing between the two or more protrusions (1) is a body fluid component measuring apparatus according to to (10). (12)本発明は、前記測定検出部が、前記体液と呈色反応する試薬を含有する試験紙と、その呈色反応によって生じた呈色を光学的に測定する手段とからなり、前記呈色を光学的に測定したデータから目的とする体液の成分の定量的または定性的な測定を行う上記(1)乃至(10)に記載の体液成分測定装置である。 (12) The present invention, the measurement detector is made up of a test paper containing the reagents for color reaction with the body fluid, and means for measuring the coloration caused by the color reaction optically, the coloration a body fluid component measuring apparatus according to a quantitative or qualitative measurement of the components of the body fluid of interest from the optically measured data (1) to (10) colors.

【0012】(13)本発明は、表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構とを有する体液成分測定装置に着脱可能に設けられ、ハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために設けられた吸入口とからなり、前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている体液収納容器である。 [0012] (13) The present invention includes a collecting mechanism for collecting body fluid from the skin, provided detachably on the body fluid component measuring apparatus and a measurement mechanism for measuring a component of body fluid, and the housing, within the housing measuring detector for measuring the components of the body fluid provided, it becomes the fluid flow path portion for introducing to the measuring detector, and the fluid from the suction port provided to direct the flow path portion, the periphery of the suction port is a body fluid storage container fluid introduction guide portion for guiding said body fluid to said suction port is provided.

【0013】(14)本発明は、表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構とを有する体液成分測定装置に着脱可能に設けられ、少なくとも一つの開口部を有するハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために前記開口部の周囲に設けられた吸入口とからなり、前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている上記(13)に記載の体液収納容器である。 [0013] (14) The present invention includes a collecting mechanism for collecting body fluid from the skin, provided detachably on the body fluid component measuring apparatus and a measurement mechanism for measuring a component of body fluid, having at least one opening housing and, measuring detector for measuring the components of the body fluid provided in said housing, a passage section for introducing the fluid to the measuring detector, and the opening of the body fluid to direct the flow path portion consists of a suction port provided around the parts, the periphery of the inlet in body fluid storage container according to the above (13) to the body fluid introduction guide portion for guiding said body fluid to said suction port is provided is there.

【0014】(15)本発明は、前記体液導入ガイド部が、前記吸入口の周囲に設けられ、前記吸入口から前記開口部の中心に向かって突出する二以上の突起である上記(14)に記載の体液収納容器である。 [0014] (15) The present invention, the body fluid introduction guide portion, the provided around the intake port, wherein a two or more projections projecting toward the center of the opening from the inlet port (14) is a body fluid container according to. (16)本発明は、前記流路部が、毛細管現象より体液を測定検出部まで導入する上記(13)乃至(15)に記載の体液収納容器である。 (16) The present invention, the flow path unit, a body fluid container according to the above (13) to (15) for introducing a fluid to the measuring detector than the capillary phenomenon.

【0015】(17)本発明は、前記体液導入ガイド部内の表面張力が、前記流路部内の表面張力よりも小さい上記(13)乃至(16)に記載の体液収納容器である。 [0015] (17) The present invention has a surface tension within the fluid introduction guide portion, a body fluid container according to less the than the surface tension of the channel portion (13) to (16). (18)本発明は、前記体液導入ガイド部内が、前記吸入口から前記開口部の中心に向かって裾広がりになっている上記(14)乃至(17)に記載の体液成分測定装置である。 (18) The present invention, in the body fluid introduction guide portion, wherein a body fluid component measuring apparatus according to from the inlet port has a flared toward the center of the opening (14) through (17).

【0016】 [0016]

【発明の実施の形態】以下、本発明の実施の形態を図面を参照しながら詳細に説明する。 BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, an embodiment of the present invention in detail with reference to the drawings. 図1は、本発明の実施の一形態である体液成分測定装置1の一部分を横方向に切断し、そこから開口部7方向を見た横断面図、図2は図1と同じ部分、すなわち体液成分測定装置1の開口部7付近の縦断面図である。 Figure 1 shows an embodiment a portion of the body fluid component measuring apparatus 1 is to cut transversely, cross-sectional view of the opening 7 direction therefrom, Figure 2 is the same section as Figure 1 of the present invention, i.e. it is a longitudinal sectional view of the vicinity of the opening 7 of the body fluid component measuring apparatus 1. 体液成分測定装置1は、ハウジング2と、ハウジング2に形成された開口部7と、開口部7の周縁に設けられた吸入口4と、測定検出部の構成要素の一つである試験紙6と、吸入口4と試験紙6とを連通する流路部3と、開口部7内に流出した体液を吸入口4に導く体液導入ガイド部5とから構成されるなる。 Body fluid component measuring apparatus 1 includes a housing 2, an opening 7 formed in the housing 2, a suction port 4 provided in the periphery of the opening 7, which is one component of the measuring detector test paper 6 When, a flow path unit 3 for communicating the suction port 4 and the test paper 6, composed of a body fluid introduction guide section 5 which guides the fluid which flows out into the opening 7 in the inlet 4.

【0017】ハウジング2の形状に関しては特に限定することなく、他の構成部分を設けることが出来る形状で有れば良い。 [0017] Without specifically defined, the shape of the housing 2, it is sufficient in shape can be provided other components. ただし、開口部7付近が、図2に示すように、ハウジング裏面8と開口部7が押し当てる表皮(例えば、指先やお腹など)との間に角度αを有するテーパー構造、あるいは開口部付近が突出している構造であることが望ましい。 However, the vicinity of the opening 7, as shown in FIG. 2, the skin is pressed against the housing back surface 8 and the opening 7 (e.g., a fingertip, etc. and stomach) tapered structures having an angle α between the or the vicinity of the opening, it is preferable that a structure that protrudes. これにより、体液成分測定装置1を操作する際の開口部7の位置の目安となり、さらに表皮に押し当てる部分を開口部7のみにすることができ、表皮の体液を採取する部位と開口部7を確実に当接させることができる。 Thus, a measure of the position of the opening 7 at the time of operating the body fluid component measuring apparatus 1, can be further portion pressed against the skin only in the opening 7, part an opening 7 for collecting the body fluid of the epidermis it can be reliably abutted against the. 角度αは、前述した効果が得られるものであれば特に限定しないが、5〜60度位が望ましい。 The angle alpha, is not particularly limited as long as the effect described above can be obtained, 5 to 60 degrees position is desirable.

【0018】ハウジング2は、ABS樹脂、ポリエチレン、ポリプロピレン、ポリスチレン、ポリ塩化ビニル、 [0018] The housing 2, ABS resin, polyethylene, polypropylene, polystyrene, polyvinyl chloride,
ポリ塩化ビニリデン樹脂、ポリフェニレンオキサイド、 Polyvinylidene chloride resin, polyphenylene oxide,
熱可塑性ポリウレタン、ポリメチレンメタクリレート、 Thermoplastic polyurethanes, polymethylmethacrylate,
ポリオキシエチレン、フッ素樹脂、ポリカーボネート、 Polyoxyethylene, fluororesin, polycarbonate,
ポリアミド、アセタール樹脂、アクリル樹脂、ポリエチレンテレフタレート等の射出成形で用いられる熱可塑性樹脂やフェノール樹脂、エポキシ樹脂、シリコーン樹脂、不飽和ポリエステル等の熱硬化性であっても良い。 Polyamide, acetal resin, an acrylic resin, a thermoplastic resin or a phenol resin used in the injection molding such as polyethylene terephthalate, epoxy resin, silicone resin, may be a thermosetting and unsaturated polyesters.
なお、測定検出部が試験紙での呈色反応を捉える光学的な測定を行うものである場合、測定精度の関係から外乱光の影響を受けにくくするように非透明なものとすることが好ましい。 Incidentally, when the measurement detector is to perform optical measurement to capture the color reaction of the test paper, it is preferable to assume non-transparent to hardly affected by disturbance light from the relationship between measurement accuracy . また、流路部3を体液が移動する様子を確認するため半透明な色つきの樹脂でも良い。 Further, it may be a semi-transparent colored resin to see how the passage portion 3 is a body fluid moves.

【0019】なお、測定検出部としては、試験紙での呈色反応を捉える光学的な測定を行うもの以外にも、呈色反応は使用せず体液自体を光学的な測定を行うものや、 [0019] As the measurement detector, in addition to perform optical measurement to capture the color reaction of the test paper even and that the color reaction performing optical measurement of body fluid itself without,
体液を電極間に導入して電極間の電流値を測定するものであってもよい。 Body fluid may be configured to measure a current value between the introducing electrode between the electrodes.

【0020】流路部3は、体液を吸入口4より試験紙6 The flow path unit 3, the test paper from the suction port 4 to fluid 6
まで導くものである。 It is intended to lead up to. その断面形状、長さ、幅などは、 Sectional shape, length and width, etc.,
測定に必要とする体液量にもよるが、デッドボリュームが大きくならないように設計するのことが望ましい。 Depending on the fluid volume requiring the measurement, it is desirable to design so that dead volume is not increased. 具体的には、断面形状としては管状、V字状溝、長方形状溝などがあげられるが、デッドボリュームから考えると薄型の長方形状溝であることが望ましい。 Specifically, the cross-sectional shape tubular, V-shaped grooves, but such a rectangular groove and the like, considering the dead volume is preferably a rectangular groove thin. 溝の深さは、 The depth of the groove,
0.05〜0.5mm程度、幅は、0.5〜3mm程度が望ましい。 About 0.05~0.5mm, width, about 0.5~3mm is desirable. 長さは、なるべく短い方が望ましく、12m Length is as short as possible is desirable, 12m
m〜15mm程度が適当であるが、この限りではない。 About m~15mm it is appropriate, but not limited thereto.

【0021】流路部3に用いる材質はハウジング2と同様のもので構わないが、アクリル樹脂等の親水性の高い材料を用いるか、もしくは表面を親水性にすることで吸引力を高めることが望ましい。 The material used for the flow path unit 3 may at the same as the housing 2, but is possible to increase the suction force by either using a highly hydrophilic such as an acrylic resin material, or the surface hydrophilic desirable. 親水性にする手段としては、オゾン処理、プラズマ処理、グロー放電、コロナ放電、紫外線照射等の物理活性化処理や、界面活性剤、水溶性シリコン、ヒドロキシプロピルセルロース、ポリエチレングリコール、ポリプロピレングリコール等の塗布等により行うことも出来る。 As a means for the hydrophilic, ozone treatment, plasma treatment, glow discharge, corona discharge, physical activation treatment or ultraviolet irradiation or the like, a surfactant, a water-soluble silicon, hydroxypropyl cellulose, polyethylene glycol, coating and polypropylene glycol It can also be carried out by, or the like. また、流路部3は、射出成形によりハウジング2と一体成形、またはハウジング2 Further, the flow path unit 3, integrally formed with the housing 2 by injection molding, or the housing 2
を切り欠き加工やプレス加工する事によりハウジング2 Housing 2 By notching or pressing a
と一体的に設けられるものでも、管状体や溝部材を固定して得れれるものであっても良い。 And also those provided integrally, or may be be obtained by fixing the tubular body and the groove member.

【0022】また、体液を流路部3を介して吸入口4から試験紙6まで導入させるときに、密閉系では毛細管現象が途中で止まってしまうことも考えられる。 Further, when to introduce fluid from the inlet port 4 via the flow path portion 3 to the test paper 6, it is conceivable to capillary action would stop on the way in a closed system. そのため空気抜けを設けることが望ましく、具体的には試験紙6 Therefore it is desirable to provide a deflation, in particular test paper 6
をハウジング2に固定するときに、図4のように、その中心に流路部3の試験紙側端部、その周囲に凹溝状の空気抜け部9を有し、試験紙6を直に接した場合に空気抜け部9により空気抜けを確保する試験紙中心固定台10 The when secured to the housing 2, as shown in FIG. 4, the test paper side end portion of the flow path portion 3 at its center, has a groove-shaped air escape portion 9 around its periphery, the test paper 6 directly test paper central fixed base 10 to secure deflation by deflation unit 9 when in contact
A、または試験紙6を接着剤及び融着によって部分的にハウジング2に固定するようために試験紙周囲固定台1 A or test paper around the fixing base 1 in order to partially fixed to the housing 2 of the test paper 6 by an adhesive, and fusion bonding,
0Bを設け、ハウジング2と試験紙6の間に空間を形成し、すなわち流路部3の試験紙側端と試験紙6を直に接しないこととして空気の抜け確保する方法があげられる。 The 0B provided, a space is formed between the housing 2 and the test paper 6, that is a method of deflated secured as to not directly contact with test paper 6 with test paper side end of the flow path portion 3 and the like. この時の空間の段差は、0.01〜0.3mm程度が好ましい。 Step space at this time, about 0.01~0.3mm are preferred.

【0023】体液導入ガイド5は、体液が接触すると吸入口4まで体液を導く機能を有するものである。 The fluid introduction guide 5 has a function of guiding the body fluid to the suction port 4 body fluid contact. 材質的には、ハウジング2や流路部3と同様で構わないが、流路部3と同様に親水性の高い材料を用いるか、もしくは表面を親水性に処理ことが望ましい。 As the material, although it may be the same as that of the housing 2 and the flow path unit 3, or a material that is highly hydrophilic in the same manner as the flow path unit 3, or the process is desirably hydrophilic surface. 形状的には、一度吸入口4まで導いた体液が開口部7周囲の表面張力によって開口部7の周囲の広がり、流路部3の体液の吸引力の低下することや、開口部7周囲と表皮の間の毛細管現象によって体液が漏れ出ることを防ぐため、体液が吸入口4周辺から流出しない構造が良い。 The shape, the spread of the periphery of the opening 7 body fluid led once to the suction opening 4 by the surface tension of the peripheral openings 7, to decrease the suction force of the body fluid of the flow path portion 3 and an opening 7 around to prevent the body fluid from leaking due to the capillary phenomenon between the epidermis, the structure body fluid does not escape around the suction port 4 is good.

【0024】具体的には、吸入口4の周囲から2本の突出したガイド51a,51bを設けたものがあげられる。 [0024] Specifically, two protruding guides 51a from the periphery of the suction port 4, those provided 51b thereof. ガイド51a,51bの間の幅および高さは、吸入口4の高さおよび幅とほぼ同じ程度が望ましい。 Guide 51a, the width and height between 51b is about the same extent as the height and width of the suction opening 4 is desirable. なお、 It should be noted that,
体液導入ガイド5の他の形状としては、吸入口4の周囲全てを覆うもの筒状や、3本あるいは4本の突出したガイドからなるものがあげられる。 Other shapes of the fluid introduction guide 5, tubular and for covering all around the inlet 4 include those comprising three or four protruding guide.

【0025】また、体液導入ガイド5をガイド51a, [0025] In addition, the body fluid introduction guide 5 of the guide 51a,
51bのような突起とする場合、図3のように、体液導入ガイド5内を吸入口側を狭め体液を点着させる側を広くする、すなわち吸入口4から開口部7の中心に向かって裾広がりにすることにより、体液導入ガイド5内の表面張力を流路部3内の表面張力よりも小さくすることができる。 If the projections, such as 51b, as shown in FIG. 3, to widen the side to the fluid introduction guide 5 is spotted narrowing bodily fluid inlet side, i.e. towards the center of the opening 7 from the inlet port 4 hem by spread, the surface tension of the fluid introduction guide 5 can be made smaller than the surface tension in the flow path portion 3. そのため、全ての体液がスムーズに流路部3に供給され、かつ体液導入ガイド5でのデッドボリュームは考慮しなくても良い、すなわち少量の体液でも測定検出部ないし試験紙6に十分に体液を供給できるため、操作者の負担を大きくすることはない。 Therefore, all the fluid is smoothly supplied to the flow path portion 3, and the dead volume of the body fluid introduction guide 5 may not be considered, i.e. a sufficiently fluid to the measuring detector to test paper 6 even with a small amount of body fluid since it is possible to supply, it is not to increase the burden on the operator.

【0026】体液導入ガイド5の内部の大きさは、具体的に、幅は1〜3mm程度、高さは0.5〜3mm程度、長さ(吸入口より突出している距離)は1〜3mm The size of the interior of the fluid introduction guide 5, specifically, the width is about 1 to 3 mm, height about 0.5 to 3 mm, a length (distance protrudes from the suction port) is 1 to 3 mm
程度であることがあげられる。 And the like to be a degree. これは、4μl程度(穿刺後表皮に表われる体液量)の体液を採取したとき、その大きさが約3mm径程度の滴になるため、それと同等の大きさとすることで体液導入ガイド5の機能が発揮できるためである。 Which, when taken body fluid of about 4 [mu] l (fluid volume appearing in the puncture after the skin), for its size becomes droplets of approximately 3mm diameter of about therewith function of fluid introduction guide 5 by a comparable size There is because that can be exhibited.

【0027】体液成分測定装置1が穿刺手段を有するものである場合、穿刺針が開口部7内の体液導入ガイド5 [0027] When the body fluid component measuring apparatus 1 is one that has a piercing means, fluid introduction guide 5 of the puncture needle in the opening 7
先端部付近、もしくは体液導入ガイド5がガイド51 Near tip or fluid introduction guide 5 guides 51,
a,51bのように複数の突起からなる場合にはその間を通過し、表皮を穿刺することになる。 a, then passing therebetween when comprising a plurality of projections as 51b, so that puncturing the skin. そして、穿刺した部位から流出した体液が必要量の滴状になると体液導入ガイド5に接触し、吸入口4から流路部3を通り試験紙6に導かれる。 When the body fluid flowing out from the punctured site is needed amount of dropwise into contact with the body fluid introduction guide 5 is guided to the flow path unit 3 as test paper 6 from the intake port 4. 開口部7内の穿刺針の通る位置としては、必要体液量から考えて遠くても体液導入ガイド先端部から3mm程度が望ましく、より望ましくは先端から1mm以内もしくは体液導入ガイド内部である。 The position through which a puncture needle in the opening 7, is preferably about 3mm from the body fluid introduction guide tip be far considered a necessary fluid volume, more desirably internal within or fluid introduction guide 1mm from the tip.

【0028】試験紙6は、例えば血液中のグルコースを測定する場合は、試薬としてグルコースオキシダーゼとペルオキシダーゼ及び呈色試薬を試験紙に含浸させ乾燥させたものがあげられる。 The test paper 6, for example when measuring the glucose in the blood, which glucose oxidase and peroxidase and a coloring reagent dried impregnated with test paper as reagents. 試験紙としては、多孔性の膜が望ましく、形態としては不織布、織布、延伸処理したシートなどがあげられる。 The test paper, porous membrane is preferably, as the form a nonwoven fabric, a woven fabric, such as stretched sheets and the like. 材質としては、ポリエステル類、ポリアミド類、ポリオレフィン類、ポリスルホン類、またはセルロース類等があげられる。 The material, polyesters, polyamides, polyolefins, polysulfones, or cellulose and the like. また、試薬を含浸させたり、体液をしみ込ませるので、親水性の材料または親水処理したものが望ましい。 Also, or impregnated with reagents, so impregnated with bodily fluids, it is desirable that the material or hydrophilic treatment hydrophilic. さらに、試験紙6 Furthermore, the test paper 6
は単層のフイルムでも多層構造物でも構わない。 It may be a multi-layer structure is also a single layer of the film is.

【0029】次に、体液成分測定装置1の使用状態を示す図5、図6、図7、図8を参照にしながら、体液成分測定装置1の使用例を説明する。 Next, FIG. 5 showing a usage state of a body fluid component measuring apparatus 1, 6, 7, with reference to FIG. 8, an example use of the body fluid component measuring apparatus 1. 図5に示すように、ハウジング2は装置本体ハウジング15に分離可能に接合し、その接合部にはOリング等のシール部材14が気密性を保つため設けられている。 As shown in FIG. 5, the housing 2 device separably joined to the body housing 15, at its joint seal member 14 such as an O-ring is provided to keep the airtightness. 測定検出部は、試験紙6 Measuring detector, test paper 6
と、その上方に設けられる光源11と、光源11から発せられ験紙部6から反射してくる光を捉える受光素子1 When the light receiving element 1 regarded as a light source 11 provided thereabove, the light reflected from the test paper 6 emitted from the light source 11
2とから構成され、試験紙6の呈色度合いを測定して得られた光学的データから、図示しない演算手段や換算手段によって血糖値等に得る構造となっている。 Is composed of two Prefecture, coloration degree of the test strip 6 from the optical data obtained by measurement has a structure to obtain the blood sugar level or the like by the calculation means and conversion means (not shown).

【0030】操作者が穿刺手段を操作することにより、 [0030] By the operator to manipulate the puncture means,
図6のように穿刺針13が皮膚16を穿刺する。 Puncture needle 13 as shown in FIG. 6 to puncture the skin 16. なお、 It should be noted that,
穿刺針13は開口部7内の体液導入ガイド5の先端部分で体液導入ガイド5を構成するガイド51a,51bの中間点を通過する。 Puncture needle 13 is the guide 51a constituting the body fluid introduction guide 5 at the distal end portion of the fluid introduction guide 5 in the opening 7, it passes through the midpoint of 51b. その後、表皮16の穿刺位置から流出した体液17が滴状に大きくなり体液導入ガイド5に接触する。 Thereafter, the body fluid 17 flowing out from the puncture position of the skin 16 is in contact with the body fluid introduction guide 5 becomes greater dropwise. その時の状態を、縦断を示す図7、および体液成分測定装置1の一部分を横方向に切断し、そこから開口部7方向を見た横断面図、横方向に切断し、そこから開口部7方向を見た横体液成分測定装置1の一部分を断面を示す図8に示す。 The state at that time, FIG. 7 shows a longitudinal and a portion of the body fluid component measuring apparatus 1 is cut transversely, cross-sectional view of the opening 7 direction therefrom, and cut transversely, opening 7 from which a portion of the lateral body fluid component measuring apparatus 1 viewed direction shown in FIG. 8 showing a cross-section. 操作者によっては、体液の流出量が少ない事も考えられるため、体液成分測定装置1に補助的に吸引手段を設け、穿刺後又は穿刺と同時に表皮を吸引しうっ血させ、必要な体液量を確保しても良い。 By the operator, since it is also contemplated that the outflow amount of fluid is small, the body fluid component measuring apparatus 1 adjunctively provided a suction device, after puncturing or puncture and allowed simultaneously epidermis was aspirated congestion, ensuring fluid volume required it may be.
また、吸引手段は穿刺前に表皮を吸引し、盛り上がった表皮部分を穿刺するものであっても良い。 The suction means sucks the skin before puncture, it may be configured to puncture the raised skin portion.

【0031】なお、吸引する際に、ハウジング2の表皮16と接している部分が多いと、表皮16を押し付ける圧力が分散し、開口部7と皮膚16との密着性が悪くなり開口部7周辺の気密性を保てなくなるおそれがあるため、ハウジング2の構造を開口部7付近が突出した構造、すなわち開口部7を表皮16に押し当てた際に表皮16に対して角度を持ったテーパー構造、あるいは開口部付近が突出している構造であることが望ましい。 [0031] At the time of suction, the many portions in contact with the skin 16 of the housing 2, a pressure to press the skin 16 are dispersed, the adhesion is poor becomes opening 7 around the opening 7 and the skin 16 for airtightness may become not be maintained, tapered structures having an angle structure the structure of the housing 2 near the opening 7 is protruded, namely the opening 7 against the skin 16 when pressed against the skin 16 , or it is desirable near the opening has a structure that protrudes. これらの吸引手段とテーパー構造、あるいは開口部付近が突出している構造によって、測定に最小限に必要な量の体液を採取することができる。 These suction means and the tapered structure or by a structure near the opening portion projects, can be taken the amount of fluid required to minimize the measurement.

【0032】表皮16に流出した体液17は、ガイド5 The body fluid 17 that has flowed into the epidermis 16, the guide 5
1a,51bの間の表面張力によって体液導入ガイド5 1a, fluid introduced guide 5 by the surface tension between the 51b
内に流入し保持され、吸入口4を介して更に表面張力の大きい流路部に流入して試験紙6に導かれる。 Inflow is held within and is guided to the test paper 6 and flows further to the large flow path portion of the surface tension via the inlet 4.

【0033】なお、本発明においては、図2に示す部分、すなわち、ハウジング2と、ハウジング2内に設けられた体液中の成分を測定する測定検出部、体液を測定検出部まで導入する流路部3、および体液を流路部3内に導くために設けられた吸入口4とからなり、吸入口4 [0033] In the present invention, the portion shown in FIG. 2, i.e., the housing 2, the measurement detector for measuring a component in a body fluid provided in the housing 2, the flow path for introducing a fluid to the measuring detector part 3, and becomes fluid from the flow path portion 3 in the suction opening 4 is provided to guide the Prefecture, inlet 4
の周囲には体液を吸入口4まで導くための体液導入ガイド部5が設けられている部分が、体液収納容器として着脱自在に設けられるものであってもよい。 Portion around the the fluid introduction guide portion 5 for guiding the fluid to the suction port 4 is provided with, or may be removably mounted as a fluid container. この時、測定検出部には、少なくてもその構成の一部分、例えば試験紙6があれば良い。 In this case, the measurement detector, fewer or portion of the structure, for example if there is test paper 6.

【0034】 [0034]

【発明の効果】本発明の体液成分測定装置は、表皮から流出した測定に必要な最小限の量の血液等の体液を、体液導入ガイド内にその表面張力によってすばやく導き、 Body fluid component measuring apparatus of the present invention exhibits, a body fluid such as blood minimum amount required for measurement flowing out from skin is guided quickly by its surface tension in the body fluid introduction guide,
その後すぐに体液ガイド内より大きい表面張力を有する流路部に導き、その毛細管現象によって試験紙ないし測定検出部にまで導くことができる。 Then guided to the flow path portion having a larger surface tension than the fluid in the guide immediately, can be guided to the test paper to measurement detector by its capillary action. つまり、測定に必要な最小限の量の血液等の体液であっても、迅速かつ的確に測定を行える体液成分測定装置である。 That is, even the body fluid such as blood minimum amount necessary for the measurement, a body fluid component measuring apparatus capable of performing rapid and accurate measurement.

【0035】また、本発明の体液成分測定装置は、測定に必要な量以上の過剰な血液等の体液が流出した場合にも、過剰量を体液導入ガイド内に保持するため、開口部周縁と表皮との間の表面張力によって過剰量がハウジング外へ流出することを防ぐことができる。 Further, the body fluid component measuring apparatus of the present invention, even when the body fluid such as an amount or excess blood flows out necessary measurements, to hold the excess amount of body fluid introduction guide, and the opening portion peripheral edge excess surface tension between the skin can be prevented from flowing out to the outside of the housing. つまり、衛生的にも優れた状態で測定を行える体液成分測定装置である。 That is, a body fluid component measuring apparatus capable of measuring in a state of excellent hygienic.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】図1は、体液成分測定装置1の一部分を横方向に切断し、そこから開口部7方向を見た横断面図である。 Figure 1 is a portion of the body fluid component measuring apparatus 1 is cut transversely is a transverse sectional view of the opening 7 direction therefrom.

【図2】図2は、図1と同じ開口部7付近の体液成分測定装置1の縦断面図である。 Figure 2 is a longitudinal sectional view of a body fluid component measuring apparatus 1 in the vicinity of the same opening 7 and FIG.

【図3】図3は、別形態の体液成分測定装置1の図1と同様の横断面図である。 Figure 3 is a similar cross sectional view as Figure 1 of a body fluid component measuring apparatus 1 of another embodiment.

【図4】図4は、体液成分測定装置1の試験紙未設置状態の試験紙を設置する箇所の平面図である。 Figure 4 is a plan view of a portion of installing the test paper test paper uninstalled state of the body fluid component measuring apparatus 1.

【図5】図5は、体液成分測定装置1の使用状態を示す縦断面図である。 Figure 5 is a longitudinal sectional view showing a usage state of a body fluid component measuring apparatus 1.

【図6】図6は、体液成分測定装置1の使用状態を示す縦断面図である。 Figure 6 is a longitudinal sectional view showing a usage state of a body fluid component measuring apparatus 1.

【図7】図7は、体液成分測定装置1の使用状態を示す縦断面図である。 Figure 7 is a longitudinal sectional view showing a usage state of a body fluid component measuring apparatus 1.

【図8】図8は、図7の状態の体液成分測定装置1の一部分を横方向に切断し、そこから開口部7方向を見た横断面図である。 Figure 8 is cut a portion of the body fluid component measuring apparatus 1 in the state of FIG. 7 in the lateral direction, a cross-sectional view of the opening 7 direction therefrom.

【符号の説明】 DESCRIPTION OF SYMBOLS

1 体液成分測定装置 2 ハウジング 3 流路部 4 吸入口 5 体液導入ガイド 51a,51b ガイド 6 試験紙 7 開口部 8 ハウジング裏面 9 空気抜け部 10A 試験紙中心固定台 10B 試験紙周囲固定台 11 光源 12 受光素子 13 穿刺針 14 シール部材 15 装置本体ハウジング 16 表皮 17 体液 1 body fluid component measuring apparatus 2 housing 3 channel portion 4 inlet 5 fluid introduction guide 51a, 51b guide 6 test paper 7 opening 8 housing back surface 9 deflation portion 10A test paper around the fixing base 10B test paper around the fixing base 11 the light source 12 receiving element 13 puncture needle 14 sealing member 15 device main body housing 16 skin 17 body fluid

Claims (12)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構が一体となった装置において、 ハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために設けられた吸入口とからなり、 前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている体液成分測定装置。 A collecting mechanism for collecting body fluid from 1. A skin, in the apparatus measuring mechanism are integrated to measure the components of the body fluid, measuring a housing and a component of the body fluid provided in said housing measuring detector, the flow path portion introducing said body fluid to said measuring detector, and makes the fluid from the suction port provided to direct the flow path portion, the said body fluid around the inlet body fluid component measuring apparatus body fluid introduction guide portion is provided for guiding to the suction port.
  2. 【請求項2】表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構が一体となった装置において、 少なくとも一つの開口部を有するハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために前記開口部の周囲に設けられた吸入口とからなり、 前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている請求項1に記載の体液成分測定装置。 2. A collecting mechanism for collecting body fluid from the skin, the device measuring mechanism are integrated to measure the components of the body fluid, a housing having at least one opening, wherein provided in the housing measuring detector for measuring components in body fluid, the flow path portion introducing said body fluid to said measuring detector, and the fluid from the suction port provided on the periphery of the opening to direct the flow path portion becomes, the body fluid component measuring apparatus according to claim 1, the body fluid introduction guide portion for guiding said body fluid to said inlet port is provided around the inlet.
  3. 【請求項3】前記体液導入ガイド部が、前記吸入口の周囲に設けられた二以上の突起である請求項1乃至2に記載の体液成分測定装置。 Wherein the fluid introduction guide portion, said inlet body fluid component measuring apparatus according to claim 1 or 2 which is two or more projections provided around the.
  4. 【請求項4】前記流路部が、毛細管現象より体液を測定検出部まで導入する請求項1乃至3に記載の体液成分測定装置。 Wherein said flow path unit, the body fluid component measuring apparatus according to claim 1 to 3 for introducing a fluid to the measuring detector than the capillary phenomenon.
  5. 【請求項5】前記体液導入ガイド部内の表面張力が、前記流路部内の表面張力よりも小さい請求項1乃至4に記載の体液成分測定装置。 The surface tension of wherein in said fluid introduction guide portion, the body fluid component measuring apparatus according to a small claims 1-4 than the surface tension of the channel portion.
  6. 【請求項6】前記体液導入ガイド部内が、前記吸入口から離れるに従い裾広がりになっている請求項1乃至5に記載の体液成分測定装置。 Wherein the body fluid introduction guide portion, the body fluid component measuring apparatus according to claim 1 to 5 has a flared increasing distance from the suction port.
  7. 【請求項7】前記開口部から穿刺針が突出する穿刺手段を有する請求項2乃至6に記載の体液成分測定装置。 7. A body fluid component measuring apparatus according to claims 2 to 6 having a piercing means piercing needle from the opening projects.
  8. 【請求項8】前記ハウジング内を減圧とし、前記開口部から前記表皮の一部または前記体液を吸引する吸引手段を有する請求項2乃至7に記載の体液成分測定装置。 8. The in said housing and vacuum body fluid component measuring apparatus according to claim 2 to 7 having a suction means for sucking a part or the body fluid of the skin from the opening.
  9. 【請求項9】前記ハウジングは、一部が突出しており、 Wherein said housing has a part protruding,
    その突出した先端に前記開口部を有する請求項2乃至8 Claims 2 to 8 with the opening to the protruding tip
    に記載の体液成分測定装置。 Body fluid component measuring apparatus according to.
  10. 【請求項10】前記ハウジングは、前記表皮から前記体液を採取するため前記開口部を前記表皮に押し当てた際に、前記表皮に対して角度を持ったテーパー構造を有する請求項1乃至9に記載の体液成分測定装置。 Wherein said housing, said opening for collecting the body fluid from the skin when pressed against the skin, to claims 1 to 9 having a tapered structure having an angle relative to the skin body fluid component measuring apparatus according.
  11. 【請求項11】前記穿刺針が前記開口部から突出する際、前記体液導入ガイドを通過する請求項2乃至10に記載の体液成分測定装置。 11. When the puncture needle protrudes from the opening, the body fluid component measuring apparatus according to claims 2 to 10 passes through the fluid introduction guide.
  12. 【請求項12】表皮から体液を採取する採取機構と、前記体液の成分を測定する測定機構とを有する体液成分測定装置に着脱可能に設けられ、 ハウジングと、前記ハウジング内に設けられた前記体液中の成分を測定する測定検出部、前記体液を前記測定検出部まで導入する流路部、および前記体液を前記流路部内に導くために設けられた吸入口とからなり、 前記吸入口の周囲には前記体液を前記吸入口まで導くための体液導入ガイド部が設けられている体液収納容器。 12. A collecting mechanism for collecting body fluid from the skin, provided detachably on the body fluid component measuring apparatus and a measurement mechanism for measuring a component of body fluid, the housing and the body fluid provided in said housing measuring detector for measuring the components in the flow path portion introducing said body fluid to said measuring detector, and makes the fluid from the suction port provided to direct the flow path portion, the periphery of the suction port fluid container body fluid introduction guide portion for guiding said body fluid to said inlet port is provided in the.
JP06390599A 1999-03-10 1999-03-10 Body fluid component measuring apparatus Expired - Lifetime JP3659832B2 (en)

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Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP06390599A JP3659832B2 (en) 1999-03-10 1999-03-10 Body fluid component measuring apparatus
DE69939598A DE69939598D1 (en) 1999-01-04 1999-12-27 Landzettenanordnung for removing and evidence of body fluids
PCT/JP1999/007325 WO2000040150A1 (en) 1999-01-04 1999-12-27 Assembly having lancet and means for collecting and detecting body fluid
AT99961409T AT408372T (en) 1999-01-04 1999-12-27 Landzettenanordnung for removing and evidence of body fluids
EP99961409A EP1139873B1 (en) 1999-01-04 1999-12-27 Body fluid collecting and detecting lancet assembly
CNB2004101019923A CN1315432C (en) 1999-01-04 1999-12-27 Body fluid collecting and detecting device
CNB998164232A CN1191786C (en) 1999-01-04 1999-12-27 Assembly having lancet and means for collecting and detecting boby fluid
US09/475,125 US6315738B1 (en) 1999-01-04 1999-12-30 Assembly having lancet and means for collecting and detecting body fluid

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WO2003026506A1 (en) * 2001-09-19 2003-04-03 Terumo Kabushiki Kaisha Apparatus for measuring component and chip
WO2004004566A1 (en) * 2002-07-02 2004-01-15 Arkray, Inc. Method of setting piercing member in piercing device, piercing device, and cam mechanism
WO2004110275A1 (en) * 2003-06-12 2004-12-23 Matsushita Electric Industrial Co., Ltd. Device and method of measuring living-body information
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US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
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WO2003026506A1 (en) * 2001-09-19 2003-04-03 Terumo Kabushiki Kaisha Apparatus for measuring component and chip
JP2005525149A (en) * 2002-02-08 2005-08-25 ローズデイル メディカル インコーポレイテッド Autonomous portable analyte monitoring device or drug delivery device
US7879057B2 (en) 2002-07-02 2011-02-01 Arkray, Inc. Method of setting lancing member to lancing device, lancing device and cam mechanism
WO2004004566A1 (en) * 2002-07-02 2004-01-15 Arkray, Inc. Method of setting piercing member in piercing device, piercing device, and cam mechanism
US9095292B2 (en) 2003-03-24 2015-08-04 Intuity Medical, Inc. Analyte concentration detection devices and methods
WO2004110275A1 (en) * 2003-06-12 2004-12-23 Matsushita Electric Industrial Co., Ltd. Device and method of measuring living-body information
US9366636B2 (en) 2005-06-13 2016-06-14 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US10226208B2 (en) 2005-06-13 2019-03-12 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit/volume correction and feedback control
US8969097B2 (en) 2005-06-13 2015-03-03 Intuity Medical, Inc. Analyte detection devices and methods with hematocrit-volume correction and feedback control
US9839384B2 (en) 2005-09-30 2017-12-12 Intuity Medical, Inc. Body fluid sampling arrangements
US8801631B2 (en) 2005-09-30 2014-08-12 Intuity Medical, Inc. Devices and methods for facilitating fluid transport
US8795201B2 (en) 2005-09-30 2014-08-05 Intuity Medical, Inc. Catalysts for body fluid sample extraction
US8382681B2 (en) 2005-09-30 2013-02-26 Intuity Medical, Inc. Fully integrated wearable or handheld monitor
US8360993B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Method for body fluid sample extraction
US8360994B2 (en) 2005-09-30 2013-01-29 Intuity Medical, Inc. Arrangement for body fluid sample extraction
US9380974B2 (en) 2005-09-30 2016-07-05 Intuity Medical, Inc. Multi-site body fluid sampling and analysis cartridge
US9060723B2 (en) 2005-09-30 2015-06-23 Intuity Medical, Inc. Body fluid sampling arrangements
US9833183B2 (en) 2008-05-30 2017-12-05 Intuity Medical, Inc. Body fluid sampling device—sampling site interface
US9636051B2 (en) 2008-06-06 2017-05-02 Intuity Medical, Inc. Detection meter and mode of operation
US10383556B2 (en) 2009-06-08 2019-08-20 Intuity Medical, Inc. Medical diagnostic devices and methods
US9897610B2 (en) 2009-11-30 2018-02-20 Intuity Medical, Inc. Calibration material delivery devices and methods
US8919605B2 (en) 2009-11-30 2014-12-30 Intuity Medical, Inc. Calibration material delivery devices and methods
US10330667B2 (en) 2010-06-25 2019-06-25 Intuity Medical, Inc. Analyte monitoring methods and systems
US9782114B2 (en) 2011-08-03 2017-10-10 Intuity Medical, Inc. Devices and methods for body fluid sampling and analysis

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