JP2000245831A - Material for removal or detoxication of myoglobin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To detoxicate or remove quickly the toxin activity of myoglobins by using a material containing one chemical structure selected from a urea bond, a thiourea bond and an amide bond for a drug that remove the toxin activity of myoglobin existing in a high concentration protein solution such as blood or the like. SOLUTION: A matter useful for detoxication or removal of myoglobins that escape easily from cells and flow into blood due to the melting and necrosis of myocytes due mainly to the compression of an external force is prepared from one containing at least one selected from a urea bond, thiourea bond and an amide bond. As a substituent that bonds with at least one kind selected from among the urea bond, thiourea bond and amide bond, a structure having a functional group that can form a hydrogen bond such as an amino group, hydroxy group, carboxy group or the like is used preferentially, and as a structure having an amino group for example, a compound (polyamine) having a plurality of amino groups such as aminohexane, monomethylaminohexane or the like is used.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to a material for eliminating (detoxifying) or removing myoglobin toxin activity. In particular, it is suitably used as a purification column for removing myoglobin as a drug that removes (detoxifies) myoglobin's toxin activity by binding to myoglobin present in a high-concentration protein solution such as in blood.

[0002]

2. Description of the Related Art Myoglobin easily escapes outside cells due to thawing and necrosis of muscle cells mainly due to compression of external force, and flows out into the blood. Myoglobin is a heme protein consisting of 153 amino acid bases that has the function of transporting oxygen into muscle tissue. It has a stronger affinity for oxygen than hemoglobin, and is responsible for supplying and storing oxygen to muscle tissue. In the blood, some of them bind to α2 globulin, but the binding is weak, and most of them are free. Attention has been paid to the mechanism of organ damage caused by this myoglobin. Acute renal failure due to nephrotoxic myoglobin can be nontraumatic as well as traumatic. Traumatic include crush syndrome and ischemia, and non-traumatic includes muscular diseases, drugs, infectious diseases and inflammatory diseases. There is a demand for a technique for removing myoglobin from the blood, and it is now believed that plasma exchange and hemofiltration are effective. However, there is a problem that useful components in blood such as albumin, complement components, and blood coagulation proteins are discarded together with myoglobin. Therefore, as an adsorbent for specifically removing myoglobin without removing useful components in blood, a myoglobin adsorbent made of a water-insoluble porous material having a carbonized surface (Japanese Patent Application Laid-Open No. 63-283747).
Have been reported. However, a water-insoluble porous body having a carbonized surface like activated carbon adsorbs myoglobin at a high rate, but has a problem that it adsorbs a drug or the like under treatment. Also, a myoglobin adsorbent comprising a water-insoluble porous material having a contact angle of 20 degrees or more (Japanese Patent Application Laid-Open No. 63-28374).
8) reports that the porous body having a contact angle of 20 ° or more is hydrophobic and has excellent specificity. However, the higher the hydrophobicity is, the lower the specificity is, and there is a possibility of adsorbing useful components such as lipids and drugs in blood. You.
Here, an adsorbent having a structure that specifically adsorbs myoglobin and is relatively difficult to remove useful components or drugs in blood is desired.

[0003]

DISCLOSURE OF THE INVENTION The present invention is intended to solve these disadvantages of the prior art, and can rapidly lose the myoglobin toxin activity (detoxification) even in a solution having a high protein concentration such as blood. It is intended to provide a material that can be removed.

[0004]

Means for Solving the Problems As a result of intensive studies, the present inventors have found that a material containing at least one chemical structure selected from a urea bond, a thiourea bond and an amide bond has affinity for myoglobin, The present invention has been reached. That is, the first invention of the present invention is a material for removing or detoxifying myoglobin, which has at least one selected from a urea bond, a thiourea bond and an amide bond. A second aspect of the present invention is a body fluid purification column using the above-described material.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION In the present invention, it preferably has at least one selected from a urea bond, a thiourea bond and an amide bond, and more preferably a group capable of further hydrophobic interaction (hydrophobic interaction). Group) is used. There is no particular limitation on the substituent bonded to at least one selected from a urea bond, a thiourea bond and an amide bond, and propane, hexane, octane,
Aliphatic compounds such as dodecane and cyclohexane, and cycloaliphatic compounds such as cyclopentane can be used, but considering the high affinity, benzene, naphthalene,
Aromatic compounds such as anthracene are more preferably used. Derivatives such as bromoheptane, chlorocyclohexane, methylbenzene, chlorobenzene, nitrobenzene, diphenylmethane, and chloronaphthalene are also suitably used. Further, as a structure following the urea bond, thiourea bond and amide bond, for example, a structure further having a functional group capable of forming a hydrogen bond such as an amino group, a hydroxyl group or a carboxyl group is preferably used. For example, as a structure having an amino group, aminohexane, monomethylaminohexane,
Dimethylaminohexane, aminooctane, aminododecane, aminodiphenylmethane, 1- (3-aminopropyl) imidazole, 3-amino-1-propene, aminopyridine, aminobenzenesulfonic acid, tris (2-
Aminoethyl) amine and the like, and more preferably, diaminoethane, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, dipropylenetriamine, polyethyleneimine, N′-methyl-2,2′diaminodiethylamine, N-acetylethylenediamine,
A compound having a plurality of amino groups (sometimes referred to as polyamine) such as 1,2-bis (2-aminoethoxyethane) is used. The structure having a hydroxyl group includes hydroxypropane, 2-ethanolamine, 1,
3-diamino-2-hydroxypropane, hydroxybutanone, hydroxybutyric acid, hydroxypyridine, etc., glucose, glucosamine, galactosamine, maltose, cellobiose, sucrose, agarose, cellulose, chitin, chitosan and other monosaccharides, oligosaccharides, polysaccharides and other sugars Quality or their derivatives can be used. Further, as the structure having a carboxyl group, for example, β-alanine, n-caproic acid, isobutyric acid, γ-amino-β-hydroxybutyric acid, and the like can be used. Most preferably,
The material of the present invention can have both an aromatic compound and a compound capable of forming a hydrogen bond as a structure following a urea, thiourea or amide group.

[0006] However, some antibiotics and components in blood may have an affinity for a material having a urea bond, a thiourea bond and an amide bond, and the removal of such a substance can be reduced as much as possible. It is preferable to reduce the number of urea bonds, thiourea bonds, or amide bonds of the material and to introduce a functional group having an affinity with other functional groups. As a material having an affinity other than the urea bond, thiourea bond and amide bond, a group capable of hydrophobic interaction is preferably used, and among them, a hydrocarbon group having 4 or more carbon atoms is preferably used. Specifically, it is preferable to introduce a saturated or unsaturated hydrocarbon compound such as a butyl group, a hexyl group, an octyl group, a dodecyl group, a cyclohexyl group, a benzyl group, a 3,3 diphenylpropyl group, and the like.

Further, polyurea, polythiourea and polyamide having plural urea bonds, thiourea bonds and amide bonds in the molecular structure can be used as the material of the present invention. In this case, any of the above structures can be used as a structure following the urea bond, thiourea bond, or amide bond. Most preferably, a compound having a hydroxyl group, an amino group, or a carboxyl group (a saccharide or a derivative thereof) And the aromatic compound can be used.

Further, the material of the present invention may be any of a monomer, an oligomer and a polymer. Therefore, the material of the present invention includes those in which the above structure or a part thereof is polymerized. That is, as the above structure or a part thereof, synthetic polymers such as nylon, polymethyl methacrylate, polysulfone, polystyrene, polyethylene, polyvinyl alcohol, and polytetrafluoroethylene, and natural materials containing cellulose, collagen, chitin, chitosan, and derivatives thereof. A polymer or the like is preferably used. That is,
It is preferable to introduce a group capable of forming a hydrogen bond into such a homopolymerized, copolymerized or blended synthetic polymer or natural polymer. Further, a material obtained by coating an inorganic material such as metal, ceramics, and glass with a suitable polymer is also preferably used. In the present invention, it is preferable to use a support for fixing the material of the present invention as a carrier,
As the carrier, for example, the above-mentioned synthetic polymer or natural polymer is preferable.

The material of the present invention can be synthesized by a generally known method. For example, when a urea bond or a thiourea bond is introduced into an aliphatic compound or an aromatic compound, a method of reacting an isocyanate compound or an isothiocyanate compound with an amino compound can be used. When an amide group is introduced into an aliphatic compound or an aromatic compound, for example, a method of reacting an acid, an acid chloride or an acid anhydride with an amino compound can be used. The mixing ratio of the amino compound and the isocyanate compound, the isothiocyanate compound, the acid, the acid chloride or the acid anhydride can be arbitrarily selected, and is usually 1 mol per 1 mol of the isocyanate compound, the isothiocyanate compound, the acid, the acid chloride or the acid anhydride. 0.1 to 10 mol of the amino compound is preferably used. As the isocyanate compound or isothiocyanate compound, for example, ethyl isocyanate, stearyl isocyanate, n-butyl isocyanate, iso-butyl isocyanate, n-propyl isocyanate, methyl isothiocyanate, ethyl isothiocyanate, n-butyl isothiocyanate, benzyl isothiocyanate, hexyl isocyanate Any of aliphatic isocyanate compounds such as methylene diisocyanate, cyclohexyl isocyanate, cyclohexyl isothiocyanate, and cyclohexyl diisocyanate or isothiocyanate compounds can be used, but phenyl isocyanate, chlorophenyl isocyanate, fluorophenyl isocyanate, bromophenyl isocyanate, bromophenyl isocyanate, Isocyanate, tolyl isocyanate, methoxyphenyl isocyanate, 1-naphthyl isocyanate, 4,4'diphenylmethane diisocyanate, 3,3 ', 5,5'tetraethyl 4,4'diisocyanatodiphenylmethane, phenylisothiocyanate, chlorophenylisothiocyanate, fluorophenyl Aromatic isocyanate compounds such as isothiocyanate, nitrophenyl isothiocyanate, tolyl isothiocyanate, methoxyphenyl isothiocyanate, 1-naphthyl isothiocyanate and the like, or isothiocyanate compounds are used. As the acid chloride, for example, any one of aliphatic acid chlorides such as isovaleryl chloride, stearoyl chloride, cyclohexanecarbonyl chloride, and 6-chloronicotinic acid chloride can be used. Aromatic acid chlorides such as 4-dichlorobenzoyl chloride, nitrobenzoyl chloride, 4-chlorobenzoyl chloride, 4-toluoyl chloride and benzo- [b] thiophen-2-carbonyl chloride can be used. As the acid anhydride, for example, acetic anhydride, succinic anhydride, phthalic anhydride, benzoic anhydride and the like can be preferably used. Further, as the amino group of the amino compound used in the present invention, a primary amino group,
Any of a secondary amino group and a tertiary amino group may be used. Examples of the amino compound include ammonia, sec-octylamine, 1- (3-aminopropyl) imidazole,
-Amino-1-propene, aminopyridine, aminobenzenesulfonic acid, tris (2-aminoethyl) amine and the like can be preferably used. Further, a polyamino compound or an amino compound having a hydroxyl group or a carboxyl group capable of introducing a group capable of forming a hydrogen bond in addition to a urea bond, a thiourea bond and an amide bond can also be preferably used. As a polyamino compound, for example,
Diaminoethane, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, dipropylenetriamine, N′-methyl-2,2′diaminodiethylamine, polyethyleneimine, N-acetylethylenediamine, 1,2-bis (2-aminoethoxy) ethane Any of these can be used. Examples of the amino compound having a hydroxyl group include 2-ethanolamine, 3-propanolamine, 6-hexanolamine, 1,3 diamino-2-hydroxypropane, 2- (2-aminoethoxy) ethanol, and 2- (2-aminoethyl Amino) Ethanol, glucamine, aliphatic amines such as N-methyl 1,3-diaminopropanol, or aromatic amines such as 4-aminophenol, diaminophenol, aminohydroxypyrimidine, diaminohydroxypyrimidine, diaminohydroxypyrazole, or serine And tyrosine and the like. It is also possible to synthesize an amino compound having a hydroxyl group from a compound having only a hydroxyl group or a compound having only an amino group by reacting epichlorohydrin and an amino compound, or 1,3 dibromo-2-hydroxypropane. is there. Also, when a group capable of forming a hydrogen bond is introduced into a saccharide, the same method as described above can be used. That is, in the case of a carbohydrate having an amino group such as chitosan or glucosamine, the above-mentioned isocyanate compound, isothiocyanate compound, acid, acid chloride or acid anhydride can be reacted. In the case of a saccharide having no amino group such as cellulose, the hydroxyl group of the saccharide is activated using epichlorohydrin, tresyl chloride, etc., and then reacted with ammonia or diaminoethane to introduce an amino group. By utilizing this amino group, a group capable of forming a hydrogen bond such as a urea bond, a thiourea bond, or an amide bond can be introduced into the saccharide. As the amino compound having a carboxyl group, for example, β-alanine, 4-amino-n-butyric acid, γ-amino-β-hydroxy-n-butyric acid, 6-amino-n-caproic acid and the like can be used.

When the material of the present invention is an oligomer or a polymer, for example, an oligomer or a polymer having an active ester group of a carboxylic acid such as an isocyanate group, a carboxyl group or a succinimide group has a group capable of forming a hydrogen bond. A method of reacting an amino group of a compound is preferably used. Oligomers and polymers having amino groups, or ammonia, diaminoethane, 1,3 diaminopropane, 1,3 diamino-2-hydroxypropane, 1,2-bis (2-aminoethoxy) ethane, tris (2-amino An oligomer or polymer having an amino group introduced with ethyl) amine, 2- (2-aminoethylamino) ethanol, or the like may be reacted with the above-mentioned isocyanate compound, isothiocyanate compound, acid, acid chloride or acid anhydride. This is the preferred method. Further, it is preferable to control the reaction time, the reaction temperature, the mixing ratio, and the like, and to use a protecting group so that the acid chloride or the isocyanate compound does not react with a group capable of forming a hydrogen bond other than the amino group. Functional groups such as an active ester group of a carboxylic acid such as an amino group, an isocyanate group, a carboxyl group or a succinimide group, an acid chloride group, and an acid anhydride group can be introduced into an oligomer or a polymer, if necessary.

Further, when the material of the present invention is polyurea or polythiourea, for example, a method of reacting a polyisocyanate compound or a polyisothiocyanate compound with a polyamino compound can be used. Normal,
The amount of the reagent is preferably 0.1 to 10 mol of the polyamine per 1 mol of the polyisocyanate compound or the polyisothiocyanate compound. As polyisocyanate compounds or polyisothiocyanate compounds, hexamethylene diisocyanate, cyclohexyl diisocyanate, tolylene diisocyanate, 4,4 'diphenylmethane diisocyanate, 3,3', 5,5 'tetraethyl 4,4' diisocyanato diphenylmethane, xylene diisocyanate, Methylene bis (4-phenylisothiocyanate) and the like are preferably used. As polyamino compounds, diaminoethane, diaminopropane, 1,
3 diamino-2-hydroxypropane, N'-methyl 1,3-
Diamino-2-propanol, diaminophenol, N,
N'-diaminopiperazine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, polyethyleneimine, dipropylenetriamine, N'-methyl-2,2'-diaminodiethylamine and the like can be preferably used. Further, when the material of the present invention is a polyamide, for example, a method of polycondensing a polycarboxylic acid and a polyamine can be used. In addition, in any of polyurea, polythiourea and polyamide, polyurea, polythiourea and polythiourea are finally introduced by sequentially introducing each functional group one by one without using polyisocyanate, polyisothiocyanate, polycarboxylic acid and the like. urea,
A method for obtaining a polyamide is also preferably performed.

All of the above reactions are typically carried out at a reaction temperature of 0 to 150 ° C. and a reaction time of 0.1 to 24 hours. Although a reaction solvent is not always necessary, the reaction is generally performed in the presence of a solvent. Examples of usable solvents include aliphatic hydrocarbons such as methanol, ethanol, isopropyl alcohol, n-butanol, hexane, acetone, N, N dimethylformamide and dimethyl sulfoxide, and aromatic hydrocarbons such as benzene, toluene and xylene. And halogenated hydrocarbons such as dichloromethane, chloroform and chlorobenzene, and ethers such as diethyl ether, tetrahydrofuran and dioxane. After completion of the reaction, the reaction solution can be purified by an operation such as column chromatography or recrystallization, if necessary, after usual post-treatments such as filtration and concentration. In the case of a water-insoluble material, washing with a glass filter or the like is also a preferable method.

Among the materials of the present invention, those insoluble in water are preferably used as a column for removing myoglobin and the like. The shape is not particularly limited, but when used as a column, beads, fibers, hollow fibers, yarn bundles, yarns, nets, knitted fabrics, woven fabrics and the like are preferable. When used as a fiber, it is preferably a sea-island type fiber. As the islands-in-the-sea fibers, polystyrene / polypropylene islands-in-the-sea fibers are preferably used because they have easy modification of polystyrene and are easy to handle by reinforcing the strength with polypropylene.

In addition, this material is not only used alone,
It can be further immobilized on an appropriate material, or mixed with another material and used as one column. Operations such as fixing or mixing may be performed before processing into the above-mentioned shape, or may be performed after processing. When a column using the material of the present invention is used as a column for extracorporeal circulation, blood extracted outside the body may be directly passed through the column, or may be used in combination with a plasma separation membrane or the like.

[0015] The material of the present invention can be suitably used as a medicament, and can detoxify myoglobin toxin (detoxification)
Therefore, treatment or prevention of acute renal failure or multiple organ failure can be achieved. It is also particularly suitable when acute renal failure is traumatic.

Hereinafter, the present invention will be described in detail with reference to examples, but the present invention is not limited to the examples.

[0017]

EXAMPLES Example 1 (1) Preparation of Modified Polystyrene Fiber United States of America comprising 50 weight ratio of sea component (a mixture of 46 weight ratio of polystyrene and 4 weight ratio of polypropylene) and 50 weight ratio of island component (polypropylene) The sea-island type composite fiber (thickness: 2.6 denier, number of islands: 16) described in Patent No. 4,661,260 (Example 1) is mixed with 50 g of N-methylol-α-.
Chloroacetamide, 400 g nitrobenzene, 40
The mixture was reacted with a mixed solution of 0 g of 98% sulfuric acid and 0.85 g of paraformaldehyde at 20 ° C. for 1 hour. Then, the fiber was washed with nitrobenzene and put into water to stop the reaction. Thereafter, the fiber was washed again with warm water to obtain a chloroacetamidomethylated crosslinked polystyrene fiber (hereinafter abbreviated as AMPSt fiber).

The reagents shown in Table 1 were dissolved in 50 ml of N, N-dimethylformamide (hereinafter abbreviated as DMF). 1 g of AMPSt fiber (chloro content: 2 mmol)
Was added with stirring. The reaction was performed at 30 ° C. for 3 hours. Then, it wash | cleaned on the glass filter using 200 ml of DMF. After washing, AMPSt fiber was added to a solution of 0.19 g of 4-chlorophenylisocyanate in 50 ml of DMF and reacted at 25 ° C. for 1 hour.
Then, it was washed with 200 ml of DMF and 200 ml of distilled water on a glass filter.

[0019]

[Table 1]

(2) Introduction of urea group, thiourea group and amide group into chitosan beads Chitosan beads having a particle diameter of 0.1 mm (manufactured by Fujibo Co., Ltd.)
12 ml of Chitopearl “AL-01” (volume upon precipitation, dry weight: 1.0 g) was stirred in 50 ml of DMF, and the beads and the solution were separated by a glass filter.
This operation is repeated once for 5 minutes for 20 times,
Completely replaced with MF.

Beads were gradually added to a solution prepared by dissolving the reagents in Table 2 in 100 ml of DMF, and reacted at room temperature for 1 hour with stirring. Thereafter, the beads and the solution were separated using a glass filter, and the beads were added to 50 ml of DMF.
Washing was carried out by stirring for 5 minutes in water. This washing operation was repeated 20 times to completely remove the unreacted reagent. Next, a washing operation with distilled water was performed in the same manner, and DM
By substituting F with distilled water, chitosan beads having a urea bond, a thiourea bond, and an amide bond were obtained.

[0022]

[Table 2]

(3) Removal Test of Myoglobin Using Modified AMPSt Fiber and Modified Chitosan Beads An adsorption removal test of myoglobin was performed using the modified AMPSt fiber prepared in (1) above and the modified chitosan beads prepared in (2) above. Myoglobin (purchased from Sigma)
Was used. The adsorption test was performed using rabbit plasma. Blood was collected from rabbits using an anticoagulant, and 300
Plasma was obtained by centrifugation at 0 rpm for 15 minutes. Rabbit plasma 1m with 100ng / ml myoglobin
35 mg of the modified AMPSt fiber of Table 1 or 0.1 ml of the modified chitosan beads of Table 2 (volume at the time of precipitation) was added to 1 and shaken at 37 ° C. for 1 hour. After 1 hour of reaction, the concentration of myoglobin in the solution was measured using an enzyme immunoassay. At this time, the albumin concentration was measured using an enzyme immunoassay, and the sodium ion concentration was measured using an electrode method. Table 3 shows the results. This result indicates that a material having a urea bond, a thiourea bond, or an amide bond, and preferably also a hydrophobic interaction group, specifically adsorbs myoglobin. In addition, it was shown that albumin and sodium, which are useful components in blood, do not adsorb.

[0024]

[Table 3]

COMPARATIVE EXAMPLE 1 Myoglobin removal test using polystyrene fiber The myoglobin adsorption removal test using polystyrene fiber before introducing the chloroacetamidomethyl group in Example 1 (1) was performed. The experiment used the same method as in Example 1 (3). Table 4 shows the results. From the results, the urea bond,
It was shown that polystyrene fibers having no thiourea bond or amide bond did not adsorb myoglobin. This indicates that polystyrene fibers are not practical.

[0026]

[Table 4]

Example 2 Myoglobin removal test using modified AMPSt fiber-circulation method Using the modified AMPSt fiber (e) of Example 1 (1),
A test for removing myoglobin by a circulation method was performed. A column was filled with 1 g of each fiber, and 10 ml of the rabbit plasma prepared by the method of Example 3 was added thereto at 37 ° C. at 1 ml / mi.
Table 5 shows the concentration of myoglobin when circulated at n for 60 minutes. It was shown that myoglobin can be adsorbed even under flow conditions such as extracorporeal circulation. In addition, it was shown that albumin and sodium, which are useful components in blood, do not adsorb.

[0028]

[Table 5]

[0029]

According to the present invention, a urea bond, a thiourea bond or an amide bond, and preferably further contains a hydrophobic interacting group capable of rapidly detoxifying or removing myoglobin even in a solution having a high protein concentration such as plasma. Material provided. By using the material of the present invention, the toxin activity of myoglobin present in body fluids such as blood and plasma can be lost (detoxification), so that treatment or prevention of acute renal failure or multiple organ failure can be achieved. In addition, by using a water-insoluble material among these materials, it is possible to efficiently remove myoglobin from body fluids such as blood and plasma, thereby forming a column for removing myoglobin, thereby enabling acute renal failure or multiple organs. Treatment and prevention of insufficiency etc. become possible.

Claims (20)

[Claims] 1. A material for removing or detoxifying myoglobin, which has at least one selected from a urea bond, a thiourea bond and an amide bond. 2. The material for removing or detoxifying myoglobin according to claim 1, which has a functional group containing an amino group. 3. The material for removing or detoxifying myoglobin according to claim 2, wherein said amino group is secondary or tertiary. 4. The material for removing or detoxifying myoglobin according to claim 2, wherein said amino group is a polyamine. 5. The material for removing or detoxifying myoglobin according to claim 1, which has a functional group containing a hydroxyl group. 6. The material for removing or detoxifying myoglobin according to claim 5, wherein said hydroxyl group is a hydroxyl group of a saccharide. 7. The material for removing or detoxifying myoglobin according to claim 6, wherein said carbohydrate is selected from chitosan, cellulose and derivatives thereof. 8. The material for removing or detoxifying myoglobin according to claim 1, which has a functional group containing an aromatic compound. 9. The material for removing or detoxifying myoglobin according to claim 1, which has a hydrophobic interacting group. 10. The material for removing or detoxifying myoglobin according to claim 9, wherein the hydrophobic interaction group is a hydrocarbon chain having 4 or more carbon atoms. 11. The material for removing or detoxifying myoglobin according to claim 1, further comprising a carrier. 12. The method according to claim 12, wherein the carrier is polystyrene, polysulfone,
The material for removing or detoxifying myoglobin according to claim 11, wherein the material is selected from polymethyl methacrylate or a derivative thereof. 13. The material for removing or detoxifying myoglobin according to claim 11, wherein said carrier is a fiber. 14. The material for removing or detoxifying myoglobin according to claim 13, wherein said fiber is a sea-island type fiber. 15. The material for removing or detoxifying myoglobin according to claim 1, wherein the material is water-insoluble. 16. The material for removing or detoxifying myoglobin according to claim 1, which is used for treating acute renal failure or multiple organ failure. 17. The material for removing or detoxifying myoglobin according to claim 16, wherein the acute renal failure is traumatic. 18. A body fluid purification column using the material according to claim 1. 19. A method for removing or detoxifying myoglobin from a liquid by passing a liquid containing myoglobin through a column filled with the material for removal or detoxification according to any one of claims 1 to 17. 20. The method for removing or detoxifying myoglobin from a liquid according to claim 19, wherein the liquid is blood or plasma.