JP2000233020A - Washing method and washing device for blood treating device - Google Patents

Washing method and washing device for blood treating device

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Publication number
JP2000233020A
JP2000233020A JP11036351A JP3635199A JP2000233020A JP 2000233020 A JP2000233020 A JP 2000233020A JP 11036351 A JP11036351 A JP 11036351A JP 3635199 A JP3635199 A JP 3635199A JP 2000233020 A JP2000233020 A JP 2000233020A
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Japan
Prior art keywords
cleaning
hollow fiber
cleaning liquid
washing
blood
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JP11036351A
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Japanese (ja)
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Hironobu Sugiyama
博信 杉山
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Nikkiso Co Ltd
日機装株式会社
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Priority to JP11036351A priority Critical patent/JP2000233020A/en
Publication of JP2000233020A publication Critical patent/JP2000233020A/en
Application status is Pending legal-status Critical

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Abstract

PROBLEM TO BE SOLVED: To improve the efficiency of washing work by letting a washing liquid flow in the interior of a hollow fiber membrane, detecting a specified physical property value in the substantially continuous state, and comparing the detected physical property value with a reference value to end washing work in removing a deposit adhering to the hollow fiber membrane of a blood treating device. SOLUTION: In the case of washing a hemodialyzer 4, after the start of washing work, reference values Es1, Es2 are set in a control device 9, subsequently, a pump 7 is operated to supply a washing liquid 2 in a washing liquid tank 3 through a line 5 to the hemodialyzer 4, thereby washing away a deposit. At this time, the physical property value of the washing liquid 2 of a line 6 is detected by a detector 8 and input to the control device 9, and when it reaches the reference value Es1, the supply method of the washing liquid 2 is switched. Substantially simultaneously with the supply of the washing liquid 2 by a line 17, the physical property value of the washing liquid 2 is detected, and the physical property value is input to the control device 9 to judge whether it reaches the reference value Es2 or not. If yes, the operation of the pump 7 is stopped to stop the supply of the washing liquid 2.

Description

【発明の詳細な説明】 DETAILED DESCRIPTION OF THE INVENTION

【0001】 [0001]

【発明の属する技術分野】本発明は、中空糸型血液透析器等の血液処理器の中空糸膜に付着した付着物を除去する洗浄方法及び洗浄装置に係わり、特に、洗浄作業の終了時期を的確に把握することができて洗浄作業の効率化を図り得る血液処理器の洗浄方法及び洗浄装置に関する。 BACKGROUND OF THE INVENTION The present invention relates to a cleaning method and cleaning apparatus for removing deposits adhering to the hollow fiber membrane of the blood treatment device such as a hollow fiber hemodialyzer, in particular, the termination time of the cleaning operation It relates to a cleaning method and cleaning apparatus of the blood processing device for obtaining improve efficiency of the cleaning work can be accurately grasped.

【0002】 [0002]

【従来の技術】従来、血液処理器としての人工透析治療で使用された中空糸型血液透析器(以下、単に血液透析器という)は使用後に洗浄されるが、この洗浄時の洗浄効果(洗浄度合い)を確認する方法としては、限外濾過速度あるいは濾過圧力を測定することによって行うのが一般的である。 Conventionally, hemodialysis treatment hollow fiber hemodialyzer used in as blood treating device (hereinafter, simply referred to as hemodialyzer) but are cleaned after use, cleaning effect during the wash (wash as a method for ascertaining the degree), carried out by measuring the ultrafiltration rate or filtration pressure is generally used. この限外濾過速度の測定は、血液透析器の中空糸膜の片側から一定の圧力を加えると共に、圧力の高い方もしくは低い方に密閉系を作り、圧力の高い方から低い方へ一定時間内に中空糸膜を通過する洗浄液の量(減少量もしくは増加量)を測定することによって行っている。 Measurement of the ultrafiltration rate, as well as applying a constant pressure from one side of the hollow fiber membrane hemodialyzer creates a closed system in higher or lower of the pressure, within a predetermined time from high to low-pressure It is carried out by measuring the amount of the cleaning liquid passing through the hollow fiber membrane (decrease or increase) on. また、濾過圧力の測定は、洗浄液を血液透析器の透析液側から血液側に一定量濾過させながら圧力測定を行うものである。 The measurement of the filtration pressure is a cleaning liquid to perform pressure measurements while a certain amount filtered blood side from the dialysate side of the hemodialyzer.

【0003】 [0003]

【発明が解決しようとする課題】しかしながら、限外濾過速度を測定する方法にあっては、中空糸膜を一定時間内に通過する洗浄液の減少量や増加量を測定する方法であり、洗浄時の中空糸膜の洗浄状態を把握することができないため、一定時間の洗浄終了後の洗浄液の減少量や増加量の数値が洗浄不足の数値であった場合には、再度洗浄を実施する必要が生じ、この洗浄不足を防止するためには、予め余分な洗浄時間を設定する必要があって洗浄過剰になり易い等、洗浄作業を効率的に行うことが難しいという問題点があった。 [SUMMARY OF THE INVENTION However, in the method for measuring the ultrafiltration rate is a method of measuring the decrease or increase of the cleaning liquid passing through the hollow fiber membrane within a certain time, during cleaning for inability to grasp the cleaning state of the hollow fiber membrane, when value of decrease or increase of the washing liquid after the end cleaning a certain time is a numerical value of insufficient cleaning, it should be performed again washed occur, in order to prevent the insufficient cleaning, it was pre-extra cleaning tends time excessive cleaning is necessary to set such a problem that the cleaning work it is difficult to perform efficient point.

【0004】また、濾過圧力を測定する方法にあっては、血液透析器の膜面積に限外濾過が比例し、中空糸膜の種類により限外濾過性能が異なることから、血液透析器毎に濾過圧力が異なることになるため、例えば洗浄の合否を判断する基準値を血液透析器のそれぞれに対応して一々設定する必要があり、限外濾過速度を測定する方法と同様に、洗浄作業を効率的に行うことが難しいという問題点があった。 [0004] Further, in the method of measuring the filtration pressure, ultrafiltration is proportional to membrane area of ​​a hemodialyzer, depending on the type of the hollow fiber membrane from the ultrafiltration performance differs for each hemodialyzer since filtration pressure will be different, for example, a reference value for determining the acceptability of the cleaning must be set one by one corresponding to each of the hemodialyzer, similar to the method for measuring the ultrafiltration rate, the cleaning operation there is a problem that it is difficult to perform efficiently.

【0005】本発明はこのような事情に鑑みてなされたもので、請求項1または2記載の発明の目的は、中空糸膜の洗浄作業の終了を的確に行うことができて、洗浄作業の効率を向上させ得る血液処理器の洗浄方法を提供することにある。 [0005] The present invention has been made in view of such circumstances, an object of the present invention according to claim 1 or 2, in can be the termination of the cleaning operation of the hollow fiber membrane accurately, the cleaning operation to provide a method for cleaning blood treating device capable of improving the efficiency. また、請求項3または4記載の発明の目的は、中空糸膜の洗浄作業の終了を的確に行うことができて、洗浄作業の効率を向上させ得る血液処理器の洗浄装置を提供することにある。 Another object of the invention of claim 3, wherein, in can be the termination of the cleaning operation of the hollow fiber membrane accurately, to provide a cleaning device of the blood processing device capable of improving the efficiency of the cleaning operation is there.

【0006】 [0006]

【課題を解決するための手段】かかる目的を達成すべく、本発明のうち請求項1記載の発明は、筒状ケーシング内に多数の中空糸膜からなる中空糸束が装填された血液処理器の中空糸膜に付着した付着物を除去する洗浄方法であって、中空糸膜の少なくとも内部に洗浄液を流し、この洗浄液の所定の物性値を略連続状態で検出し、 To achieve the SUMMARY OF THE INVENTION The above object, According to one aspect of the present invention, a blood processing device in which the hollow fiber bundle is loaded comprising a number of hollow fiber membranes in the tubular casing a cleaning method for removing deposits adhering to the hollow fiber membrane, passing a cleaning liquid to at least the interior of the hollow fiber membrane, and detecting a predetermined physical property value of the washing liquid in a substantially continuous state,
この検出した物性値と予め定めた基準値とを比較して洗浄作業を終了させることを特徴とする。 To terminate the cleaning operation is compared with a predetermined reference value with the detected physical properties and features.

【0007】また、請求項2記載の発明は、物性値が洗浄液の電気伝導度もしくは吸光度であり、該物性値が所定値に達した時もしくは物性値の変化率が所定値に達した時に、洗浄作業を終了させることを特徴とする。 Further, when the invention of claim 2, physical properties are electrical conductivity or absorbance of the cleaning liquid, the agent of value change rate when or physical data reaches a predetermined value has reached a predetermined value, characterized in that to terminate the cleaning operation.

【0008】このように構成することにより、使用済みの血液処理器内に例えば生理食塩水等の洗浄液を流して、各中空糸膜の内部やその内外面間に流すと、中空糸膜の内外の表面に付着している血液成分等の付着物が、 [0008] With this configuration, by supplying a cleaning liquid such as, for example, saline used blood treatment vessel, the flow between the interior and the inner and outer surfaces of the hollow fiber membranes, and out of the hollow fiber membrane deposits, such as blood components adhered to the surface,
洗い流されて洗浄液中に含有される。 Washed away contained in the cleaning liquid. この付着物が含有した洗浄液は、付着物の含有量に応じて電気伝導度や吸光度等の物性値が初期状態から徐々に変化し、この洗浄液の物性値が略連続状態で検出される。 Cleaning liquid this coating has contained, physical properties such as electric conductivity and absorbance depending on the content of the deposit gradually changes from an initial state, physical properties of the cleaning liquid is detected in a substantially continuous state. そして、検出した物性値が例えば予め定めた基準値に達した場合や、物性値の変化率が所定値に達した場合に、中空糸膜が十分に洗浄されたものとして洗浄作業を終了する。 Then, and when the detected physical property value reaches a reference value predetermined for example, if the rate of change of the physical property value reaches a predetermined value, and ends the cleaning operation as the hollow fiber membrane is thoroughly washed. つまり、 That is,
付着物を洗い流す洗浄液の物性値を時事刻々検出して監視し、この物性値を基準値と比較することによって洗浄作業の終了時期が判断されることになり、洗浄不足で再度洗浄を行ったり洗浄過剰となることがなくなり、洗浄作業の効率が向上する。 Monitoring the physical properties of the cleaning liquid to wash away deposits varies continuously detected and, the physical properties will be end time of the cleaning operation by comparing the reference value is determined, washed and go again washed with wash shortage prevents to be excessive, the efficiency of the cleaning operation can be improved.

【0009】また、請求項3記載の発明は、筒状ケーシング内に多数の中空糸膜からなる中空糸束が装填された血液処理器の中空糸膜に付着した付着物を除去する洗浄装置であって、血液処理器内に洗浄液を供給することによって中空糸膜の少なくとも内部に洗浄液を流し得る洗浄液供給手段と、該洗浄液供給手段の作動により血液処理器内を流れた洗浄液の所定の物性値を略連続状態で検出する検出手段と、該検出手段で検出した物性値と予め定めた基準値とを比較して洗浄終了時期を判断する制御手段と、を具備することを特徴とする。 [0009] The invention of claim 3 wherein is a cleaning device for removing the extraneous matters hollow fiber bundle comprising a plurality of hollow fiber membranes inside the cylindrical casing is attached to the hollow fiber membrane of the blood processing vessel loaded there are, at least a cleaning liquid supply means for internal can flow a cleaning liquid to a predetermined physical property value of the cleaning liquid flowing through the blood processing vessel by the operation of the cleaning liquid supply means of the hollow fiber membrane by supplying a cleaning liquid into the blood treatment device the to a detection means for detecting in a substantially continuous state, characterized by comprising control means for determining the completion of the washing time is compared with a predetermined reference value and the physical properties detected by the detecting means.

【0010】また、請求項4記載の発明は、洗浄液供給手段が、中空糸膜の内外にそれぞれ洗浄液を供給することによって、該洗浄液が中空糸膜の各膜を通過する如く構成されていることを特徴とする。 Further, an invention according to claim 4, wherein, the cleaning liquid supply means, by supplying the respective cleaning liquid into and out of the hollow fiber membrane, it is composed as the cleaning fluid passes through each membrane of the hollow fiber membrane the features.

【0011】このように構成することにより、使用済みの血液処理器内に洗浄液供給手段から洗浄液が供給されて、この洗浄液が各中空糸膜の内部を流れると、中空糸膜の表面に付着している血液成分等の付着物が、洗い流されて洗浄液中に含有される。 [0011] With this arrangement, is supplied cleaning liquid from the cleaning liquid supply means in the used blood treatment vessel, the cleaning liquid flows through the inside of each hollow fiber membrane, attached to the surface of the hollow fiber membrane deposits, such as blood components are is contained washed away in the washing liquid. この時、洗浄液供給手段で、例えば洗浄液が中空糸膜の各膜を通過するように供給することによって、中空糸膜の内外面に付着している付着物が確実に洗い流される。 At this time, in the cleaning liquid supply means, for example by cleaning liquid supply so as to pass through each membrane of the hollow fiber membrane, deposits adhering to the inner and outer surfaces of the hollow fiber membrane is reliably washed away.

【0012】この付着物が含有した洗浄液は、付着物の含有量に応じてその物性値が初期状態から徐々に変化し、この洗浄液の物性値が検出手段で略連続状態で検出される。 [0012] cleaning solution the coating has contained, its physical properties are gradually changed from an initial state in accordance with the content of the deposits, physical properties of the cleaning liquid is detected in a substantially continuous state detecting means. そして、検出手段で検出された物性値は、制御手段で予め定めた基準値と比較され、洗浄作業の終了時期が判断される。 Then, the detected physical value by the detecting means is compared with a predetermined reference value by the control unit, end time of the cleaning operation is determined. これにより、付着物を洗い流す洗浄液の物性値を時事刻々検出して監視し、この物性値を基準値と比較することによって洗浄作業の終了時期が判断されることになり、洗浄不足や洗浄過剰を防止できて、洗浄作業の効率が向上する。 Thus, to monitor the physical properties of the cleaning liquid to wash away deposits varies continuously detected and, end timing of the cleaning operation by comparing the physical properties and the reference value is to be determined, the insufficient cleaning and washing excess can be prevented, the efficiency of the cleaning operation can be improved.

【0013】 [0013]

【発明の実施の形態】以下、本発明の実施の形態の一例を図面に基づいて詳細に説明する。 BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, will be described in detail with reference to an embodiment of the present invention with reference to the drawings. 図1〜図4は、本発明に係わる血液処理器の洗浄装置の一実施例を示し、図1がその基本構成図、図2がその洗浄方法の一例を示すフローチャート、図3及び図4が物性値としての電気伝導度の変化を示すグラフである。 1 to 4 show an embodiment of the cleaning device of the blood processing apparatus according to the present invention, FIG. 1 is a basic configuration diagram, flowchart FIG. 2 shows an example of the cleaning method, FIGS. 3 and 4 it is a graph showing the change in electrical conductivity as physical properties.

【0014】図1において、洗浄装置1は、所定の洗浄液2が貯留される洗浄液タンク3と、この洗浄液タンク3内の洗浄液2を血液処理器としての血液透析器4に供給するため、ライン5、6に洗浄液2の流れを生成させるポンプ7と、ライン6に設けられ血液透析器4から戻される洗浄液2の物性値を検出する検出器8と、この検出器8の検出信号に基づいてポンプ7等を制御する制御装置9を有している。 [0014] In FIG. 1, the cleaning apparatus 1 is provided with a cleaning liquid tank 3 in which a predetermined washing solution 2 is stored, for supplying the cleaning liquid 2 in the cleaning liquid tank 3 to the blood dialyzer 4 as blood treating device, line 5 a pump 7 for generating a flow of cleaning liquid 2 to 6 and a detector 8 for detecting the physical properties of the cleaning liquid 2 that is returned from the blood dialyzer 4 provided on line 6, the pump based on the detection signal from the detector 8 and a control unit 9 for controlling the 7 or the like.

【0015】前記血液透析器4は、円筒状のケーシング10内に図示しない多数の中空糸膜からなる中空糸束が装填されており、ケーシング10の一方の開口端部には血液流入口11を有する蓋13が固着され、他方の開口端部には血液流出口12を有する蓋14が固着されている。 [0015] The hemodialyzer 4, a hollow fiber bundle of multiple hollow fiber membranes (not shown) in a cylindrical casing 10 which is loaded, one blood inlet 11 to the open end of the casing 10 the lid 13 having been fixed, the other open end is secured lid 14 having a blood outlet port 12. また、ケーシング10の蓋13側端部の側面には透析液流出口15が設けられ、ケーシング10の蓋14側端部の側面には透析液流入口16が設けられている。 Further, the side surface of the lid 13 side end portion of the casing 10 is provided a dialysate outlet 15, dialysate inlet 16 is provided on a side surface of the lid 14 side end portion of the casing 10.

【0016】そして、この血液透析器4は、血液流入口11にライン5によって前記ポンプ7が接続され、血液流出口12にライン6によって検出器8が接続されると共に、透析液流出口15には血液透析器4内に洗浄液2 [0016] Then, the hemodialyzer 4, the pump 7 by a line 5 to the blood inlet 11 is connected with detector 8 by line 6 to the blood outlet port 12 is connected to a dialysate outlet port 15 the cleaning liquid 2 in the blood dialyzer 4
を供給するライン17の下流側が接続され、このライン17の上流側は前記タンク洗浄液タンク3に接続されるか、あるいは洗浄液タンク3とは別に配置した洗浄液タンクに接続されている。 The is connected downstream of the supply line 17 is connected to a cleaning liquid tank which is disposed separately from the upstream side the one is connected to the tank solution tank 3, or the cleaning liquid tank 3 in the line 17. また、透析液流入口16には、 In addition, the dialysate inlet port 16,
キャップ18が装着されるように構成されている。 Cap 18 is configured to be mounted.

【0017】なお、図1において、矢印イは血液透析器4のライン5の血液側(血液流入口11)から洗浄液2 [0017] In FIG. 1, arrow b the cleaning liquid 2 from the blood side of the line 5 of the hemodialyzer 4 (blood inlet 11)
を流した場合の流れを示し、矢印ロは血液透析器4のライン7の透析液側(透析液流出口15)から洗浄液2を流した場合の流れを示している。 Shows the flow in passing the arrow B indicates the flow in passing a cleaning liquid 2 from the dialysate side of the line 7 of the hemodialyzer 4 (dialysate outlet port 15). また、前記ポンプ7、 In addition, the pump 7,
ライン5、6及びライン17によって洗浄液供給手段が構成され、この洗浄液供給手段のポンプ7と検出手段としての検出器8が、制御手段としての制御装置9に接続されている。 Cleaning liquid supply means is constituted by the line 5, 6 and line 17, the detector 8 as a detection means pump 7 of the cleaning liquid supply means is connected to the controller 9 as control means.

【0018】次に、前記洗浄装置1による洗浄方法の一例を図2のフローチャート及び図3、図4のグラフ等に基づいて説明する。 Next, flowcharts and 3 of Figure 2 an example of a cleaning method according to the cleaning apparatus 1 will be described based on the graph such as in Fig. なお、このフローチャートは、制御装置9によって自動的に実行される。 Incidentally, the flowchart is performed automatically by the control device 9. 先ず、洗浄装置1 First, the cleaning device 1
に洗浄しようとする血液透析器4を接続すると共に、血液透析器4の透析液流入口16にキャップ18を装着し、この状態で洗浄作業が開始(S100)される。 With connecting hemodialyzer 4 to be cleaned, the cap 18 is attached to the dialysate inlet port 16 of the hemodialyzer 4, the cleaning operation is started (S100) in this state. 洗浄作業が開始されると、制御装置9に、検出した物性値と比較する2つの基準値Es1、Es2を設定(S10 When the cleaning operation is started, the control unit 9, sets two reference values ​​EsI, Es2 to be compared with the detected physical properties (S10
1)する。 1). この基準値Es1、Es2のうち、基準値E The reference value EsI, among Es2, the reference value E
s1は血液透析器4の血液側に洗浄液を供給させた場合の物性値の基準値であり、基準値Es2は血液透析器4 s1 is the reference value of the physical property value when to supply a cleaning liquid to the blood side of a hemodialysis device 4, the reference value Es2 blood dialyzer 4
の透析液側に洗浄液を供給させた場合の物性値の基準値である。 Is a reference value of the physical property value when the washings were supplied to the dialysate side.

【0019】そして、基準値Es1、Es2が設定されると、ポンプ7を作動させて洗浄液タンク3から洗浄液2を汲み上げ、ライン5を介して血液透析器4に供給する。 [0019] When the reference value EsI, Es2 is set, the pump 7 is operated pump up the cleaning liquid 2 from the cleaning solution tank 3 is supplied to the blood dialyzer 4 via line 5. このポンプ7の作動で洗浄液2が血液透析器4の血液流入口11、各中空糸膜内部、血液流出口12(すなわち血液透析器4の血液側)を介してライン6に流れ、 Blood inlet 11 of the cleaning liquid 2 is hemodialyzer 4 by operation of the pump 7, within each hollow fiber membranes, the flow in the line 6 via the blood outflow port 12 (i.e. the blood side of the hemodialyzer 4),
これにより洗浄液タンク3内の洗浄液2がライン5、6 Thus the cleaning liquid 2 in the cleaning liquid tank 3 lines 5 and 6
に供給(S102)される。 Supplied (S102) to. この洗浄液2の供給で各中空糸膜の内表面に付着している血液成分等の付着物が洗い流され、この洗い流された付着物は洗浄液2中に含有さつつ排液として外部に排出されることになる。 Deposits blood components like adhering to the inner surface of the hollow fiber membranes in the supply of the cleaning liquid 2 is washed away, and is discharged to the outside as drained while the flushed the deposits contained in the cleaning liquid 2 It will be.

【0020】また、洗浄液2の供給開始と略同時に検出器8により、ライン6の洗浄液2の物性値E1が検出(S103)される。 Further, the supply start at substantially the same time the detector 8 of the cleaning liquid 2, physical properties E1 of the cleaning liquid 2 in line 6 is detected (S103). この時、検出器8は、ライン6を流れる洗浄液2の物性値E1を時事刻々検出し、その検出した物性値E1を制御装置9に出力する。 At this time, the detector 8, the physical property value E1 of the cleaning liquid 2 flowing in the line 6 varies continuously detects and outputs a physical property value E1 which is the detection to the control unit 9. この物性値Eとしては、電気伝導度が使用され、この電気伝導度は、例えば洗浄液2が生理食塩水で、血液として臨床の代わりに牛血を使用した場合、図3に示す変化(グラフ)となる。 As the physical property value E, is the electric conductivity is used, the electrical conductivity, for example, the cleaning liquid 2 in saline, using the bovine blood in place of clinical as blood, varies as shown in FIG. 3 (graph) to become. なお、この場合の検出器8としてはテスターが使用される。 Incidentally, the tester as the detector 8 in this case is used.

【0021】この図3から明らかなように、電気伝導度は、付着物が洗い流される初期段階においては、洗い流される付着物の量に応じて急激な変化を示すが、その後洗い流される付着物の量が徐々に少なくなり、これに追従して電気伝導度も緩やかな変化に代わり、付着物が十分に洗い流された後には飽和状態(略直線状態)となる。 The amount of the 3 As is apparent from the electrical conductivity, deposits in the initial stage to be washed away, shows a rapid change in accordance with the amount of deposit to be washed away, the deposits subsequently washed away There gradually decreases, this instead a gradual change electrical conductivity to follow, in a saturated state (approximately linear state) after the coating has been washed away sufficiently.

【0022】検出器8で物性値E1が検出されると、この検出した物性値E1が制御装置9に入力されて、ステップS101で設定した基準値Es1に到達したか否か、すなわちE1=Es1か否かが判断(S104)される。 [0022] Physical properties E1 is detected by the detector 8, the detected physical property value E1 is inputted to the control unit 9, whether the host vehicle has reached the reference value Es1 set in step S101, i.e. E1 = Es1 whether it is determined (S104). そして、図3の時間T1に示すように、E1=E Then, as shown in the time T1 of FIG. 3, E1 = E
s1になると、ライン17を介して血液透析器4の透析液側に洗浄液2を供給(S105)する。 When becomes s1, the cleaning liquid 2 is supplied (S105) via the line 17 to the dialysate side of the hemodialyzer 4. すなわち、ステップS104で「YES」となった時点で、洗浄液2 That is, when it becomes "YES" in step S104, the cleaning liquid 2
の供給方法(洗浄方法)を血液側から透析液側に切り替える。 Switching the method of supply (cleaning method) in the dialysate side of the blood side.

【0023】この時、血液透析器4の透析液流入口16 [0023] In this case, the dialysate inlet of the blood dialyzer 4 16
がキヤップ18で閉塞されているため、ライン17から血液透析器4内に供給される洗浄液2は、各中空糸膜の外面から内面に向かって通過し、中空糸膜内を流れてライン6に流出する。 There because it is closed by cap 18, the cleaning liquid 2 to be supplied to the hemodialyzer 4 from the line 17, the outer surface passes toward the inner surface of each hollow fiber membrane, the line 6 flows through the hollow fiber membranes leak. この洗浄液2の各中空糸膜の内外面間の通過によって、中空糸膜の厚み方向にトラップされている付着物が洗浄液2で洗い流され、この付着物も中空糸膜内面の付着物と同様に洗浄液2中に含有される。 By passage between the inner and outer surfaces of the hollow fiber membranes of this cleaning liquid 2, deposits trapped in the thickness direction of the hollow fiber membrane is washed with a washing liquid 2, as in the deposits also hollow fiber membrane inner surface the deposit contained in the cleaning liquid 2.

【0024】また、ライン17による洗浄液2の供給と略同時に供給する洗浄液2の物性値E2が検出(S10 Further, the cleaning liquid 2 by the line 17 supplies a substantially detected physical value E2 of supplying cleaning fluid 2 at the same time (S10
6)される。 6) by the. この物性値E2は、ライン5から供給されている洗浄液2にライン17から供給された洗浄液2が合成された洗浄液2の物性値であり、物性値E1と同様に検出器8によって検出される。 The physical property values ​​E2 is the physical property value of the cleaning solution 2 in which the cleaning liquid 2 was synthesized supplied from the line 17 to the cleaning liquid 2 which is supplied from the line 5, is detected by the detector 8 as well as physical property values ​​E1. この物性値E2としては、供給している洗浄液2の電気伝導度が図3に示す場合、その電気伝導度が例えば図4に示す変化(グラフ) As the physical property value E2, when the electrical conductivity of the cleaning liquid 2 which supply shown in FIG. 3, the change indicating that the electrical conductivity in FIG. 4, for example (graph)
となり、初期に急激な変化をし、その後緩やかに変化して略直線状態となり、飽和するまでの時間は、図3に示す供給時の変化に比較して短くなる。 Next, the initial and abrupt changes in, becomes substantially straight state and thereafter gradually changes, time until saturation is shorter as compared to the change at the time of supply as shown in FIG.

【0025】そして、洗浄液2の物性値E2が検出されると、この物性値E2が制御装置9に入力され、ステップS101で設定した基準値Es2に達したか否かが判断(S107)される。 [0025] When the physical property value E2 of the cleaning liquid 2 is detected, the physical property value E2 is input to the control unit 9, whether or not reached the reference value Es2 set in step S101 is determined (S107) . この判断S107で「YES」 "YES" in this determination S107
の場合、すなわち、図4の時間T2に示すように、E2 For, i.e., as shown in the time T2 in FIG. 4, E2
=Es2となった時点で、ポンプ7の作動を停止させ、 = When it becomes a Es2, it stops the operation of the pump 7,
洗浄液2の供給を停止(S108)させる。 Stopping the supply of the cleaning liquid 2 (S108) makes. これにより、洗浄作業が終了(S109)し、この時、洗浄液2 Accordingly, the cleaning operation is completed (S109), at this time, the cleaning liquid 2
の物性値E2が、予め実験等によって十分な洗浄効果が得られる基準値Es2に達した際に、洗浄作業を終了するため、血液透析器4を確実に洗浄することができる。 Property value E2 is, when reaching the reference value Es2 a sufficient cleaning effect can be obtained in advance by experiments or the like, in order to terminate the cleaning operation, it is possible to reliably clean the hemodialyzer 4.

【0026】このように、上記実施例の洗浄装置1による洗浄方法によれば、先ず血液透析器4の血液側に洗浄液2を流して中空糸膜内面の付着物を洗い流し、その後洗浄液2を透析液側に流して中空糸膜間の付着物を洗い流すと共に、付着物が含有した洗浄液2の電気伝導度からなる物性値E1、E2を検出器8で検出し、この検出した物性値E1、E2が予め設定した基準値Es1、E [0026] Thus, according to the cleaning method using the cleaning apparatus 1 of the above embodiment, first wash away deposits of the hollow fiber membrane inner surface by flowing a cleaning liquid 2 in the blood side of a hemodialysis device 4, then dialyzed washing solution 2 with wash deposits between the hollow fiber membranes by passing the liquid side, detected by the detector 8 the physical property values ​​E1, E2 which deposits consist electrical conductivity of the cleaning liquid 2 containing, the detected physical values ​​E1, E2 reference value EsI, E but a preset
s2に到達した場合に、洗浄液2の供給方法を切り替えたり、洗浄液2の供給を停止させて洗浄作業を終了するため、血液透析器4の洗浄作業を洗浄液2の物性値E When it reaches the s2, or switching methods supply the cleaning liquid 2, for ending the cleaning operation stops the supply of the cleaning liquid 2, the cleaning operation of the hemodialyzer 4 of the cleaning liquid 2 physical properties E
1、E2に基づいて自動制御しつつ行うことができると共に、予め設定した基準値Es1、Es2との比較で終了時期を判断することができる。 1, it is possible to carry out while automatically controlled on the basis of E2, it is possible to determine the end time in comparison with the reference value EsI, Es2 previously set.

【0027】特に、使用する洗浄液2の物性値を予め実験等により求め、これを制御装置9に設定するだけで、 [0027] In particular, previously determined by experiments or the like physical property values ​​of the cleaning liquid 2 for use, simply by setting to the control unit 9,
洗浄効果が十分に得られる時点で、自動的に洗浄作業を終了することができるため、従来のように、洗浄不足により再洗浄を行う必要もなくなったり、洗浄過剰による洗浄時間のロス発生を防止することができる。 When the cleaning effect can be sufficiently obtained, automatically for the cleaning operation can be terminated, as in the prior art, it must be lost or to re-cleaned by insufficient cleaning, preventing the loss occurrence washing time by washing excess can do. その結果、血液透析器4の洗浄作業の効率を大幅に向上させることが可能になる。 As a result, it becomes possible to greatly improve the efficiency of the cleaning operation of the hemodialyzer 4.

【0028】また、洗浄液2の種類に応じて実験等によって求めた基準値Es1、Es2を制御装置9に設定するだけで、十分な洗浄効果が得られる時期で洗浄作業を終了させることができるため、従来のように、血液透析器4の大きさや形態等の種類毎に一々基準値を設定する必要もなくなり、洗浄作業をより容易に行うことができる等、洗浄作業の一層の効率化を図ることができる。 Moreover, simply by setting the reference value EsI, Es2 determined by experiments or the like according to the type of the cleaning liquid 2 in the control unit 9, it is possible to finish the cleaning work in time to sufficient cleaning effect is obtained , as in the prior art, eliminates the need to configure every time the reference value for each type of such size and form of the hemodialyzer 4, etc. can be cleaned work more easily, achieve further efficiency of the cleaning operation be able to.

【0029】さらに、洗浄時に得られたデータに基づいて、洗浄時間を予測することができると共に、洗浄中に洗浄があとどの程度必要か、あるいは現在の洗浄程度がどの程度かを予測したり確認することができ、洗浄作業を行う時期等を所望に設定できて、人工透析治療の効率化を図ることができる。 Furthermore, based on data obtained during cleaning, check it is possible to predict the washing time, or washed in washing extent necessary after, or or to predict how much the current degree of cleaning it is possible to, the timing, etc. for cleaning work can be set to a desired, it is possible to improve the efficiency of the dialysis treatment. またさらに、洗浄装置1を、例えばテスター等からなる検出器8と、ポンプ7及び洗浄液タンク3等で構成することができるため、比較的安価で使い勝手に優れた洗浄装置1を得ることが可能になる。 Furthermore, the cleaning apparatus 1, for example, a detector 8 consisting of a tester or the like, it is possible to configure a pump 7 and the washing tank 3 and the like, as possible to obtain a cleaning device 1 which is excellent in a relatively inexpensive and easy to use Become.

【0030】なお、図2に示すフローチャートにおいては、2つの基準値Es1、Es2を設定して、血液透析器4の血液側を供給している洗浄液2の物性値E1が基準値Es1に達した場合に、ライン17から透析液側に洗浄液2を供給して、洗浄方法を切り替えるようにしたが、この洗浄方法の切替タイミングは、洗浄液2の物性値E1に限らず、例えば血液側の付着物が除去されるまで時間を実験等により求め、この時間が経過した時点で透析液側に洗浄液2を供給するようにすることもできる。 [0030] Note that in the flowchart shown in FIG. 2, by setting two reference values ​​Es1, Es2, physical property value E1 of the cleaning liquid 2 which supplies the blood side of a hemodialysis device 4 has reached the reference value Es1 If, by supplying a cleaning liquid 2 in the dialysate from the line 17, has been to switch the cleaning method, the switching timing of the cleaning method is not limited to the physical property value E1 of the cleaning liquid 2, for example, the blood side of the deposit There obtained by experiments or the like time until removed, it can also be adapted to supply the cleaning liquid 2 in the dialysate side at this time has elapsed. また、上記フローチャートにおいては、洗浄液2を先ず血液透析器4の血液側に供給して洗浄液2を各中空糸膜の内部に流し、その後透析液側に供給して洗浄液2 In the above flowchart, the cleaning liquid 2 is first fed to the blood side of the hemodialyzer 4 The wash solution was drained 2 inside each hollow fiber membrane, and supplies thereafter dialysate side cleaning liquid 2
を各中空糸膜の外面から内面(膜)に流したが、これを逆にすることも可能であるし、各中空糸膜の内部にのみ流すこともできる。 The was flowed to the inner surface (membrane) from the outer surface of the hollow fiber membranes, which it is also possible to reverse, it is also possible to flow only inside the respective hollow fiber membranes.

【0031】また、上記実施例においては、検出した物性値E2が基準値Es2に達した場合に洗浄終了であると判断するようにしたが、本発明はこれに何等限定されるものでもなく、例えば図5及び図6に示すようにして終了時期を判断しても良い。 Further, in the above embodiment, the detected physical value E2 is to be determined that the cleaning completion when it reaches the reference value Es2, the present invention this without limitation any way, for example, as shown in FIGS. 5 and 6 may be determined when it ends. すなわち、図5に示す終了判断は、ステップS101で物性値の基準変化率Ecを設定し、ステップS106で検出した物性値E2の変化率Eyを算出(S201)する。 In other words, end judgment shown in FIG. 5 sets a reference change rate Ec physical data in step S101, calculates a change rate Ey physical data E2 detected in step S106 (S201) to. この変化率Eyは、物性値E2を所定の間隔で検出する場合、今回検出した物性値E2と直前に検出した物性値E2の比較で算出し、 The rate of change Ey, when detecting a physical property value E2 at predetermined intervals, calculated in comparison physical properties E2 detected immediately before the physical property value E2 detected this time,
この算出した変化率Eyが基準変化率Ec以下か否かを判断(S107)する。 The calculated rate of change Ey is determined whether the reference change rate Ec hereinafter (S107). そして、検出した変化率Eyが基準変化率Ec以下の場合に、すなわち物性値E2が飽和してほとんど変化しなくなった時点で終了判断し、洗浄液2の供給を停止(S108)させる。 Then, the detected change rate Ey is the case of less than the reference change rate Ec, that is, saturated physical properties E2 terminates determine when it becomes hardly changes, stop the supply of the cleaning liquid 2 (S108) makes.

【0032】また、図6に示す終了判断は、ステップS Further, the end determination shown in FIG. 6, step S
101で物性値の基準値Es2と許容範囲αを設定し、 101 between the reference value Es2 physical data set the allowable range alpha,
検出した物性値E2が基準値Es2に対して許容範囲α Tolerance detected physical value E2 is the reference value Es2 alpha
内に入った場合に終了判断するようにしたものである。 It is obtained so as to end determination when entering the inside.
この図5及び図6の終了判断においても、各種基準値を予め設定することにより、血液透析器4が十分に洗浄された時点で洗浄作業を自動的に終了することができ、上記実施例と同様の作用効果が得られる。 Also in end judgment in FIG. 5 and FIG. 6, by setting the various reference values ​​previously can hemodialyzer 4 automatically terminates the cleaning operation when it is thoroughly washed, and the examples the same effect can be obtained.

【0033】またさらに、上記実施例においては、制御装置9により、ポンプ7等を自動停止させる場合について説明したが、本発明は、検出器8により洗浄液2の状態(物性値)が時事刻々検出され、これをモニター表示させることができるため、自動停止に限らず洗浄液2の状態をモニターで目視確認しつつ、手動でポンプ7を停止させることもできる。 [0033] Furthermore, in the above embodiment, the control device 9, has been described to automatically stop the pump 7 or the like, the present invention, the state of the cleaning liquid 2 by the detector 8 (physical properties) of every moment detected is, which since it is possible to monitor display, while checking visually the state of the cleaning liquid 2 is not limited to the automatic stop by the monitor, it is also possible to stop the pump 7 manually.

【0034】また、上記実施例においては、洗浄液2の物性値が電気伝導度であり、これを検出する検出器8としてテスターを使用する場合について説明したが、物性値としては例えば吸光度等を使用することもできるし、 Further, in the above embodiment, the physical property values ​​of the cleaning liquid 2 is an electric conductivity, it has been described to use the tester as a detector 8 to detect this, for example using absorbance such as a physical property value it can also be,
検出器8としては、例えば洗浄液2中の異物の衝突により所定の信号を発する圧電素子等を使用することもできる。 As the detector 8 can also be used a piezoelectric element or the like that emits a predetermined signal by the collision of the foreign matter, for example in the cleaning liquid 2. さらに、洗浄液2として生理食塩水以外の適宜の液体を使用することもできるし、血液処理器として血液透析器以外の処理器に適用する等、本発明に係わる各発明の要旨を逸脱しない範囲において種々変更可能であることはいうまでもない。 Moreover, they can be used an appropriate liquid other than saline as a wash 2, etc. to be applied to the hemodialyzer other processor as a blood processor, without departing from the spirit and scope of the invention according to the present invention but that various changes may be.

【0035】 [0035]

【発明の効果】以上詳述したように、請求項1または2 As described above in detail, according to claim 1 or 2
記載の発明によれば、洗浄液を中空糸膜の内部やその内外面間に流して、中空糸膜の表面に付着している血液成分等の付着物を洗い流し、この付着物が含有された洗浄液の電気伝導度等の物性値を略連続状態で検出して、この検出値を基準値と比較して洗浄作業の終了時期を判断するため、洗浄作業の終了が的確に行えて、洗浄不足や洗浄過剰を防止できると共に、所定の基準値を設定するだけで各種血液処理器に適用できる等、洗浄作業の効率を向上させることができる。 According to the invention described, the cleaning liquid and flowed between the internal and the inner and outer surfaces of the hollow fiber membrane, washing away deposits such as blood components adhered to the surface of the hollow fiber membrane, the deposit is contained washing solution by detecting the physical values ​​of the electrical conductivity and the like in a substantially continuous state, in order to determine the end time of the cleaning operation by comparing the detected value with a reference value, and termination of the cleaning operation is accurately performed, shortage Ya washed with the excessive cleaning can be prevented, and the like that can be applied to various blood processing device by simply setting the predetermined reference value, it is possible to improve the efficiency of the cleaning operation.

【0036】また、請求項3または4記載の発明によれば、洗浄液供給手段で供給される洗浄液により中空糸膜の表面に付着している血液成分等の付着物を洗い流し、 Further, according to the invention of claim 3 or 4, wherein, wash away the deposits, such as blood components by the cleaning liquid supplied by the cleaning liquid supply means is attached to the surface of the hollow fiber membrane,
この付着物が含有した洗浄液の物性値が検出手段で略連続状態で検出されると共に、検出した物性値が制御手段で予め定めた基準値と比較されて洗浄作業の終了時期が判断されるため、洗浄作業の終了を的確に行えて、洗浄不足や洗浄過剰を防止できる等、洗浄作業の効率を向上させることができるという効果を奏する。 Together is detected in a substantially continuous state physical properties of the cleaning liquid the deposits contained detection means, since the end time of the cleaning operation is compared with a predetermined reference value with the detected physical value control means is determined brings to accurately perform the termination of the cleaning operation, such as an insufficient cleaning and washing excess can be prevented, the effect of the efficiency of the cleaning operation can be improved.

【図面の簡単な説明】 BRIEF DESCRIPTION OF THE DRAWINGS

【図1】本発明に係わる血液処理器の洗浄装置の一実施例を示す基本構成図 Basic configuration diagram showing an embodiment of a cleaning device of the blood processing apparatus according to the invention, FIG

【図2】同その洗浄方法の一例を示すフローチャート 2 is a flowchart showing an example of the Part cleaning method

【図3】同物性値としての電気伝導度の変化を示すグラフ 3 is a graph showing the change in electrical conductivity of the same physical properties

【図4】同電気伝導度の他の変化を示すグラフ Figure 4 is a graph showing another variation of the electric conductivity

【図5】同洗浄方法の他の例を示す要部のフローチャート FIG. 5 is a flowchart of a main part showing another example of the cleaning method

【図6】同洗浄方法のさらに他の例を示す要部のフローチャート Further flowchart of a main part showing another example of Figure 6 the washing method

【符号の説明】 DESCRIPTION OF SYMBOLS

1 洗浄装置 2 洗浄液 3 洗浄液タンク 4 血液透析器 5、6 ライン 7 ポンプ 8 検出器 9 制御装置 10 ケーシング 11 血液流入口 12 血液流出口 15 透析液流出口 16 透析液流入口 17 ライン 18 キャップ 1 cleaning device 2 cleaning solution 3 solution tank 4 hemodialyzer 5,6 line 7 pump 8 detectors 9 control device 10 casing 11 blood inlet 12 blood outlet port 15 dialysate outlet port 16 dialysate inlet 17 line 18 Cap

Claims (4)

    【特許請求の範囲】 [The claims]
  1. 【請求項1】筒状ケーシング内に多数の中空糸膜からなる中空糸束が装填された血液処理器の前記中空糸膜に付着した付着物を除去する洗浄方法であって、 前記中空糸膜の少なくとも内部に洗浄液を流し、この洗浄液の所定の物性値を略連続状態で検出し、この検出した物性値と予め定めた基準値とを比較して洗浄作業を終了させることを特徴とする血液処理器の洗浄方法。 1. A cleaning method for removing a large number of deposits in which the hollow fiber bundle of the hollow fiber membranes were attached to the hollow fiber membrane of the blood treatment device loaded in the cylindrical casing, the hollow fiber membranes at least internally flushed with cleaning liquid, blood the predetermined physical property value of the washing liquid was detected in substantially continuous state, characterized in that to terminate the cleaning operation is compared with a predetermined reference value with the detected physical properties of the method of cleaning processor.
  2. 【請求項2】前記物性値が洗浄液の電気伝導度もしくは吸光度であり、該物性値が所定値に達した時もしくは物性値の変化率が所定値に達した時に、洗浄作業を終了させることを特徴とする請求項1記載の血液処理器の洗浄方法。 Wherein said physical property value is the electrical conductivity or absorbance of the washing liquid, when the rate of change or physical properties when 該物 resistance value reaches the predetermined value has reached a predetermined value, to terminate the cleaning operation the method of cleaning a blood processor of claim 1, wherein.
  3. 【請求項3】筒状ケーシング内に多数の中空糸膜からなる中空糸束が装填された血液処理器の前記中空糸膜に付着した付着物を除去する洗浄装置であって、 前記血液処理器内に洗浄液を供給することによって中空糸膜の少なくとも内部に洗浄液を流し得る洗浄液供給手段と、該洗浄液供給手段の作動により血液処理器内を流れた洗浄液の所定の物性値を略連続状態で検出する検出手段と、該検出手段で検出した物性値と予め定めた基準値とを比較して洗浄終了時期を判断する制御手段と、を具備することを特徴とする血液処理器の洗浄装置。 3. A number of cleaning apparatus for removing deposits hollow fiber bundle of the hollow fiber membranes were attached to the hollow fiber membrane of the blood treatment device loaded in the cylindrical casing, said blood processor detection and cleaning liquid supply means can flow the washing liquid in at least the hollow fiber membrane by supplying a cleaning liquid, a predetermined physical property value of the cleaning liquid flowing through the blood processing vessel by the operation of said cleaning liquid supplying means in a substantially continuous state within blood processor of the cleaning apparatus, characterized by comprising: a detection means, and control means for determining the completion of the washing time is compared with a predetermined reference value and the physical properties detected by the detecting means, the for.
  4. 【請求項4】前記洗浄液供給手段は、中空糸膜の内外にそれぞれ洗浄液を供給することによって、該洗浄液が中空糸膜の各膜を通過する如く構成されていることを特徴とする請求項3記載の血液処理器の洗浄装置。 Wherein said cleaning liquid supply means, by supplying a respective cleaning liquid into and out of the hollow fiber membrane, according to claim 3, characterized in that it is composed as the cleaning fluid passes through each membrane of the hollow fiber membrane blood treatment instrument cleaning apparatus according.
JP11036351A 1999-02-15 1999-02-15 Washing method and washing device for blood treating device Pending JP2000233020A (en)

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