JP2000217544A - Food for dumping prevention - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a food for dumping prevention capable of preventing a dumping, keeping a blood sugar value in a normal region and ingesting a fluid food to a patient without generating diarrhea by containing a solution containing a thickening agent such as a low methoxylpectin. SOLUTION: This food is a solution for preventing a dumping and consists of the solution containing one kind or two or more kinds of thickening agents selected from a low methoxylpectin, alginic acid and carrageenan (concentration of which is preferably 0.5-12 w/v %). Further, the food for dumping prevention is obtained by pairing the above solution with a calcium solution, or pairing a solution containing λ-carrageenan with a casein magnesium solution, and it is preferable to pair the solution containing the low methoxylpectin with the calcium solution containing 70-120 mg calcium based on 1 g low methoxylpectin as a solid portion.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a food for preventing dumping. More specifically, the present invention relates to a food for preventing "dumping", which is a side effect when nutrition is taken using a liquid diet.

[0002]

2. Description of the Related Art Patients who are ingesting nutrients by a liquid diet, when a certain amount of the liquid diet accumulates in the stomach, the liquid diet rapidly drops from the stomach to the intestine (dumping), and the sugars are reduced. It is rapidly absorbed to cause hyperglycemia and symptoms of diarrhea (hereinafter, these symptoms are referred to as "dumping syndrome"). Conventionally, in order to prevent such a symptom, the administration speed of the liquid food has been reduced, or the liquid food has been gelled and taken.

[0003]

However, if the administration rate is reduced, the administration must be continued for a long time, and if the liquid food is gelled, it must be forcibly pushed.
There is a problem that the tube is clogged when administered by tube. Therefore, an object of the present invention is to prevent or prevent dumping due to ingestion of a liquid food and to provide a food for preventing dumping which is suitable for tube administration.

[0004]

Means for Solving the Problems The present inventors have conducted various studies to solve the above-mentioned problems, and as a result, completed the present invention.
That is, the present invention provides (1) low methoxyl pectin,
Anti-dumping food comprising a solution containing one or more thickeners selected from alginic acid and carrageenan, (2) one or more thickeners selected from low methoxyl pectin, alginic acid and carrageenan (3) a solution containing lambda carrageenan and a casein magnesium solution as a pair, (4) a solution containing low methoxyl pectin, and a solid A dumping preventive food comprising a calcium solution containing 70 to 120 mg of calcium per 1 g of low methoxyl pectin in terms of minutes, (5) a solution containing a thickener having a concentration of 0.5 to 12 w / v%. It comprises the anti-dumping food according to any one of claims 1 to 4. is there.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.
In the present invention, "%" means "% by weight" unless otherwise specified. In the present invention, the term "preventive food for dumping" refers to administration of a liquid meal to a patient who is administered by tube before or after administration of the liquid meal, or at the same time, in order to prevent / prevent dumping syndrome. Refers to food. The anti-dumping food of the present invention capable of preventing such dumping is, as one embodiment, a solution containing one or more thickeners selected from low methoxyl pectin, alginic acid, and carrageenan. .

In the present invention, "low methoxyl pectin (hereinafter also referred to as" LM pectin ")" refers to pectin having a degree of esterification of 50% or less. LM pectin has the property of increasing the viscosity by reacting with calcium, and the present invention utilizes this reaction or property. That is, L
M pectin reacts with calcium contained in a liquid diet in the stomach to increase / decrease viscosity to prevent / prevent dumping. Examples of the LM pectin include citrus pectin such as lemon, lime, orange, and grapefruit, and apple pectin. Such LM pectin is preferably 6 g or more per 1000 kcal of liquid food. This is because, as is clear from the results of the test examples described below, the liquid food can be made to have an appropriate viscosity that can prevent damping. However, if the amount is too large, the effect is hardly changed.

In the present invention, "alginate" refers to a hydrocolloid polysaccharide obtained by extracting from seaweed, and includes sodium alginate (hereinafter also referred to as "Na alginate"). These polysaccharides have a property of gelling by reacting with calcium, and the present invention utilizes this reaction or property. As is clear from the results of the test examples described below, these polysaccharides are preferably used in an amount of 9 g or more per 1000 kcal of liquid food. However, if the amount is too large, the effect hardly changes.

In the present invention, "carrageenan" refers to carrageenan classified into kappa type, iota type and lambda type, respectively. The former two have the property of reacting with calcium to gel and increase the viscosity, and the lambda type has the property of reacting with milk proteins such as sodium caseinate, albumin and whey to gel and increase the viscosity. is there. In particular, iota-type carrageenan has the property of reacting with magnesium to form a gel, and the present invention utilizes these reactions or properties. These carrageenans may be used in an amount of 0.5 g or more per 1000 kcal of liquid food. However, if the amount is too large, the effect is hardly changed.

[0009] In one embodiment, the anti-dumping food of the present invention comprises a solution containing one or more of the above-mentioned thickeners. The combination of the thickeners is arbitrary. Here, “solution” refers to an aqueous solution. Generally, Shimizu is used. Specifically, the thickener is dissolved in clear water to form a solution, and the concentration is desirably 0.5 to 12 w / v% or less. This is because if the concentration is too low, it is necessary to consume a large amount of it, so that it is not preferable as a food for preventing dumping. On the other hand, if the concentration is too high, the tube is clogged when administered by tube.

[0010] In another aspect, the present invention provides a method for preventing dumping comprising a solution containing one or more thickeners selected from low methoxyl pectin, alginic acid and carrageenan, and a calcium solution. Offer food. When a liquid food with a low calcium content is used, a separate calcium solution may be used. In that case, the thickener solution and the calcium solution are paired. "Pair" means that each solution is separately packaged into one set (kit).

In the present invention, the form of "calcium" is not particularly limited as long as it is suitable for food. For example, calcium chloride, calcium acetate, fermented L-type calcium lactate, synthetic calcium lactate, calcium gluconate, calcium monophosphate, calcium malate, calcium sulfate, calcium hydroxide, calcium citrate,
Dicalcium phosphate, tricalcium phosphate, bone meal,
Examples thereof include calcium carbonate, shell powder, and eggshell powder, but calcium chloride, calcium lactate, and calcium gluconate are preferred because of their high solubility in fresh water and high calcium content. One or more of these calcium is dissolved in clear water to form a calcium solution. The concentration is not particularly limited, but it is preferable that the concentration is, for example, 70 to 120 mg of calcium per 1 g of LM pectin in terms of solid content. This is because, as is clear from the results of the test examples described later, the viscosity of the thickener reacts with calcium to make the liquid food an appropriate viscosity that can prevent dumping.

The anti-dumping food of the present invention is not particularly limited in the form of its packaging material and container, and for example, a transparent pouch (polyethylene bag), an aluminum pouch bag or the like is preferably used.

Hereinafter, the method for producing the anti-dumping food of the present invention will be described by taking the case of an LM pectin solution as an example. First, an LM pectin solution is prepared. Dissolve LM pectin in clear water, fill and seal in the desired container. Then, when storing for a long time, preferably 105 to 1
Heat sterilize at 21 ° C for 5-60 minutes. The pH of the obtained solution is adjusted with an edible acid, for example, citric acid (pH 3 to 4).
In this case, the heating temperature may be reduced to about 90 to 95C.

In the case of the anti-dumping food according to another embodiment of the present invention, which is a combination of a calcium solution, a magnesium solution, a milk protein solution, etc., these solutions are separately prepared. Calcium, magnesium, or milk protein is dissolved in clear water, filled into a desired container and sealed. For long-term storage, preferably at 105-121 ° C. for 5 hours.
Heat sterilize for ~ 60 minutes. This is paired with a solution containing a thickener, for example, the above-mentioned LM pectin solution in a container, to obtain the anti-dumping food of the present invention.

A solution containing a thickener such as an LM pectin solution or a solution such as calcium is preferably heated to 105 to 121 ° C. before filling in a container.
A desired container may be filled and sealed aseptically.

The anti-dumping food of the present invention thus produced can be used for patients using a liquid diet. As a method for using only a solution containing a thickener, for example, an LM pectin solution is administered, and then a liquid food that is usually taken is administered. Alternatively, in the case of a combination of a solution containing a thickener and a calcium solution, for example, if an example of a dumping preventive food composed of a LM pectin solution and a calcium solution is described, an LM pectin solution is used. After the liquid diet is sequentially administered, the calcium solution is administered. It does not matter which of the LM pectin solution and the calcium solution is administered first, but in order to prevent the two from reacting and coagulating in the tube, administer a small amount of fresh water during administration of both tubes. Should be washed. As another method, after the LM pectin solution is administered, a liquid diet mixed with a calcium solution in advance may be administered. As still another method, the calcium solution may be administered after the LM pectin solution and the liquid food are sequentially administered. This method is preferred.

The anti-dumping food of the present invention is useful for patients using such a liquid diet, for example, patients with cerebral damage and lack of masticatory power or those who cannot take solids by stomach surgery. In this case, it is possible to prevent / prevent dumping by mixing the liquid food and the anti-dumping food in the stomach, and using the cations (calcium, calcium, etc.) contained in the liquid food as a polysaccharide such as LM pectin. (Eg, magnesium), or reacts with cations in these cation solutions supplemented separately to form an appropriate gel (viscosity of 500 mPa · S or more). As a result, the viscosity of food (liquid food) in the stomach increases, It is presumed that rapid fall was prevented and dumping was prevented. This is apparent from the fact that, when the liquid food is administered, the anti-dumping food of the present invention does not cause a rapid rise in blood sugar level or diarrhea, as will be shown in the following test examples.

[0018]

The present invention will be described below in more detail with reference to Examples and Test Examples. Example 1 100 ml of a 2.8 w / v% LM pectin solution was filled in an aluminum pouch, sealed, and heat-sterilized at 110 ° C. for 30 minutes to obtain a dumping preventive food of the present invention. The anti-dumping food of the present invention was used in the following manner for a patient without masticatory force who was administered a liquid diet of 1200 kcal a day in three divided doses by tube. After injecting one bag of the anti-dumping food of the present invention by tube using a syringe, a single dose of a liquid meal is tube-administered as usual. After continuing this method for one week, the patient had a normal blood glucose level and had never had diarrhea even after receiving the liquid diet.

Example 2 First, 50 ml of a 10 w / v% LM pectin solution was filled in an aluminum pouch, sealed, and sterilized by heating at 110 ° C. for 30 minutes. On the other hand, 40 ml of a 1 w / v% calcium chloride solution
Each was sealed in an aluminum pouch and heat-sterilized at 110 ° C. for 30 minutes. The LM pectin solution and the calcium solution thus obtained were paired to obtain the anti-dumping food of the present invention. The anti-dumping food of the present invention was used in the following manner for a patient without masticatory force who was administered a liquid diet of 1200 kcal a day in three divided doses by tube. First, one bag of the LM pectin solution is infused via a tube with a syringe, and then a single dose of a liquid meal is tube-administered as usual. Further, one bag of the calcium solution is administered. After one week of such a procedure, the patient had a normal blood glucose level even after receiving a liquid diet, and had diarrhea for 1 week.
Did not wake up.

Example 3 First, 50 ml of a 1 w / v% lambda carrageenan solution was filled in an aluminum pouch, sealed, and sterilized by heating at 110 ° C. for 30 minutes. On the other hand, 40 ml of a 1 w / v% magnesium casein solution is filled in an aluminum pouch, sealed, and sterilized by heating at 110 ° C. for 30 minutes. The lambda carrageenan solution and the magnesium caseinate solution thus obtained were used as a pair to prepare a dumping preventive food of the present invention. The anti-dumping food of the present invention is applied to a liquid diet of 1200 kcal per day.
Was used as follows for patients without masticatory power who were administered three times by tube. First, one bag of the lambda carrageenan solution is infused via a tube via a syringe, and then a single dose of a liquid meal is administered via a tube as usual. Further, one bag of magnesium casein solution is administered. After continuing this method for one week, the patient had a normal blood glucose level and had never had diarrhea even after receiving the liquid diet.

Example 4 First, a citric acid solution was added to a solution of 7% w / v sodium alginate and LM pectin (one-to-one) to adjust the pH to 3.8, and 50 ml was filled into an aluminum pouch bag at 95 ° C.
For 10 minutes. Meanwhile, a 1 w / v% calcium gluconate solution was heated at 105 ° C. for 8 minutes. The mixture was filtered through a filter having a pore size of 0.2 μm, and sterilized polyethylene bags were aseptically filled in 50 ml portions and sealed. The sodium alginate, the LM pectin (1: 1) solution, and the calcium solution thus obtained were paired to obtain the anti-dumping food of the present invention. When the anti-dumping food of the present invention was administered to a patient in the same manner as in Example 2, the patient had a normal blood sugar level and did not cause any diarrhea even when the liquid diet was administered.

Test Example 1 (Amount of LM pectin to liquid liquid food) Test method: 1000 ml of a commercially available liquid liquid food (1 kcal / ml: containing 60 mg% of calcium) having a concentration (w / v%) as shown in Table 1 100 ml of the LM pectin solution was added and the viscosity was measured. Test results: as shown in Table 1. That is, from the table,
LM pectin 6.0 g per 1000 kcal liquid food
Above is the viscosity (500 mP
a.S or more).

[0023]

[Table 1]

Test Example 2 (Amount of sodium alginate to liquid liquid food) Test method: 1000 ml of a commercially available liquid liquid food (1 kcal / ml: containing 60 mg% of calcium) having a concentration (w / v%) shown in Table 2 Sodium alginate solution 100
ml was added and the viscosity was measured. Test results: as shown in Table 2. That is, from the table,
If the sodium alginate is 9.0 g or more per 1000 kcal of liquid food, the viscosity (5
00 mPa · S or more).

[0025]

[Table 2]

Test Example 3 (Amount of Lambda Carrageenan to Liquid Liquid Food) Test Method: Concentration (w / v%) shown in Table 3 in 1000 ml of a commercially available liquid liquid food (1 kcal / ml: containing 3 g% sodium caseinate) Lambda carrageenan solution 10
0 ml was added and the viscosity was measured. Test results: as shown in Table 3. That is, from the table,
For a liquid food of 1000 kcal, if the lambda carrageenan is 0.5 g or more, the viscosity which can prevent dumping (5
00 mPa · S or more).

[0027]

[Table 3]

Test Example 4 (Amount of calcium based on LM pectin) Test method: 1000 ml of a commercially available liquid food (1 kcal / ml: containing 30 mg% of calcium) was mixed with 1000 ml of LM pectin.
0 ml (5 w / v%) and 100 ml of a calcium solution having the concentration shown in Table 4 were sequentially added, and the viscosity was measured. Test results: as shown in Table 4. That is, from the table,
Calcium 70 per 1 g of LM pectin in terms of solid content
When the viscosity is up to 120 mg, the viscosity (5
00 mPa · S or more).

[0029]

[Table 4]

Test Example 5 (Effect of Administration of LM Pectin Solution) Test Method: Ten patients who are prone to diarrhea and do not have masticative power are randomly selected and given to each of the patients three times a day in the morning, afternoon, and evening. , A commercially available liquid food (1 kcal / m
l: 60 mg% of calcium) was administered via tube over 60 minutes. This administration was performed for 3 days. On the next day after the administration, the 2.8 w / v% LM pectin solution 10
After administration of 0 g by tube over 5 minutes, a commercially available liquid diet (1 k
cal / ml: calcium 60mg%) 400ml
Was administered by gavage over 60 minutes. This administration was performed for 3 days. On the evening of the third day when the administration of the liquid diet alone was completed,
Immediately after the administration of the liquid diet, blood was collected from each patient six times every 30 minutes, and the blood sugar level was measured, and the patient was examined for diarrhea. In the evening of the third day when the combined administration of the pectin solution and the liquid diet was completed, the same test as in the case of the administration of the liquid diet alone was performed on each patient to investigate the blood glucose level and diarrhea. . Test results: (1) Blood glucose level changes as shown in Table 5. When this is graphed, it becomes as shown in Fig. 1. In the case of administration of the liquid diet alone, the blood glucose level greatly exceeds the normal range after administration, whereas when the pectin solution is administered in combination, the blood glucose level falls almost in the normal range. Can understand. FIG. 1 (FIGS. 2 to 6 are the same)
The middle normal range (upper limit) and the normal range (lower limit) are blood sugar level indices which are standardized by the Japanese Diabetes Society. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients, but the symptoms were improved in 7 patients after the combined administration of the pectin solution.

[0031]

[Table 5]

Test Example 6 (Effect of administration of sodium alginate solution) Test method: The same as Test Example 5 except that the 2.8 w / v% LM pectin solution of Test Example 5 was replaced with a 4.0 w / v% sodium alginate solution. Tested. Test results: (1) Blood sugar level changes as shown in Table 6. FIG. 2 shows a graph of this, and it can be understood that the blood glucose level falls substantially in the normal range when the sodium alginate solution is co-administered. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients. Thereafter, when the sodium alginate solution was co-administered, the symptoms improved in 7 patients.

[0033]

[Table 6]

Test Example 7 (Effect of administration of lambda carrageenan solution) Test method: The same as Test Example 5 except that the 2.8 w / v% LM pectin solution of Test Example 5 was replaced with a 1.0 w / v% lambda carrageenan solution. Tested. Test results: (1) Blood sugar level changes as shown in Table 7. FIG. 3 is a graph showing this, and it can be understood that the blood glucose level falls substantially in the normal range when the lambda carrageenan solution is administered in combination. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients. After that, the combined use of the lambda carrageenan solution improved the symptoms in 6 patients.

[0035]

[Table 7]

Test Example 8 (Administration effect of LM pectin and sodium alginate solution) Test method: Instead of the 2.8 w / v% LM pectin solution of Test Example 5, 4.0 w / v% LM pectin and sodium alginate (2: 1) The same test as in Test Example 5 was performed using the solution. Test results: (1) The blood sugar level changes as shown in Table 8. FIG. 4 is a graph showing this, and it can be understood that the blood glucose level falls substantially in the normal range when the LM pectin and sodium alginate solution are co-administered. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients, but after that, when LM pectin and sodium alginate solution were administered in combination, the symptom was improved in 8 patients.

[0037]

[Table 8]

Test Example 9 (Administration effect of sodium alginate solution and calcium solution as a pair) Test method: Using a 4.0 w / v% sodium alginate solution instead of the 2.8 w / v% LM pectin solution of Test Example 5 The same test as in Test Example 5 was performed except that 35 g of a 1.0 w / v% calcium solution was further tube-administered over 3 minutes after tube administration of the liquid diet. Test results: (1) The blood sugar level changes as shown in Table 9. FIG. 5 shows a graph of this, and it can be understood that the blood sugar level falls within the normal range when the sodium alginate solution and the calcium solution are combined and administered in pairs. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients, but the symptoms were improved in 7 patients after the combined administration of a sodium alginate solution and a calcium solution.

[0039]

[Table 9]

Test Example 10 (Administration Effect of Lambda Carrageenan and Magnesium Casein Solution as a Pair) Test Method: Using a 1.0 w / v% lambda carrageenan solution instead of the 2.8 w / v% LM pectin solution of Test Example 5 The same test as in Test Example 5 was conducted except that a liquid diet was administered by tube and then 50 g of a 1.0 w / v% magnesium caseinate solution was administered by tube over 5 minutes. Test results: (1) The blood sugar level changes as shown in Table 10. FIG. 6 shows a graph of this, and it can be understood that when the lambda carrageenan solution and the magnesium caseinate solution are administered in combination, the blood sugar level falls within the normal range. (2) In addition, administration of the liquid diet alone caused diarrhea in all 10 patients. Thereafter, the combination of a lambda carrageenan solution and a magnesium caseinate solution improved the symptoms in 9 patients.

[0041]

[Table 10]

[0042]

As described above, by using the anti-dumping food of the present invention, it is possible to prevent the dumping, maintain the blood glucose level in a normal range, and allow the patient to ingest the liquid diet without diarrhea.

[0043]

[Brief description of the drawings]

1 to 5 are graphs showing changes over time in blood glucose level,

FIG. 1 shows a case where LM pectin is used as a thickener.

FIG. 2 shows a case where sodium alginate was used as a thickener.

FIG. 3 shows a case where lambda carrageenan is used as a thickener.

FIG. 4 shows a case where LM pectin and sodium alginate were used as thickeners.

FIG. 5 shows a case where sodium alginate was used as a thickening agent and a calcium solution was administered in pairs.

FIG. 6 uses lambda carrageenan as a thickener,
The case where magnesium casein solution is administered in pairs is shown.

────────────────────────────────────────────────── ───

[Procedure amendment]

[Submission date] May 15, 2000 (2000.5.1)
5)

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Claims

[Correction method] Change

[Correction contents]

[Claims]

[Procedure amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0004

[Correction method] Change

[Correction contents]

[0004]

Means for Solving the Problems The present inventors have conducted various studies to solve the above-mentioned problems, and as a result, completed the present invention.
That is, the present invention provides (1) a method for preventing damping.
A solution of low-methoxyl pectin, damping preventive food consisting of a solution containing one or more thickener is selected from alginic acid and carrageenan, (2)
A solution for preventing dumping, wherein a solution containing one or more thickeners selected from low methoxyl pectin, alginic acid and carrageenan is paired with a calcium solution to prevent dumping; ) Dumping preventive food comprising a pair of a solution containing lambda carrageenan and a magnesium caseinate solution ;
A dumping preventive food comprising a solution containing low methoxyl pectin and a calcium solution containing 70 to 120 mg of calcium per 1 g of low methoxyl pectin in terms of solids, 5) a solution for preventing dumping,
The anti-dumping food according to any one of claims 1 to 4, wherein the concentration of the solution containing the thickener is 0.5 to 12 w / v%.

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Yuko Ito 5-13-13 Sumiyoshi-cho, Fuchu-shi, Tokyo, Japan 1Kupy Corporation Research Institute (72) Inventor Kazuhiko Kaneda 1-4-13 Shibuya, Shibuya-ku, Tokyo F-term (Ref.) 4K018 LB10 LE04 LE05 MD04 MD37 MD38 MD39 MD71 ME14 4B041 LC10 LD03 LH06 LH10 LK02 4C076 AA12 BB04 CC40 DD22 DD43 EE30 EE36 EE41 EE58 FF17 FF70

Claims (5)

[Claims] An anti-dumping food comprising a solution containing one or more thickeners selected from low methoxyl pectin, alginic acid and carrageenan. 2. An anti-dumping food comprising a calcium solution and a solution containing one or more thickeners selected from low methoxyl pectin, alginic acid and carrageenan. 3. An anti-dumping food comprising a solution containing lambda carrageenan and a magnesium caseinate solution. 4. An anti-dumping food comprising a solution containing low methoxyl pectin and a calcium solution containing 70 to 120 mg of calcium per 1 g of low methoxyl pectin in terms of solid content. 5. A solution containing a thickener having a concentration of 0.5 to 12 watts.
The anti-dumping food according to any one of claims 1 to 4, which is / v%.