JP2000166966A - Adhesive tape to be sticked on skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To stabilize adhesion at the time of sweating, etc., and to reduce a pain, etc., at the time of releasing by setting the follow-up property, a water vapor transmission ratio, counter-bakelite adhesion respectively to a specific value. SOLUTION: As a supporter of an adhesive tape for sticking a skin, an extensible film whose extensible film follow-up property is not smaller than the 4.2 fold of film stress at the time of extending by 15% is used. In addition, its water vapor transmission ratio is not smaller than 500 g/m2 24 h and the counter bakelite adhesion is not larger than 1.5N/15 mm. As this extensible supporter, a polyurethane film, a polyurethane nonwoven fabric, etc., can be used. Its thickness is desirably about 40 to 200 μm in usual. For example, the copolymer of isononyeacrylate/methoxynonaethyleneglycol acrylate/nonaethylene glycol methacrylate, e.g. is used as the adhesive and a polyolefin type permeable film is formed as a supporter. Thus adhesion is stabilized.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a pressure-sensitive adhesive tape for application to the skin, and more particularly to a pressure-sensitive adhesive tape which is stable when sweating or applied for a long period of time, and which is effective in reducing pain, exfoliation and skin irritation during exfoliation. The present invention relates to a small amount of pressure-sensitive adhesive tape for applying to skin. The pressure-sensitive adhesive tape for application to the skin of the present invention is particularly suitable as a medical pressure-sensitive adhesive tape for protecting an affected skin or a surgical site.

[0002]

2. Description of the Related Art Conventionally, various types of pressure-sensitive adhesive tapes for application to the skin have been developed for protecting affected skin areas and transdermal absorption of drugs. Such an adhesive tape for skin application is generally
It has a structure in which a pressure-sensitive adhesive layer containing a drug is formed on one side of a flexible support as needed. The pressure-sensitive adhesive tape for skin application has good skin-following properties that can follow the shape and movement of the skin surface to be applied, has no moisture retention due to sweating, has excellent moisture permeability, pain and exfoliation of the stratum corneum during exfoliation It is required that there is no skin damage, that the skin stickiness can be maintained for a long time, and that there is no skin disorder such as rash, itching, and erythema. However, since the pressure-sensitive adhesive tape for skin application is often applied to the skin surface for a long period of time, there has been a problem that skin irritation and the like always accompany as a side effect.

Conventionally, various proposals have been made to reduce various problems such as skin irritation. For example, a method of reducing exfoliation of keratinocytes during exfoliation by forming a crosslinked pressure-sensitive adhesive layer containing an acrylate polymer and a liquid component compatible with the polymer on a support ( JP-A-5-65224), a method of reducing skin damage and skin irritation by imparting moisture permeability to a support and an adhesive layer (JP-A-5-279251, JP-A-7-157423) JP-A-7-275340), a method of reducing skin irritation and exfoliation of the stratum corneum by using a support made of a water-absorbing polymer and an adhesive containing a water-absorbing substance (Japanese Patent Laid-Open No. 6-275340). No. 16541, JP-A-7-206710), a method for preventing the occurrence of irritation, rash, itching, erythema and the like on the human body by reducing the amount of residual monomers in the adhesive (JP-A-5-13) 022 JP), by using a stretchable support, imparting skin followability (JP-7-
138152, JP-A-8-117268)
And so on.

However, various factors are complicatedly involved in the development of skin irritation due to the application of the adhesive tape for application to the skin, and it is sufficient to improve a single factor or two types of factors to solve the problem. Does not reach. In addition, for example, if measures are taken to reduce skin irritation, problems such as a decrease in tackiness and skin followability are likely to occur, and it has been difficult to properly balance various properties.

[0005]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a skin-adhering property, a moisture-permeable property and a skin-adhesive property each within an appropriate range, and these properties are highly balanced. Time and stickiness at the time of sticking for a long time,
An object of the present invention is to provide a pressure-sensitive adhesive tape for skin application, in which pain upon exfoliation, exfoliation, and skin irritation are significantly reduced.

The present inventors have conducted intensive studies to overcome the problems of the prior art, and as a result, have found that an acrylic pressure-sensitive adhesive, rubber Tape with a pressure-sensitive adhesive layer composed of a pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive, a vinyl ether-based pressure-sensitive adhesive, etc., in which the stretchability of the stretchable film (defined later), moisture permeability, and adhesive strength are within specified ranges. It has been found that a certain pressure-sensitive adhesive tape has appropriate skin-following properties, moisture permeability, and skin adhesiveness, and is suitable as a pressure-sensitive adhesive tape for applying to skin. ADVANTAGE OF THE INVENTION The adhesive tape for skin affixing of this invention has the stable adhesiveness at the time of perspiration or prolonged application, and also has little pain at the time of peeling, exfoliation of keratin, and skin irritation. The present invention has been completed based on these findings.

[0007]

According to the present invention, there is provided a pressure-sensitive adhesive tape for skin sticking, comprising a pressure-sensitive adhesive layer formed on at least one surface of a stretchable support having moisture permeability, and (1) following a stretchable film. When the stretchability is 15%, the stress of the stretchable film is 4.2 times or less, and (2) the moisture permeability is 500 g / m ² · 24 h.
Above, and (3) the adhesive strength to bakelite is 1.5 N / 1
A pressure-sensitive adhesive tape for applying to skin, which is not more than 5 mm, is provided.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION (Support) As a support for use in the pressure-sensitive adhesive tape for application to the skin of the present invention, a film or nonwoven fabric having high moisture permeability and good stretchability can be used.
As an objective index of the elasticity of the support, a stress at 15% elongation can be used. The stress at the time of 15% elongation of the support used in the present invention is usually 15 N / 15 mm or less, preferably 8 N / mm or less. 15% of support
When the stress at the time of extension is within this range, an adhesive tape which can easily follow the movement of the skin surface to be applied can be obtained.
The lower limit of the stress when the support is stretched by 15% is usually 1 N / 1.
It is about 5 mm. Here, the stress at the time of the 15% elongation of the support was set at 100 mm / min using an Instron type tensile tester with a sample of 15 mm × 150 mm in an atmosphere of a humidity of 23 ± 2 ° C. and a relative humidity of 65 ± 5%. It is a value measured as the stress when elongating at a rate of 15%.

The moisture permeability of the support of the present invention is determined according to JIS Z-
It can be objectively evaluated based on the moisture permeability measured under the B condition of 0208 (temperature: 40 ° C., relative humidity: 90%). The moisture permeability of the support used in the present invention is usually 500 g / m
^It is at least 2.24 h, preferably at least 700 g / m ² · 24 h, more preferably at least 1000 g / m ² · 24 h. When the moisture permeability of the support is within the above range, moisture generated by perspiration at the time of application can be effectively evaporated, and an adhesive tape which is less likely to cause skin irritation can be obtained. The upper limit of the moisture permeability of the support is usually 10,000 g / m ² · 24.
h.

Specific examples of such a stretchable support having moisture permeability include a polyurethane film, a polyester elastomer film, a polyolefin-based breathable film, a polyvinyl alcohol film, a polyurethane nonwoven fabric, a polyester elastomer nonwoven fabric, and a thermoplastic polyolefin. Nonwoven fabrics and the like can be mentioned. The thickness of the support is usually 40 to 200 μm, preferably 50 to 1 μm.
50 μm.

(Adhesive) The adhesive used in the adhesive tape for skin of the present invention is preferably one which is hard to exfoliate keratinocytes from the skin surface at the time of peeling and hardly damages the skin surface. As the pressure-sensitive adhesive having such pressure-sensitive adhesive properties, the adhesive strength against bakelite when formed into a pressure-sensitive adhesive tape can be used as an index. The adhesive used in the present invention has an adhesive strength to bakelite of 1.5 N / 15 mm or less, preferably 1.3 N / 1.
5 mm or less. The lower limit of the adhesive strength against bakelite is usually about 0.6 N / 15 mm. Here, the adhesive strength against bakelite is a value obtained by measuring the adhesive strength of an adhesive tape having a width of 15 mm to a bakelite panel according to the 180-degree peeling method of JIS Z-0237. The pressure-sensitive adhesive used in the present invention preferably has excellent moisture permeability. When a pressure-sensitive adhesive layer is formed on the support, the pressure-sensitive adhesive has a moisture permeability of 500 g / m ² · 24 h or more, preferably 700 g / m 2. ² · 24h or more, more preferably 1000
g / m ² · 24 h or more.

Examples of the pressure-sensitive adhesive used for the pressure-sensitive adhesive tape for application to the skin of the present invention include acrylic pressure-sensitive adhesives, rubber pressure-sensitive adhesives, silicone pressure-sensitive adhesives, and vinyl ether pressure-sensitive adhesives. Among these pressure-sensitive adhesives, from the viewpoint of initial tack or skin irritation, an acrylic resin obtained by (co) polymerizing a monomer or a monomer mixture containing an alkyl (meth) acrylate as a main component monomer is used. Based adhesives are preferred. From the viewpoints of stable skin adhesiveness, high moisture permeability, reduction of exfoliation of keratin, and reduction of skin pain at the time of exfoliation, (meth) acrylic acid alkoxypolyalkylene glycol ester and a hydroxyl group- or carboxyl group-containing monomer are used as comonomers. Acrylic pressure-sensitive adhesives comprising an acrylic copolymer obtained by using the above in combination with a pressure-sensitive adhesive component are particularly preferred.

More specifically, preferred acrylic pressure-sensitive adhesives include 50 to 97.5% by weight, preferably 70 to 95% by weight, of an alkyl (meth) acrylate having an alkyl group having 4 to 12 carbon atoms. (Meth) alkoxypolyalkylene glycol esters of acrylic acid 2-4
Copolymers of 9.5% by weight, preferably 4 to 29% by weight, and 0.5 to 15% by weight, preferably 1 to 10% by weight of a monomer having a hydroxyl group or a carboxyl group can be mentioned. The copolymer may further be obtained by copolymerizing another copolymerizable vinyl monomer within a range of about 0 to 30% by weight.

Examples of the alkyl (meth) acrylate having an alkyl group having 4 to 12 carbon atoms include n-butyl acrylate, isobutyl acrylate, t-butyl acrylate, 2-ethylhexyl acrylate and n-acrylate. -Octyl, isooctyl acrylate, isononyl acrylate, decyl acrylate, dodecyl acrylate, n-butyl methacrylate, isobutyl methacrylate, t-butyl methacrylate, 2-ethylhexyl methacrylate, n-octyl methacrylate, isooctyl methacrylate , Isononyl methacrylate, decyl methacrylate, dodecyl methacrylate and the like. Among them, 2-ethylhexyl acrylate,
Preferred are n-octyl acrylate, isooctyl acrylate, and isononyl acrylate. These (meta)
The alkyl acrylates can be used alone or in combination of two or more.
The (meth) acrylic acid alkoxypolyalkylene glycol ester is represented by the following formula (1)

[0015]

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(In the formula, R ₁ and R ₂ are each independently a hydrogen atom or a methyl group, R ₃ is an alkyl group having 1 to 20 carbon atoms, and n is an integer of 2 to 12.) It is a (meth) acrylic-ester type monomer represented by these.

Specific examples of the monomer represented by the formula (1) include, for example, methoxydiethylene glycol acrylate (R ₁ = H, R ₂ = H, R ₃ = CH ₃ , n =
2), methoxydiethylene glycol methacrylate (R
₁ = CH ₃ , R ₂ = H, R ₃ = CH ₃ , n = 2), methoxydipropylene glycol acrylate (R ₁ = H, R
₂ = CH ₃ , R ₃ = CH ₃ , n = 2), methoxydipropylene glycol methacrylate (R ₁ = CH ₃ , R ₂ =
CH ₃ , R ₃ = CH ₃ , n = 2), ethoxydiethylene glycol acrylate (R ₁ = H, R ₂ = H, R ₃ = C
₂ H ₅ , n = 2), ethoxydiethylene glycol methacrylate (R ₁ ＣＨCH ₃ , R ₂ ＨH, R ₃ ＣC ₂ H ₅ ,
n = 2), ethoxydipropylene glycol acrylate (R ₁ = H, R ₂ = CH ₃ , R ₃ = C ₂ H ₅ , n =
2), ethoxydipropylene glycol methacrylate (R ₁ ＣＨCH ₃ , R ₂ ＣＨCH ₃ , R ₃ ＣC ₂ H ₅ , n =
2), methoxytriethylene glycol acrylate (R
₁ = H, R ₂ = H, R ₃ = CH ₃ , n = 3), methoxytriethylene glycol methacrylate (R ₁ = CH ₃ ,
R ₂ = H, R ₃ = CH ₃ , n = 3), methoxytripropylene glycol acrylate (R ₁ = H, R ₂ = CH)
₃ , R ₃ ＣＨCH ₃ , n = 3), methoxytripropylene glycol methacrylate (R ₁ ＣＨCH ₃ , R ₂ ＣＨCH
₃ , R ₃ = C ₂ H ₅ , n = 3), methoxypolyethylene glycol acrylate (R ₁ = H, R ₂ = H, R ₃ = C
H ₃ , n = 4 to 10), methoxypolyethylene glycol methacrylate (R ₁ ＣＨCH ₃ , R ₂ ＨH, R ₃ ＣＨCH ₃
, N = 4 to 10), methoxypolypropylene glycol acrylate (R ₁ = H, R ₂ = CH ₃ , R ₃ = CH
₃ , n = 4 to 10), methoxypolypropylene glycol methacrylate (R ₁ = CH ₃ , R ₂ = CH ₃ , R ₃ =
CH ₃ , n = 4 to 10).

Examples of the hydroxyl group or carboxyl group-containing monomer include hydroxyalkyl (meth) acrylate and carboxyalkyl (meth) acrylate. Specific examples of these monomers include, for example, 2-hydroxyethyl acrylate, 2-carboxyethyl acrylate, 2-hydroxypropyl acrylate, 2-carboxypropyl acrylate, 3-hydroxypropyl acrylate, 3-hydroxyacrylate Carboxypropyl, 4-hydroxybutyl acrylate, 4-carboxybutyl acrylate, 2-hydroxyethyl methacrylate, 2-carboxyethyl methacrylate, 2-hydroxypropyl methacrylate, 2-methacrylic acid
Examples thereof include carboxypropyl, 3-hydroxypropyl methacrylate, 3-carboxypropyl methacrylate, 4-hydroxybutyl methacrylate, and 4-carboxybutyl methacrylate. The hydroxyl- or carboxyl-containing monomer is represented by the formula (2)

[0019]

Embedded image

(Wherein, R ₄ and R ₅ are each independently a hydrogen atom or a methyl group, and m is an integer of 2 to 12). ) A hydroxyl group-containing (meth) acrylate monomer such as polypropylene glycol acrylate, and formula (3)

[0021]

Embedded image

(Wherein, R ₆ is a hydrogen atom or a methyl group, X is a divalent organic group having 2 or more carbon atoms,
It may contain a hetero atom such as an oxygen atom, a nitrogen atom and a sulfur atom. ))-Containing (meth) acrylic acid ester-based monomers represented by the formula (1).

In the formula (3), the carbon number of X is preferably about 2 to 50, more preferably about 2 to 30. Heteroatoms are often oxygen atoms. Specific examples of X include, for example, a linear or branched alkylene group having 2 or more carbon atoms, —R ₇ —OCO—R ₈ — (where R
₇ and R ₈ are alkylene groups), —R ₉ —OCO
—R ₁₀ —OCO—R ₁₁ — (provided that R ₉ , R ₁₀ , and R
₁₁ is an alkylene group). Specific examples of the (meth) acrylic acid ester having a carboxyl group represented by the formula (3) include, for example, 2-carboxyethyl acrylate, 2-acryloyloxyethyl succinic acid, ω-carboxypolycaprolactone acrylate, and the like. Is mentioned.

Examples of other copolymerizable vinyl monomers include, for example, methyl acrylate, ethyl acrylate,
Alkyl (meth) acrylates such as isopropyl acrylate, methyl methacrylate, ethyl methacrylate, isopropyl methacrylate, tridecyl acrylate, tridecyl methacrylate; acrylic acid, methacrylic acid, maleic acid, maleic anhydride, itaconic acid, etc. Carboxyl group-containing monomers; (meth) acrylamides such as acrylamide, methacrylamide, N-methylolacrylamide and derivatives thereof: epoxy group-containing monomers such as glycidyl acrylate and glycidyl methacrylate; vinyl esters such as vinyl acetate; acrylonitrile, methacrylonitrile Unsaturated nitriles; vinyl aromatic compounds such as styrene; and the like.

The pressure-sensitive adhesive used in the present invention may optionally contain various general-purpose additives to the acrylic pressure-sensitive adhesive. A transdermally absorbable drug can be added to the adhesive, if desired. Drugs include, for example, angina pectoris, corticosteroids, analgesics and anti-inflammatory agents,
Hypnotic analgesics, anti-inflammatory agents, antiallergic agents, antihistamines, coronary vasodilators, antibacterial agents, humectants, vitamins, antitussives, anesthetics, antitumor agents, fragrances and the like. These are compounded in an effective amount as required.

(Skin Adhesive Tape for Adhering to Skin) The skin adhesive tape of the present invention can be produced by applying an adhesive on at least one surface of a moisture-permeable stretchable support according to a conventional method. An adhesive may be applied on a separator and transferred to a support. To apply the pressure-sensitive adhesive, a solution obtained by uniformly dissolving or dispersing the base polymer and, if necessary, the additive component in an organic solvent may be applied to a support or a separator and dried. The thickness of the pressure-sensitive adhesive layer is usually 20 to 60 μm, preferably 30 to 50 μm.
μm.

The pressure-sensitive adhesive tape for application to the skin of the present invention has the following various properties. (1) The stretchability of the stretchable film at the time of 15% elongation is 4.2 times or less, preferably 4.0 times or less of the stretchable film stress.
(2) Moisture permeability of 500 g / m ² · 24 h or more, preferably 700 g / m ² · 24 h or more, more preferably 100 or less
0 g / m ² · 24 h or more; (3) Bakelite adhesion to 1.5 N / 15 mm or less, preferably 1.3 N / 15 mm or less, more preferably 1.2 N / 15 mm or less.

Here, the stretchability of the stretchable film is defined as follows. The adhesive tape sample is stuck on the stretchable film and measured using an Instron-type tensile tester, as will be described in detail in the measurement method described later. The stress of the pressure-sensitive adhesive tape sample when the stretchable film was stretched by 15% at a speed of 100 mm / min. The value (magnification) obtained by dividing the measured value of this stress by the stress when the stretchable film was stretched by 15% was obtained. It needs to be less than 4.2 times. In Examples and Comparative Examples, a polyurethane film (thickness: 27 μm) having a stress at the time of 15% elongation of 0.84 N / 15 mm was used as the stretchable film. This is because the polyurethane film resembles the condition of human skin. From this value (magnification), skin followability can be evaluated. The skin following property of the pressure-sensitive adhesive tape of the present invention can be actually measured by attaching to the skin of the human body, but since there is an individual difference in the skin of the human body, the following property of the stretchable film is used as an objective index. Things.

The stretchability of the stretchable film is usually from 2.5 to
It is in the range of 3.5 N / 15 mm (3.0 to 4.2 times). The upper limit of the moisture permeability is usually 5000 g / m ² · 24 h
It is about. The lower limit of bakelite adhesion is usually
It is about 0.6 N / 15 mm. Since the pressure-sensitive adhesive tape for applying skin of the present invention has such various properties, it has good skin followability, little water retention at the time of application, and good adhesion at the time of publication or long-time application. In addition, there is a feature that pain at the time of peeling, exfoliation of the skin, and skin irritation are small. Therefore, the pressure-sensitive adhesive tape for application to the skin of the present invention can be used for the purpose of protecting the skin protection such as protection of the affected part of the skin and the affected part after the operation, and percutaneous absorption of the drug.

[0030]

The present invention will be described below more specifically with reference to examples and comparative examples. In the following examples and comparative examples, parts and% are unless otherwise specified.
Based on weight.

Example 1 As an adhesive, isononyl acrylate / methoxynonaethylene glycol acrylate / nonaethylene glycol methacrylate (83 parts / 1
Pressure-sensitive adhesive solution obtained by adding 0.6 part of Coronate L (manufactured by Nippon Polyurethane) to 100 parts of the copolymer (solid content) using an acrylic copolymer obtained by copolymerizing 6 parts / 1 part) [ (Solvent: toluene / ethyl acetate = 7/3 (weight ratio);
Concentration 30% by weight)]. This pressure-sensitive adhesive solution was applied on a separator having a surface subjected to silicone treatment so as to have a thickness of 38 μm after drying, and dried at 120 ° C. for 3 minutes. After that, on the surface of the pressure-sensitive adhesive layer, a thickness of 80
Laminate a polyolefin-based breathable film of μm,
After aging at 50 ° C. for 1 week, an adhesive tape for application to the skin was prepared.

Example 2 Among the monomer components of the pressure-sensitive adhesive,
An adhesive tape for application to the skin was prepared in the same manner as in Example 1 except that the hydroxyl group-containing monomer was changed to ethylene glycol methacrylate.

Comparative Example 1 As an adhesive, isononyl acrylate / methoxynonaethylene glycol acrylate / nonaethylene glycol methacrylate (83 parts / 1
Pressure-sensitive adhesive solution obtained by adding 0.6 part of Coronate L (manufactured by Nippon Polyurethane) to 100 parts of the copolymer (solid content) using an acrylic copolymer obtained by copolymerizing 6 parts / 1 part) [ (Solvent: toluene / ethyl acetate = 7/3 (weight ratio);
Concentration 30% by weight)]. The pressure-sensitive adhesive solution was applied to a separator having a surface subjected to silicone treatment so as to have a thickness of 38 μm after drying, and dried at 120 ° C. for 3 minutes. Then, on the pressure-sensitive adhesive layer surface, a thickness of 10
A 0 μm EMMA (ethylene-methyl methacrylate copolymer) film was bonded and aged at 50 ° C. for 1 week to prepare a pressure-sensitive adhesive tape for skin application.

Comparative Example 2 Using an isononyl acrylate / acrylic acid (98 parts / 2 parts) copolymer as an adhesive, an adhesive solution [(solvent: toluene / ethyl acetate = 7 /
3 (weight ratio); concentration 30% by weight)]. This adhesive solution was applied to a separator having a surface treated with silicone so that the thickness after drying was 38 μm.
Dry at 0 ° C. for 3 minutes. Thereafter, a rayon nonwoven fabric having a thickness of 100 μm is attached to the adhesive layer surface as a support,
It was aged at 40 ° C. for 1 week to prepare a pressure-sensitive adhesive tape for application to the skin.

[Comparative Example 3] As an adhesive, an isononyl acrylate / acrylic acid (96 parts / 4 parts) copolymer was used, and an adhesive solution [(solvent: toluene / ethyl acetate = 7 /
3 (weight ratio); concentration 30% by weight)]. This adhesive solution was applied to a separator having a surface treated with silicone so that the thickness after drying was 38 μm.
Dry at 0 ° C. for 3 minutes. Thereafter, a polyethylene film having a thickness of 120 μm was adhered to the surface of the pressure-sensitive adhesive layer as a support, and aged at 40 ° C. for one week to prepare a pressure-sensitive adhesive tape for skin application.

<Performance Evaluation> The performance of each of the pressure-sensitive adhesive tapes obtained in the above Examples and Comparative Examples was evaluated by the following method. (1) Evaluation of properties Followability of stretchable film As shown in FIG. 1, the stress at 15% elongation was 0.84 N /
A 15 mm polyurethane film 1 (thickness: 27 μm) is cut into a size of 18 mm × 150 mm, and the gripping distance between the chucks 3 and 4 of the Instron type tensile tester is 100 m.
m. Adhesive tape 2 cut to 15 mm × 98 mm is adhered onto polyurethane film 1, and the stress of adhesive tape 2 when polyurethane film 1 is stretched by 15% at a speed of 100 mm / min is made to follow stretchable film, and polyurethane film 1 It was compared with the stress at 15% elongation. The measurement atmosphere was a temperature of 23 ± 2 ° C,
The relative humidity was 65 ± 5%.

Adhesive Strength Against Bakelite The adhesive strength of each adhesive tape having a width of 15 mm to a bakelite panel was measured in accordance with the 180-degree peeling method of JIS Z-0237. Measurement atmosphere is temperature 23 ± 2
° C and a relative humidity of 65 ± 5%. Moisture permeability The moisture permeability of each adhesive tape was measured under the JIS Z-0208 B condition (temperature: 40 ° C., relative humidity: 90%).

(2) Performance Evaluation Skin Followability As shown in FIG. 2, two non-stretchable strip-shaped non-stretchable films 6 and 7 each having a width of 15 mm and having a width of 20 mm were placed on the inner forearm 5 of six adult males. One end of one non-stretchable film 6 was fixed, and one end of the other non-stretchable film 7 was connected to a strain gauge 8 (digital force gauge). A 15 mm × 18 mm adhesive tape 9 is stuck between two non-stretchable films at an interval of 1 mm each, and the stress when stretched by 15% is compared with the viscoelasticity of the skin, and the skin following property is evaluated. Index. The measurement atmosphere is
The temperature was 23 ± 2 ° C. and the relative humidity was 65 ± 5%.

Skin Adhesive Strength and Skin Irritation Two 15 mm × 70 mm adhesive tapes were affixed to the inside of the forearm of eight adult males in the lateral direction. Pasting 1 hour and 2
Four hours later, the skin adhesive strength was measured at a peeling angle of 90 degrees using an Instron tensile tester. The samples stuck for 24 hours were evaluated for water retention, pain during peeling, and skin irritation one hour after peeling. For the water retention, the horny layer conductivity of the epidermis before and after application was measured by SKICON200 (manufactured by IBS Co., Ltd.). Pain at the time of exfoliation has four stages (0:
None, 1: mild pain, 2: severe pain, 3: unbearable pain), and expressed as an average value. Also, skin irritation
The skin reaction 1 hour after exfoliation was evaluated according to Japanese standards.
Table 1 shows the evaluation results of each pressure-sensitive adhesive tape.

[0040]

[Table 1]

(Footnote) * 1: The stress when the stretchable film is stretched by 15% is 0.8.
4N / 15mm * 2: The stress (skin viscoelasticity) at 15% elongation of the skin is
0.31N / 15mm

[0042]

According to the present invention, the adhesiveness at the time of sweating or at the time of sticking for a long time is stable, and the pain at the time of peeling, exfoliation of keratin,
And a pressure-sensitive adhesive tape for applying to the skin with less skin irritation. INDUSTRIAL APPLICABILITY The pressure-sensitive adhesive tape for application to the skin of the present invention is suitable for applications such as protection of affected skin and percutaneous absorption of drugs.

[Brief description of the drawings]

FIG. 1 is an explanatory diagram showing a method for measuring the stretchability of an adhesive tape according to an elastic film.

FIG. 2 is an explanatory diagram showing a method for measuring the skin following property of an adhesive tape.

[Explanation of symbols]

 1: Stretchable film 2: Adhesive tape 3: Chuck 4: Chuck 5: Inside forearm 6: Non-stretchable film 7: Non-stretchable film 8: Strain gauge 9: Adhesive tape

Continued on the front page F-term (reference) 4C076 AA74 AA77 AA78 BB31 CC01 CC04 CC13 CC15 CC22 CC27 CC32 EE03A EE06A EE10G EE22A EE24A FF02 FF17 4C081 AA03 AA12 BB02 BB04 BB08 BB09 CA051 CA051 CA052 CA052 CA051 CA051 DC05 DC06

Claims (1)

[Claims] 1. A pressure-sensitive adhesive tape for applying to the skin, wherein a pressure-sensitive adhesive layer is formed on at least one surface of a stretchable support having moisture permeability, and (1) the stretchable film conforms to the stretchable film when stretched by 15%. 4.2 times or less of stress, (2) moisture permeability is 5
An adhesive tape for adhering to skin, characterized in that the adhesive tape has an adhesive force of not less than 00 g / m ² · 24 h and (3) an adhesive force against bakelite of 1.5 N / 15 mm or less.