JP2000141097A - Method for compression forming of tablet and device therefor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve productivity of tablets without making a forming device into a large size by making material supplied to a compression forming part into tablet-shape through compression forming and taking it out, and after that cleaning the compression-formed surface. SOLUTION: A material is supplied through material supplying means 3 to a compression forming part 13 formed of a tip end surface of a fitted lower pestle 10 and a side surface of a through hole 2. Then, through the rotation of a turn table 1, the compression forming part 13 reaches a position of a first compression forming means and stops there. Eccentric rollers 11, 12 turn, add pressure on the upper and lower pestles 9, 10, and the material is preliminarily compression-formed to discharge contained air. In a similar mechanism, a second compression-forming means completes compression-forming of the material. By a driving mechanism, the lower pestle 10 is made to ascend, and a tablet projected over the turn table 1 from the through hole 2 is discharged through a discharging guide. When the turn table 1 turns and the through hole 2 stops at a position of a cleaning means, a brush sets to working to clean the compression-forming surface of both the pestles 9, 10.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a tablet compression molding method and a tablet compression molding apparatus.

[0002]

2. Description of the Related Art Photographic processing agents such as color developing agents or bleach-fixing materials have heretofore been provided in liquid form.

However, in addition to the heavy weight of the liquid, the liquid splashes and spills during use often contaminates the hands and clothes of the user, and in addition to the handling, such as the generation of offensive odor. Was extremely bad.

[0004] From the viewpoint of preventing such problems, the present applicant has been working on the development of tablets of photographic processing agents, and has been providing the products to the market several years ago.

[0005] However, in the conventional photographic tablet compression molding technique, high-precision granules are once prepared before being formed into tablets.
Thereafter, a method of compression-molding an appropriate amount of granules to obtain tablets was employed.

This molding method cannot be said to have high production efficiency because considerable man-hours have to be spent to produce granules, and as a result, there is a demand from customers who want to provide a large amount of tablets at low cost. It was not enough to be satisfied.

[0007]

The photographic processing agent is water-soluble. On the other hand, in order to improve the handling when the material (powder) is supplied to the molding apparatus, a water-soluble lubricant is used together with the binder. It was necessary to mix the agent in the powder in advance.

The mixing of the lubricant improves the fluidity of the raw material when supplying the raw material in powder form to a predetermined portion of the molding apparatus, and the raw material adheres to the molding surface of the molding apparatus. It was effective in preventing the phenomenon.

However, many experiments have shown that the incorporation of a large amount of such a lubricant into the material may affect the physical properties of the molded tablet, and may adversely affect photographic performance. Investigated by

[0010] The present invention has been made in view of the above points,
An object of the present invention is to provide a tablet compression molding method and a tablet compression molding apparatus that can be expected to increase productivity with a simple mechanism without increasing the size of the molding apparatus.

Another object of the present invention is to provide a tablet compression molding method and a tablet compression molding method which maintain the quality as a photographic processing agent while keeping the mixing ratio of a lubricant as far as possible, and enable the production of tablets which are advantageous in cost. An object of the present invention is to provide a tablet compression molding device.

[0012]

The above problem can be mainly achieved by the following constitution.

That is, the invention according to claim 1 includes a step of compressing and molding the material supplied to the compression molding section into a tablet, a step of discharging the tableted material from the compression molding section, Cleaning the compression molding surface of the compression molding section after discharging the material.

According to this configuration, even if a part of the material adheres to the compression molded portion after molding, the material can be easily removed from the compression molded portion. (Synonymous with the raw materials), and it is possible to produce tablets with good quality.

In addition, since the tablet has a simple structure, the productivity is good and a tablet which is inexpensive can be manufactured.

According to a fifth aspect of the present invention, there are provided a plurality of through holes provided at equal intervals along a circumferential direction of a horizontally disposed turntable, and a plurality of upper punches which can be fitted into the through holes. And the lower punch, and are configured to be synchronously rotated while maintaining the relative positional relationship, and are formed by the tip surface of the lower punch and the inner wall of the through hole when viewed in the rotation direction of the turntable. Material supply means for supplying a predetermined amount of tablet material to the compression molding section, and compression molding means for applying a predetermined pressure to the material supplied to the compression molding section via the tip surfaces of the punches to perform compression molding And taking-out means for taking out the compression-molded tablet from the compression-molding part by using the vertical movement of the lower punch, and using the rotation of a punch rotating in the same direction, from above the lower punch, Tablet removing means for removing tablets, A cleaning means for cleaning the compression molding surface, it was placed in this order, a configuration.

With this configuration, by cleaning the tip surfaces of the upper punch and the lower punch after taking out the tablet, after one rotation of the turntable, when supplying the material to the compression molding portion again, Adhesive material is removed from the tip surfaces of the upper punch and the lower punch, and a compression molding apparatus capable of continuously producing tablets with reduced quality variation as much as possible can be obtained.

Further, a device with a simple mechanism and high production efficiency can be achieved without increasing the size.

The invention according to claim 8 is characterized in that two cylindrical members having a plurality of concave portions arranged on the respective surfaces are opposed to each other with a predetermined gap and are rotated synchronously, whereby the two cylindrical members are rotated. The tablet material supplied to the gap between the cylindrical members through the material supply means is compression-molded through the approaching movement of the opposing concave portion, and the compression-molded material is discharged using the rotation of the cylindrical member. Thereafter, the concave portion is cleaned by a cleaning means positioned so as to come into contact with the two cylindrical members.

According to this configuration, a continuous production type compression molding apparatus which has a simple structure and does not leave tablet material on the compression molding surface and is advantageous in cost can be obtained.

[0021]

Embodiments of the present invention will be described below with reference to the drawings.

(Embodiment 1) FIG. 1 is a schematic view of a tablet compression molding apparatus according to Embodiment 1 of the present invention, and FIG. 2 is a schematic perspective view of a tablet compression molding apparatus according to Embodiment 1 of the present invention. Drawing 3 and Drawing 3 are explanatory views of a mechanism of a compression molding part of a tablet compression molding device concerning Embodiment 1 of the present invention.

First, an overview of a tablet compression molding apparatus (hereinafter, simply referred to as a molding apparatus) will be described with reference to FIGS.

In FIG. 1, a plurality of through-holes 2 (28 in the case of the embodiment) are provided at equal intervals along the circumferential direction at the peripheral edge of a circular turntable 1 placed horizontally. .

Further, around the turntable 1,
A material supply unit (mechanism) 3 for supplying a material to a compression molding unit, which will be described later, a first compression molding unit (mechanism) 4 for applying a preload to the material supplied to the molding unit, as viewed in the rotation direction of the turntable 1; A second compression molding means (mechanism) 5 for applying a main pressure to the material after the preload is applied, a removing means (not shown) for removing the molded tablet from the molding section, and placing the removed tablet on the turntable. Discharge guide (tablet removing means) 6 for removing from the surface, cleaning means (mechanism) 7 for cleaning the compression molding surface (part) after taking out the tablet, and between the cleaning means and the material supply means. Positioned dehumidification air blowing means (mechanism)
8 are arranged in this order.

In this embodiment, the cleaning means 7 comprises a brush and an injection means (described later) for injecting a lubricant.

In FIG. 2, reference numerals 9 and 10 denote cylindrical upper punches and lower punches, and both punches are provided by the number corresponding to the respective through holes 2.

At least the tip surfaces (substantially compression-molded surfaces) of the punches 9 and 10 are mirror-finished by hard chrome plating, and each has a corresponding through hole 2 from above and below. It is configured to be able to be fitted to.

Here, the term "fitting" refers to a state in which the outer periphery of the punch can reciprocate up and down by sliding on the inner wall of the corresponding through hole 2.

When the turntable 1 is rotated, a pair of the punches 9 and 1 corresponding to the through holes 2 are provided.
0 also revolves, and always maintains the relative positional relationship with the corresponding through hole.

An eccentric roller 11 for applying a downward pressing force to the upper punch 9 is disposed above the turntable 1 at the position of the first compression molding means (preload) 4. Eccentric roller 12 for applying upward pressing force to punch 10
Are arranged below the turntable 1. Less than,
The pressing force is simply called pressure.

At the position of the second compression molding means (main pressure) 5, an eccentric roller 11 which applies a larger downward pressure to the upper punch 9 than that of the first compression molding means 4 is provided.
-1 is arranged above the turntable 1, and similarly, an eccentric roller 12-1 for applying an upward pressure to the lower punch 10 is arranged below the turntable 1.

In the present embodiment, the preload is set to about 1 ton and the main pressure is set to about 10 tons.

Further, the diameter of the forming part (synonymous with the fitting part) of the punch was 30 mm.

Next, the operation of the above-configured apparatus will be described with reference to FIGS.

The rotation of the turntable 1 causes the through holes 2
When it reaches the position of the material supply means 3 shown in FIG. 1 and stops, as shown in FIG. 3A, the upper punch 9 retreats in the direction of the upward arrow of the turntable 1 by a drive mechanism (not shown), and moves downward. The punch 10 is fitted in the through hole 2 for a predetermined length.

As described above, the tablet material is inserted into the compression molded portion (recess) 13 formed by the tip surface of the lower punch 10 and the side wall (through hole forming surface) of the through hole 2 via the material supply means 3. Supply.

As a tablet material, a powder of a photographic processing agent or a powder obtained by processing the powder into granules in advance with a binder (the accuracy may be coarse) is used.

Next, the compression molding section 13 supplied with the material
Reaches the position of the first compression molding means 4 shown in FIG. 1 and stops, as shown in FIG.
2 rotates and gradually applies pressure to the upper punch 9 and the lower punch 10.

In other words, the material in the compression molding portion 13 is preliminarily compression molded with the pressure caused by the movement of the punches 9 and 10 in the direction of the arrow, and at the same time, the air contained in the material is removed. Unplug.

Next, with further rotation of the turntable 1, the upper punch 9 retreats above the turntable 1 again as shown in FIG.

When the compression molding portion 13 having the pre-pressed material reaches the position of the second compression molding means 5 shown in FIG. 1 and stops, as shown in FIG.
1-1 and 12-1 act to apply a pressure larger than the above-mentioned pressure to the upper punch 9 and the lower punch 10, and as a result, the compression molding of the material in the compression molding section 13 is completed. A photographic processing agent as a tablet is completed.

Next, during the rotation of the turntable 1,
The lower punch 10 is raised via a drive mechanism (not shown),
The tablets protrude from the compression molding portion 13, that is, the upper surface of the turntable 1 from the through hole 2 (FIG. 3).
(See (c)) and take out the tablet.

The tablet take-out means is an appropriate mechanism, such as a cam, for imparting the above-mentioned movement amount to the lower punch.

The tablet is discharged from the turntable by a rotation of the turntable 1 via a discharge guide 6 fixedly arranged close to the upper surface of the turntable 1.

When the turntable 1 further rotates and the through-hole 2 reaches the section where the cleaning means 7 is located and stops, the brush operates to clean the compression-molded surfaces of the punches 9 and 10. I do.

That is, while the turntable 1 rotates and the through-hole 2 and the two punches reach the cleaning location, the tip surface (forming surface) of the lower punch 10 is placed on the surface of the turntable 1. And a related means (member) is formed so that a predetermined gap can be formed between the upper punch 9 and the lower punch 10 in this state.

Then, a brush 14 (see FIG. 4) constituting the cleaning means 7 is moved from a predetermined position and enters the gap formed as described above, and the tip of the brush is moved through the movement of the brush. The surfaces are cleaned by contacting at least the tip surfaces (compression molding surfaces) of both punches.

After cleaning the tip surfaces of both punches, the brush is retracted to a predetermined position.

FIG. 4 shows the cleaning state, FIG. 4 (a) shows a reciprocating cleaning method of the brush 14, and FIG. 4 (b) shows a rotating cleaning method of the brush.

The brush according to the present embodiment (hereinafter referred to as “brush”)
The brush 14 or the contact type brush) 14 is formed by implanting a hair material of NC nylon having a diameter of 0.2 mm around the outer periphery of a hollow pipe-shaped support. It is shaped like a single part (shaft).

The brush bristle material has a diameter of 0.2 mm to 0.2 mm.
A 5 mm one is preferred. If it is less than the above-mentioned numerical range, the stiffness is weak and the scraping effect is small.

The brush is formed by adhering a material having air permeability such as a nonwoven fabric or a sponge to the support, in addition to a resin bristle material, as long as the brush has a moderate stiffness and a desirable cleaning ability. You may.

As described above, the support of the contact type brush 14 is in the form of a hollow pipe.
After cleaning the tip end surface of the lower punch and the tip end surface of the lower punch 10 with a contact brush 14, a lubricant is mixed into compressed air sent into a shaft tube 15 which is a support of the contact brush 14, and the lubricant is mixed. An agent is sprayed from the root of the brush to the tip surfaces of the punches 9 and 10.

When the lubricant does not need to be sprayed on the compression molding surface as described above, the support does not need to be hollow,
Needless to say, no injection means such as a compressor is required, and the mechanism and control can be simplified accordingly.

In a case where the lubricant is sprayed, a fine hole may be provided near the flocking hole of the flocking brush, and the lubricant may be sprayed through the fine hole. At the time of flocking, the flocking holes may not be completely closed, and the lubricant may be blown out from the gap. In other words, the configuration that allows the lubricant to be blown out from the root of the brush is controlled. Simple and preferred.

As another configuration, the periphery of the support is, for example, 4
As described above, the shaping surfaces of the two punches are configured to be cleaned with a brush formed by flocking the upper and lower two surfaces, and a lubricant is supplied from a large number of fine holes provided on the other two surfaces. It can be configured to squirt.

In this case, the brush may be of a reciprocating type or a rotating type, and the cleaning in the contact state and the control of spraying the lubricant on the molding surface may be performed alternately or repeatedly. May be separated.

The lubricant is a surfactant, and has an effect of preventing material from adhering to the tip surface of the upper punch 9 and the tip surface of the lower punch 10.

It is needless to say that the cleaning by the contact brush and the supply of the lubricant may be at different positions by different mechanisms.

As a lubricant for a photographic processing agent, a water-soluble lubricant is used which is slightly different in lubricity from those for other fields.

Next, with further rotation of the turntable 1, the through hole 2, the upper punch 9 and the lower punch 10
Reaches the position of the dehumidifying air blowing means 8 shown in FIG. 1 and stops and blows dehumidifying air from the dehumidifying air blowing means 8 to the tip surfaces of the punches 9 and 10.

The location where the dehumidifying air is blown is preferably between the discharge guide 6 and the material supply mechanism 3 as in the location where the brush is attached.

The dehumidifying air has the effect of blowing off the powder adhering in addition to drying the tip surface of the upper punch 9 and the tip surface of the lower punch 10.

Incidentally, the dehumidified air referred to herein for a photographic processing agent refers to air conditioned at a dew point of 15 ° C. or less. If the dew point exceeds 15 ° C., there is a risk that the material absorbs moisture and has an adverse effect.

[0066] In embodiments, the air flow rate of the dehumidifying air was set to 0.3m ³ /h~0.7m ³ / h.

If it is less than the above range, there is no spraying effect, and if it exceeds the above range, the powder may be scattered.
It is more likely that the working environment will deteriorate.

The step of blowing the dehumidifying air can be omitted depending on the working environment.

By repeating the above steps from the material supply and the compression molding to the dehumidifying air, the photographic material is continuously and efficiently formed into tablets.

Examples of preferred surfactants for tableting include compounds (surfactants) represented by formulas [I] to [VI].

The compound (surfactant, fluorine-based anionic surfactant) represented by the general formula [I] will be described.

[0072]

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[Wherein, Rf represents a saturated or unsaturated alkyl group containing at least one fluorine atom, X represents a sulfonamide,

[0074]

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Wherein Y represents an alkylene oxide group or an alkylene group, and Rf 'represents a saturated or unsaturated hydrocarbon group containing at least one fluorine atom. Furthermore, A is _{-SO 3 M, -OSO 3 M,} -COOM, -OPO
₃ (M ₁ ) (M ₂ ), —PO ₃ (M ₁ ) (M ₂ ), etc., represents a hydrophilic group, M, M ₁ , M ₂ represent H, Li, K, Na or NH ₄ ; Represents 0 or 1, and n represents 0 or an integer of 1 to 10. In the general formula [I], Rf represents a saturated or unsaturated alkyl group containing at least one fluorine atom (for example, an alkyl group, an alkenyl group, or an alkynyl group), preferably having 4 to 12 carbon atoms, more preferably Carbon number 6 ~
9 alkyl groups. A preferably include _{-SO 3 M, M, M 1} , M 2 is preferably Li, K, Na and most preferably Li. m is 0 or 1, n is 0 or 1
Represents an integer of 10, preferably m = 0 and n = 0.

The typical exemplary compounds represented by the general formula [I] are shown below, but are not limited thereto.

[0077]

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[0078]

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Among the above compounds, particularly preferred compounds are
(I-1), (I-2) and (I-4).

These compounds can be synthesized by a usual method, and are also available as commercial products.

Next, the compound (surfactant) represented by the general formula [II] will be described.

[0082]

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In the above general formula [II], R ₁ represents an alkyl group or an alkenyl group, R ₂ represents a hydrogen atom, an alkyl group or a hydroxyalkyl group, and R ₃ and R ₄ independently represent a hydrogen atom, a hydroxyl group, Alkyl group or -COOM
₂ (M ₂ represents a hydrogen atom or an alkali metal atom), X represents —CO— or —SO ₂ —, Y represents —O—,
—S— or —CONR ₅ — (R ₅ represents a hydrogen atom, an alkyl group or a hydroxyalkyl group), M ₁ represents a hydrogen atom or an alkali metal atom, 1 is 0 or 1, and m is 0 to 2 And n represents an integer of 1 to 3.

R ₁ is preferably a straight-chain or branched alkyl or alkenyl group having 5 to 20 carbon atoms, and R ₂ is preferably a hydrogen atom, a straight-chain or branched alkyl group having 1 to 5 carbon atoms or hydroxyalkyl. Group.

Next, specific examples of the compound represented by the general formula [II] are shown below.

[0086]

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[0087]

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[0088]

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[0089]

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In addition to the above compounds, JP-A-62-56961
Compounds [II] -1 to 55 described on pages 4 to 6 can also be used.

The above-mentioned exemplified compounds are known compounds or are commercially available and can be obtained by ordinary routes.

Next, the compound (surfactant) represented by the general formula [III] or [IV] will be described.

[0093]

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In the formula, R ₁ , R ₂ , R ₃ , R ₄ and R ₅ each represent an alkyl group, an aralkyl group, an alkenyl group, a styryl group, a cinnamyl group, and l ₁ , l ₂ , l ₃ , l ₄ , L ₅ each represents an integer of 0 or 1, and n represents an integer of 2 to 100. However, when R ₃ is an alkyl group and l ₃ is 1,
At least one of l ₁ , l ₂ , l ₄ and l ₅ is 1.
When l ₁ , l ₂ , l ₃ , l ₄ , and l ₅ are 0, the corresponding R ₁ , R
₂ , R ₃ , R ₄ and R ₅ are hydrogen atoms.

In the above formula, R ₁ , R ₂ , R ₃ , R ₄ and R
_The alkyl group represented by ₅ has 1 to 20 carbon atoms, and may be a chain or a cyclic group. Examples of the chain group include linear and branched groups. Include, for example, methyl, ethyl, n-propyl, i-propyl, butyl, t-butyl, sec-butyl, amyl, hexyl,
Each group includes heptyl, octyl, nonyl, decyl, octadecyl and the like. The aralkyl group represented by R ₁ , R ₂ , R ₃ , R ₄ and R ₅ has 7 to 20 carbon atoms,
Specifically, for example, benzyl, phenethyl, dibenzyl,
Each group such as 2-naphthylmethyl is exemplified.

The alkenyl group represented by R ₁ , R ₂ , R ₃ , R ₄ and R ₅ has 3 to 20 carbon atoms, and specifically includes, for example, allyl, 4-hexenyl, 4-decenyl, 9-
Each group such as octadecenyl is exemplified.

The aromatic ring of the aralkyl group and the styryl group may have a substituent. Examples of the substituent include an alkyl group (for example, each group such as methyl, ethyl, propyl, t-amyl, nonyl, etc.), and an alkoxy group. Groups (e.g., methoxy, ethoxy, propoxy, 2-ethoxyethoxy, etc.) and aryloxy groups (e.g., phenoxy, p-tolyloxy, o-chlorophenoxy, etc.). Specifically, for example, p-methoxybenzyl, 2,
4-dimethylbenzyl, p-phenoxyphenethyl, p
-Butyl styrene and the like.

[0098]

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In the formula, R represents an alkyl group having 4 to 25 carbon atoms which may have a linear or branched substituent or

[0100]

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(Wherein R ₁₁ and R ₁₂ each represent a hydrogen atom or an alkyl group having 1 to 20 carbon atoms which may have a substituent, and 1 represents an integer of 0 to 4). n and m each represent 0 or an integer of 1 to 25, but do not become 0 at the same time. A and B are respectively

[0102]

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And n ₁ , m ₁ and l ₁ may be 0, 1, 2 or 3 respectively.
However, m ₁ in A and B does not become 0 at the same time, and when n or m is 0, m ₁ does not become 0). D
Represents a hydrogen atom.

The following are examples of compounds represented by the general formula [III] or [IV].

[0105]

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[0106]

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[0107]

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[0108]

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[0109]

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[0110]

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Next, the compound (surfactant) represented by the general formula [V] will be described.

[0112]

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[0113] wherein, R ₁ represents a monovalent organic group, R ₂
Represents an ethylene group or a propylene group, and m represents 4 to 5
Represents an integer of 0. X ₁ is a hydrogen atom, —SO ₃ M or —
Represents PO ₃ M. Wherein M represents a hydrogen atom, an alkali metal atom or -NH _4. Next, the compound represented by the general formula [V] will be further described. In the general formula [V], R ₁ is a monovalent organic group, for example, having 6 to 20 carbon atoms, preferably 6 to 6 carbon atoms. 12
Hexyl, heptyl, octyl,
Represents nonyl, decyl, undecyl or dodecyl;
Or an aryl group substituted with an alkyl group having 3 to 20 carbon atoms, and the substituent preferably has 3 carbon atoms.
~ 12 alkyl groups, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl,
Represents undecyl or dodecyl. The aryl group is phenyl, tolyl, xinyl, buphenyl or naphthyl, and is preferably phenyl or tolyl. The position where the alkyl group is bonded to the aryl group may be any of the ortho, meta and para positions. R ₂ represents an ethylene group or a propylene group, and m represents an integer of 4 to 50. X ₁ represents a hydrogen atom, -SO ₃ M or -PO ₃ M _2,
M is a hydrogen atom, an alkali metal atom (Na, K or Li
Etc.) or represent -NH _4.

The following are specific illustrative compounds represented by the general formula [V].

[0115]

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[0116]

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Next, the compound (surfactant) represented by the general formula [VI] will be described.

[0118] In formula (VI) _{R- (O) x S y O} z M [wherein, R represents a substituted or unsubstituted aliphatic group, an aromatic group or a heterocyclic group, x is 0 or 1, y represents 1 or 2, z represents an integer of 2 to 8, and M represents a cation. In the general formula [VI], examples of the aliphatic group represented by R include an alkyl group, an alkenyl group, and an alkynyl group. Examples of the alkyl group include methyl, ethyl, i-
Examples include propyl, butyl, t-butyl, pentyl, cyclopentyl, hexyl, cyclohexyl, octyl, dodecyl and the like. These alkyl groups further include a halogen atom (eg, a halogen atom such as chlorine, bromine, and fluorine) and an alkoxy group (eg, methoxy, ethoxy,
1-dimethylethoxy, hexyloxy, dodecyloxy, etc.), aryloxy groups (for example, phenoxy,
Groups such as naphthyloxy), aryl groups (such as phenyl and naphthyl), alkoxycarbonyl groups (such as methoxycarbonyl, ethoxycarbonyl, butoxycarbonyl, and 2-ethylhexylcarbonyl), and aryloxycarbonyl groups (such as methoxycarbonyl, ethoxycarbonyl, butoxycarbonyl, and 2-ethylhexylcarbonyl). For example, each group such as phenoxycarbonyl and naphthyloxycarbonyl), alkenyl group (each group such as vinyl and allyl), heterocyclic group (for example, 2-pyridyl, 3-pyridyl, 4-pyridyl, morpholyl, piperidine, piperazyl, pyrimidine) , Pyrazoline, furyl, etc.), alkynyl group (eg, propargyl group, etc.), amino group (eg, amino,
Groups such as N, N-dimethylamino and anilino), cyano group, and sulfamide group (for example, methylsulfonylamino,
Ethylsulfonylamino, butylsulfonylamino, octylsulfonylamino, phenylsulfonylamino, etc.).

Examples of the alkenyl group include a vinyl group,
Examples include an allyl group and the like, and examples of the alkynyl group include a propargyl group.

Examples of the aromatic group represented by R include a phenyl group and a naphthyl group.

The heterocyclic group represented by R includes, for example, pyridyl group (each group such as 2-pyridyl, 3-pyridyl, 4-pyridyl), thiazolyl group, oxazolyl group, imidazolyl group, furyl group, phenyl group, Examples thereof include a pyrrolyl group, a pyrazinyl group, a pyrimidinyl group, a pyridazinyl group, a selenazolyl group, a sulfolanyl group, a pipedilinyl group, a pyrazolyl group, and a tetrazolyl group.

The above-mentioned alkenyl group, alkynyl group, aromatic group and heterocyclic group each represent an alkyl group represented by R, a substituent of the alkyl group, a group shown as a substituent atom, a group similar to the atom, Can be replaced by

The cation represented by M is preferably a metal ion or an organic cation. Examples of the metal ion include a lithium ion, a sodium ion, and a potassium ion. Examples of the organic cation include an ammonium ion (an ion such as ammonium, tetramethylammonium, and tetrabutylammonium) and a phosphonium ion (eg, tetraphenylphosphonium). Ion), guanidyl ion and the like.

Specific examples of the compound represented by the general formula [VI] are shown below, but the present invention is not limited thereto.

VI-1 C ₂ H ₅ SO ₃ Na VI-2 CH ₃ (CH ₂ ) ₆ SO ₃ Na VI-3 CH ₃ (CH ₂ ) ₇ SO ₃ Na VI-4 CH ₃ (CH ₂ ) ₅ OSO _{3 Na VI-5 CH 3 (} CH 2) 6 OSO 3 Na VI-6 CH 3 (CH 2) 7 OSO 3 Na VI-7 CH 3 O (CH 2) 2 SO 3 Na

[0126]

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In the tableting, saccharides are preferable as the binder which is previously mixed into the material together with the lubricant, and the following can be used.

The saccharides referred to herein include monosaccharides, polysaccharides in which a plurality of these are glycosidically bonded to each other, and their decomposed products.

Monosaccharides include single polyhydroxyaldehydes, polyhydroxyketones and their reduced derivatives,
It is a general term for a wide range of derivatives such as oxidized derivatives, deoxy derivatives, amino derivatives and thio derivatives.

Many saccharides are represented by the general formula CnH ₂ nOn, and in the present invention, including the compounds derived from the saccharide skeleton represented by the general formula, are defined as monosaccharides.

Preferred among these monosaccharides are:
These are sugar alcohols in which the aldehyde group and ketone group of the sugar are reduced to primary and secondary alcohol groups, respectively.

Polysaccharides include celluloses, starches,
Glycogens and the like are included, celluloses include derivatives such as cellulose ethers in which some or all of the hydroxyl groups are etherified, and starches are various degradation products from hydrolysis to maltose. Including certain dextrins. Cellulose may be in the form of an alkali metal salt from the viewpoint of solubility.

Among these polysaccharides, those preferably used are celluloses, dextrins and cyclodextrins, more preferably cyclodextrins.

Specific examples of the monosaccharide according to the present invention are shown below.

[Exemplary Compounds] B- (1) Glyceraldehyde B- (2) Dihydroxyacetone (including dimer) B- (3) D-erythrose B- (4) L-erythrose B- (5) D-threose B- (6) L-threose B- (7) D-ribose B- (8) L-ribose B- (9) D-arabinose B- (10) L-arabinose B- (11) D- Xylose B- (12) L-xylose B- (13) D-Lixose B- (14) L-Lixose B- (15) D-Xylulose B- (16) L-Xylulose B- (17) D-Ribulose B -(18) L-ribulose B- (19) 2-deoxy-D-ribose B- (20) D-allose B- (21) L-allose B- (22) D-altrose B- (23) L-altrose B- (24) D-glucose B- (25) L-glucose B- (26) D-mannose B- (27) L-mannose B- (28) D-growth B- (29) L -Growth B- (30) D-Idose B- (31) L-Idose B- (32) D-Galactose B- (33) L-Galactose B- (34) D-Talose B- (35) L-Talose B- (36) D-Quinoboth B- (37) Digitarose B- (38) Digitoxose B- (39) Shimarose B- (40) D-Sorbose B- (41) L-Sorbose B- (42) D-Tagatose B- (43) D-fucose B- (44) L-fucose B- (45) 2-deoxy-D-glucose B- (46) D-psicose B- (47) D-fructo B- (48) L-fructose B- (49) L-rhamnose B- (50) D-glucosamine B- (51) D-galactosamine B- (52) D-mannosamine B- (53) D-glycero- D-galactoheptose B- (54) D-glycero-D-mannoheptose B- (55) D-glycero-L-mannoheptose B- (56) D-glycero-D-gloheptose B- (57) D-glycero- D-idoheptose B- (58) D-glycero-L-glucoheptose B- (59) D-glycero-L-taloheptose B- (60) D-altroheptulose B- (61) D-mannoheptulose B -(62) D-Altro-3-heptulose B- (63) D-glucuronic acid B- (64) L-glucuronic acid B- (65) -Acetyl-D-glucosamine B- (66) glycerin B- (67) D-trait B- (68) L-trait B- (69) erythrit (trade name, Mitsubishi Chemical Food Erythritol) B- (70) D- Arabit B- (71) L-Arabit B- (72) Adnit B- (73) Xylit B- (74) D-Sorbit B- (75) L-Sorbit B- (76) D-Mannit B- (77) ) L-mannit B- (78) D-id B- (79) L-id B- (80) D-talit B- (81) L-talit B- (82) Zulucit B- (83) Allozurshit The sugar alcohols preferably used among the exemplified compounds are B- (66) to (83), and more preferably B- (69) and (74). Is (83).

The following are specific examples of the polysaccharides and saccharide hydrolyzates according to the present invention.

C- (1) Maltose C- (2) Cellobiose C- (3) Trehalose C- (4) Gentiobiose C- (5) Isomaltose C- (6) Lactose C- (7) Raffinose C- (8) ) Gentianose C- (9) Stachyose C- (10) Xylan C- (11) Araban C- (12) Glycogen C- (13) Dextran C- (14) Inulin C- (15) Levan C- (16) Galactan C- (17) Agarose C- (18) Amylose C- (19) Sucrose C- (20) Agarobiose C- (21) Methylcellulose C- (22) Dimethylcellulose C- (23) Trimethylcellulose C- (24) Ethylcellulose C- (25) Diethylcellulose C- (26) Triethylcellulose C- (2 7) Carboxymethylcellulose C- (28) Carboxyethylcellulose C- (29) Aminoethylcellulose C- (30) Hydroxymethylcellulose C- (31) Hydroxyethylmethylcellulose C- (32) Hydroxypropylcellulose C- (33) Hydroxypropylmethylcellulose C -(34) Hydroxypropylmethylcellulose acetate succinate C- (35) Carboxymethylhydroxyethylcellulose C- (36) α-dextrin C- (37) β-dextrin C- (38) γ-dextrin C- (39) σ- Dextrin C- (40) ε-Dextrin C- (41) α-Limit dextrin C- (42) β-Limit dextrin C- (43) Phosphorylase Limit dextrin C- (44) Soluble starch C- (45) Thin nori starch C- (46) White dextrin C- (47) Yellow dextrin C- (48) British gum C- (49) α-cyclodextrin C- (50) β-cyclodextrin C -(51) γ-cyclodextrin C- (52) methyl-α-cyclodextrin C- (53) methyl-β-cyclodextrin C- (54) methyl-γ-cyclodextrin C- (55) hydroxypropyl-α -Cyclodextrin C- (56) Hydroxypropyl-β-cyclodextrin C- (57) Hydroxypropyl-γ-cyclodextrin C- (58) Maltocyclodextrin Saccharides are widely and naturally present, and commercially available products can be easily prepared. Available at Also, various derivatives can be easily synthesized by performing reduction, oxidation, dehydration, or the like.

As commercial products, cyclodextrins such as α-100H and β-100 manufactured by Shimizu Minato Seika Co., Ltd.
γ-100, K-100, Isoelite P, Isoelite PH, Methyl-β-CD, Hydroxypropyl-β-
Pine flow, Paindex series, Foodtex, Max100, Glister P, TK-16, manufactured by Matsutani Chemical Industry Co., Ltd.
MPD, H-PDX, Stakodex, NOF Corporation
Oil Q series manufactured by the company.

Preferred compounds as other binders are those represented by the following general formula.

HO- (A ₁ -O) l _1- (A ₂ -O) l _2-
(A ₃ -O) l ₃ -H In the formula, A ₁ , A ₂ and A ₃ each represent a substituted or unsubstituted linear or branched alkylene group, which may be the same or different .

Examples of the substituent include a hydroxy group, a carboxy group, a sulfonyl group, an alkoxy group, a carbamoyl group and a sulfamoyl group.

Those preferably used are A ₁ , A ₂ , A
₃ is unsubstituted. Most preferably, A ₁ , A ₂ , and A ₃ are each —CH ₂ CH ₂ —,
CH (CH ₃ ) —CH ₂ —.

L ₁ , l ₂ and l ₃ are each 0 or 0
Represents an integer of 500. Here, l ₁ + l ₂ + l ₃ ≧ 5.

Of these, at least one of l ₁ , l ₂ and l ₃ is preferably 15 or more, and more preferably 20 or more.

The most preferred compound represented by the general formula is polyethylene glycol (sometimes referred to as PEG).

In the case of polyethylene glycol,
Those having an average molecular weight in the range of 2,000 to 20,000 are preferred, and those in the range of 3,000 to 15,000 are particularly preferred.

(Embodiment 2) FIG. 5A is a schematic diagram for explaining the function of a tablet compression molding apparatus according to Embodiment 2 of the present invention, and FIG. It is a schematic diagram which shows the state of the surface of two cylindrical members which comprise.

In FIG. 5 (a), two cylindrical members 2 opposed to each other with a small gap at the closest position.
1 has a mirror-finished surface made of hard chrome plating, and has a plurality of aligned concave portions (also referred to as compression molding surfaces) 22.

The two cylindrical members 21, 21
Are controlled to rotate in the direction of the arrow so that the outer peripheries of the opposed (corresponding) concave portions 22 coincide at the closest position.

The material supply means (mechanism) 23 disposed above the two cylindrical members 21 is a funnel-shaped supply port 24 corresponding to the insertion port formed by the cylindrical members 21 and 21. It has.

Further, downstream of the discharge port 25 formed by the cylindrical members 21, 21, at least during rotation,
A dedicated cleaning means 26 is provided for contacting the compression molded surface 22 of each cylindrical member 21, 21 for cleaning.

The cleaning means 26 includes a brush roller in which the bristle material described in the first embodiment is implanted in a roller-shaped shaft tube, and a lubricant spraying means.

During the operation of the cleaning means 26, the concave portion 22 of the cylindrical member 21 is cleaned by the brush roller, and the lubricant blown out by the compressed air through the shaft pipe is removed by the concave portion 22. Spray.

Of course, the cleaning means 26 using the brush roller (having the same function as the contact-type brush in the first embodiment) and the lubricant supply mechanism may be separately provided and provided at separate positions. .

Further, a dehumidifying air blowing means (mechanism) 27 is disposed at a position further downstream than the cleaning means 26 when viewed in the rotation direction of the cylindrical member 21.

On the other hand, below the outlet 25, a crusher 29 for disassembling a plurality of chains (hereinafter referred to as briquettes) 28 of tablets discharged from the outlet 25 into single tablets is arranged. Further, a sieve 30 having a transport function is disposed below the sieve.

The crusher 29 has a structure in which a plurality of propeller members are fixedly arranged on a shaft, and the shaft can be gently rotated.

The operation of the present apparatus configured as described above is as follows.

When the two cylindrical members 21 are rotating, the material is supplied from the material supply means 23 through the supply port 24.

The material overflows into each of the concave portions 22 aligned on the surfaces of the two cylindrical members 21 and is stored slightly.

The rotation of the cylindrical members 21, 21
The corresponding recesses 22 gradually approach, and at the same time, the material in the recesses is sequentially compressed, and the compression molding ends at the re-approaching position of the recesses.

After the completion of the molding, the tablets are discharged from the discharge port 25 as briquettes 28 in which several tablets are connected.

After the tablets are discharged, the concave portion 22 is cleaned at the position of the cleaning means 26 by the brush contact of the rotating brush roller, and at the same time, the lubricant is sprayed.

After the dehumidifying air is blown at the position of the dehumidifying air blowing means 27 and preparation for receiving a new material is completed, the dehumidifying air reaches the lower portion of the supply port 24 of the material supplying means 23 again, and the above-described operation is repeated. , To produce tablets continuously.

On the other hand, the briquettes 28 discharged and dropped from the discharge port 25 are crushed by a crusher 29 into tablets, and are separated into single tablets and powdered materials by a sieve 30 provided below the crusher 29. It is transported to an appropriate place.

[0166]

According to the present invention, since the production efficiency is high despite the simple structure, a large amount of tablets can be provided to customers at low cost. In addition, when the photographic processing agent was made into tablets, the mixing ratio of the lubricant was suppressed as far as possible, thereby enabling the production of tablets with stable physical properties.

[Brief description of the drawings]

FIG. 1 is a schematic diagram of a tablet compression molding apparatus according to Embodiment 1.

FIG. 2 is a schematic perspective view of the tablet compression molding apparatus according to the first embodiment.

FIG. 3 is an explanatory view of a mechanism of a compression molding section of the tablet compression molding apparatus according to the first embodiment.

4A and 4B are schematic diagrams illustrating a cleaning state, in which FIG. 4A illustrates a reciprocating brush cleaning method, and FIG. 4B illustrates a brush rotation cleaning method.

FIG. 5 (a) is a schematic diagram for explaining the function of a tablet compression molding apparatus according to Embodiment 2, and FIG. 5 (b) is a diagram showing the surface of two cylindrical members constituting the apparatus. It is a schematic diagram which shows a situation.

[Explanation of symbols]

 Reference Signs List 1 turntable 2 through hole 3 material supply means (mechanism) 4 first compression molding means (mechanism) 5 second compression molding means (mechanism) 6 discharge guide 7 cleaning means (mechanism) 8 dehumidifying air blowing means (mechanism) 9 Punch 10 Lower punch 11, 11-1 Eccentric roller 12, 12-1 Eccentric roller 13 Compression molding part 14 Brush 15 Shaft tube 21 Cylindrical member 22 Depression 23 Material supply means (mechanism) 24 Supply port 25 Discharge port 26 Cleaning means 27 Dehumidifying air blowing means (mechanism) 28 Briquette 29 Crusher 30 Sieve

Continued on the front page (51) Int.Cl. ⁷ Identification FI FI Theme Court II (Reference) G03C 5/26 520 G03C 5/26 520 (72) Inventor Hiroki Kawashima 1st Sakuramachi, Hino City, Tokyo In-house ( 72) Inventor Hiroshi Yoshimoto 1st Sakuracho, Hino-shi, Tokyo Konica Stock Company In-house F-term (Reference) 2H016 AE00 AF00 BK00 BL00 3L113 AB03 AC25 AC30 AC31 AC45 AC46 AC48 AC49 AC54 AC59 AC65 AC90 BA02 CA10 DA04 DA06 DA07 DA13 DA14 DA24

Claims (12)

[Claims] A step of compressing and molding the material supplied to the compression molding section to form a tablet; a step of discharging the tableted material from the compression molding section; and a step of discharging the material after discharging the material. Cleaning the compression molding surface of the compression molding section. 2. The tablet compression molding method according to claim 1, wherein the cleaning is performed by contacting a flocking brush. 3. The tablet compression molding method according to claim 1, wherein the cleaning is performed by contact with a flocking brush and spraying a lubricant. 4. The tablet compression molding method according to claim 1, further comprising a step of blowing dehumidified air after the cleaning step. 5. A plurality of through holes provided at equal intervals along the circumferential direction of a horizontally placed turntable; a plurality of upper punches and lower punches fittable into the through holes;
Are configured to be rotated synchronously while maintaining the relative positional relationship, and when viewed in the rotation direction of the turntable, a compression molded portion formed by the tip surface of the lower punch and the inner wall of the through hole is formed. Material supply means for supplying a predetermined amount of tablet material; compression molding means for applying a predetermined pressure to the material supplied to the compression molding section via the tip surfaces of the punches to perform compression molding; A take-out means for taking out the tablet from the compression molding part by using the vertical movement of the lower punch, and a tablet for removing the tablet from above the lower punch using rotation of a punch rotating in the same direction. A tablet compression molding apparatus, comprising: removing means; and cleaning means for cleaning the compression molding surfaces of both punches in this order. 6. The tablet compression molding apparatus according to claim 5, wherein the cleaning means includes a brush which can be brought into contact with and separated from the compression molding surfaces of the punches to be cleaned. 7. The cleaning means includes a brush which can be brought into contact with and separated from the compression molding surfaces of the punches to be cleaned, and an injection means which injects a lubricant from the root of the brush. The tablet compression molding device according to claim 5, wherein 8. Two cylindrical members having a plurality of concave portions arranged on their respective surfaces are opposed to each other with a predetermined gap and rotated synchronously to supply material to the gap between the two cylindrical members. The material of the tablet supplied via the means is compression-molded through the approaching movement of the recesses facing each other, and the compressed material is discharged using the rotation of the cylindrical member. A tablet compression molding apparatus, wherein said concave portion is cleaned by cleaning means positioned so as to be in contact with said cylindrical member. 9. The tablet compression molding apparatus according to claim 8, wherein the cleaning means includes a brush provided on a side substantially opposite to the gap with respect to each of the two cylindrical members. 10. The cleaning device according to claim 1, wherein the cleaning device includes a brush provided on a side substantially opposite to the gap with respect to each of the cylindrical members, and a spraying device for spraying a lubricant from a root of the brush. The tablet compression molding apparatus according to claim 8, wherein 11. The tablet compression molding according to claim 5, wherein dehumidifying air blowing means for blowing dehumidifying air is disposed between said cleaning means and said material supply means. apparatus. 12. The tablet compression molding apparatus according to claim 5, wherein the tablet comprises a photographic processing agent.