JP2000024016A - Indwelling tube - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an indwelling tube which has a simple structure, high sealability after needle puncturing, durability against frequent punctures, and long life in an organism. SOLUTION: This indwelling tube 1 for an organism is to constitute, for instance, a substitute blood vessel (artificial blood vessel) used for forming a shunt for dialysis and has a tubular main body 2 and a needle puncture part 3 integrally formed with the main body 2. Both ends of the main body 2 are opened and jointed to a blood vessel. The needle puncture part 3 is constituted of a thick wall part thicker than the wall of the main body 2 and is formed into a protrusion outward protruded than the outer periphery face of the main body 2. The needle puncture part 3 has self-closing performance after a puncture. A plurality of needle puncture parts 3 like that can be formed along the longitudinal direction of the main body 2.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an in-vivo indwelling tube which is used by being inserted and indwelled in a living body.

[0002]

2. Description of the Related Art Conventionally, it has been used for a portion that comes into contact with a living body,
As a medical material that requires puncture with a needle tube, a rubber film, a woven fabric, a knitted fabric, a nonwoven fabric, a drawn polytetrafluoroethylene, or the like made of a synthetic fiber is used.

For example, in the treatment of renal dysfunction (artificial dialysis), an indwelling tube made of polytetrafluoroethylene is used as a blood vessel for blood access from outside the body.

However, when the injection needle is punctured into the in-vivo indwelling tube and the needle is removed, blood leaks out from the puncture hole due to poor sealing properties of the needle puncture portion. In addition, durability against frequent punctures is low, and blood leakage may occur due to formation of an aneurysm, cracks, breakage, and the like.

[0005] Such leakage of blood serves as a breeding ground for bacterial growth, resulting in ulceration or continuation of chronic inflammation. Therefore, abandon the placement of the in-vivo indwelling tube,
The physical, mental, and financial burden on the patient was great, including the need for reoperation.

As a method of solving such a problem, a method of attaching a puncture port for puncturing an injection needle to an indwelling tube in vivo has been considered.

However, in this method, since the puncture port formed of a separate member is fixed to the indwelling tube, the number of parts is large and the structure is complicated.
Joint (fixed part) between the indwelling tube and the puncture port
It is necessary to ensure the sealing property (liquid tightness) of the puncture port, which requires a fixing part structure for joining the puncture port and the indwelling indwelling tube. There are many problems to be solved, such as difficulty in freely setting the arrangement, shape, size, and the like.

[0008]

SUMMARY OF THE INVENTION An object of the present invention is to provide an in vivo indwelling tube having a simple structure, a high sealing property after puncturing of a puncture needle, an excellent durability against frequent punctures, and a long life. Is to do.

[0009]

This and other objects are achieved by the present invention which is defined below as (1) to (7).

(1) There is a main body formed of a tubular member through which a fluid can pass, and at least one needle stick portion having a self-closing property after puncturing is formed integrally with the main body. An in-vivo indwelling tube characterized in that it is made.

(2) It has a plurality of needle sticks,
The above (1), which is arranged along the longitudinal direction of the main body.
2. The in-vivo indwelling tube according to item 1.

(3) It has a plurality of needle sticks, and one of the needle sticks and the other needle stick are different in shape, size, height or physical characteristics. The in-vivo indwelling tube according to (1) or (2) above.

(4) The needle piercing portion is formed of a thicker portion than the wall thickness of the main body (1) to (3).
The in-vivo indwelling tube according to any one of the above.

(5) The in-vivo indwelling tube according to any one of the above (1) to (4), wherein the needle stick portion is formed over substantially the entire circumference of the main body.

(6) The main body is formed of a laminate of a plurality of layers, and the needle stick portion is formed of any one of the layers.
The in-vivo indwelling tube according to any one of the above (1) to (5), wherein the indwelling tube is integrated with at least one.

(7) The indwelling tube according to any one of the above (1) to (6), which constitutes a blood vessel substitute.

[0017]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a living body indwelling tube according to the present invention.

FIG. 1 is a perspective view showing an embodiment of the indwelling tube of the present invention, and FIG. 2 is a sectional view taken along line AA in FIG.
The in-vivo indwelling tube 1 of the present invention shown in these figures constitutes a blood vessel substitute (artificial blood vessel), and can be used, for example, for forming an internal shunt for artificial dialysis.

The in-vivo indwelling tube 1 has a tubular main body (in-vivo indwelling tube main body) 2. Both ends of the main body 2 are open and are anastomosed with blood vessels. Thereby, the main body 2
Blood flows through the lumen.

The material of the main body 2 may be either a porous body or a non-porous body. Further, the main body 2 preferably has flexibility, and more preferably has elasticity.

Examples of the porous body include a woven fabric, a knitted fabric, a braided product (for example, a warp knit, a weft knit, a triaxial knit, a bag weave and a braid), a nonwoven fabric, and a porous resin film. In addition, those in which pores are formed by stretching, a blade, a wet extraction method, a dry extraction method, or the like can be used. By constituting the whole or a part of the main body 2 with such a porous body, when the in-vivo indwelling tube 1 is used as a substitute blood vessel or the like, the formed neointima is excellent in stability and tissue healing properties. Is obtained. As a non-porous body,
Examples include a resin tube and a rubber tube.

The constituent material of the main body 2 is not particularly limited. As the polymer material, for example, polyester,
Polyester elastomer, polyurethane, polyurethane urea, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, ethylene-propylene copolymer, polystyrene, ethylene-vinyl acetate copolymer,
Examples thereof include polytetrafluoroethylene, polyamide, acrylic resin, silicone, and various other biocompatible materials.

Preferred examples of the polyester include:
Examples include polyethylene terephthalate and polybutylene terephthalate. Preferred examples of the polyester elastomer include a polyester-polyether block copolymer and a polyester-polyester copolymer.

Preferred examples of the polyester-polyether block copolymer include those having a hard segment of polyethylene terephthalate, polyethylene terephthalate and polyethylene isophthalate, polyethylene terephthalate-polyethylene isophthalate copolymer, and poly (1,4-cyclohexanedimethylene). Terephthalate)
And the like, wherein the soft segment is an aliphatic polyether such as polyethylene glycol. Specifically, for example, Pelprene-P-type (manufactured by Toyobo Co., Ltd.) And Arnitel E, P (manufactured by Akzo).

Further, a preferable example of the polyester-polyester copolymer is that the hard segment is an aromatic polyester such as polyethylene terephthalate, polyethylene terephthalate copolymer, poly (1,4-cyclohexane dimethylene terephthalate), and soft segment. Examples thereof include those in which the segment is an aliphatic polyester such as ethylene sebacate, and specific examples include Pelprene-S-type (Pelprene-S-type: manufactured by Toyobo Co., Ltd.).

Examples of the polyurethane include those made of various thermoplastic polyurethanes, and preferable examples thereof include polyols (eg, polytetramethylene glycol), polytetramethylene glycol-silicone block copolymer, and polyethylene glycol- A silicone block copolymer can be used.

The constituent materials of the main body 2 include, for example,
Antithrombotic agents such as heparin, urokinase, TPA (thrombolytic agent) and prostacyclin (PGI ₂ ), and biocompatible materials such as elastin, collagen, gelatin, chitin, chitosan and the like can also be dispersed and compounded. .

The inner surface and / or the outer surface of the main body 2 may be subjected to various surface treatments such as antithrombotic treatment, in particular, coating.

The shape and dimensions (length, inner diameter, outer diameter, etc.) of the main body 2 of the indwelling tube 1 can be appropriately set according to conditions such as the purpose of use, the type, the site used in the living body, and the like. . For example, when used as a substitute blood vessel as in this embodiment, the dimensions of the main body 2 of the in-vivo indwelling tube 1 are determined according to the case and the indwelling site, for example, about 10 to 200 cm in length,
The inner diameter can be about 1 to 40 mm and the outer diameter can be about 1.2 to 50 mm.

A needle puncture portion 3 for puncturing a puncture needle such as a suture needle, an injection needle, or a catheter (hereinafter collectively referred to as a “puncture needle”) is formed in the middle of the main body 2. ing.

The needle stick portion 3 is formed of a thicker portion than the wall thickness of the main body 2 and has a convex shape protruding outward from the outer peripheral surface of the main body 2. The thickness (height) of the needle stick portion 3 is not particularly limited, but is 1. of the wall thickness of the main body 2 (the average thickness of the tube wall).
It is preferably about 5 to 15 times, more preferably about 1.5 to 5 times. If the thickness of the needle stick 3 is too small, it is difficult to confirm the position of the needle stick 3 by palpation when the indwelling indwelling tube 1 is implanted subcutaneously. If it is too much, the physical effect on the living body becomes large, and becomes a clinical problem.

The needle puncture portion 3 is piercable by a puncture needle, and after extracting the punctured puncture needle, has a self-occluding property (puncture) capable of closing the puncture hole by its own elasticity. Post-self-occlusion). Thereby, the sealing property at the punctured portion is ensured, and liquid leakage (blood leakage) from the puncture hole is prevented. Further, such an operation / effect is maintained even when puncturing is performed frequently.

Such a needle stick 3 is formed integrally with the main body 2 (or a part thereof). In this case, the main body 2
And the needle piercing portion 3 may be integrally formed of the same material, or the main body 2 and the needle piercing portion 3 may be formed of different materials in two colors (multicolor molding).

As the constituent material of the needle stick portion 3, in addition to the constituent material of the main body 2, various kinds of materials such as natural rubber, isoprene rubber, chlorinated polyisoprene, nitrile rubber, acrylic rubber, butylene rubber, and geronized butyl rubber can be used. Various thermoplastic elastomers such as rubber materials, ethylene vinyl acetate elastomers, butadiene elastomers, polyamide elastomers, polyester elastomers, urethane elastomers, α-olefin elastomers, and styrene elastomers are exemplified. Further, a combination of any two or more of these (for example,
Copolymer, polymer alloy, multilayer structure, etc.).

Further, the above-described antithrombotic agent and biocompatible material can be dispersed and compounded also in the constituent material of the needle stick portion 3.

As described above, according to the present invention, the needle stick 3 is
It is formed integrally with the main body, and does not attach and fix the needle stick as a separate member to the main body. Therefore, the following advantages can be obtained.

The number of parts is reduced, and the structure is simplified.

It does not require the work of attaching the needle stick, and is easy to manufacture.

There is no need for a special sealing structure at the joint (fixing portion) between the main body and another member fixed thereto to ensure the sealing property (liquid tightness).

The arrangement, shape, size and the like of the needle stick can be freely set.

It can be manufactured at low cost.

FIG. 3 is a perspective view showing another embodiment of the in-vivo indwelling tube of the present invention, and FIG. 4 is a sectional view taken along line BB in FIG. Hereinafter, the in-vivo indwelling tube 1 shown in these figures will be described.
The following description focuses on differences from the above-described embodiment, and a description of similar items is omitted.

The in-vivo indwelling tube 1 has a tubular main body 2 similar to that described above, and a needle stick portion 4 is integrally formed in the middle thereof. The needle stick portion 4 is formed in a band shape over the entire circumference of the main body 2, that is, so as to surround the outer circumference of the main body 2. As a result, the following various advantages can be obtained.

First, at the time of indwelling the indwelling tube 1 in the living body (during surgery), the needle bar 4 has no direction with respect to the axis of the indwelling tube 1. Surgery can be performed without considering the direction of rotation with respect to the axis of the
Operability in surgery is significantly improved.

After the indwelling tube 1 is placed in the living body (after surgery), even if the indwelling tube 1 is rotated in the living body, the needle stick 4 is always located on the skin side, The puncture of the puncture needle can be performed effectively.

Second, since the needle stick portion 4 is formed over the entire circumference of the main body 2, as shown by a dashed line in FIG.
Even when the puncture needle 10 is pierced too deeply, the needle tip 11 of the puncture needle 10 is pierced by the needle puncture portion 4 on the opposite side (downward in FIG. 4) to the skin side, stops, and is prevented from penetrating. Thereby, damage to the living tissue can be prevented or reduced. Further, even when the puncture depth of the puncture needle 10 is deeper and the needle tip 11 of the puncture needle 10 has also penetrated the needle puncture portion 4 on the side opposite to the skin side (downward in FIG. 4), the puncture is performed The needle puncture 4 exhibits the self-occluding property after puncturing as described above, so that blood leakage can be prevented.

The shape, width and height (thickness) of the needle stick 4
These conditions may be the same over the entire circumference of the main body 2 or may change in the circumferential direction.

The needle stick 4 is not limited to being formed over the entire circumference of the main body 2, but may be partially missing along the circumferential direction.

Further, one or two or more band-shaped needle sticks 4 may be formed in a spiral shape on the outer periphery of the main body 2.

In the present invention, a plurality of needle sticks may be formed integrally with the main body 2. Each needle stick may be arranged along the longitudinal direction of the main body 2, arranged along the circumferential direction of the main body 2, or a combination of these.

FIGS. 5 to 7 each show a case where a plurality of needle sticks are arranged along the longitudinal direction of the main body 2. Hereinafter, with respect to the in vivo indwelling tube 1 shown in these,
The following description focuses on differences from the above-described embodiment, and a description of similar items is omitted.

As shown in FIG. 5, two needle sticks 5 and 6 are arranged at a predetermined interval along the longitudinal direction of the main body 2. By providing the plurality of needle sticks 5 and 6 in this manner, the punctured portion of the skin can be dispersed at a plurality of places, so that damage to the skin and surrounding tissues is reduced.

Further, as shown in FIG. 5, the shapes of the needle stick 5 and the needle stick 6 are different. Thus, when the indwelling tube 1 is implanted under the skin, the needle stick 5 and the needle stick 6 can be distinguished (identified) by palpation (by touch when touched by hand from above the skin). it can. For example, when both ends of the main body 2 are anastomosed to blood vessels (particularly veins), by distinguishing the needle sticks 5 and 6, the central side and the peripheral side of the blood vessels are distinguished and grasped. It is possible,
As a result, it is possible to determine which of the needle sticks 5 and 6 is the blood extraction side and which is the blood supply side.

The in-vivo indwelling tube 1 shown in FIGS.
As in the embodiment shown in FIG. 5, two needle sticks 7 and 8 are arranged at a predetermined interval along the longitudinal direction of the main body 2. Also in this case, the needle sticks 7 and 8 are not the same. That is, both the needle sticks 5 and 6 are circular, but have different sizes (diameters) (see FIG. 6).
Further, their heights (thicknesses) (see FIG. 7) are different. Even with such a configuration, the needle stick 7 and the needle stick 8 can be distinguished (identified), and the same effect as described above can be obtained.

In the present invention, the plurality of needle sticks may be any as long as they can be distinguished.
The embodiment is not limited to those having different shapes, sizes, and heights (thicknesses) as in the embodiment shown in FIGS. 5 to 7, and may have different physical characteristics between the needle stick portions. Examples of those having different physical properties include a case where the stiffness and hardness of both needle sticks are different, a case where a magnetic powder is blended into only one needle stick and both needle sticks are magnetic and non-magnetic, etc. Is mentioned.

Although not shown, the needle stick 4 existing over the entire circumference of the main body 2 as shown in FIGS.
A plurality may be formed along the longitudinal direction of the main body 2. Also in this case, one or two or more of the conditions such as the shape, width, height (thickness), and physical characteristics of each needle stick part are different, and they can be distinguished (identified). Is preferable.

FIGS. 8 and 9 are cross sectional views showing other embodiments of the indwelling tube of the present invention. Less than,
The in-vivo indwelling tube 1 shown in these figures will be described focusing on differences from the above-described embodiment, and the description of the same items will be omitted.

The in-vivo indwelling tube 1 shown in FIG.
It is constituted by a laminate formed by laminating an inner layer 21 and an outer layer 22. The constituent materials of the inner layer 21 and the outer layer 22 include the same constituent materials as those of the main body 2 described above. In this case, the constituent materials of the inner layer 21 and the outer layer 22 preferably have different compositions and physical properties.

By combining such an inner layer 21 and an outer layer 22, the advantages of both layers can be obtained, and the flexibility (flexibility), rigidity, tension, torsion, compression, etc. of the main body 2 can be obtained. Physical properties such as strength, chemical resistance,
The degree of freedom in designing chemical properties such as durability, biocompatibility, and antithrombotic properties is expanded.

For the main body 2 having such a multilayer structure,
A needle stick 9 similar to the needle stick 3 is formed integrally with the outer layer 22.

On the other hand, the in-vivo indwelling tube 1 shown in FIG. 9 is also formed of a laminate in which the main body 2 is formed by laminating the inner layer 21 and the outer layer 22 in the same manner as described above. In this case, the needle stick 9 similar to the needle stick 3 is formed integrally with the inner layer 21.

The number of layers in the main body 2 having a multilayer structure is as follows.
There may be three or more layers, and the needle stick provided on the
What is necessary is just to form integrally with any one or more layers of each layer. Further, between the layers, for example, between the inner layer 21 and the outer layer 22, a reinforcing member such as a layer, a net, or a line may be interposed.

As an example of such a reinforcing member, a reinforcing material having crush resistance and kink resistance, more specifically, a helically installed elastic reinforcing material (Japanese Unexamined Patent Application Publication No.
-337143) can be used.

In the embodiment shown in FIGS. 8 and 9 as well, the shape, arrangement, number of formed needle punctures 9 and the like are not limited to those shown in FIGS. The configuration of the needle stick can be applied.

The in-vivo indwelling tube 1 of the present invention can be formed by, for example, extrusion molding, multicolor molding (two-color molding), injection molding or the like.
And the needle sticks 3 to 9 can be formed at the same time.

Other manufacturing methods include, for example, a method in which a material for forming a needle stick is joined to the outer peripheral surface of the main body 2 formed into a desired shape, and these are heat-treated and heat-sealed. A method of fusing, a method of bonding with a solvent, an adhesive or the like can be used.

It goes without saying that the method of manufacturing the indwelling tube 1 is not limited to these.

When the in-vivo indwelling tube 1 of the present invention is used, for example, as a substitute blood vessel for forming an internal shunt for artificial dialysis,
Even if the puncture is performed with a puncture needle, since the needle puncture has self-occluding properties after puncture, blood leakage can be prevented quickly after the puncture needle is removed, and frequent punctures can be performed. Even if it is performed, such effects and effects will not be impaired.
The effect can be exhibited in the long term.

Therefore, for example, adverse effects due to blood leakage (internal bleeding) such as formation of ulcers due to bacterial propagation and continuation of chronic inflammation can be prevented, and the indwelling tube 1 can be placed in the living body without performing reoperation. It can be continued over a long period of time, greatly reducing the physical, mental and financial burden on the patient.

The application of the in vivo indwelling tube of the present invention is not limited to the above-mentioned one. For example, it requires puncture with a puncture needle such as a graft for blood access requiring patency under severe conditions. It can be used for all in vivo indwelling tubes. In addition, it can be used as, for example, a stent graft, an artificial trachea, a colostomy, a high-performance catheter, an implantable drug solution port, and an artificial esophagus.

As described above, the in-vivo indwelling tube according to the present invention has been described with reference to the illustrated embodiments, but the present invention is not limited to these embodiments.

[0072]

Next, specific examples of the present invention will be described.

Example 1 A polyester elastomer material containing 5 wt% of heparin as an antithrombotic agent (Perprene 90H, manufactured by Toyobo Co., Ltd. (Perprene-P-
Using (type)), a tubular main body and two needle sticks were simultaneously formed by injection molding, and the main body was cut into a predetermined length.

The dimensions of the main body were 6 mm in inner diameter, 8 mm in outer diameter, and 20 cm in length. The needle stick has the shape shown in FIGS. 6 and 7, one needle stick has a diameter of 6 mm and a height (thickness) of 3 mm, and the other needle stick has a diameter of 4 mm and a height of 4 mm. (Thickness) was 2 mm, and the installation interval between both needle sticks was 100 mm.

(Example 2) An olefin-based elastomer resin (Tuffmer, manufactured by Mitsui Petrochemical Co., Ltd.) was prepared as a main body-forming material, and an oil-added styrene-based elastomer (squalane + septon (Kuraray Co., Ltd.) was used as a needle stick forming material. )) Was prepared.

Using these materials, a tubular main body and two needle sticks were simultaneously formed by two-color molding, and the main body was cut into a predetermined length.

The dimensions of the main body were 6 mm in inner diameter, 8 mm in outer diameter, and 20 cm in length. The two needle sticks are formed on the entire circumference of the main body as shown in FIGS. 3 and 4, respectively. One needle stick has a width of 20 mm and a height (thickness) of 3 m.
m, the other needle stick part was 10 mm in width and 3 mm in height (thickness), and the installation interval between both needle stick parts was 100 mm.

(Embodiment 3) Body production

On the outer surface of a porous tubular body (inner layer) made of a polyester-based elastic conjugate fiber, an undiluted solution of liquid silicone rubber (Siastic, manufactured by Dow Corning Asia) and sodium chloride (special grade reagent, manufactured by Nacalai Tesque) were applied. Apply the mixture, then air-dry to a layer thickness of about 100μ
m of silicone rubber layer (outer layer) was formed. Next, sodium chloride was sufficiently extracted in water to make the silicone rubber layer porous.

2. Formation of a needle stick part As a needle stick part, a high-viscosity liquid silicone rubber from which a solvent has been sufficiently removed is processed into a disk shape having a diameter of 10 mm, and this needle stick part is joined to the outer peripheral surface of the main body via a solvent, Integrated.
This needle stick was integrated with the silicone rubber layer (outer layer) of the main body.

As described above, a disk-shaped needle stick having a diameter of 10 mm and a thickness of 5 mm was integrated with the body composed of the polyester resin porous layer (inner layer) and the silicone rubber porous layer (outer layer). An indwelling tube was obtained.

(Comparative Example 1) The tubular main body of the multilayer laminated structure manufactured in Example 3 was used as an indwelling tube in a living body. This indwelling tube is not provided with a needle stick as in the first to third embodiments.

Comparative Example 2 An inner diameter of 6 mm, an outer diameter of 7.2 mm and a length of 20 conventionally used as a dialysis graft.
An in-vivo indwelling tube composed of cm Gore-Tex fiber (Gore-Tex: manufactured by Gore) was prepared. This indwelling tube is not provided with a needle stick as in the first to third embodiments.

<Experiment> Examples 1 to 3 and Comparative Examples 1 and 2
The effect of an in vivo indwelling tube was confirmed by an animal experiment.

By incision surgery, each indwelling tube was implanted in a loop into the canine femoral artery and vein. 3 weeks after transplantation, 16
Punctures were performed 20 times a day with a gauge needle 10 times for 5 days with 1 cool.

As for the method of puncturing the injection needle, in Examples 1 and 2, each needle puncture was checked by touching the outside of the skin with a hand, and each needle puncture was evenly punctured. Also in Example 3, puncture was performed on the needle stick while confirming the needle stick by palpation from above the skin. In addition, in Comparative Examples 1 and 2, puncturing was performed at an arbitrary part of the indwelling tube in a living body.
In each case, puncturing was performed so as not to puncture the same site as much as possible, that is, so that the punctured sites were separated as much as possible.

<Experimental Results> The in vivo indwelling tubes of Examples 1 to 3 were all cool, and almost all blood leaks from the puncture hole after the needle was removed were observed immediately after the start of needle insertion until the end. Did not.

On the other hand, in Comparative Example 1, blood leakage from the puncture hole stopped about 15 minutes after the needle was removed until the first cool. Time has extended.

In Comparative Example 2, it took time to stop the blood leakage from immediately after the start of needle insertion to the end, and after removing the needle, it took 3 hours.
Even after 0 minutes, blood leakage may continue from the puncture hole.

[0090]

As described above, according to the in-vivo indwelling tube of the present invention, the needle stick has the function of immediately closing the puncture hole after puncturing with the puncture needle. For example, it is possible to prevent liquid such as blood from leaking from the inside of the tube main body, and to prevent gas or liquid from entering the inside of the in-vivo indwelling tube main body. Further, even when puncturing is performed frequently, such an effect can be obtained continuously, and the durability is excellent.

Further, since the needle stick is formed integrally with the main body, the number of parts is small, the structure is simplified, the manufacture is easy, and the arrangement, shape, and size of the needle stick are easy. And the like can be set freely.

When the needle stick is formed over almost the entire circumference of the body of the indwelling tube, the indwelling operation of the indwelling tube is facilitated, and rotation after the indwelling tube can be coped with. Even if the puncture depth of the puncture needle is too deep, penetration of the puncture needle can be prevented, and damage to surrounding living tissue can be suppressed.

When forming a plurality of needle sticks,
Since the punctured portion of the living body (such as skin) can be dispersed at a plurality of locations, damage to the punctured site of the living body and surrounding tissues is reduced.

In particular, when one of the plurality of needle sticks is made different in shape, size, height or physical characteristics from the other needle stick, Can be distinguished (identified) from outside the body.

[Brief description of the drawings]

FIG. 1 is a perspective view showing an embodiment of an indwelling tube according to the present invention.

FIG. 2 is a sectional view taken along line AA in FIG.

FIG. 3 is a perspective view showing another embodiment of the indwelling tube of the present invention.

FIG. 4 is a sectional view taken along line BB in FIG. 3;

FIG. 5 is a perspective view showing another embodiment of the in-vivo indwelling tube of the present invention.

FIG. 6 is a perspective view showing another embodiment of the in-vivo indwelling tube of the present invention.

FIG. 7 is a sectional view taken along line CC in FIG. 6;

FIG. 8 is a cross-sectional view showing another embodiment of the indwelling tube of the present invention.

FIG. 9 is a cross-sectional view showing another embodiment of the indwelling tube of the present invention.

[Explanation of symbols]

 Reference Signs List 1 indwelling tube in living body 2 main body 21 inner layer 22 outer layer 3 needle stick part 4 needle stick part 5 needle stick part 6 needle stick part 7 needle stick part 8 needle stick part 9 needle stick part 10 puncture needle 11 needle tip

Claims (7)

[Claims] 1. A body having a tubular member through which a fluid can pass, and at least one needle stick having a self-closing property after puncturing is formed integrally with the body. A living body indwelling tube, characterized in that: 2. The in-vivo indwelling tube according to claim 1, further comprising a plurality of needle sticks, which are arranged along a longitudinal direction of the main body. 3. It has a plurality of needle sticks, one of which
The in-vivo indwelling tube according to claim 1 or 2, wherein the one needle stick and the other needle stick have different shapes, sizes, heights, or physical characteristics. 4. The in-vivo indwelling tube according to claim 1, wherein the needle stick portion is constituted by a thick portion that is thicker than a wall thickness of the main body. 5. The in-vivo indwelling tube according to claim 1, wherein the needle stick is formed over substantially the entire circumference of the main body. 6. The device according to claim 1, wherein the main body is formed of a laminate of a plurality of layers, and the needle stick is integrated with at least one of the layers. The in-vivo indwelling tube according to the above. 7. The in vivo indwelling tube according to claim 1, which constitutes a blood vessel substitute.