JP2000001430A - Laminated material for plaster - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a laminated material for plaster having sufficiently high flexibility and resistance to the agent used in the plaster. SOLUTION: The laminated material 1 for plaster is produced by using a flexible thermoplastic elastomer layer 11 as a substrate for the plaster and laminating a polyolefin resin layer 12 resistant to the agent to both faces of the thermoplastic elastomer layer 11. The plaster produced by using the laminated material 1 for plaster has high flexibility and, accordingly, gives excellent feeling when applied to the diseased part of skin. Since the laminated material has excellent resistance to the drug, the wrinkling, slacking, etc., of the substrate is eliminated and the working efficiency is improved in the production of the plaster.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a laminated material for applying a patch, and the laminated material of the present invention is used as an anti-inflammatory analgesic agent, a wound guard film, a bandage film, a protect film, etc. It is used as

[0002]

2. Description of the Related Art Conventionally, a patch is often used in which a drug is applied to a substrate such as a nonwoven fabric or a plastic film. The patch comprises a drug such as an anti-inflammatory agent and an adhesive, and is adhered to the skin by the adhesive. When a nonwoven fabric is used as a base for a patch, there is a drawback that when the patch is stuck to a predetermined skin surface, a sense of discomfort occurs in that the stuck part has a different color from the skin or a texture.

[0003]

In order to improve the drawbacks when a nonwoven fabric is used as a base for a patch, a plastic film is used as the base for the patch. At present, chemical resistance and flexibility are not yet sufficient. In particular, when highly medicinal components are used as a patch, it is necessary to mix a "dissolving agent" for applying these components to a base material such as a nonwoven fabric and an "adjunct agent" for enhancing the transdermal absorption effect. A flexible film is required that is resistant to these "dissolving agents" and "adjuncts" and that improves the fit when applied to the skin. Therefore, a flexible plastic film that is resistant to a medicinal component, a dissolving agent, an auxiliary agent, and the like as a patch has been desired. The present invention solves these problems by laminating a film that is resistant to each component contained in the patch on both sides of a flexible film, and has flexibility and chemical resistance. It is intended to provide a laminated material for a patch having a certain quality.

[0004]

In order to solve the conventional problems, a patch base has the following structure. A laminate for applying a patch, wherein the laminate comprises a laminate in which a chemical resistant resin layer is laminated on both sides of a flexible resin layer. Further, the laminate is a laminate in which the flexible resin layer is made of a thermoplastic elastomer and the chemical-resistant resin layer is made of a polyolefin-based resin, and the laminate has a modulus at 10% elongation of 1 to 10.
A laminate for patches was characterized in that the laminate had a weight of kg / cm ² . The flexible resin layer is a polyester-based elastomer, a polyamide-based elastomer, a polyurethane-based elastomer, a polystyrene-based elastomer, or a polyolefin-based elastomer, and has a thickness of 15%.
To 100 μm. The chemical-resistant resin layer has a density of 0.919 to 0.919.
A patch for a patch was characterized by being 0.945 g / cm ³ of polyethylene and having a thickness of 0.5 to 50 μm. The modulus here means 10% of laminated material
It shows the tensile strength when extended.

That is, a laminate comprising a thermoplastic elastomer layer and a polyolefin resin layer laminated on both sides thereof as a base for a patch, wherein the laminate has a modulus at 10% elongation of 1 to 10 kg / cm ² . By using, the flexibility of the laminated material is obtained by the thermoplastic elastomer layer, and the resistance to the medicine is provided by the polyolefin-based resin layer, so that the conventional problem can be solved. Therefore, by applying the patch medicine using the laminated material of the present invention, there is no problem in manufacturing the base such as swelling and curling of the base material due to a medicinal ingredient, a dissolving agent, an auxiliary agent, etc., and the patch is efficiently manufactured. can do. Also,
When this patch is applied to the affected area, it is flexible,
The uncomfortable feeling of discomfort was reduced, and the problems of the conventional patch could be largely improved.

[0006]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the drawings. FIG. 1 is a schematic cross-sectional view showing an example of a patch for a patch of the present invention, and FIG. 2 is a schematic cross-sectional view of a patch manufactured using the patch for a patch of the present invention. FIG. 3 is an explanatory diagram when a patch is manufactured according to the first embodiment, and FIG. 4 is an explanatory diagram when a patch is manufactured according to the third embodiment.

[0007] As shown in FIG. 1, the patch laminate of the present invention is basically a three-layer laminate in which a polyolefin resin layer 12 is laminated on both surfaces of a thermoplastic elastomer layer 11. The laminate is characterized in that the modulus at 10% elongation is 1 to 10 kg / cm ² to impart flexibility and chemical resistance to the laminate. 10
If the modulus at% elongation is less than 1 kg / cm ^2, it will remain deformed when attached to the skin and bent.
Wrinkles and loosening occur and peel from the skin. On the other hand, if the modulus of the laminated material at 10% elongation is less than 1 kg / cm ² , wrinkles and loosening are likely to occur when applying a chemical to the laminated material, and a stable product cannot be obtained. On the other hand, when the modulus at 10% elongation exceeds 10 kg / cm ² , the resistance to bending increases, which becomes an obstacle when bending the attached portion. Therefore, a laminated film having a modulus at 10% elongation of 1 to 10 kg / cm ² is a substrate having optimal flexibility as a substrate for a patch.

[0008] Examples of the thermoplastic elastomer used in the present invention include polyester-based elastomer, polyamide-based elastomer, polyurethane-based elastomer, polystyrene-based elastomer, and polyolefin-based elastomer.

Examples of the polyester elastomer include a polyether polyester such as a block copolymer of polybutylene terephthalate and an aliphatic polyether, and a polyester polyester such as a block copolymer of polybutylene terephthalate and an aliphatic polyester. is there. Examples of the polyurethane elastomer include a polyester polyurethane, an aliphatic ester polyurethane, an adipate polyurethane, and a polyether polyurethane. Examples of the polyamide-based elastomer include a polyamide-polyether block copolymer and a polyamide-polyester block copolymer. As a polyolefin-based elastomer, ethylene-propylene copolymer,
There is an ethylene-propylene terpolymer. Examples of the styrene-based elastomer include a polystyrene-polybutadiene block copolymer, a polystyrene-polyisoprene block copolymer, and a polystyrene-polyolefin block copolymer.

The above thermoplastic elastomer may be used alone.
Yes, but a blend of several can be used. Ma
In addition, among the above thermoplastic elastomers, environmental pollution during combustion
Considering dyeing issues and work efficiency during manufacturing,
Olefin-based elastomers are preferred. Poly Olefi
The density of the elastomer is 0.87 to 0.90.
g / cm ^Three, MFR 0.3-2.5g / 10min, bending
The elastic modulus is 300-2000kg / cm^TwoStuff used
It is. The thickness of the layer is preferably in the range of 15 to 100 μm.
is there.

The polyolefin resin used in the present invention has a density in the range of 0.919 to 0.945 g / cm ³ . As these resins, a simple substance such as low-density polyethylene, linear low-density polyethylene, medium-density polyethylene, and polypropylene, or a blend thereof can be used. The thickness of the polyolefin-based resin layer is in the range of 0.5 to 50 μm. Among the polyolefin-based resins, low-density polyethylene is preferred.

As a method of laminating the polyolefin resin and the thermoplastic elastomer, a conventionally known dry lamination method, wet lamination method, coextrusion method and the like can be used. For example, a polyether-polyester elastomer and polypropylene are separately formed into a film, and the two films are laminated by a dry lamination method using a urethane-based adhesive to form a laminated material. Examples of the adhesive used for the lamination include a urethane resin, a polyester resin, and an acrylic resin. In some cases, a blend film of polypropylene and ethylene-propylene rubber and polypropylene are co-extruded by a co-extrusion method to produce a laminated film. As the multilayer co-extrusion method, there are a multilayer T-die method and a multilayer inflation method, but a multilayer T-die method is preferable for lowering the modulus value.

As a method for producing a patch, a method similar to the conventional method can be used. That is, a medicinal component such as an antiphlogistic analgesic and an auxiliary agent are dissolved in a dissolving agent to prepare a coating solution, which is applied to the polyolefin resin surface of the laminated material by a comma coating method, a spreading method, etc., and dried. Thereafter, a liner (protective layer) such as a release-treated polyolefin film, polyester film, or release paper is laminated on the drug surface to prepare a patch. In use, the liner of the patch is peeled off and adhered to the affected part of the skin.

[0014]

Next, the present invention will be described in more detail with reference to examples. (Example 1) As a thermoplastic elastomer, the density: 0.1.
88 g / cm ³ , melt flow rate (MFR): 1.
A polypropylene-based elastomer (hereinafter referred to as a PP-based elastomer) having 5 g / 10 minutes and a flexural modulus of 980 kgf / cm ² was used.
Using polyethylene (hereinafter referred to as PE) having a density of 0.923 g / cm ³ , this was extruded from a T-die at an extrusion temperature of 270 ° C. by a three-layer co-extrusion method, and as shown in FIG. 10 μ / PP elastomer 40 μ / P
A laminated film having a three-layer structure of E 10 μ was prepared, and was used as a patch 1 for a patch. The modulus at 10% elongation of the obtained laminated material for patch 1 was 1.6 kg / cm ² .

Next, as shown in FIG. 3 (b), an anti-inflammatory analgesic having the following composition is applied to one of the PE layers 12a of the patch laminate 1 by a spreading method, and the anti-inflammatory analgesic after drying is applied. A drug layer 13 having a coating amount of the agent of 50 g / m ² was formed. Composition of antiphlogistic analgesic ・ glycol salicylate 5 parts by weight ・ l-menthol 7 parts by weight ・ nonylate vanillylamide 0.01 parts by weight ・ acrylic adhesive 40 parts by weight

As shown in FIG. 3 (c), a 12 μm-thick polyethylene terephthalate film (hereinafter referred to as a PET film) 14a which has been subjected to a release treatment as a liner is laminated on the drug layer 13 to form a patch 2. Was prepared. As a result, since the base material was not affected by the anti-inflammatory analgesic, a stable product was obtained without producing wrinkles, loosening, or the like due to swelling or the like during production or storage. Furthermore, since the flexibility was maintained by the PP-based elastomer, the sticking feeling was good even when stuck to the affected skin.

Example 2 As a thermoplastic elastomer, the density was 0.88 g / cm ³ , and the MFR was 0.45 g / cm ³ .
10 minutes, using a PP-based elastomer having a flexural modulus of 850 kgf / cm ² , and using a PE having a density of 0.923 g / cm ³ as a polyolefin-based resin, by a three-layer co-extrusion inflation method. A laminated film was prepared at an extrusion temperature of 230 ° C., and as shown in FIG.
Laminated material 1 for patch was composed of μ / PE 5μ. The modulus at 10% elongation of the obtained laminated material for patch 1 was 1.
It was 9 kg / cm ² .

Next, as shown in FIG. 3 (b), an anti-inflammatory analgesic was applied to one of the PE layers 12a of the patch laminate 1 in the same manner as in Example 1, and the applied amount was 50 g / m 2. ^{A second} drug layer 13 was formed. Further, in the same manner as in Example 1, a 12 μm-thick PET film subjected to a release treatment was laminated on the drug layer 12a to prepare a patch 2 as shown in FIG. 3 (c). As a result, since the base material was not affected by the anti-inflammatory analgesic, a stable product was obtained without producing wrinkles, loosening, or the like due to swelling or the like during production or storage.
Furthermore, since the flexibility was maintained by the PP-based elastomer, the sticking feeling was good even when stuck to the affected skin.

Example 3 Density: 0.88 g / cm ³ , MFR: 1.6 g / 1 as a thermoplastic elastomer
0 min, flexural modulus: 450 kgf / cm ² of PP-based elastomer and polyolefin-based resin, density:
Using a 0.923 g / cm ³ PE, this was subjected to a three-layer coextrusion T-die method to form a 16 μm thick PET film 1.
5 was extruded in three layers at an extrusion temperature of 270 ° C.
As shown in (a), a four-layered PET 16 μ / PE 5
Lamination material 1 for patch was made of μ / PP elastomer 55 μ / PE 5μ. The modulus at 10% elongation of the resulting patch 1 was 1.7 kg / cm ² .

Next, as shown in FIG. 4 (b), an anti-inflammatory analgesic was applied on the PE layer 12a side of the patch laminate 1 in the same manner as in Example 1, and the applied amount was 50 g / m ² . The drug layer 13 was formed. Further, similarly to the first embodiment, the medicine layer 13
12μ thick PET film 1 with a release treatment applied to it
4a was laminated to prepare Patch 2 as shown in FIG. 4 (c). As a result, since the base material was not affected by the anti-inflammatory analgesic, a stable product was obtained without producing wrinkles, loosening, or the like due to swelling or the like during production or storage. Furthermore, since the flexibility was maintained by the PP-based elastomer, the sticking feeling was good even when stuck to the affected skin.

[0021]

According to the present invention, as a base for a patch,
A laminate was prepared by laminating a polyolefin-based resin layer on both sides of a thermoplastic elastomer layer.
By setting the modulus at% elongation to 1 to 10 kg / cm ² , it is possible to impart flexibility and resistance to a drug component used in a patch to the laminate. Therefore, wrinkles, loosening, and the like due to swelling and the like do not occur on the substrate during production and storage, and a stable product can be obtained. Furthermore, even when the patch is applied to the skin, the uncomfortable feeling of discomfort disappears,
A clear sticking feeling can be obtained.

[Brief description of the drawings]

FIG. 1 is a schematic cross-sectional view showing an example of the patch laminate of the present invention.

FIG. 2 is a schematic cross-sectional view of a patch manufactured using the patch laminate of the present invention.

FIG. 3 is an explanatory diagram when a patch is manufactured according to Example 1.

FIG. 4 is an explanatory view when a patch is manufactured according to Example 3.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Patch material 2 Patches 11 Thermoplastic elastomer layer 11a PP elastomer layer 12 Polyolefin resin layer 12a PE layer 13 Drug layer 14 Liner 14a PET film (for liner) 15 PET film (for laminate)

Claims (4)

[Claims] 1. A laminate for applying a patch, characterized in that the laminate comprises a laminate in which a chemical resistant resin layer is laminated on both sides of a flexible resin layer. 2. The laminate according to claim 1, wherein the flexible resin layer is made of a thermoplastic elastomer, and the chemical-resistant resin layer is made of a polyolefin-based resin. ^2. The patch laminate according to claim 1, wherein the weight is 10 kg / cm ² . 3. The flexible resin layer is a polyester-based elastomer, a polyamide-based elastomer, a polyurethane-based elastomer, a polystyrene-based elastomer, or a polyolefin-based elastomer, and has a thickness of 15 to 15.
3. The method according to claim 1, wherein the distance is 100 μm.
The laminate for a patch according to item 1. 4. The chemical-resistant resin layer has a density of 0.91.
2. A polyethylene of 9 to 0.945 g / cm < ³ > and a thickness of 0.5 to 50 [mu] m.
And the laminate for a patch according to claim 2.