JOP20200192A1 - Anti-tigit antibodies - Google Patents

Anti-tigit antibodies

Info

Publication number
JOP20200192A1
JOP20200192A1 JOP/2020/0192A JOP20200192A JOP20200192A1 JO P20200192 A1 JOP20200192 A1 JO P20200192A1 JO P20200192 A JOP20200192 A JO P20200192A JO P20200192 A1 JOP20200192 A1 JO P20200192A1
Authority
JO
Jordan
Prior art keywords
tigit antibodies
antibodies
tigit
cancer
diseases
Prior art date
Application number
JOP/2020/0192A
Other languages
Arabic (ar)
Original Assignee
Merck Sharp And Dohme Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53938463&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200192(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp And Dohme Llc filed Critical Merck Sharp And Dohme Llc
Publication of JOP20200192A1 publication Critical patent/JOP20200192A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to anti-TIGIT antibodies, as well as use of these antibodies in the treatment of diseases such as cancer and infectious disease.
JOP/2020/0192A 2014-08-19 2020-08-05 Anti-tigit antibodies JOP20200192A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462038912P 2014-08-19 2014-08-19
US201562126733P 2015-03-02 2015-03-02

Publications (1)

Publication Number Publication Date
JOP20200192A1 true JOP20200192A1 (en) 2022-10-30

Family

ID=53938463

Family Applications (2)

Application Number Title Priority Date Filing Date
JOP/2015/0195A JO3664B1 (en) 2014-08-19 2015-08-17 Anti-tigit antibodies
JOP/2020/0192A JOP20200192A1 (en) 2014-08-19 2020-08-05 Anti-tigit antibodies

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JOP/2015/0195A JO3664B1 (en) 2014-08-19 2015-08-17 Anti-tigit antibodies

Country Status (31)

Country Link
US (4) US20160355589A1 (en)
EP (1) EP3183267A1 (en)
JP (3) JP6920194B2 (en)
KR (2) KR102321168B1 (en)
CN (2) CN113583131A (en)
AP (1) AP2017009765A0 (en)
AU (3) AU2015305754B2 (en)
BR (1) BR112017003108A8 (en)
CA (1) CA2957722C (en)
CL (2) CL2017000310A1 (en)
CO (1) CO2017001561A2 (en)
CR (1) CR20170060A (en)
DO (1) DOP2017000046A (en)
EA (1) EA036311B1 (en)
GE (1) GEP20217331B (en)
GT (1) GT201700033A (en)
IL (1) IL250583B (en)
JO (2) JO3664B1 (en)
MA (1) MA40475A (en)
MD (1) MD4733C1 (en)
MX (2) MX2017002229A (en)
MY (2) MY184288A (en)
NI (1) NI201700019A (en)
PE (1) PE20170289A1 (en)
PH (1) PH12017500296A1 (en)
SG (1) SG11201701161QA (en)
TN (1) TN2017000024A1 (en)
TW (2) TWI790593B (en)
UA (1) UA122395C2 (en)
WO (1) WO2016028656A1 (en)
ZA (1) ZA201700955B (en)

Families Citing this family (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008266951B2 (en) 2007-06-18 2013-12-12 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor PD-1
EP2279412B1 (en) 2008-04-09 2017-07-26 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
ES2707580T3 (en) 2011-09-23 2019-04-04 Oncomed Pharm Inc VEGF / DLL4 binding agents and uses thereof
PL3081576T3 (en) 2013-12-12 2020-03-31 Shanghai Hengrui Pharmaceutical Co., Ltd. Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
KR102433464B1 (en) 2014-05-28 2022-08-17 아게누스 인코포레이티드 Anti-gitr antibodies and methods of use thereof
UA122395C2 (en) * 2014-08-19 2020-11-10 Мерк Шарп Енд Доум Корп. ANTIBODY AGAINST TIGIT
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
PT3653221T (en) 2015-02-19 2022-11-08 Compugen Ltd Anti-pvrig antibodies and methods of use
EP3978929A1 (en) 2015-02-19 2022-04-06 Compugen Ltd. Pvrig polypeptides and methods of treatment
MA42043A (en) 2015-05-07 2018-03-14 Agenus Inc ANTI-OX40 ANTIBODIES AND METHODS OF USE THEREOF
TWI715587B (en) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit-binding agents and uses thereof
JP6976241B2 (en) 2015-08-14 2021-12-08 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. Anti-TIGIT antibody
US10323091B2 (en) 2015-09-01 2019-06-18 Agenus Inc. Anti-PD-1 antibodies and methods of use thereof
EP3344658B1 (en) 2015-09-02 2022-05-11 Yissum Research Development Company of The Hebrew University of Jerusalem Ltd. Antibodies specific to human t-cell immunoglobulin and itim domain (tigit)
EP3353204B1 (en) 2015-09-23 2023-10-18 Mereo BioPharma 5, Inc. Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer
RU2729379C1 (en) 2015-10-01 2020-08-06 Потенза Терапевтикс, Инк. Anti-tigit antigen-binding proteins and methods for use thereof
MY189018A (en) 2015-11-18 2022-01-19 Merck Sharp & Dohme Pd1 and/or lag3 binders
CN116063542A (en) 2015-12-02 2023-05-05 阿吉纳斯公司 Antibodies and methods of use thereof
UA125898C2 (en) * 2016-03-04 2022-07-06 Джн Байосайєнсіз, Ллк Antibodies to tigit
US10894823B2 (en) 2016-03-24 2021-01-19 Gensun Biopharma Inc. Trispecific inhibitors for cancer treatment
SG10201912563XA (en) 2016-05-27 2020-02-27 Agenus Inc Anti-tim-3 antibodies and methods of use thereof
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
EP3471754A1 (en) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 antibodies
RU2764548C2 (en) 2016-08-09 2022-01-18 Кимаб Лимитед Anti-icos antibodies
PT3347379T (en) * 2016-08-17 2020-02-18 Compugen Ltd Anti-tigit antibodies, anti-pvrig antibodies and combinations thereof
CN107815467B (en) 2016-08-31 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized gene modified animal model
WO2018041120A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric tigit
KR20230133934A (en) 2016-10-11 2023-09-19 아게누스 인코포레이티드 Anti-lag-3 antibodies and methods of use thereof
WO2018083248A1 (en) 2016-11-03 2018-05-11 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses & methods
AU2017355512A1 (en) 2016-11-04 2019-05-23 Aximmune, Inc. Beta-alethine, immune modulators, and uses thereof
CA3041340A1 (en) 2016-11-09 2018-05-17 Agenus Inc. Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof
CN110662552A (en) * 2016-11-30 2020-01-07 昂科梅德制药有限公司 Methods of cancer treatment comprising TIGIT binding agents
WO2018102746A1 (en) * 2016-12-02 2018-06-07 Rigel Pharmaceuticals, Inc. Antigen binding molecules to tigit
AU2017373945A1 (en) 2016-12-07 2019-06-20 Agenus Inc. Antibodies and methods of use thereof
US10232053B2 (en) 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
US10537637B2 (en) 2017-01-05 2020-01-21 Gensun Biopharma Inc. Checkpoint regulator antagonists
AU2018226646A1 (en) * 2017-03-03 2019-09-19 Rinat Neuroscience Corp. Anti-GITR antibodies and methods of use thereof
JOP20190203A1 (en) 2017-03-30 2019-09-03 Potenza Therapeutics Inc Anti-tigit antigen-binding proteins and methods of use thereof
US20200024351A1 (en) 2017-04-03 2020-01-23 Jounce Therapeutics, Inc. Compositions and Methods for the Treatment of Cancer
KR20190137911A (en) 2017-04-21 2019-12-11 신라젠(주) Anticancer Vaccinia Virus and Gateway Inhibitor Combination Therapy
KR20190141223A (en) 2017-04-26 2019-12-23 브리스톨-마이어스 스큅 컴퍼니 Antibody Production Methods to Minimize Disulfide Bond Reduction
MA50957A (en) 2017-05-01 2020-10-14 Agenus Inc ANTI-TIGIT ANTIBODIES AND THEIR METHODS OF USE
JOP20190260A1 (en) 2017-05-02 2019-10-31 Merck Sharp & Dohme Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof
US11845798B2 (en) 2017-05-02 2023-12-19 Merck Sharp & Dohme Llc Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
EP3618855A4 (en) * 2017-05-02 2021-02-17 Merck Sharp & Dohme Corp. Stable formulations of anti-tigit antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof
JP7348072B2 (en) 2017-06-01 2023-09-20 コンピュジェン リミテッド Triple combination antibody therapy
WO2018229163A1 (en) 2017-06-14 2018-12-20 King's College London Methods of activating v delta 2 negative gamma delta t cells
GB201709808D0 (en) 2017-06-20 2017-08-02 Kymab Ltd Antibodies
SG11202000660QA (en) * 2017-07-27 2020-02-27 Iteos Therapeutics Sa Anti-tigit antibodies
BE1025333B1 (en) * 2017-07-27 2019-01-23 Iteos Therapeutics S.A. ANTI-TIGIT ANTIBODIES
WO2019023504A1 (en) 2017-07-27 2019-01-31 Iteos Therapeutics Sa Anti-tigit antibodies
EP3689909A4 (en) * 2017-09-29 2021-12-29 Jiangsu Hengrui Medicine Co., Ltd. Tigit antibody, antigen-binding fragment thereof, and medical use thereof
US11629189B2 (en) 2017-12-19 2023-04-18 Kymab Limited Bispecific antibody for ICOS and PD-L1
CA3082280A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against tigit
TWI816729B (en) * 2017-12-30 2023-10-01 英屬開曼群島商百濟神州有限公司 Anti-tigit antibodies and their use as therapeutics and diagnostics
EP3740508A4 (en) * 2018-01-15 2022-03-23 Nanjing Legend Biotech Co., Ltd. Antibodies and variants thereof against tigit
WO2019152574A1 (en) * 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Methods for treating cancer or infection using a combination of an anti-pd-1 antibody, an anti-lag3 antibody, and an anti-tigit antibody
JP7156607B2 (en) * 2018-02-06 2022-10-19 アイ－エムエービー バイオファーマ （ハンジョウ） カンパニー リミテッド Antibodies against T-cell immunoreceptor (TIGIT) with IG and ITIM domains and uses thereof
MX2020008795A (en) 2018-02-28 2020-10-08 Yuhan Corp Anti-tigit antibodies and uses thereof.
CN111918873A (en) 2018-03-27 2020-11-10 百时美施贵宝公司 Real-time monitoring of titre using UV signals
US20190300610A1 (en) * 2018-03-29 2019-10-03 Hummingbird Bioscience Pte. Ltd. Vista antigen-binding molecules
AR114789A1 (en) * 2018-04-18 2020-10-14 Hoffmann La Roche ANTI-HLA-G ANTIBODIES AND THE USE OF THEM
JP2021522801A (en) 2018-05-09 2021-09-02 イッサム リサーチ デベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド Antibodies specific for humannectin 4
SG11202011461TA (en) 2018-06-01 2020-12-30 Compugen Ltd Anti-pvrig/anti-tigit bispecific antibodies and methods of use
EP3813880A4 (en) 2018-06-29 2022-07-13 Gensun Biopharma Inc. Antitumor immune checkpoint regulator antagonists
SG11202100746WA (en) * 2018-07-25 2021-03-30 Innovent Biologics Suzhou Co Ltd Anti-tigit antibody and use thereof
AU2019324170A1 (en) 2018-08-23 2021-02-18 Seagen, Inc. Anti-TIGIT antibodies
CN112996805A (en) 2018-08-30 2021-06-18 Hcw生物科技公司 Multi-chain chimeric polypeptides and uses thereof
AU2019328313A1 (en) 2018-08-30 2021-02-25 HCW Biologics, Inc. Single-chain chimeric polypeptides and uses thereof
CN110511912B (en) * 2018-08-30 2024-03-22 浙江煦顼技术有限公司 Functional modulation of immune cells
WO2020047473A1 (en) 2018-08-30 2020-03-05 HCW Biologics, Inc. Single-chain and multi-chain chimeric polypeptides and uses thereof
EP3877418A4 (en) * 2018-11-05 2022-08-17 Merck Sharp & Dohme Corp. Dosing regimen of anti-tigit antibody for treatment of cancer
JP2022514702A (en) 2018-12-21 2022-02-14 オーエスイー・イミュノセラピューティクス Bifunctional anti-PD-1 / IL-7 molecule
KR20210113282A (en) 2019-01-07 2021-09-15 아이테오스 벨지움 에스에이 anti-TIGIT antibody
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
WO2020172658A1 (en) 2019-02-24 2020-08-27 Bristol-Myers Squibb Company Methods of isolating a protein
EP3938396A1 (en) 2019-03-11 2022-01-19 Jounce Therapeutics, Inc. Anti-icos antibodies for the treatment of cancer
CN111744013B (en) * 2019-03-29 2022-07-26 江苏恒瑞医药股份有限公司 Methods and pharmaceutical combinations for treating diseases using anti-TIGIT antibodies in combination with PD-1 inhibitors
CN111744007B (en) * 2019-03-29 2023-05-12 江苏恒瑞医药股份有限公司 anti-TIGIT antibody pharmaceutical composition and application thereof
WO2020237221A1 (en) 2019-05-23 2020-11-26 Bristol-Myers Squibb Company Methods of monitoring cell culture media
TWI760751B (en) * 2019-05-29 2022-04-11 美商美國禮來大藥廠 Tigit and pd-1/tigit-binding molecules
JP7297095B2 (en) * 2019-06-13 2023-06-23 グリーン クロス コーポレーション ANTIBODY AGAINST TIGIT AND USES THEREOF
US11738052B2 (en) 2019-06-21 2023-08-29 HCW Biologics, Inc. Multi-chain chimeric polypeptides and uses thereof
US10851157B2 (en) 2019-07-01 2020-12-01 Gensun Biopharma, Inc. Antagonists targeting the TGF-β pathway
AU2020314129A1 (en) * 2019-07-15 2022-02-24 Shanghai Junshi Biosciences Co., Ltd. Anti-tigit antibodies and application thereof
US20220251194A1 (en) * 2019-07-30 2022-08-11 Merck Sharp & Dohme Corp. Anti-pd-1/lag3/tigit trispecific antibodies and anti-pd-1/lag3 bicpecific antibodies
US11667709B2 (en) 2019-09-24 2023-06-06 Industrial Technology Research Institute Anti-TIGIT antibodies and methods of use
CA3155173A1 (en) * 2019-09-27 2021-04-01 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
US20220340660A1 (en) * 2019-10-01 2022-10-27 Merck Sharp & Dohme Corp. Biomarkers for anti-tigit antibody treatment
IL292757A (en) 2019-11-05 2022-07-01 Merck Patent Gmbh Anti-tigit antibodies and uses thereof
WO2021091960A1 (en) 2019-11-05 2021-05-14 Jounce Therapeutics, Inc. Methods of treating cancer with anti-pd-1 antibodies
TW202124452A (en) * 2019-11-14 2021-07-01 中國大陸商上海藥明生物技術有限公司 A novel antibody against tigit
US20230057899A1 (en) 2019-12-05 2023-02-23 Compugen Ltd. Anti-pvrig and anti-tigit antibodies for enhanced nk-cell based tumor killing
TW202136287A (en) 2019-12-17 2021-10-01 法商Ｏｓｅ免疫治療公司 Bifunctional molecules comprising an il-7 variant
MX2022008412A (en) 2020-01-07 2022-08-08 Univ Texas Improved human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy.
JP2023519106A (en) 2020-02-11 2023-05-10 エイチシーダブリュー バイオロジックス インコーポレイテッド CHROMATOGRAPHIC RESIN AND USES THEREOF
EP4103601A2 (en) 2020-02-11 2022-12-21 HCW Biologics, Inc. Methods of treating age-related and inflammatory diseases
CA3169243A1 (en) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methods of activating regulatory t cells
CA3170025A1 (en) 2020-03-13 2021-09-16 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pvrig binding protein and its medical uses
WO2021216468A1 (en) * 2020-04-19 2021-10-28 Askgene Pharma Inc. Human tigit specific single domain antibodies and methods of use
CN115836087A (en) 2020-04-29 2023-03-21 Hcw生物科技公司 anti-CD 26 protein and application thereof
CN113563470B (en) 2020-04-29 2023-02-10 广州昂科免疫生物技术有限公司 Antibody combined with TIGIT antigen and preparation method and application thereof
WO2021224438A1 (en) 2020-05-07 2021-11-11 Institut Curie Antxr1 as a biomarker of immunosuppressive fibroblast populations and its use for predicting response to immunotherapy
CN114507284B (en) * 2020-05-09 2023-05-26 华博生物医药技术（上海）有限公司 Antibodies against TIGIT, methods of preparation and uses thereof
IL298608A (en) 2020-06-01 2023-01-01 Hcw Biologics Inc Methods of treating aging-related disorders
WO2021247003A1 (en) 2020-06-01 2021-12-09 HCW Biologics, Inc. Methods of treating aging-related disorders
JP2023528036A (en) 2020-06-02 2023-07-03 アーカス バイオサイエンシズ インコーポレイティド Antibody to TIGIT
BR112022025801A2 (en) 2020-06-18 2023-10-03 Hoffmann La Roche METHODS FOR TREATING A PATIENT AND FOR TREATING A PATIENT WITH ADVANCED ESCC, KIT, ANTIBODY, USE OF AN ANTIBODY, AND USE OF A BINDING ANTAGONIST
WO2021258337A1 (en) * 2020-06-24 2021-12-30 Huahui Health Ltd. Human monoclonal antibodies against tigit for immune related diseases
CN111718415B (en) * 2020-07-03 2021-02-23 上海洛启生物医药技术有限公司 anti-TIGIT nano antibody and application thereof
TW202216778A (en) 2020-07-15 2022-05-01 美商安進公司 Tigit and cd112r blockade
WO2022044010A1 (en) 2020-08-26 2022-03-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Anti-t-cell immunoglobulin and itim domain (tigit) antibodies for the treatment of fungal infections
JP2023544410A (en) 2020-10-05 2023-10-23 ブリストル－マイヤーズ スクイブ カンパニー Methods for concentrating proteins
JP2023548538A (en) 2020-11-08 2023-11-17 シージェン インコーポレイテッド combination therapy
US11028172B1 (en) * 2020-11-10 2021-06-08 Lepu Biopharma Co., Ltd. Anti-TIGIT antibodies and uses thereof
WO2022112198A1 (en) 2020-11-24 2022-06-02 Worldwide Innovative Network Method to select the optimal immune checkpoint therapies
TW202222345A (en) * 2020-11-26 2022-06-16 大陸商信達生物製藥（蘇州）有限公司 Formulations containing anti-tigit/pd-1 bispecific antibody as well as preparation method and use thereof
US20240018248A1 (en) 2020-12-02 2024-01-18 Vib Vzw An ltbr agonist in combination therapy against cancer
WO2022124864A1 (en) * 2020-12-10 2022-06-16 주식회사 유틸렉스 Anti-tigit antibody and use thereof
TW202241935A (en) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 Chimeric antigen receptor system with adaptable receptor specificity
US20240050646A1 (en) * 2020-12-22 2024-02-15 Regina E. HERZLINGER Methods, systems, and apparatus for administering an antibody treatment via infusion
JP2024500190A (en) * 2020-12-22 2024-01-04 レジーナ イー． ヘルツリンガー， Methods, systems, and devices for administering monoclonal and/or polyclonal antibody treatments by bolus injection
US11806507B2 (en) * 2020-12-22 2023-11-07 Regina E. HERZLINGER Methods, systems, and apparatus for administering an antibody treatment via infusion
WO2022148781A1 (en) 2021-01-05 2022-07-14 Institut Curie Combination of mcoln activators and immune checkpoint inhibitors
WO2022152245A1 (en) 2021-01-14 2022-07-21 上海君实生物医药科技股份有限公司 Anti-tigit antibody pharmaceutical composition and application thereof
CN114984227A (en) * 2021-03-02 2022-09-02 百奥泰生物制药股份有限公司 Application of anti-TIGIT antibody in drug combination
WO2022184068A1 (en) * 2021-03-02 2022-09-09 百奥泰生物制药股份有限公司 Application of anti-tigit antibody in treating tumors or cancers
AU2022253351A1 (en) 2021-04-09 2023-10-12 Ose Immunotherapeutics New scaffold for bifunctional molecules with improved properties
BR112023020662A2 (en) 2021-04-09 2024-02-06 Seagen Inc CANCER TREATMENT METHODS WITH ANTI-TIGIT ANTIBODIES
US20240182572A1 (en) 2021-04-09 2024-06-06 Ose Immunotherapeutics Scaffold for bifunctional molecules comprising pd-1 or cd28 and sirp binding domains
TW202304965A (en) 2021-05-04 2023-02-01 美商艾吉納斯公司 Anti-tigit antibodies, anti-cd96 antibodies, and methods of use thereof
CN117916263A (en) 2021-05-10 2024-04-19 美帝马布生物公司 Anti-TIGIT antibodies and uses thereof
CN116940595A (en) * 2021-05-18 2023-10-24 苏州鑫康合生物医药科技有限公司 anti-TIGIT antibodies and uses thereof
CN115466327A (en) * 2021-06-10 2022-12-13 北京天广实生物技术股份有限公司 Antibodies that bind to TIGIT and uses thereof
TW202320848A (en) 2021-07-28 2023-06-01 美商建南德克公司 Methods and compositions for treating cancer
WO2023036340A1 (en) * 2021-09-13 2023-03-16 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Protein complexes targeting il21 pathway
CA3231553A1 (en) 2021-09-15 2023-03-23 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition comprising anti-pvrig/tigit bispecific antibody
TW202328195A (en) 2021-09-15 2023-07-16 大陸商江蘇恆瑞醫藥股份有限公司 Proteins that specifically bind to pd-1 and the pharmaceutical use thereof
CN115838424A (en) * 2021-09-22 2023-03-24 上海康岱生物医药技术股份有限公司 Monoclonal antibody targeting TIGIT
TW202321308A (en) 2021-09-30 2023-06-01 美商建南德克公司 Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
CN114181310B (en) * 2022-02-14 2022-07-05 中山康方生物医药有限公司 anti-TIGIT antibody, and pharmaceutical composition and use thereof
WO2023168363A1 (en) 2022-03-02 2023-09-07 HCW Biologics, Inc. Method of treating pancreatic cancer
WO2023170606A1 (en) 2022-03-08 2023-09-14 Alentis Therapeutics Ag Use of anti-claudin-1 antibodies to increase t cell availability
WO2023173011A1 (en) 2022-03-09 2023-09-14 Bristol-Myers Squibb Company Transient expression of therapeutic proteins
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer
WO2023215719A1 (en) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2023240058A2 (en) 2022-06-07 2023-12-14 Genentech, Inc. Prognostic and therapeutic methods for cancer
WO2023239226A1 (en) * 2022-06-10 2023-12-14 메디맵바이오 주식회사 Fusion protein comprising antibody binding specifically to tigit and interleukin-15, and use thereof
KR20230171885A (en) * 2022-06-10 2023-12-21 메디맵바이오 주식회사 Fusion protein comprising anti-TIGIT antibody, interleukin-15, and interleukin-15 receptor alpha sushi domain, and uses thereof
WO2024003360A1 (en) 2022-07-01 2024-01-04 Institut Curie Biomarkers and uses thereof for the treatment of neuroblastoma
WO2024028386A1 (en) 2022-08-02 2024-02-08 Ose Immunotherapeutics Multifunctional molecule directed against cd28

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
JP2532858B2 (en) 1985-04-01 1996-09-11 セルテツク リミテツド Transformed myeloma cell line
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
DE3785186T2 (en) 1986-09-02 1993-07-15 Enzon Lab Inc BINDING MOLECULE WITH SINGLE POLYPEPTIDE CHAIN.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5677425A (en) 1987-09-04 1997-10-14 Celltech Therapeutics Limited Recombinant antibody
ATE135370T1 (en) 1988-12-22 1996-03-15 Kirin Amgen Inc CHEMICALLY MODIFIED GRANULOCYTE COLONY EXCITING FACTOR
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
DK1136556T3 (en) 1991-11-25 2005-10-03 Enzon Inc Process for the preparation of multivalent antigen-binding proteins
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US6129914A (en) 1992-03-27 2000-10-10 Protein Design Labs, Inc. Bispecific antibody effective to treat B-cell lymphoma and cell line
AU4116793A (en) 1992-04-24 1993-11-29 Board Of Regents, The University Of Texas System Recombinant production of immunoglobulin-like domains in prokaryotic cells
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
DK0656946T4 (en) 1992-08-21 2010-07-26 Univ Bruxelles Immunoglobulins without light chains
AU6796094A (en) 1993-04-29 1994-11-21 Raymond Hamers Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of (camelidae)
JPH08511420A (en) 1993-06-16 1996-12-03 セルテック・セラピューテイクス・リミテッド Body
US5532210A (en) 1994-06-08 1996-07-02 E. I. Du Pont De Nemours And Company High temperature superconductor dielectric slow wave structures for accelerators and traveling wave tubes
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
ES2258817T3 (en) 1997-05-21 2006-09-01 Biovation Limited METHOD FOR THE PRODUCTION OF NON-IMMUNOGEN PROTEINS.
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
GB9818110D0 (en) 1998-08-19 1998-10-14 Weston Medical Ltd Needleless injectors and other devices
US6096002A (en) 1998-11-18 2000-08-01 Bioject, Inc. NGAS powered self-resetting needle-less hypodermic jet injection apparatus and method
US6329511B1 (en) 1998-12-01 2001-12-11 Protein Design Labs, Inc. Humanized antibodies to γ-interferon
KR100940380B1 (en) 1999-01-15 2010-02-02 제넨테크, 인크. Polypeptide Variants with Altered Effector Function
US7368527B2 (en) 1999-03-12 2008-05-06 Human Genome Sciences, Inc. HADDE71 polypeptides
EP1173462A1 (en) 1999-03-26 2002-01-23 Human Genome Sciences, Inc. 50 human secreted proteins
ES2571230T3 (en) 1999-04-09 2016-05-24 Kyowa Hakko Kirin Co Ltd Procedure to control the activity of an immunofunctional molecule
JP4668498B2 (en) 1999-10-19 2011-04-13 協和発酵キリン株式会社 Method for producing polypeptide
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
AU7684201A (en) 2000-06-28 2002-01-08 Glycofi Inc Methods for producing modified glycoproteins
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US6374470B1 (en) 2000-10-06 2002-04-23 Milliken & Company Face plate for spun-like textured yarn
US7408041B2 (en) 2000-12-08 2008-08-05 Alexion Pharmaceuticals, Inc. Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof
CA2838062C (en) 2001-08-03 2015-12-22 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
CA2476518A1 (en) 2002-02-22 2003-09-04 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US7193069B2 (en) 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
AU2003226356A1 (en) 2002-04-12 2003-10-27 Ramot At Tel Aviv University Ltd. Prevention of brain inflammation as a result of induced autoimmune response
US20060182755A1 (en) 2002-09-11 2006-08-17 Genentech, Inc. Novel composition and methods for the treatment of psoriasis
ATE493433T1 (en) 2002-09-11 2011-01-15 Genentech Inc NEW COMPOSITION AND METHOD FOR TREATING IMMUNE DISEASES
WO2004035537A2 (en) 2002-10-16 2004-04-29 Euro-Celtique S.A. Antibodies that bind cell-associated ca 125/o772p and methods of use thereof
US20090047213A1 (en) * 2003-04-14 2009-02-19 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD59
US7410483B2 (en) 2003-05-23 2008-08-12 Novare Surgical Systems, Inc. Hand-actuated device for remote manipulation of a grasping tool
US7312320B2 (en) 2003-12-10 2007-12-25 Novimmune Sa Neutralizing antibodies and methods of use thereof
WO2005120571A2 (en) 2004-06-07 2005-12-22 Ramot At Tel Aviv University Ltd. Method of passive immunization against disease or disorder characterized by amyloid aggregation with diminished risk of neuroinflammation
CA2573745A1 (en) 2004-07-21 2007-01-12 Glycofi, Inc. Immunoglobulins comprising predominantly a glcnac2man3glcnac2 glycoform
CN101023102B (en) * 2004-09-17 2013-05-29 霍夫曼-拉罗奇有限公司 Anti-OX40L antibodies
EP1891107B1 (en) 2005-05-12 2011-07-06 ZymoGenetics, Inc. Compositions and methods for modulating immune responses
KR101245462B1 (en) 2005-07-08 2013-03-20 바이오겐 아이덱 엠에이 인코포레이티드 Sp35 antibodies and uses thereof
AU2007311946A1 (en) * 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient
AU2007334264A1 (en) * 2006-11-15 2008-06-26 Medarex, Inc. Human monoclonal antibodies to BTLA and methods of use
EP2115002B1 (en) * 2007-02-02 2014-08-20 Baylor Research Institute Vaccines based on targeting antigen to dcir expressed an antigen-presenting cells
BRPI0807710B1 (en) * 2007-02-23 2021-12-14 Merck Sharp & Dohme Corp ANTIBODIES THAT BIND HUMAN IL-23P19 AND IL-23, ANTIBODY, ISOLATED NUCLEIC ACID, EXPRESSION VECTOR, MICROBIAL HOST CELL, METHOD OF PRODUCTION OF A POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION
BRPI0809594A2 (en) 2007-04-03 2019-08-27 Micromet Ag polypeptide, nucleic acid sequence, vector, host, process for producing a polypeptide, pharmaceutical composition, use of a polypeptide, method for preventing, treating or ameliorating a disease in an individual in need thereof, kit, method for the identification of a polypeptide (s)
AU2015202123B2 (en) 2008-04-09 2017-06-15 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
EP2279412B1 (en) 2008-04-09 2017-07-26 Genentech, Inc. Novel compositions and methods for the treatment of immune related diseases
ES2624835T3 (en) 2009-08-06 2017-07-17 Immunas Pharma, Inc. Antibodies that specifically bind to the A beta oligomers and use thereof
CA2775573A1 (en) 2009-10-09 2011-04-14 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-her 3 antibodies
CN102781958B (en) 2009-12-05 2017-07-11 马尔瓦有限责任公司 Based on the malaria vaccine for pushing up multiple worm Ferlin, Ferlin sample albumen and other albumen for containing C2 domains
EA024701B1 (en) * 2010-04-13 2016-10-31 Селлдекс Терапьютикс Инк. Antibodies that bind human cd27 and uses thereof
BR112012031329A2 (en) 2010-06-09 2016-10-11 Zymogenetics Inc vstm3 dimeric fusion proteins and related compositions and methods
PT2609118T (en) 2010-08-23 2017-03-22 Univ Texas Anti-ox40 antibodies and methods of using the same
UA112434C2 (en) 2011-05-27 2016-09-12 Ґлаксо Ґруп Лімітед ANTIGENCY BINDING SPECIFICALLY Binds to ALL
US9205144B2 (en) 2011-06-03 2015-12-08 Dana-Farber Cancer Institute, Inc. Identification of conserved peptide blocks in homologous polypeptides
KR20130062168A (en) 2011-12-02 2013-06-12 고려대학교 산학협력단 Recombinant fluorescent nanoparticles
US9732156B2 (en) 2012-02-29 2017-08-15 Gilead Biologics, Inc. Methods of treating rheumatoid arthritis using antibodies to matrix metalloproteinase 9
ES2875535T3 (en) 2012-03-29 2021-11-10 Biogen Ma Inc Biomarkers for use in Integrin Therapy Applications
WO2013151999A1 (en) 2012-04-02 2013-10-10 President And Fellows Of Harvard College Cancer treatment and immune system regulation through fat10 pathway inhibition
WO2013184912A2 (en) 2012-06-06 2013-12-12 Oncomed Pharmaceuticals, Inc. Binding agents that modulate the hippo pathway and uses thereof
RS58528B1 (en) 2012-12-03 2019-04-30 Bristol Myers Squibb Co Enhancing anti-cancer activity of immunomodulatory fc fusion proteins
BR112015013127A2 (en) * 2012-12-04 2017-09-26 Oncomed Pharm Inc immunotherapy with binding agents
CN103073644B (en) * 2012-12-31 2014-03-12 中国科学技术大学 Specific anti-mouse TIGIT monoclonal antibody and preparation method, identification and application thereof
US20140314741A1 (en) 2013-04-18 2014-10-23 Developmen Center For Biotechnology Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases
MY183503A (en) * 2013-07-16 2021-02-23 Genentech Inc Method of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
CA2935285A1 (en) 2014-02-21 2015-08-27 Medimmune, Llc Anti-pcsk9-glp-1 fusions and methods for use
CN107073108A (en) 2014-07-16 2017-08-18 豪夫迈·罗氏有限公司 Use TIGIT inhibitor and the method for anti-cancer agent therapy cancer
UA122395C2 (en) * 2014-08-19 2020-11-10 Мерк Шарп Енд Доум Корп. ANTIBODY AGAINST TIGIT
WO2016073282A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Combination therapy comprising ox40 binding agonists and tigit inhibitors
PL3221346T3 (en) 2014-11-21 2021-03-08 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
SG10202006538TA (en) 2014-12-23 2020-08-28 Bristol Myers Squibb Co Antibodies to tigit
TWI715587B (en) 2015-05-28 2021-01-11 美商安可美德藥物股份有限公司 Tigit-binding agents and uses thereof
JP6764474B2 (en) 2015-09-25 2020-09-30 ジェネンテック， インコーポレイテッド Anti-TIGIT antibody and usage

Also Published As

Publication number Publication date
AU2021202360A1 (en) 2021-05-13
MD4733B1 (en) 2020-12-31
CA2957722A1 (en) 2016-02-25
TWI724997B (en) 2021-04-21
GEP20217331B (en) 2021-12-10
PE20170289A1 (en) 2017-04-05
MD20170032A2 (en) 2017-08-31
TN2017000024A1 (en) 2018-07-04
CR20170060A (en) 2017-04-18
CN113583131A (en) 2021-11-02
JP2020162614A (en) 2020-10-08
EA036311B1 (en) 2020-10-26
JP7487256B2 (en) 2024-05-20
JP2017532007A (en) 2017-11-02
US20200270346A1 (en) 2020-08-27
US10618958B2 (en) 2020-04-14
KR102050082B1 (en) 2019-11-29
MY184288A (en) 2021-03-30
PH12017500296B1 (en) 2017-06-28
KR20190133078A (en) 2019-11-29
US20170198042A1 (en) 2017-07-13
US20160355589A1 (en) 2016-12-08
UA122395C2 (en) 2020-11-10
MX2022001105A (en) 2022-02-14
CN107148430A (en) 2017-09-08
AP2017009765A0 (en) 2017-02-28
CN107148430B (en) 2021-08-27
PH12017500296A1 (en) 2017-06-28
MD4733C1 (en) 2021-07-31
CL2017000310A1 (en) 2017-08-18
BR112017003108A8 (en) 2023-04-11
TW202144422A (en) 2021-12-01
AU2019200426B2 (en) 2021-01-21
TW201609813A (en) 2016-03-16
EA201790413A1 (en) 2017-08-31
JO3664B1 (en) 2020-08-27
GT201700033A (en) 2019-09-30
TWI790593B (en) 2023-01-21
JP2022105108A (en) 2022-07-12
AU2015305754B2 (en) 2018-10-25
AU2015305754A1 (en) 2017-02-23
NI201700019A (en) 2017-03-08
CA2957722C (en) 2022-05-31
BR112017003108A2 (en) 2017-12-05
KR20170041272A (en) 2017-04-14
JP7066777B2 (en) 2022-05-13
WO2016028656A1 (en) 2016-02-25
MX2017002229A (en) 2017-05-09
CO2017001561A2 (en) 2017-05-19
DOP2017000046A (en) 2017-08-31
CL2019001926A1 (en) 2019-11-29
ZA201700955B (en) 2022-11-30
US20180066055A1 (en) 2018-03-08
EP3183267A1 (en) 2017-06-28
IL250583B (en) 2022-07-01
SG11201701161QA (en) 2017-03-30
KR102321168B1 (en) 2021-11-02
IL250583A0 (en) 2017-04-30
MA40475A (en) 2017-06-28
AU2019200426A1 (en) 2019-02-07
MY198017A (en) 2023-07-26
JP6920194B2 (en) 2021-08-18

Similar Documents

Publication Publication Date Title
JOP20200192A1 (en) Anti-tigit antibodies
MX2019012233A (en) Anti-sirp alpha antibodies.
MX2022007522A (en) Anti-cd27 antibodies.
WO2017030823A3 (en) Anti-tigit antibodies
PH12016501763A1 (en) Multispecific antibodies
MX2017008819A (en) Anti-cd47 antibodies and uses thereof.
PH12017500002A1 (en) Anti-cdh6 antibody drug conjugates
MY192927A (en) Fused bicyclic compounds for the treatment of disease
PH12016502061A1 (en) Novel antii-rnf43 antibodies and methods of use
MX2017008456A (en) Fused bicyclic compounds for the treatment of disease.
AR120118A2 (en) ANTI-TIGIT ANTIBODIES
EA202091619A3 (en) ANTIBODIES AGAINST TIGIT