JOP20180131B1 - Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation - Google Patents

Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation

Info

Publication number
JOP20180131B1
JOP20180131B1 JOP/2018/0131A JOP20180131A JOP20180131B1 JO P20180131 B1 JOP20180131 B1 JO P20180131B1 JO P20180131 A JOP20180131 A JO P20180131A JO P20180131 B1 JOP20180131 B1 JO P20180131B1
Authority
JO
Jordan
Prior art keywords
alkyl
c1andndash
aryl
cancer
preparation
Prior art date
Application number
JOP/2018/0131A
Other languages
Arabic (ar)
Inventor
Moh’d Kamel Al-sheikh Ahmad
Abdul Raheem Mohamed Arafat Tawfiq
Fawzi Moh'd Abuqatouseh Luay
Mazin Omar Mallah Eyad
Original Assignee
Univ Of Petra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Of Petra filed Critical Univ Of Petra
Priority to JOP/2018/0131A priority Critical patent/JOP20180131B1/en
Priority to PCT/JO2019/050005 priority patent/WO2020136693A1/en
Publication of JOP20180131A1 publication Critical patent/JOP20180131A1/en
Application granted granted Critical
Publication of JOP20180131B1 publication Critical patent/JOP20180131B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present disclosure provides a compound of Formula (I) or any pharmaceutically acceptable salt thereof for use in treating cancer in a subject, a method for preparing the same, and a pharmaceutical composition thereof: Formula (I) wherein R1 comprises H; C1andndash;C3 alkyl; or C3andndash;C6cycloalkyl; R2 comprises H; or C1andndash;C2 alkyl; C1andndash;C2 andndash;O alkyl; R3 comprises H; C1andndash;C2 alkyl, aryl or substituted aryl, H2C-aryl or substituted H2C-aryl; and R4 comprises H; C1andndash;C3 alkyl; O-alkyl or O-aryl.
JOP/2018/0131A 2018-12-24 2018-12-24 Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation JOP20180131B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JOP/2018/0131A JOP20180131B1 (en) 2018-12-24 2018-12-24 Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation
PCT/JO2019/050005 WO2020136693A1 (en) 2018-12-24 2019-01-07 Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JOP/2018/0131A JOP20180131B1 (en) 2018-12-24 2018-12-24 Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation

Publications (2)

Publication Number Publication Date
JOP20180131A1 JOP20180131A1 (en) 2020-06-24
JOP20180131B1 true JOP20180131B1 (en) 2023-03-28

Family

ID=71129264

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2018/0131A JOP20180131B1 (en) 2018-12-24 2018-12-24 Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation

Country Status (2)

Country Link
JO (1) JOP20180131B1 (en)
WO (1) WO2020136693A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002226048A1 (en) * 2000-12-11 2002-06-24 Smith Kline Beecham Corporation Urotensin-ii receptor antagonists
WO2003035066A1 (en) * 2001-10-23 2003-05-01 Celltech R & D Limited 2-aminoquinolone derivatives for use as impdh inhibitors
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use

Also Published As

Publication number Publication date
JOP20180131A1 (en) 2020-06-24
WO2020136693A1 (en) 2020-07-02

Similar Documents

Publication Publication Date Title
CR20220312A (en) Substituted tricyclic compounds
MX2020007485A (en) Antiproliferative compounds and methods of use thereof.
GEP20207160B (en) New piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
EA201692095A1 (en) IMIDAZO [4,5-C] QUINOLIN-2-NEW COMPOUNDS AND THEIR APPLICATION IN CANCER TREATMENT
ZA202100485B (en) Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same
GEP20207126B (en) New ammonium derivatives, a process for their preparation and pharmaceutical compositions containing them
TN2019000204A1 (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
MX2018010878A (en) Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections.
MX2024009886A (en) Quinoline derivatives as alpha4beta7 integrin inhibitors.
GEP201606560B (en) Macrocyclic derivatives for the treatment of proliferative diseases
BRPI0409198A (en) quinolin-2-one derivatives for the treatment of airway diseases
EA201391486A1 (en) METHODS AND COMPOSITIONS FOR THE TREATMENT OF PARKINSON'S DISEASE
MX2021006544A (en) Cdk9 inhibitors and polymorphs thereof for use as agents for treatment of cancer.
PH12019500839A1 (en) Therapeutic compounds and methods of use thereof
MX2021010122A (en) Imidazopyridinyl compounds and use thereof for treatment of neurodegenerative disorders.
SG10201810404XA (en) Combination comprising a glucocorticoid and edo-s101
MX2021012105A (en) Pyrrole compounds.
SA521431048B1 (en) Pyrrolidine Compounds
EA201491982A1 (en) ANTIBACTERIAL QUINOLINE DERIVATIVES
MX2018014080A (en) Use of carbamate compound for preventing or treating fibromyalgia or functional syndrome associated with fibromyalgia.
MX2018010177A (en) 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds.
MX2021014458A (en) Tricyclic compounds.
JOP20180131B1 (en) Substituted quinolone compounds, their use in the treatment of cancer, and a method for preparation
WO2016112304A8 (en) Furoquinolinediones as inhibitors of tdp2
MX2021012499A (en) Improved inhibitors of the notch transcriptional activation complex and methods for use of the same.