JO3801B1 - طريقة للحصول على كبسولات صغيرة - Google Patents

طريقة للحصول على كبسولات صغيرة

Info

Publication number
JO3801B1
JO3801B1 JOP/2012/0111A JOP20120111A JO3801B1 JO 3801 B1 JO3801 B1 JO 3801B1 JO P20120111 A JOP20120111 A JO P20120111A JO 3801 B1 JO3801 B1 JO 3801B1
Authority
JO
Jordan
Prior art keywords
stream
component
solution
reactor
preparing
Prior art date
Application number
JOP/2012/0111A
Other languages
English (en)
Inventor
Bernardini Marco
Borgo Francesca
Freschi Giorgio
Russo Edoardo
Original Assignee
Sipcam Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sipcam Spa filed Critical Sipcam Spa
Application granted granted Critical
Publication of JO3801B1 publication Critical patent/JO3801B1/ar

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/16—Interfacial polymerisation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/26—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests in coated particulate form
    • A01N25/28—Microcapsules or nanocapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

<strong>طريقة مستمرة لتحضير كبسولات دقيقة محتوية على عنصر فعال غير مذاب فى الماء، للإستخدام فى المجال الصيدلى والكيمياء الزراعية، متضمنة:</strong> <strong> (1) تحضير فى مفاعل أول تحت التقليب محلول مائى محتوى على واحدة أو أكثر من العوامل المخفضة للتوتر السطحى،</strong> <strong> (2) تحضير فى مفاعل ثانى تحت التقليب محلول متضمن عنصر فعال غير ممتزج فى طور مائى ومكون أول لتحضير بوليمر متعدد التكثيف مشكلاً غلاف الكبسولة الدقيقة،</strong> <strong> ونجد أن الشحن الآنى لمفاعل أنبوبى بتيار من المحلول المائى (1) وتيار من المحلول (2)، يمثل نسبة تيار المحلول (2)/تيار المحلول (1) المتضمنة بين 0,5 و2,0،</strong> <strong> وبعد ذلك إختيارياً فى الفترة من 0-10 ثانية، يتم دخول تيار (3) من المكون الثانى فى المفاعل لتحضير بوليمر متعدد التكثيف، الذى يتفاعل مع المكون الأول،</strong> <strong> وتكون التيارات (1)، (2) و(3) تحت ظروف التدفق المضطرب فى المفاعل الأنبوبى،</strong> <strong> وتكون النسبة بين مكافئات المكون الأول ومكافئات المكون الثانى بين 0,9 و1,1، </strong> <strong> وتشحن تيارات (1)، (2) و(3) بإستمرار إلى المفاعل الأنبوبى</strong>.
JOP/2012/0111A 2011-05-09 2012-05-08 طريقة للحصول على كبسولات صغيرة JO3801B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000784A ITMI20110784A1 (it) 2011-05-09 2011-05-09 Processo per l'ottenimento di microcapsule

Publications (1)

Publication Number Publication Date
JO3801B1 true JO3801B1 (ar) 2021-01-31

Family

ID=44555187

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0111A JO3801B1 (ar) 2011-05-09 2012-05-08 طريقة للحصول على كبسولات صغيرة

Country Status (16)

Country Link
US (1) US9764302B2 (ar)
EP (2) EP2522421B1 (ar)
CY (1) CY1119922T1 (ar)
DK (1) DK2522421T3 (ar)
ES (2) ES2890048T3 (ar)
HR (2) HRP20211499T1 (ar)
HU (2) HUE056468T2 (ar)
IL (1) IL219622A (ar)
IT (1) ITMI20110784A1 (ar)
JO (1) JO3801B1 (ar)
LT (1) LT2522421T (ar)
NO (1) NO2522421T3 (ar)
PL (2) PL2522421T3 (ar)
PT (2) PT3300795T (ar)
RS (2) RS56800B1 (ar)
SI (1) SI2522421T1 (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016112116A2 (en) 2015-01-06 2016-07-14 Monsanto Technology Llc Modulation of release rate from microencapsulated pesticides
CN109197869B (zh) * 2018-10-25 2021-07-06 湖南人文科技学院 一种丙草胺微囊悬浮剂及其制备方法
CN109717187A (zh) * 2018-12-21 2019-05-07 江苏艾津农化有限责任公司 一种氯乙酰胺类除草剂微囊悬浮剂及其制备方法
CN112138669B (zh) * 2020-09-30 2022-08-19 广东石油化工学院 一种连续化制备铜锌铝催化剂的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577515A (en) 1963-12-13 1971-05-04 Pennwalt Corp Encapsulation by interfacial polycondensation
DE3020781C2 (de) * 1980-05-31 1982-11-18 Hoechst Ag, 6000 Frankfurt Druckbeständige Mikrokapseln mit einer Polyamid-Außenhülle und einer durch Polyurethan-Polyharnstoff oder Polyharnstoff strukturierten Innenmasse und Verfahren zu ihrer Herstellung
US4454083A (en) * 1981-12-21 1984-06-12 Appleton Papers Inc. Continuous microencapsulation
US4936901A (en) * 1986-07-09 1990-06-26 Monsanto Company Formulations of water-dispersible granules and process for preparation thereof
US5925464A (en) * 1995-01-19 1999-07-20 Dow Agrosciences Llc Microencapsulation process and product
US5705174A (en) 1995-06-07 1998-01-06 American Cyanamid Company Process for the preparation of microcapsule compositions
US6001312A (en) * 1996-04-17 1999-12-14 Wang; Taylor G. Reactor for making uniform capsules
DE19925311B4 (de) * 1999-05-27 2004-06-09 Schering Ag Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln
US9486416B2 (en) * 2009-12-22 2016-11-08 Evonik Corporation Emulsion-based process for preparing microparticles and workhead assembly for use with same

Also Published As

Publication number Publication date
SI2522421T1 (en) 2018-03-30
DK2522421T3 (da) 2018-01-29
ITMI20110784A1 (it) 2012-11-10
NO2522421T3 (ar) 2018-04-21
PL3300795T3 (pl) 2021-12-20
EP3300795A1 (en) 2018-04-04
ES2890048T3 (es) 2022-01-17
US9764302B2 (en) 2017-09-19
PL2522421T3 (pl) 2018-04-30
PT2522421T (pt) 2018-02-23
HRP20180151T1 (hr) 2018-03-23
HRP20211499T1 (hr) 2021-12-24
RS56800B1 (sr) 2018-04-30
EP3300795B1 (en) 2021-06-30
HUE056468T2 (hu) 2022-02-28
CY1119922T1 (el) 2018-12-12
IL219622A0 (en) 2012-07-31
PT3300795T (pt) 2021-09-13
LT2522421T (lt) 2018-03-12
HUE036386T2 (hu) 2018-07-30
IL219622A (en) 2017-05-29
EP2522421A1 (en) 2012-11-14
EP2522421B1 (en) 2017-11-22
US20120286438A1 (en) 2012-11-15
ES2659742T3 (es) 2018-03-19
RS62378B1 (sr) 2021-10-29

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