JO2715B1 - مشتقات أمين-ن[(4.5ثنائي فينيل بيريميدين-2-ي ل)ميثيل] وتحضيرها واستخداماتها في العلاج - Google Patents
مشتقات أمين-ن[(4.5ثنائي فينيل بيريميدين-2-ي ل)ميثيل] وتحضيرها واستخداماتها في العلاجInfo
- Publication number
- JO2715B1 JO2715B1 JOP/2006/0207A JOP20060207A JO2715B1 JO 2715 B1 JO2715 B1 JO 2715B1 JO P20060207 A JOP20060207 A JO P20060207A JO 2715 B1 JO2715 B1 JO 2715B1
- Authority
- JO
- Jordan
- Prior art keywords
- unsubstituted
- substituted
- phenyl
- alkyl
- therapeutics
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P11/06—Antiasthmatics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات متمثلة بالصيغة :التي فيها X يمثل مجموعة R1 تمثل - ألكيل (C1-12) غير مستبدلة او مستبدلة - شق كربوحلقي (C3-12)غير أروماتي غير مستبدلة او مستبدلة-مثيل ألكيل حلقي (C3-7) غير مستبدلة او مستبدلة - فنيل ، غير مستبدلة او مستبدلة -بنزيل,غير مستبدل او مستبدل- فنثيل، غير مستبدلة او مستبدلة - بنزهيدريل : بنزهيدريل مثيل - 1،2،3،4- رابع هيدرونفثالينيل غير مستبدلة او مستبدلة - شق اروماتي حلقي مخلط - R2 تمثل ذرة هيدروجين او الكيل(C1-3) .ءR3-تمثل ذرة هيدروجين او الكيل (C1-5)ء - R4 تمثل فنيل غير مستبدل او مستبدل - R5 تمثل فنيل غير مستبدل او مستبدل - R6 تمثل ذرة هيدروجين او الكيل (C1-3) n تمثل صفر ، 1 او 2؛ الك تمثل الكيل ((C1-4غير مستبدل او مستبدل بشرط ان R4 و R5 غير متشابهين في وقت واحد وتمثل فنيل مستبدلة مع الكوكسي (C1-4) طريقة التحضير والاستخدام في العلاج.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0507359A FR2888237B1 (fr) | 2005-07-08 | 2005-07-08 | Derives de n-[(4,5-diphenylpyrimidin-2-yl)methyl] amine, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
JO2715B1 true JO2715B1 (ar) | 2014-03-15 |
Family
ID=35954079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2006/0207A JO2715B1 (ar) | 2005-07-08 | 2006-07-02 | مشتقات أمين-ن[(4.5ثنائي فينيل بيريميدين-2-ي ل)ميثيل] وتحضيرها واستخداماتها في العلاج |
Country Status (15)
Country | Link |
---|---|
US (1) | US7541361B2 (ar) |
EP (1) | EP1937672B1 (ar) |
JP (1) | JP2009500381A (ar) |
AR (1) | AR054824A1 (ar) |
AT (1) | ATE441643T1 (ar) |
DE (1) | DE602006008971D1 (ar) |
DO (1) | DOP2006000160A (ar) |
FR (1) | FR2888237B1 (ar) |
GT (1) | GT200600298A (ar) |
JO (1) | JO2715B1 (ar) |
PA (1) | PA8685401A1 (ar) |
PE (1) | PE20070346A1 (ar) |
TW (1) | TW200738691A (ar) |
UY (1) | UY29658A1 (ar) |
WO (1) | WO2007006928A1 (ar) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009137404A1 (en) * | 2008-05-05 | 2009-11-12 | Amgen Inc. | Urea compounds as gamma secretase modulators |
GB201103419D0 (ar) | 2011-02-28 | 2011-04-13 | Univ Aberdeen | |
AR094929A1 (es) | 2013-02-28 | 2015-09-09 | Bristol Myers Squibb Co | Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2 |
CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992002513A1 (en) * | 1990-08-06 | 1992-02-20 | Fujisawa Pharmaceutical Co., Ltd. | Heterocyclic compounds |
CA2499497A1 (en) * | 2002-09-27 | 2004-04-08 | Merck & Co., Inc. | Substituted pyrimidines |
US20040259887A1 (en) * | 2003-06-18 | 2004-12-23 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
-
2005
- 2005-07-08 FR FR0507359A patent/FR2888237B1/fr not_active Expired - Fee Related
-
2006
- 2006-07-02 JO JOP/2006/0207A patent/JO2715B1/ar active
- 2006-07-04 DO DO2006000160A patent/DOP2006000160A/es unknown
- 2006-07-06 AT AT06778797T patent/ATE441643T1/de not_active IP Right Cessation
- 2006-07-06 PE PE2006000806A patent/PE20070346A1/es not_active Application Discontinuation
- 2006-07-06 PA PA20068685401A patent/PA8685401A1/es unknown
- 2006-07-06 WO PCT/FR2006/001621 patent/WO2007006928A1/fr active Application Filing
- 2006-07-06 EP EP06778797A patent/EP1937672B1/fr active Active
- 2006-07-06 DE DE602006008971T patent/DE602006008971D1/de active Active
- 2006-07-06 JP JP2008519965A patent/JP2009500381A/ja active Pending
- 2006-07-06 GT GT200600298A patent/GT200600298A/es unknown
- 2006-07-07 TW TW095124916A patent/TW200738691A/zh unknown
- 2006-07-07 UY UY29658A patent/UY29658A1/es unknown
- 2006-07-07 AR ARP060102939A patent/AR054824A1/es not_active Application Discontinuation
-
2008
- 2008-01-03 US US11/968,855 patent/US7541361B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
GT200600298A (es) | 2007-07-10 |
FR2888237A1 (fr) | 2007-01-12 |
PE20070346A1 (es) | 2007-05-04 |
EP1937672A1 (fr) | 2008-07-02 |
UY29658A1 (es) | 2007-01-31 |
DOP2006000160A (es) | 2007-01-31 |
TW200738691A (en) | 2007-10-16 |
JP2009500381A (ja) | 2009-01-08 |
FR2888237B1 (fr) | 2007-08-31 |
AR054824A1 (es) | 2007-07-18 |
EP1937672B1 (fr) | 2009-09-02 |
ATE441643T1 (de) | 2009-09-15 |
US20080176867A1 (en) | 2008-07-24 |
WO2007006928A1 (fr) | 2007-01-18 |
PA8685401A1 (es) | 2007-01-17 |
US7541361B2 (en) | 2009-06-02 |
DE602006008971D1 (de) | 2009-10-15 |
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