JO1242B1 - pyrimidone derivatives - Google Patents
pyrimidone derivativesInfo
- Publication number
- JO1242B1 JO1242B1 JO19831242A JOP19831242A JO1242B1 JO 1242 B1 JO1242 B1 JO 1242B1 JO 19831242 A JO19831242 A JO 19831242A JO P19831242 A JOP19831242 A JO P19831242A JO 1242 B1 JO1242 B1 JO 1242B1
- Authority
- JO
- Jordan
- Prior art keywords
- group
- substituted
- optionally substituted
- pyridyl
- alkyl
- Prior art date
Links
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention provides histamine H2-antagonist compounds of formula (I):- <CHEM> and pharmaceutically acceptable salts thereof, where W is a 2-furanyl or 2-thienyl group optionally substituted in the 5-position with a group R<1>R<2>N(CH2)a-; a 2-pyridyl group optionally substituted in the 4-or 6-position with a group R<1>R<2>N(CH2)a-; a phenyl group substituted in the 3- or 4-position with a group R<1>R<2>N(CH2)a-; a 4-imidazolyl group optionally substituted in the 5-position with methyl or bromine; a 2-pyridyl group optionally substituted in the 3-position with C1-4 alkyl, C1-4 alkoxy, halogen, amino or hydroxy; a 2-thiazolyl group or a 2-guanidino-4-thiazolyl group; X is (CH2)b in which b is from 3 to 6, or (CH2)dS(CH2)e in which d and e are the same or different and are from 1 to 3 or, when W is substituted phenyl or 2-pyridyl substituted in the 4- or 6- position with a group R<1>R<2>N(CH2)a-, O(CH2), in which f is from 2 to 5; Z is hydrogen or C1-4 alkyl; A is C1-C5 alkylene or (CH2)pA<1>(CH2)q- where A<1> is oxygen or sulphur and p and q are such that their sum is from 1 to 4; B is an optionally substituted pyridyl, where the optional substituent is one or more C1-4 alkyl. or C1-4 alkoxy or hydroxy groups or halogen atoms or an N-oxo group or a phenyl group optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups or halogen atoms or B is a 6-(2,3-dihydro-1,4-benzodioxinyl) or a 5-(1,3-benzodioxolyl) group or B is a 2-furanyl or 2-thienyl group optionally substituted in the 5-position with a group R<1>R<2>N(CH2)a-; a phenyl group substituted in the 3-of 4-position with a group R<1>R<2>N(CH2)a- or a 3-pyridyl group substituted in the 5- or 6-position or a 4-pyridyl group substituted in the 2-position by a group R<1>R<2>N(CH2)a-; R<1> and R<2> can be the same or different and are hydrogen or C1-4 alkyl or together form a 1,4-butanediyl, 1,5-pentanediyl, 1,6-hexanediyl or 1,7-heptanediyl group; and a is 1 to 4.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JO19831242A JO1242B1 (en) | 1983-02-28 | 1983-02-28 | pyrimidone derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JO19831242A JO1242B1 (en) | 1983-02-28 | 1983-02-28 | pyrimidone derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
JO1242B1 true JO1242B1 (en) | 1985-04-20 |
Family
ID=48087240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JO19831242A JO1242B1 (en) | 1983-02-28 | 1983-02-28 | pyrimidone derivatives |
Country Status (1)
Country | Link |
---|---|
JO (1) | JO1242B1 (en) |
-
1983
- 1983-02-28 JO JO19831242A patent/JO1242B1/en active
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUP0003355A2 (en) | Thieno[2,3-d]pyrimidinedione derivatives and pharmaceutical compositions containing them, process for their preparation and use thereof | |
KR830007630A (en) | Method for preparing amine derivative | |
FI861262A (en) | 5- 5- (6-IMIDAZO (1,2-A) PYRIDYL) PYRIDINDERIVATIVE | |
ES8403465A1 (en) | Pyrimidone derivatives. | |
NO905368D0 (en) | SEROTONIN ANTAGONISTS, THEIR PREPARATION AND USE. | |
KR860002504A (en) | Method for preparing aminoalkoxybenzopyranone | |
JO1164B1 (en) | A process for preparing certain pyrimidone derivatives useful as histamine h2- antagonists | |
JO1242B1 (en) | pyrimidone derivatives | |
DE3264253D1 (en) | PYRIDINE DERIVATIVES AS HISTAMINE H2 ANTAGONISTS | |
ES485912A1 (en) | Pyrimidinone derivatives, processes for preparing them and pharmaceutical compositions containing them. | |
PT91826A (en) | METHOD FOR PREPARING NEW PYRIDYL AND PYRIMIDYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
ATE67757T1 (en) | PYRIMIDINE COMPOUNDS. | |
OA06767A (en) | New derivatives of thioformamide and their preparation process. | |
ES8504771A1 (en) | Pyridine derivatives. | |
ATE27818T1 (en) | PYRIMIDONE DERIVATIVES. | |
FI823896L (en) | HETEROCYCLISKA FOERENINGAR | |
FI845095L (en) | AMINOIMIDAZOLONE DERIVATIVES SAOSOM HISTAMINE-H2 ANTAGONISTER. | |
HUP0001513A2 (en) | Method for producing 1,3-disubstituted 2-nitroguanidine derivatives and their intermediates | |
FI914971A (en) | 4- (4- ELLER 6- (TRIFLUORMETHYL-2-PYRIDINYL)) - 1-PIPERAZINYLALKYL SUBSTITUTE LACTAMER. | |
KR830005160A (en) | Method for preparing pyrimidone derivative |