KR830005160A - Method for preparing pyrimidone derivative - Google Patents

Method for preparing pyrimidone derivative Download PDF

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Publication number
KR830005160A
KR830005160A KR1019810001024A KR810001024A KR830005160A KR 830005160 A KR830005160 A KR 830005160A KR 1019810001024 A KR1019810001024 A KR 1019810001024A KR 810001024 A KR810001024 A KR 810001024A KR 830005160 A KR830005160 A KR 830005160A
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KR
South Korea
Prior art keywords
group
substituted
furanyl
thienyl
methylene
Prior art date
Application number
KR1019810001024A
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Korean (ko)
Inventor
헨리 브라운 토마스
Original Assignee
죤 안토니 클레이스
스미스 클라인 앤드 프랜치 레보라토리스 리미티드
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Application filed by 죤 안토니 클레이스, 스미스 클라인 앤드 프랜치 레보라토리스 리미티드 filed Critical 죤 안토니 클레이스
Publication of KR830005160A publication Critical patent/KR830005160A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음No content

Description

피리미돈 유도체의 제조방법Method for preparing pyrimidone derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

구조식(Ⅱ)의 화합물을 구조식(Ⅲ)의 피리미돈 유도체와 반응시킨 후 B1이 2-푸라닐 또는 2-티에닐이고 임의로는 W가 2-푸라닐 또는 2-티에닐인 경우에는 제조된 생성물을 치환체 R1R2N(CH2)m-(m은 1)을 제공하는 만니히 시약과 반응시킨 다음 제조된 구조식(Ⅰ)의 화합물을 염으로 변환시킴을 특징으로 하여 구조식(Ⅰ)의 화합물 및 그의 약제학적으로 무독한 산부가염을 제조하는 방법.Prepared by reacting a compound of formula (II) with a pyrimidone derivative of formula (III) and then B 1 is 2-furanyl or 2-thienyl and optionally W is 2-furanyl or 2-thienyl The product is reacted with a Mannich reagent providing the substituent R 1 R 2 N (CH 2 ) m- (m is 1) and then the compound of formula (I) prepared is converted to a salt Method for preparing a compound of the pharmaceutically acceptable nontoxic acid addition salt thereof. 상기 구조식중In the above structural formula W는 5-위치가 R1R2N(CH2)m-그룹으로 임의 치환된 2-푸라닐 또는 2-티에닐그룹, 3- 또는 4-위치가 R1R2N(CH2)m그룹으로 치환된 페닐그룹, 5-위치가 메틸 또는 브롬으로 임의 치환된 4-이미다졸릴그룹, 3-위치가 C1-4알킬, C1-4알콕시, 할로겐, 아미노 또는 하이드록시로 임의 치환된 2-피리딜그룹, 2-티아졸릴그룹 또는 2-구아니디노-4-티아졸릴그룹이며W is a 2-furanyl or 2-thienyl group optionally substituted by 5-positions of R 1 R 2 N (CH 2 ) m -groups, and 3- or 4-positions of R 1 R 2 N (CH 2 ) m Phenyl group substituted with group, 4-Imidazolyl group optionally substituted with methyl or bromine at 5-position, optionally substituted with C 1-4 alkyl, C 1-4 alkoxy, halogen, amino or hydroxy at 3-position 2-pyridyl group, 2-thiazolyl group or 2-guanidino-4-thiazolyl group, X는 메틸렌 또는 유황이고X is methylene or sulfur Y는 메틸렌 또는, 단 X가 메틸렌이고 W가 치환된 페닐그룹일 경우에는 산소이며Y is methylene or oxygen when X is methylene and W is a substituted phenyl group Z는 수소 또는 C1-4알킬이고Z is hydrogen or C 1 - 4 alkyl and B는 5-위치가 R1R2N(CH2)m-그룹으로 치환된 2-푸라닐 또는 2-티에닐그룹, 3-또는 4-위치가 R1R2N(CH2)m그룹으로 치환된 페닐그룹, 또는 R1R2N(CH2)m그룹으로 5- 또는 6-위치가 치환된 3-피리딜그룹, 2-위치가 치환된 4-피리딜그룹 또는 4- 또는 5-위치가 치환된 2-피리딜그룹이며 이때 R1과 R2는 C1-4알킬 또는 이들이 부착되어 있는 질소원자와 함께 피롤리디노, 피페리디노 또는 모르폴리노그룹이고 m은 1내지 4이고B is a 2-furanyl or 2-thienyl group in which the 5-position is substituted with a R 1 R 2 N (CH 2 ) m -group, and in the 3- or 4-position in the R 1 R 2 N (CH 2 ) m group Or a 3-pyridyl group substituted with 5- or 6-position with a phenyl group substituted with R, or R 1 R 2 N (CH 2 ) m group, a 4-pyridyl group substituted with 2-position, or 4- or 5 A 2-pyridyl group substituted at the position, wherein R 1 and R 2 are pyrrolidino, piperidino or morpholino group together with C 1-4 alkyl or a nitrogen atom to which they are attached and m is 1 to 4 ego D는 -XCH2CH2NH2또는 단 Y가 메틸렌일 경우에는 티올로 치환될 수 있는 그룹이며D is -XCH 2 CH 2 NH 2 or a group which may be substituted with thiol when Y is methylene B1은 2-푸라닐, 2-티에닐 또는 B이고B 1 is 2-furanyl, 2-thienyl or B A는 D가 -XCH2CH2NH2인 경우에는 아민에 의해 치환될 수 있는 그룹이고 D가 티올로 치환될 수 있는 그룹인 경우에는 HS-CH2-CH2NH이다.A is a group which may be substituted by an amine when D is -XCH 2 CH 2 NH 2 and HS-CH 2 -CH 2 NH when D is a group which may be substituted by thiol. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019810001024A 1980-03-29 1981-03-28 Method for preparing pyrimidone derivative KR830005160A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8010663 1980-03-29
GB8010663 1980-03-29

Publications (1)

Publication Number Publication Date
KR830005160A true KR830005160A (en) 1983-08-03

Family

ID=10512493

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810001024A KR830005160A (en) 1980-03-29 1981-03-28 Method for preparing pyrimidone derivative

Country Status (3)

Country Link
JP (1) JPS56154482A (en)
KR (1) KR830005160A (en)
ZA (1) ZA812097B (en)

Also Published As

Publication number Publication date
ZA812097B (en) 1982-05-26
JPS56154482A (en) 1981-11-30

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