ITUA20162272A1 - Procedimento per la preparazione di un agonista del recettore farnesoide x - Google Patents

Procedimento per la preparazione di un agonista del recettore farnesoide x

Info

Publication number
ITUA20162272A1
ITUA20162272A1 ITUA2016A002272A ITUA20162272A ITUA20162272A1 IT UA20162272 A1 ITUA20162272 A1 IT UA20162272A1 IT UA2016A002272 A ITUA2016A002272 A IT UA2016A002272A IT UA20162272 A ITUA20162272 A IT UA20162272A IT UA20162272 A1 ITUA20162272 A1 IT UA20162272A1
Authority
IT
Italy
Prior art keywords
agonist
procedure
preparation
farnesoid receptor
farnesoid
Prior art date
Application number
ITUA2016A002272A
Other languages
English (en)
Inventor
Gabriele Razzetti
Anna Iuliano
Luca Giannotti
Grazia Iannucci
Emanuele Attolino
Original Assignee
Dipharma Francis Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma Francis Srl filed Critical Dipharma Francis Srl
Priority to ITUA2016A002272A priority Critical patent/ITUA20162272A1/it
Priority to US16/090,853 priority patent/US10752654B2/en
Priority to CN201780034255.1A priority patent/CN109311933A/zh
Priority to PCT/EP2017/057868 priority patent/WO2017174515A1/en
Priority to EP17718343.1A priority patent/EP3440092A1/en
Publication of ITUA20162272A1 publication Critical patent/ITUA20162272A1/it
Priority to US16/929,186 priority patent/US20200339622A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
ITUA2016A002272A 2016-04-04 2016-04-04 Procedimento per la preparazione di un agonista del recettore farnesoide x ITUA20162272A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ITUA2016A002272A ITUA20162272A1 (it) 2016-04-04 2016-04-04 Procedimento per la preparazione di un agonista del recettore farnesoide x
US16/090,853 US10752654B2 (en) 2016-04-04 2017-04-03 Method for preparing a farnesoid X receptor agonist
CN201780034255.1A CN109311933A (zh) 2016-04-04 2017-04-03 制备法尼醇x受体激动剂的方法
PCT/EP2017/057868 WO2017174515A1 (en) 2016-04-04 2017-04-03 Method for preparing a farnesoid x receptor agonist
EP17718343.1A EP3440092A1 (en) 2016-04-04 2017-04-03 Method for preparing a farnesoid x receptor agonist
US16/929,186 US20200339622A1 (en) 2016-04-04 2020-07-15 Method for preparing a farnesoid x receptor agonist

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUA2016A002272A ITUA20162272A1 (it) 2016-04-04 2016-04-04 Procedimento per la preparazione di un agonista del recettore farnesoide x

Publications (1)

Publication Number Publication Date
ITUA20162272A1 true ITUA20162272A1 (it) 2017-10-04

Family

ID=56413755

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUA2016A002272A ITUA20162272A1 (it) 2016-04-04 2016-04-04 Procedimento per la preparazione di un agonista del recettore farnesoide x

Country Status (1)

Country Link
IT (1) ITUA20162272A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072598A1 (en) * 2001-03-12 2002-09-19 Roberto Pellicciari Steroids as agonists for fxr
CN105777835A (zh) * 2014-12-25 2016-07-20 重庆药友制药有限责任公司 一种制备鹅去氧胆酸类似物的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072598A1 (en) * 2001-03-12 2002-09-19 Roberto Pellicciari Steroids as agonists for fxr
CN105777835A (zh) * 2014-12-25 2016-07-20 重庆药友制药有限责任公司 一种制备鹅去氧胆酸类似物的方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GOBBINI M ET AL: "Novel analogues of Istaroxime, a potent inhibitor of Na^+,K^+-ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 18, no. 12, 15 June 2010 (2010-06-15), pages 4275 - 4299, XP027072347, ISSN: 0968-0896, [retrieved on 20100520], DOI: 10.1016/J.BMC.2010.04.095 *
SEPE V ET AL: "Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 55, no. 1, 12 January 2012 (2012-01-12), pages 84 - 93, XP002711362, ISSN: 0022-2623, [retrieved on 20111129], DOI: 10.1021/JM201004P *
WEI-SHAN ZHOU ET AL: "Stereocontrolled conversion of hyodeoxycholic acid into chenodeoxycholic acid and ursodeoxycholic acid", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 1, 1 January 1990 (1990-01-01), GB, pages 1 - 3, XP055320230, ISSN: 0300-922X, DOI: 10.1039/p19900000001 *

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