ITMI931063A1 - Procedimento per la purificazione di ciclosporina a - Google Patents

Procedimento per la purificazione di ciclosporina a

Info

Publication number
ITMI931063A1
ITMI931063A1 IT001063A ITMI931063A ITMI931063A1 IT MI931063 A1 ITMI931063 A1 IT MI931063A1 IT 001063 A IT001063 A IT 001063A IT MI931063 A ITMI931063 A IT MI931063A IT MI931063 A1 ITMI931063 A1 IT MI931063A1
Authority
IT
Italy
Prior art keywords
cyclosporine
purification procedure
purification
procedure
cyclosporine purification
Prior art date
Application number
IT001063A
Other languages
English (en)
Inventor
Jano Balint
Gyorgy Deak
Judit Dencs
Csaba Haidufi
Laszlo Hanak
Erno Karacsony
Anita Karczub
Janos Kelemen
Vilmos Keri
Berta Mako
Gyula Marton
Istvan Melczer
Edit Nagy
Ferenc Radnai
Gyongyi Strbka
Tibor Szanya
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of ITMI931063A0 publication Critical patent/ITMI931063A0/it
Publication of ITMI931063A1 publication Critical patent/ITMI931063A1/it
Application granted granted Critical
Publication of IT1272446B publication Critical patent/IT1272446B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
ITMI931063A 1992-05-25 1993-05-24 Procedimento per la purificazione di ciclosporina a IT1272446B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9201728A HU213553B (en) 1992-05-25 1992-05-25 Process for isolating of cyclosporin-a

Publications (3)

Publication Number Publication Date
ITMI931063A0 ITMI931063A0 (it) 1993-05-24
ITMI931063A1 true ITMI931063A1 (it) 1994-11-24
IT1272446B IT1272446B (it) 1997-06-23

Family

ID=10981925

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI931063A IT1272446B (it) 1992-05-25 1993-05-24 Procedimento per la purificazione di ciclosporina a

Country Status (5)

Country Link
US (1) US5382655A (it)
CA (1) CA2096892C (it)
CZ (1) CZ285518B6 (it)
HU (1) HU213553B (it)
IT (1) IT1272446B (it)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0725076B1 (en) * 1995-02-01 2001-06-06 National Research Development Corporation of India A process for the preparation of cyclosporin A from tolypocladium species
GB9618952D0 (en) * 1996-09-11 1996-10-23 Sandoz Ltd Process
US5650288A (en) * 1995-07-14 1997-07-22 Macfarlane; Gordon D. Immunophilin-bound immunosuppressant assay
DE19611094C2 (de) 1996-03-21 1999-06-17 Dresden Arzneimittel Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens
US5709797A (en) * 1996-06-05 1998-01-20 Poli Industria Chimica S.P.A. Method of isolating cyclosporins
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
HU223054B1 (hu) * 1997-03-25 2004-03-01 BIOGAL Gyógyszergyár Rt. Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
US6423233B1 (en) * 2000-08-15 2002-07-23 Biogal Gyogyszergyar Rt. Purification process
KR100496929B1 (ko) * 1997-03-25 2005-09-30 테바 기오기스제르갸르 레스즈베니타르사사그 시클로스포린의정제방법
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
ATE423130T1 (de) 1997-10-08 2009-03-15 Isotechnika Inc Deuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agenzien
DE69939335D1 (de) 1998-12-30 2008-09-25 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DK1436321T3 (da) 2001-10-19 2006-11-13 Isotechnika Inc Syntese af cyclosporinanaloger
WO2004082629A2 (en) 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
EP1809656A4 (en) 2004-09-29 2009-03-25 Amr Technology Inc CYCLOSPORINAL KINANALOGA AND ITS PHARMACEUTICAL APPLICATIONS
EP1804823A4 (en) 2004-09-29 2010-06-09 Amr Technology Inc NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
HUP1500502A2 (en) * 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a
CN108250275A (zh) * 2016-12-29 2018-07-06 天津领世生物科技开发有限公司 一种从发酵液中分离纯化环孢菌素a的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
US4215199A (en) * 1978-06-05 1980-07-29 Sandoz Ltd. Antibiotic production
EP0098456B1 (en) * 1980-02-14 1989-05-24 Sandoz Ag Peptides comprising a (1s,2r,3r)- or (1r,2s,3s)-1-nitrilo-1-carbonyl-3-methyl-2-oxy-heptane or -hept-5-ene residue useful in the total synthesis of cyclosporins, and processes for their production
EP0296123B1 (en) * 1987-06-19 1994-08-31 Sandoz Ag Cyclic peptolides

Also Published As

Publication number Publication date
CZ98593A3 (en) 1994-02-16
CA2096892A1 (en) 1993-11-26
US5382655A (en) 1995-01-17
HU9201728D0 (en) 1992-08-28
CA2096892C (en) 1998-08-18
CZ285518B6 (cs) 1999-08-11
IT1272446B (it) 1997-06-23
HUT68163A (en) 1995-05-29
ITMI931063A0 (it) 1993-05-24
HU213553B (en) 1997-07-28

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970529