ITMI920722A1 - ANTICOAGULANTS AND PROCESSES FOR THEIR PREPARATION - Google Patents

ANTICOAGULANTS AND PROCESSES FOR THEIR PREPARATION

Info

Publication number
ITMI920722A1
ITMI920722A1 IT000722A ITMI920722A ITMI920722A1 IT MI920722 A1 ITMI920722 A1 IT MI920722A1 IT 000722 A IT000722 A IT 000722A IT MI920722 A ITMI920722 A IT MI920722A IT MI920722 A1 ITMI920722 A1 IT MI920722A1
Authority
IT
Italy
Prior art keywords
anticoagulants
processes
preparation
Prior art date
Application number
IT000722A
Other languages
Italian (it)
Inventor
Benito Casu
Giordana Grazioli
Helgi H Hannesson
Barbara Jann
Klaus Jann
Marion Kusche
Ulf Lindahl
Annamaria Naggi
Pasqua Oreste
Nahid Razi
Giangiacomo Torri
Giorgio Zoppetti
Original Assignee
Italfarmaco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italfarmaco Spa filed Critical Italfarmaco Spa
Publication of ITMI920722A0 publication Critical patent/ITMI920722A0/en
Publication of ITMI920722A1 publication Critical patent/ITMI920722A1/en
Application granted granted Critical
Publication of IT1254564B publication Critical patent/IT1254564B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Materials For Medical Uses (AREA)
ITMI920722A 1991-03-28 1992-03-26 ANTICOAGULANTS AND PROCESSES FOR THEIR PREPARATION IT1254564B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9106757A GB2254083A (en) 1991-03-28 1991-03-28 Anticoagulants from e.coli saccharide

Publications (3)

Publication Number Publication Date
ITMI920722A0 ITMI920722A0 (en) 1992-03-26
ITMI920722A1 true ITMI920722A1 (en) 1993-09-26
IT1254564B IT1254564B (en) 1995-09-25

Family

ID=10692438

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI920722A IT1254564B (en) 1991-03-28 1992-03-26 ANTICOAGULANTS AND PROCESSES FOR THEIR PREPARATION

Country Status (12)

Country Link
JP (1) JPH07501684A (en)
AU (1) AU1430892A (en)
CA (1) CA2107124A1 (en)
FI (1) FI934141A0 (en)
GB (2) GB2286193A (en)
HU (1) HUT67208A (en)
IE (1) IE920982A1 (en)
IT (1) IT1254564B (en)
PT (1) PT100316A (en)
TW (1) TW209225B (en)
WO (1) WO1992017507A1 (en)
ZA (1) ZA922313B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2684385B1 (en) * 1991-11-28 1997-08-01 Sanofi Elf HEPAROSANES-N, HIGH MOLECULAR MASS O-SULPHATES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
IT1270823B (en) * 1993-06-04 1997-05-13 Italfarmaco Spa HIGH POLYESACCHARIDES WITH HIGH ANTI-THROMBOTIC AND ANTI-COAGULANT ACTIVITY
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
IT1271057B (en) * 1994-11-04 1997-05-26 Inalco Spa POLYSACCHARIDES HAVING A HIGH CONTENT OF HYDURONIC ACID
IT1282994B1 (en) * 1996-05-10 1998-04-03 Inalco Spa DERIVATIVES OF THE POLYSACCHARIDE K5 HAVING HIGH ANTI-COAGULANT ACTIVITY
AUPO556297A0 (en) 1997-03-11 1997-04-10 Australian National University, The Sulfated oligosaccharides having anticoagulant/ antithrombotic activity
ITMI991465A1 (en) * 1999-07-02 2001-01-02 Inalco Spa PROCESS FOR THE PREPARATION OF K4 AND K5 POLYSACCHARIDES FROM ESCHERICHIACOLI
US20020062019A1 (en) 2000-03-30 2002-05-23 Pasqua Oreste Glycosaminoglycans derived from K5 polysaccharide having high anticoagulant and antithrombotic activities and process for their preparation
SV2003000753A (en) 2000-12-05 2003-06-16 Brigham & Womens Hospital USE OF ZWITTERIONIC POLYSACARIDS FOR THE SPECIFIC MODULATION OF IMMUNE PROGRESS
ITMI20010397A1 (en) * 2001-02-27 2002-08-27 Giorgio Zoppetti HIGHLY N, O-SULPHATED DERIVATIVES OF POLYSACCHARIDE K5 AND THEIR PREPARATION
ITMI20010779A1 (en) * 2001-04-12 2002-10-12 Giorgio Zoppetti USE OF BACTERIAL SULPHATE POLYSACCHARIDES SUITABLE FOR THE INHIBITION OF ANGIOGENESIS
CN1671744A (en) 2002-06-18 2005-09-21 格利考斯2000有限公司 Low molecular weight oversulfated polysaccharide
US20120253029A1 (en) 2002-06-18 2012-10-04 Pasqua Anna Oreste Process for the preparation of highly o-sulfated epimerized derivatives of k5 polysaccharide and intermediates therein
JP2006522135A (en) 2003-03-31 2006-09-28 ザ ブライアム アンド ウィミンズ ホスピタル インコーポレーテッド Zwitterionic immunomodulators for the treatment of asthma and allergies
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
JP2011503104A (en) 2007-11-09 2011-01-27 カリフォルニア インスティテュート オブ テクノロジー Immunomodulatory compounds and related compositions and methods
ITMI20091445A1 (en) * 2009-08-07 2011-02-08 Inalco S P A A Socio Unico SEMI-SYNTHETIC DERIVATIVES OF K5 POLISACCARIDE FOR THE PREVENTION AND TREATMENT OF TISSUE DAMAGE ASSOCIATED WITH ISCHEMIA AND / OR REPERFUSION
EP2555753B1 (en) 2010-04-07 2018-08-01 California Institute of Technology Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems
EP2571982A4 (en) 2010-05-20 2014-01-01 California Inst Of Techn Antigen specific tregs and related compositions, methods and systems
CN102199175A (en) * 2011-04-07 2011-09-28 福州大学 Preparation and purification method for heparitin sulfate disaccharide, and purified product thereof
US9539281B2 (en) 2011-07-12 2017-01-10 The Brigham And Women's Hospital, Inc. Lipid-containing PSA compositions, methods of isolation and methods of use thereof
WO2014182966A1 (en) 2013-05-10 2014-11-13 California Institute Of Technology Probiotic prevention and treatment of colon cancer
WO2016201342A1 (en) 2015-06-10 2016-12-15 California Institute Of Technology Sepsis treatment and related compositions methods and systems
CA2997211A1 (en) 2015-08-19 2017-02-23 President And Fellows Of Harvard College Lipidated psa compositions and methods
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504535B1 (en) * 1981-04-28 1987-08-14 Choay Sa DISACCHARIDES DERIVED FROM URONIC ACID AND GLUCOSAMINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE CONTROL OF BLOOD COAGULATION
FR2548189B1 (en) * 1983-07-01 1986-04-11 Choay Sa NEW PRODUCTS CONTAINING OLIGOSACCHARIDES, THEIR PREPARATION AND THEIR BIOLOGICAL AND BIOCHEMICAL APPLICATIONS
EP0333243A3 (en) * 1988-03-10 1989-09-27 Akzo N.V. Sulphated k5 antigen and sulphated k5 antigen fragments
IT1217458B (en) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S SULFOAMINO DERIVATIVES OF CONDROITIN SULPHATES, DERMATAN SULPHATE AND HYALURONIC ACID AND THEIR PHARMACOLOGICAL PROPERTIES
FR2669932B1 (en) * 1990-12-03 1994-07-01 Sanofi Sa NOVEL HEPAROSANE-N, O-SULFATE, ITS PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT.

Also Published As

Publication number Publication date
WO1992017507A1 (en) 1992-10-15
HUT67208A (en) 1995-02-28
GB9508157D0 (en) 1995-06-07
AU1430892A (en) 1992-11-02
FI934141A (en) 1993-09-22
CA2107124A1 (en) 1992-09-29
IE920982A1 (en) 1992-10-07
GB2254083A (en) 1992-09-30
FI934141A0 (en) 1993-09-22
TW209225B (en) 1993-07-11
IT1254564B (en) 1995-09-25
GB2286193A (en) 1995-08-09
JPH07501684A (en) 1995-02-23
ITMI920722A0 (en) 1992-03-26
GB9106757D0 (en) 1991-05-15
ZA922313B (en) 1993-08-02
PT100316A (en) 1993-07-30
HU9302732D0 (en) 1994-01-28

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