ITMI20040801A1 - Processo per la preparazione di amediplase mediante tecniche di dna ricombinante - Google Patents

Processo per la preparazione di amediplase mediante tecniche di dna ricombinante

Info

Publication number
ITMI20040801A1
ITMI20040801A1 ITMI20040801A ITMI20040801A1 IT MI20040801 A1 ITMI20040801 A1 IT MI20040801A1 IT MI20040801 A ITMI20040801 A IT MI20040801A IT MI20040801 A1 ITMI20040801 A1 IT MI20040801A1
Authority
IT
Italy
Prior art keywords
amediplase
techniques
preparation
recombinant dna
recombinant
Prior art date
Application number
Other languages
English (en)
Inventor
Stephen Hugh Collins
Giuseppe Raucci
Luigi Rotondaro
Original Assignee
Menarini Biotech S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Biotech S R L filed Critical Menarini Biotech S R L
Priority to ITMI20040801 priority Critical patent/ITMI20040801A1/it
Publication of ITMI20040801A1 publication Critical patent/ITMI20040801A1/it
Priority to PCT/EP2005/004312 priority patent/WO2005103264A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ITMI20040801 2004-04-23 2004-04-23 Processo per la preparazione di amediplase mediante tecniche di dna ricombinante ITMI20040801A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI20040801 ITMI20040801A1 (it) 2004-04-23 2004-04-23 Processo per la preparazione di amediplase mediante tecniche di dna ricombinante
PCT/EP2005/004312 WO2005103264A1 (en) 2004-04-23 2005-04-22 Process for the preparation of recombinant amediplase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI20040801 ITMI20040801A1 (it) 2004-04-23 2004-04-23 Processo per la preparazione di amediplase mediante tecniche di dna ricombinante

Publications (1)

Publication Number Publication Date
ITMI20040801A1 true ITMI20040801A1 (it) 2004-07-23

Family

ID=34966847

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI20040801 ITMI20040801A1 (it) 2004-04-23 2004-04-23 Processo per la preparazione di amediplase mediante tecniche di dna ricombinante

Country Status (2)

Country Link
IT (1) ITMI20040801A1 (it)
WO (1) WO2005103264A1 (it)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5326700A (en) * 1990-11-06 1994-07-05 Eli Lilly And Company DNA sequences encoding t-PA derivatives with cleavable sites

Also Published As

Publication number Publication date
WO2005103264A1 (en) 2005-11-03

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