IT9022032A0 - L-2'-desossiuridine e composizioni farmaceutiche che le contengono. - Google Patents

L-2'-desossiuridine e composizioni farmaceutiche che le contengono.

Info

Publication number
IT9022032A0
IT9022032A0 IT9022032A IT2203290A IT9022032A0 IT 9022032 A0 IT9022032 A0 IT 9022032A0 IT 9022032 A IT9022032 A IT 9022032A IT 2203290 A IT2203290 A IT 2203290A IT 9022032 A0 IT9022032 A0 IT 9022032A0
Authority
IT
Italy
Prior art keywords
desoxyuridines
contain
pharmaceutical compositions
pharmaceutical
compositions
Prior art date
Application number
IT9022032A
Other languages
English (en)
Other versions
IT9022032A1 (it
IT1246983B (it
Inventor
Stefano Iotti
Francesco Paolo Colonna
Anna Maria Garbesi
Silvio Spadari
Federico Foscher
Giovanni Ciarrocchi
Federico Arcamone
Original Assignee
Consiglio Economia Aziendale
Menarini Ricerche Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consiglio Economia Aziendale, Menarini Ricerche Sud filed Critical Consiglio Economia Aziendale
Priority to IT02203290A priority Critical patent/IT1246983B/it
Publication of IT9022032A0 publication Critical patent/IT9022032A0/it
Priority to PCT/EP1991/002134 priority patent/WO1992008727A1/en
Priority to AU89232/91A priority patent/AU8923291A/en
Publication of IT9022032A1 publication Critical patent/IT9022032A1/it
Application granted granted Critical
Publication of IT1246983B publication Critical patent/IT1246983B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT02203290A 1990-11-13 1990-11-13 L-2'-desossiuridine e composizioni farmaceutiche che le contengono. IT1246983B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT02203290A IT1246983B (it) 1990-11-13 1990-11-13 L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
PCT/EP1991/002134 WO1992008727A1 (en) 1990-11-13 1991-11-09 L-2'-desoxyuridines and pharmaceutical compositions containing them
AU89232/91A AU8923291A (en) 1990-11-13 1991-11-09 L-2'-desoxyuridines and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02203290A IT1246983B (it) 1990-11-13 1990-11-13 L-2'-desossiuridine e composizioni farmaceutiche che le contengono.

Publications (3)

Publication Number Publication Date
IT9022032A0 true IT9022032A0 (it) 1990-11-13
IT9022032A1 IT9022032A1 (it) 1992-05-13
IT1246983B IT1246983B (it) 1994-12-12

Family

ID=11190463

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02203290A IT1246983B (it) 1990-11-13 1990-11-13 L-2'-desossiuridine e composizioni farmaceutiche che le contengono.

Country Status (3)

Country Link
AU (1) AU8923291A (it)
IT (1) IT1246983B (it)
WO (1) WO1992008727A1 (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204466A (en) * 1990-02-01 1993-04-20 Emory University Method and compositions for the synthesis of bch-189 and related compounds
US6069252A (en) 1990-02-01 2000-05-30 Emory University Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
US5914331A (en) * 1990-02-01 1999-06-22 Emory University Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
GB9218810D0 (en) * 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
US20020120130A1 (en) 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
ATE284894T1 (de) * 1994-10-24 2005-01-15 Genencor Int L-pyranosyl-nukleoside
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
IL129126A0 (en) * 1996-10-16 2000-02-17 Icn Pharmaceuticals Monocyclic l-nucleosides analogs and uses thereof
EP1302474A1 (en) * 1996-10-16 2003-04-16 Ribapharm, Inc. Monocyclic L-nucleosides, analogs and uses thereof
BR9908270A (pt) 1998-02-25 2004-06-29 Univ Emory 2-fluoro-nucleosìdeos, composições farmacêuticas e seus usos
ES2579903T3 (es) 1998-08-10 2016-08-17 Centre National De La Recherche Scientifique (Cnrs) Beta-L-2'-desoxi-nucleósidos para el tratamiento de la hepatitis B
AU2007216721B2 (en) * 1998-08-10 2011-05-19 Centre National De La Recherche Scientifique Beta-L-2'-Deoxy Nucleosides for the Treatment of Hepatitis B
EP1431304B1 (en) * 1998-08-10 2014-12-03 Novartis AG Beta - L-2'-Deoxy-Nucleosides for the treatment of Hepatitis B
US6444652B1 (en) 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
CN101120947B (zh) * 1998-08-10 2010-11-24 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2′-脱氧-核苷
AU2011211428B2 (en) * 1998-08-10 2013-02-07 Centre National De La Recherche Scientifique Beta-L-2'-Deoxy Nucleosides for the treatment of Hepatitis B
EP1600452A3 (en) * 1999-11-12 2008-09-10 Pharmasset, Inc. Synthesis of 2'-deoxy-L-nucleosides
TR200601782T2 (tr) * 1999-11-12 2006-09-21 Pharmasset Ltd. 2'-Deoksi-L-Nükleositlerin sentezi.
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en) 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
MY141594A (en) * 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
CN1646141B (zh) 2000-10-18 2014-06-25 吉利德制药有限责任公司 用于治疗病毒感染和异常细胞增殖的修饰核苷类化合物
EP1478322A4 (en) 2001-06-22 2007-08-08 Pharmasset Ltd Beta 2'-OR 3'-HALONUCLEOSIDE
TWI244393B (en) 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
PT1572095E (pt) 2002-09-13 2015-10-13 Novartis Ag Β-l-2'-desoxinucleósidos para tratamento de estirpes resistentes de vhb
US8895531B2 (en) 2006-03-23 2014-11-25 Rfs Pharma Llc 2′-fluoronucleoside phosphonates as antiviral agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK167377B1 (da) * 1985-09-17 1993-10-25 Wellcome Found 3'-azidopyrimidinnucleosider eller farmaceutisk acceptable salte eller estere deraf til anvendelse ved behandling af eller profylakse for en human retrovirusinfektion
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
FR2640267B2 (fr) * 1988-01-19 1992-02-14 Univ Paris Curie Procede de synthese de l'azido-3(prime)-desoxy-3(prime)-thymidine et analogues
FR2627492B1 (fr) * 1988-02-24 1990-08-10 Irceba Nouveaux derives de l'amino-5(prime)-dideoxy-2(prime)-5(prime)-uridine, procede pour les preparer et compositions pharmaceutiques contenant ces composes
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives

Also Published As

Publication number Publication date
IT9022032A1 (it) 1992-05-13
IT1246983B (it) 1994-12-12
WO1992008727A1 (en) 1992-05-29
AU8923291A (en) 1992-06-11

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971128