IT9020407A1 - SYSTEM FOR INHALATION ADMINISTRATION OF POWDER DRUGS PREPARED IN SPECIAL CONTAINERS - Google Patents

Description

Description of an invention entitled:

"SYSTEM FOR THE INHALATION ADMINISTRATION OF PHARMA-CI POWDER PREDOSED IN PARTICULAR CONTAINERS"

DESCRIPTION

The present invention relates to a system for 1 sum <1> nitration via inhalers of pre-dosed powder drugs in containers, the drug dose contained in the container being administrable by means of a dispensing device.

Systems for bronchial and / or nasal administration of powdered drugs are well known. The drug is in the form of a very fine or micronized powder and is enclosed, pre-dosed, in capsules.

These capsules normally have an overall cylindrical shape, with the two ends shaped like a hemispherical cap. Known capsules are normally formed by two "cup" insertable parts. They generally consist of substantially rigid gelatine.

Dispensing devices which use the aforementioned capsules are for example described in US-A-3807400, 3906950, 3991 761, 4013075 and 4884565.

As can be seen from recent literature, many drugs, in the form of dry and very fine powder, are administered by inhalation in the treatment of asthma, such as Disodium Chromoglycate, Salbutamol, Isoprenaline, Reproterol and others .

Generally known dispensing devices are provided with suitable means for piercing the capsule. As those skilled in the art know, according to the mode of operation, the delivery devices are divided into inhalers and insufflators.

In the case of insufflators, an air current generated by a manual pump, and for inhalers an air current generated by the aspiration produced by the patient, allows the powder contained in the capsule to escape through holes produced in the same by drilling means. .

In these known dispensing devices, the holes in the capsule can be made in various areas thereof, preferably at the two opposite ends thereof or in proximity to these ends. The holes are drilled with various suitable means, as can be seen by way of example in U- "S-A-3991 761, 380> 400, 3906950, 4884565 and GB-A 1 122284.

Other dispensing devices provide suitable means for shearing the hemispherical caps of the capsule, as in US-A-4013075.

It has been experimentally verified that the complete release of the powder from the capsule, once opened, is related to the drilling means, but above all to the physical characteristics of the capsule.

In fact, the wear of the known capsule opening means and the variability of the physical characteristics of the gelatin capsule, as well as the formation of fragments of the capsule shell, can lead to incomplete emptying of the open capsule and / or malfunctions of the capsule. dispensing device, with repercussions on its efficiency.

As those skilled in the art know, gelatin capsules can generally have a moisture content ranging from 8% to 153⁄4. It is difficult to obtain and maintain a homogeneous moisture content around the value of 10% -1Ì%, which has proved to be the optimal range of values.

In fact, if the gelatin of the capsule has a humidity value below this range, the perforation or opening means can produce fractures or extensive cracks of the capsule, such as to compromise the operation of the device used.

If, on the other hand, the capsule has a moisture content higher than the aforesaid values, the perforation means may even be ineffective, or produce, in correspondence with the perforation, recessed edges due to the inward deformation of the gelatin of the envelope. These recessed edges can hold significant quantities of drug inside the capsule.

From what has been said it can be understood that the key element on which the proper functioning of the entire administration system depends first of all is the capsule. However, as we have seen, the characteristics of the gelatin capsules are variable. These characteristics, at the time of use, may therefore be different from the optimal ones, for oils the aforementioned drawbacks may occur.

The present invention aims to obviate the drawbacks presented by the administration systems of the known art.

The aforesaid object is achieved thanks to the administration system according to the present invention, characterized in that the drug container used in the delivery device has at least one removable appendix extending from the body of the container, the removal of the appendix releasing in the aforesaid container body an opening of predetermined dimensions; and that the dispensing device is equipped with means for removing the appendages of the container.

The openings that are released in the body of the container can therefore be "calibrated", that is, have well-defined and constant dimensions.

Preferably, the appendages of the container will be two, arranged in such a position as to free, once removed, two relative openings arranged on opposite sides of the container body.

Obviously, the removable appendages may also be more than two, for example four, two by two opposite each other. The number of appendages may also be conditioned by the type of device used.

Apart from the aforesaid appendages, the body of the container may conveniently have a conventional shape, such as that of known capsules, that is, an overall cylindrical shape with its two ends in the shape of a hemispherical cap.

In this case, the openings which become free following the removal of the relative appendages of the container will be conveniently provided in correspondence with one or both of the hemispherical caps of the body of the container. In this case, according to a preferred embodiment of the present invention, the container will have two appendages, the relative two openings released by their removal being circular and each being located on one of the two hemispherical caps, these openings being coaxial with each other and with respect to the body of the container.

The aforesaid two opposite appendages will preferably be rectilinear and extending in the opposite direction, coaxially to the body of the container.

Each removable appendix can have a predetermined breaking line or zone to facilitate the removal of the appendix, in correspondence with which the appendix itself is separated from the body of the container. The predetermined breaking line or section of each removable appendage will be suitably provided at the base of the appendix itself.

Preferably the container will be of suitable thermo-formable material, obviously of the non-toxic type.

As already mentioned, the dispensing device of the administration system according to the present invention comprises means for removing the removable appendages of the container. Apart from the aforementioned means for removing the appendages of the container, which replace the conventional means for piercing or cutting the capsule of the known dispensing devices, the dispensing devices of the administration system according to the invention may be similar to one of the numerous known insufflators or inhalers.

In particular, a first type of delivery device can be obtained by modifying the inhaler described in the aforementioned US-A-3991 761 in the aforementioned manner, the inventor of which is the same as the present application. This known inhaler is of the type comprising:

(i) a first piece having a mouthpiece including an inhalation channel;

(ii) a second piece comprising:

(1) a chamber in which the capsule is placed, a chamber with a volume substantially greater than that of the capsule and in communication with the delivery channel;

(2) at least one air intake tangentially disposed with respect to said cylindrical chamber, to generate a swirling and vibrating motion of the capsule. The inhaler further comprises means for piercing the capsule. In the inhaler modified according to the invention these latter means will obviously not be provided. In addition to the means for removing the aforementioned appendages of the container, it will comprise a mouthpiece or a nasal adapter, and a chamber, in communication with said mouthpiece or nasal adapter, to accommodate the container equipped with removable appendages and containing the drug to be administered, at least one air intake is provided in the walls of the chamber to generate a whirling and vibrating motion of the container, once opened, when the patient exerts a suction action through said mouthpiece or nasal adapter.

Preferably, a seat is provided in a wall of the aforesaid chamber to accommodate the container with relative appendages. Conveniently the said chamber is cylindrical in shape.

In the latter case, the seat for the container is provided in one of the two bases of the cylindrical chamber. In particular, in a preferred embodiment of the inhaler, the aforementioned seat for the container is adapted to accommodate the type of container with a body in the shape of a conventional capsule, but equipped with two opposite rectilinear appendages, coaxial with each other and with respect to the body of the container.

The inhaler may comprise two pieces that can be separated or rotated relative to each other for the insertion of the container into its seat. In particular, the first piece may comprise the delivery channel with its mouthpiece or nasal adapter, this first piece delimiting the aforementioned cylindrical chamber with the exception of its wall in which the seat for the capsule is provided, and the second piece comprising the remaining wall of the chamber in which the housing for the container is foreseen. In this seat, suitable slits will be provided through which the relative appendages, which can be removed from the capsule, protrude outwards.

The first piece of the inhaler will further comprise an interference element for each of said removable appendages of the container, to cause their removal when the two pieces of the inhaler are arranged in the position of use. Said interference element may, for example, be in the form of a step which beats transversely against the relative appendix of the container when the two pieces are brought together, causing their removal. The interference element may also have the shape of an inclined plane which, by joining the two pieces of the inhaler, performs the same function.

Therefore, in both cases, by placing the drug container in its seat and joining the two pieces of the inhaler, the appendages are automatically removed and the relative calibrated openings free.

A second type of dispensing device of the administration system according to the invention is obtained by modifying the insufflatone described in US-A-4884565, the inventor of which is the same as the present application. Said insufflatone is of the type comprising a manual pump and an insufflatone body, the pump generating a flow of air to be fed to an insufflation opening provided in said insufflatone body. The latter also features a delivery channel leading to a nasal adapter. The seat for the capsule is provided in a movable element with respect to said body, the movable element being movable between two positions: a first position for loading the capsule and for drilling it, and a second dispensing position in which the interior of the capsule is in communication with both the insufflation opening and the delivery channel.

This known insufflatone is equipped with means for piercing the capsule when the rotatable element is in its first position.

In the insufflatone according to the administration system of the present invention, which will clearly lack the conventional means of perforation, the body of the insufflatone has an insufflation opening to which an air flow generated by a manual pump is fed, and a delivery channel with relative mouthpiece or nasal adapter, a seat for the container of the drug being provided in a movable element with respect to said body, this movable element being movable between two positions: a first position for loading the container and a second dispensing position in which the inside of the container is in communication both with the insufflation opening and with the dispensing channel, the container being open as a result of the interference of its appendages with the relative interference elements provided in the body of the insufflator following the displacement of the movable element from its first to its second position, in second position of the internal movable element of the container being in communication both with the insufflation opening and with the delivery channel of the insufflator body.

The aforesaid movable element will preferably be a rotatable element. In particular, the seat for the container has a slot for each removable appendix, each appendix projecting freely outside the rotatable element when the latter is in its first position.

Therefore, once the drug container has been inserted into its seat and the rotating element has been moved from its first to its second position (in which the capsule is open), a current is generated by manually operating the blower pump. of air that carries away the dose of the drug powder contained in the container, the air stream containing the drug escaping through the delivery channel to reach the nasal cavity and / or the bronchi of the patient.

Also in this case the single interference element, which causes the removal of the relative appendix of the container, will preferably be in the form of a step or an inclined plane.

From what has been said previously, it should be clear that many other types of known dispensing devices could be modified to make dispensing devices that fall within the administration system of the present invention, and in the limit new ones could be created, provided that the seat for the container of the drug dose is suitable for receiving the container with its appendages, and provided that means are provided for removing the appendages of the container.

The invention will be more easily understood from the following description of some of its embodiments. In this description reference will be made to the attached drawings, in which:

fig. 1 is a side view of a container according to the administration system of the present invention; fig. 2 is a longitudinal axial section, with an appendix shown in the removal phase;

fig. 2 'is an enlarged representation of the detail Λ of fig. 2;

fig. 3 is a side view, partially sectioned, of an inhaler according to the administration system of the present invention;

fig. 4 is a plan view, from above, of the first part of the inhaler, in which the seat for the capsule is also seen;

the f1g. 5 is a section along the line V-V of fig.4; fig. 6 is a section along the line VI-VI of fig.

4;

fig. 7 is a side view, partially sectioned and in the same direction as fig. 3, of the second piece of the inhaler;

fig. 8 is a side view thereof, also partially sectioned and perpendicular to that of fig. 7;

fig. 9 is a cross section of it taken along the line IX-IX of fig. 7;

fig. 10 is a cross section taken along the line X-X of fig. 7;

fig. Π is a side view, partially in section, of an insufflatone according to the administration system of the present invention;

fig. 12 is a cross section along the line XII-XII of fig. 10, the insufflatone being devoid of the cap; <1> fig. 13 is an axial vertical section along the line XIII-XIII of fig. 11; and fig. 14 is a view of the revolving element of the insufflaton alone, in which the seat for the container of the drug is seen.

The container 10 shown in Figures 1, 2 and 2 * is made of a rigid and non-toxic terinoformable material.

The container 10 has a body 12, generally cylindrical, completed at its two ends by respective hemispherical caps 14. From each spherical cap 14, coaxially with the container body, a linear appendage 16 departs, slightly tapered towards the outside and rounded at its free end.

The capsule is actually formed by two parts 20,22 that can be inserted into each other, with a cup joint, as can be clearly seen in figure 2. In the particular embodiment illustrated, the body of the container therefore has the shape of a conventional capsule. However, it is clear that it may also have a different shape, for example spherical. Returning to figures 1, 2 and 2 ', the appendages 16 are detachable from the body of the container, as shown for the lower appendage 16' in fig. 2. For this purpose, the appendages 16, 16 'are hollow at their base, as can be seen in fig.

2'. A weaker area is thus identified, in correspondence with which the rupture will occur. Therefore, if a certain force is exerted on the adjuster 16,16 'with a component orthogonal to the axis 24 of the container, the appendix will come off at its base.

The relative opening 26.26 'is thus freed, the dimensions of which are thus well defined and established a priori, according to requirements. They will be chosen in such a way as to obtain an easy and complete release of the powdered drug contained in the container 10 when the latter, once opened, is in a stream of air. It is therefore understood that the "calibrated" openings 26,26 * have characteristics of constancy and precision which cannot be reached with conventional drilling or shearing means. Furthermore, once the appendix or appendages have been removed, there is no obstacle to the escape of the dust.

The container 10 can be used for example in the inhaler shown in Figures 3 to 10. This inhaler 30 has been substantially obtained by modifying the inhaler described in the aforementioned patent US-A-3991 761, which has proved to be largely reliable, as well as simple and convenient to use. In the new inhaler, the means for removing the two removable appendages of the drug container will clearly replace the conventional means for piercing the capsule. In the right half of fig. 3 the inhaler 30 is shown in side view, as it is presented to the user, with the cap 32 on. In the left part of the same figure a vertical axial section can be seen, executed according to the axis greater than one of its horizontal cross-sections.

As can be seen in fig. 3, the inhaler 30 is made up of three parts or pieces, namely the lower part 34, the upper part 36 and the aforementioned cap 32.

For greater clarity, the lower part 34, or first piece, isolated, is visible in figures 4,5 and 6, while the upper part 36, or second piece, is also represented isolated, in figs. 7,8,9 and 10.

The lower part 34 has a base 38 carrying a hollow body 40 closed at the top by a wall 42. In the latter there is a seat 44 for the container 10 of the drug dose, as shown in figure 4, in which the container 10 is shown (with dashed line) inserted in its seat 44.

The seat 44 has two opposite slots 46 and 46 'through which the two appendages 16,16' of the container 10 protrude outwards when the latter is in its seat 44.

As mentioned, in figs. 7, 8 and 9 the upper part 36, or second piece, of the inhaler 30 is visible. In particular in the right half of fig. 7 this upper part is shown in a side view, while in the right half there is an axial vertical section executed according to the minor axis of a horizontal cross section of the same upper part.

As can be seen in fig. 7, the upper part 36 comprises a delivery channel 56 contained in a mouthpiece 48 adapted to be brought to the patient's mouth. It is in fact through the upper opening 50 of the mouthpiece 48 that the patient exercises the aspiration which allows the inhaler to function.

At the base of the mouthpiece 48, and coaxial to it, there is a chamber 52 (visible in plan in fig. 9). This chamber is substantially cylindrical, with a diameter greater than the length of the container 10 deprived of its appendages 16 and 16 '. The chamber 52 communicates with the outside by means of air intake channels 54 and 54 'disposed tangentially to the chamber itself. In this way, when the patient exerts an aspiration through the mouth 50 of the mouthpiece 48, an air vortex is generated in the chamber 52 which causes the body 12 of the container, now deprived of its appendages 16 and 16 ', to come out of its seat 44, causing it to rotate and vibrate in a known way.

The chamber 52 is separated from the intake channel 56 of the mouthpiece 48 by a grille 58, or similar means, which prevents the container body 12 from exiting the chamber 52.

The upper part 36 of the inhaler 30 is completed at the bottom by a hollow body or skirt 60 with plan dimensions slightly greater than the external ones of the overlying portion 62 enclosing the chamber 52. This skirt 60, open at the bottom, is intended to accommodate the body cable 40 of the lower part 34 of the inhaler 30, as seen in the assembly figure 3. Inside the skirt 60 there are two opposite inclined planes 64 and 64 '(Figures 7 and 8), which provide the means for removing the appendages 16 and 16' of the container 10 in an extremely simple and practical way. In fact, once the container 10 has been inserted into its seat 44 provided in the lower part 34 of the inhaler 30, when the latter is inserted from the bottom into the upper part 36 of the inhaler 30, the appendages 16 and 16 'of the container 10 come into contact with the aforementioned inclined planes 64 and 64 * of the upper part 36. By completely pushing the lower part 34 within the upper part 36, the interference between the appendages 16, 16 'and the aforementioned respective inclined planes 60 and 64' causes the removal of these appendages, which break cleanly in correspondence with their predetermined breaking zone, that is, in correspondence with their base. The removed appendages 16 and 16 'fall downwards, outside the inhaler 30. As a consequence of the removal of the appendages 16 and 16', the respective calibrated openings 26 and 26 'are released, so that the inhaler 30 is ready for operation. In fact, it will be sufficient for the patient to bring the mouthpiece 48 to the mouth, and exert an aspiration, because the depression generated in the chamber 52 removes the body 12 of the container (deprived of the appendages 16 and 16 ') from its seat 44 so in chamber 52. Here, thanks to the swirling air flow due to the particular arrangement of the tangential air intakes 54 and 54 ', the body 12 of the container will start to rotate and vibrate clockwise in the chamber 52. The drug in powder will thus be forced out of the body 12 of the container through the calibrated openings 26,26 ', dispersing in the air stream, whereby it will be inhaled by the patient.

It is clear that in the inhaler described the mouthpiece 48 could be replaced by a nasal adapter if the aspiration exercised by the patient has to take place through a nostril. Furthermore, instead of the inclined planes 64 and 64 ', which allow to obtain a more gradual removal of the appendages 16 and 16', simple steps could be provided which interfere with these appendages.

Figures 11 to 14 show an insufflator 60 according to the administration system of the present invention. It derives from the insufflator described in US-A-4 884 565 in which, substantially, the means for piercing the capsule have been replaced by means for removing the appendages of the container according to the administration system of the present invention.

In particular, in the right half of figure 11 a front view of the insufflator is visible, with the relative cap 62 fitted, while in the left half there is an axial vertical section made along the major axis of a horizontal cross section of the insufflator. same.

As can be seen from the above figures, the insufflator 80 is composed, in addition to the cap 82 (shown fitted in figure 11), by a manual pump 84, of elastic material. The blower 84 can be pressed by the patient's hand to generate a flow of air. The pump 84 is equipped with an air intake 86 (fig. 11) equipped with a non-return valve 88. The pump 84 also has an upper hole 87 for the air outlet, in which a section of channel is inserted. 90 forming part of the body 92 of the insufflator 80, and which acts as an air insufflation channel in the body 92 of the insufflator 80.

The body 92 of the insufflator, arranged above the pump 84, has a cylindrical seat 94 in which an element 36, generally cylindrical, rotatable around a horizontal axis which intersects the vertical axis 118 of the insufflator 80, can be inserted.

The body 92 also has a delivery channel 98 equipped, at its free end, with a suitable adapter 100 to be normally inserted into the patient's nostril. However, it is obvious that instead of the adapter 100 a mouthpiece of the type of the inhaler described above could be provided.

The revolving element 96 has a seat 02 for the container 10. At the two opposite ends of this seat 98, respective slots 104 and 104 'are provided in the wall of the revolving element 96, visible in fig. 4, through which the relative appendages 16 and 16 'of the container 10 protrude outwards (in fig. 4 the capsule is represented with dashed lines).

The rotatable element 96 is also provided with a gripping flap 106 (visible in Figs. 11, 12 and 13) by means of the fingers. The flap 106 facilitates the insertion of the rotatable element 96 into the cylindrical seat 94 in the body 92, as well as its extraction from the latter.

To make it even easier to extract the cylindrical element 96 from its seat94, the insufflator 80 provides a pusher 108 which can be activated by pressing the button 110 with the fingers. In this way the rotating element 96 is easily pushed out of the body 92 of the insufflator 80, to allow the expulsion of the empty body 12 of the container and to allow it to be refilled with a new container 10.

The rotating element 96 is inserted in its cylindrical seat 94 in the angular position shown in Figures 12 and 13, with the flap arranged horizontally, which will identify what we will call the first position or insertion position of the rotating element 96. Due to the fact that the apendices 16 and 16 'protrude from the respective slots 104 and 104' of the rotating element 96, in the body 92 of the insufflator there will be provided notches 12 and 112 'to accommodate, in the aforementioned first position of the rotating element 96, the relative appendages 16 and 16 'of the container 10.

In the lateral wall of the cylindrical seat 94 in which the rotating element 96 is received, two diametrically opposite openings Π4 and H5 are provided, coaxial with the vertical axis 118 of the insufflaton 80. The first opening 114S in communication with the insufflation channel 90, and the second in communication with the dispensing channel 90 of the adapter 10a With the rotating element 96 inserted in its cylindrical seat 94 (the container 10 having been previously inserted in its seat 102 in the rotating element 96) and arranged in the aforementioned first position (figures 11 , 12 and 13), the appendages 16 and 16 'of the capsule 10 s1 find in the relative recesses e11?' provided in the body 92 of the insufflator. As can be easily understood, starting to rotate the rotating element 96 by means of the flap 10 to bring it into what we have called its second position, rotated by 90 ° with respect to the aforementioned first position, the appendages 16 and 16 'of the container 10 strike against the steps formed by the recesses 112 and 112 '. Continuing in the rotation, said appendages are removed. The calibrated openings 26 and 26 'thus become free in the body 12 of the container. The detached appendages 16 and 16 'can be expelled due to the fact that the recesses 112 and 112' are in communication with the outside.

Instead of the steps formed by the walls of the recesses 112 and 112 *, inclined planes may be provided for a more gradual breakage, similar to that of the inhaler described above.

Therefore, when the rotatable member 96 is in its second position, the blowing opening 114 which is in communication with the interior of the pump 84, the slots 104 and 104 in the side wall of the rotatable member 96, the calibrated openings 26 and 26 * in the body 12 of the container 10, and the opening 116 in communication with the dispensing channel 98 of the adapter 100 are all aligned.

By exerting pressure on the pump 84 with the hand, a current of air will be generated which passes through the open container, removing the powdered drug contained in it, and exits, loaded with powdered drug, from the delivery channel98 of the adapter 103⁄4 4 to reach the patient's nasal cavity and / or bronchi.

Once this operation has been carried out, by pressing the push button HO of the pusher with the fingers it is possible to extract the rotating element 96 from its seat 94, so as to be able to replace the body 12, now empty, with a new container 10.

Conveniently, in order to avoid even the smallest loss of powdered drug, the rotation of the rotatable element 96 from its first to its second position will be carried out by keeping the blow plate horizontal so that the rotation rate of the rotatable element is vertical.

Claims (21)

CLAIMS 1. System for the administration by inhalation of powdered drugs, pre-dosed in substantially rigid containers, the drug dose contained in the container being administered by means of a delivery device, characterized in that the container (10) of the drug used in the device dispenser (30; 60) has at least one appendix (16,16 ') that can be removed from the body (12) of the container (10), the removal of the appendix (16,16') releasing in the aforementioned body (12 ) of the container (10) an opening (26,26 ') of predetermined dimensions, and that the dispensing device (30; 60) is equipped with means (64,64 *; 92,92') for the removal of the appendages (6,16 ') of the container (10). Administration system according to claim 1, characterized in that the openings (26,26 ') released following the removal of the appendages (16,16') of the container (10) are arranged on opposite sides of the container itself. Administration system according to claim 1 or 2, wherein the body (12) of the container (10) has an overall cylindrical shape with its two ends in the shape of a hemispherical cap (14,14 '), the openings (26 , 26 ') which are released following the removal of said appendages (16,16 *) being on the hemispherical caps (14,14') of the body (12) of the container (10). Administration system according to claim 3, wherein the two removable appendages (16,16 ') of the container (10) are two, one for each hemispherical cap (14,14') of the body (12) of the container, the relative two openings (26,26 ') free from the removal of the appendages (16,16') being circular and coaxial with each other and with respect to the body (12) of the container (10). Administration system according to claim 4, wherein the two appendages (16,16 ') of the container (10) are straight and extend in the opposite direction, coaxially to the body (12) of the container (10). Administration system according to any one of the preceding claims, wherein each appendix (16,16 ') of the container (10) has a predetermined breaking line or zone at the base of the appendix. 7. Administration system according to any one of the preceding claims, characterized in that the container 10 is of thermoformable material. Administration system according to any one of the preceding claims, characterized in that the delivery device is an inhaler (30). Inhaler (30) according to claim 8, comprising a delivery channel (56) ending in a mouthpiece (48) or a nasal adapter, and a chamber (52) in communication with said delivery channel (56) and adapted to accommodate the container (10) containing the drug dose to be delivered, at least one air intake (54,54 ') being provided in the walls of the chamber (52) to generate a whirling motion of the body (12) of the container (10) when the patient exerts a suction action through said mouthpiece (48) or nasal adapter. 10. Inhaler according to claim 9, wherein a seat (44) is provided in a wall (42) of the chamber (52) for receiving the container (10). Π. Inhaler according to claim 9 or 10, wherein the chamber (52) is cylindrical in shape. 12. Inhaler according to claim 11, wherein the seat (44) for the container (10) is provided in one of the two bases (42) of the borehole (52). 13. Inhaler according to claim 12, characterized in that it comprises two pieces (34,36) which can be separated or rotated with respect to each other for the insertion of the container (10) in its seat (44). 14. Inhaler according to claim 13, wherein the first piece (36) of which the inhaler (30) is composed comprises the delivery channel (56), said first piece delimiting the aforementioned cylindrical chamber (52) with the exception of the its wall (42) in which the seat (44) of the container (10) is provided; and the second piece (34) comprises the remaining wall (42) of said chamber (52) which has the seat (44) for the container (10). 15. Inhaler according to claim 14, wherein the seat (44) of the container (10) has a slot (46,46 ') for each appendix (16,16') of the container (10), through which the relative slot appendix protrudes outward of the second piece (34) of the inhaler (30), the first piece (36) of the inhaler (30) including an interference element 64,64 ') for each of the aforementioned appendages (16, 16 *) to cause its removal when the two pieces (34,36) are placed in the position of use. 16. Inhaler according to claim 15, wherein the interfering element is stepped. 17. Inhaler according to claim 15, wherein the interference element is in the shape of an inclined plane (64,64 '). Administration system according to any one of claims 1 to 7, characterized in that the delivery device is an insufflatone (00). 19. Insufflatone according to claim 18, wherein the body (92) of the insufflator has an insufflation opening (90) to which an air flow generated by a manual pump (84) is fed, and a delivery channel (98), a seat (102) for the container (10) of the drug being provided in an element (96) movable with respect to said body (92), this movable element (96) being movable between two positions: a first position for loading the container (10), and a second dispensing position in which the interior of the container (10) is in communication with both the insufflation opening (90) and the delivery channel (98), the container (10) resulting open as a consequence of the interference of its appendages (16,16 '} with relative interference elements (112,112') provided in the body (92) of the insufflatone (80) following the displacement of the movable element (96) from its first to its second position, in the second position of the element m the interior of the container (10) being in communication both with the insufflation opening (90) and with the delivery channel (98) of the insufflatone body (80). Insufflaton according to claim 19, wherein the movable element (96) is a rotatable element with respect to the body (92) of the insufflaton (80). 21. Insufflatone according to claim 20, wherein the seat (102) of the container (10) has a slot (104,104 ') for each appendix (16,16') of the container, the appendages (16,16 ') of the container ( 10) projecting freely outside the rotatable element (96) when the latter is in its first position.