IT8823098A0 - Procedimento per la sintesi di peptidi retro-inversi e nuovi intermedi in tale procedimento - Google Patents

Procedimento per la sintesi di peptidi retro-inversi e nuovi intermedi in tale procedimento

Info

Publication number
IT8823098A0
IT8823098A0 IT8823098A IT2309888A IT8823098A0 IT 8823098 A0 IT8823098 A0 IT 8823098A0 IT 8823098 A IT8823098 A IT 8823098A IT 2309888 A IT2309888 A IT 2309888A IT 8823098 A0 IT8823098 A0 IT 8823098A0
Authority
IT
Italy
Prior art keywords
retro
synthesis
new intermediates
peptides
reversed
Prior art date
Application number
IT8823098A
Other languages
English (en)
Other versions
IT1227907B (it
Inventor
Massimo Pinori
Felice Centini
Antonio Silvio Verdini
Original Assignee
Eniricerche S P A Milano Sclav
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eniricerche S P A Milano Sclav filed Critical Eniricerche S P A Milano Sclav
Publication of IT8823098A0 publication Critical patent/IT8823098A0/it
Priority to IT8823098A priority Critical patent/IT1227907B/it
Priority to US07/450,572 priority patent/US5061811A/en
Priority to AT89203194T priority patent/ATE102949T1/de
Priority to EP89203194A priority patent/EP0375040B1/en
Priority to ES89203194T priority patent/ES2061956T3/es
Priority to DE68913935T priority patent/DE68913935T2/de
Priority to CA002006560A priority patent/CA2006560A1/en
Priority to JP1336182A priority patent/JPH02221294A/ja
Application granted granted Critical
Publication of IT1227907B publication Critical patent/IT1227907B/it
Priority to US07/742,873 priority patent/US5116947A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT8823098A 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento IT1227907B (it)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
ES89203194T ES2061956T3 (es) 1988-12-23 1989-12-14 Procedimiento para la preparacion de peptidos retro-inversos y nuevos compuestos intermedios de los mismos.
AT89203194T ATE102949T1 (de) 1988-12-23 1989-12-14 Verfahren zur herstellung von retro-inversopeptiden und dessen zwischenprodukte.
EP89203194A EP0375040B1 (en) 1988-12-23 1989-12-14 Process for the preparation of retro-inverso peptides and new intermediates thereof
US07/450,572 US5061811A (en) 1988-12-23 1989-12-14 Process for the preparation of retro-inverso peptides and 1,3-dioxane-4,6-dione intermediates thereof
DE68913935T DE68913935T2 (de) 1988-12-23 1989-12-14 Verfahren zur Herstellung von Retro-Inverso-Peptiden und dessen Zwischenprodukte.
CA002006560A CA2006560A1 (en) 1988-12-23 1989-12-22 Process for the preparation of retro-inverso peptides and new intermediates thereof
JP1336182A JPH02221294A (ja) 1988-12-23 1989-12-25 ペプチド合成法
US07/742,873 US5116947A (en) 1988-12-23 1991-08-09 Process for the preparation of retro-inverso peptides and new intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Publications (2)

Publication Number Publication Date
IT8823098A0 true IT8823098A0 (it) 1988-12-23
IT1227907B IT1227907B (it) 1991-05-14

Family

ID=11203765

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8823098A IT1227907B (it) 1988-12-23 1988-12-23 Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Country Status (8)

Country Link
US (2) US5061811A (it)
EP (1) EP0375040B1 (it)
JP (1) JPH02221294A (it)
AT (1) ATE102949T1 (it)
CA (1) CA2006560A1 (it)
DE (1) DE68913935T2 (it)
ES (1) ES2061956T3 (it)
IT (1) IT1227907B (it)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200506A (en) * 1987-03-19 1993-04-06 Eniricerche S.P.A. Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento
US5218089A (en) * 1988-12-23 1993-06-08 Sclavo S.P.A. Retro-inverso analogues of thymopentin and the method for their synthesis
AU1194092A (en) * 1991-02-06 1992-09-07 Georgetown University Receptor blocking peptides of fibroblast growth factor receptor
CN1091138A (zh) * 1992-08-27 1994-08-24 迪金研究有限公司 疫苗
EP2823812A1 (en) * 1998-02-02 2015-01-14 Trustees Of Tufts College Dipeptidylpeptidase IV inhibitors for use in the treatment of Type II diabetes
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US6610820B1 (en) * 1999-10-12 2003-08-26 University Of Lausanne Cell-permeable peptide inhibitors of the JNK signal transduction pathway
CA2468192A1 (en) * 2001-11-26 2003-06-05 Trustees Of Tufts College Peptidomimetic inhibitors of post-proline cleaving enzymes
JP2005511636A (ja) * 2001-11-26 2005-04-28 トラスティーズ オブ タフツ カレッジ 自己免疫疾患の治療方法及びそれに関する試薬
DE60234713D1 (de) * 2001-12-18 2010-01-21 Endocube Sas Neue mit dem zelltod assoziierte proteine aus der thap familie und par4 verwandte signalwege, die bei der kontrolle von apoptosis involviert sind
US7858297B2 (en) * 2001-12-18 2010-12-28 Centre National De La Recherche Scientifique Cnrs Chemokine-binding protein and methods of use
EP1485408A2 (en) 2002-03-13 2004-12-15 Bayer CropScience S.A. Mutagenesis of aspergillus fungi and genes essential for growth
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
JP5857056B2 (ja) 2010-10-14 2016-02-10 ザイジェン インフラメーション エルティーディー 慢性又は非慢性の炎症性眼疾患を治療するためのｊｎｋシグナル伝達経路の細胞透過性ペプチド阻害剤の使用
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
CN105307670A (zh) 2013-06-26 2016-02-03 埃克西金炎症有限公司 Jnk信号转导途径的细胞渗透肽抑制剂用于治疗多种疾病的新用途
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3783280T2 (de) * 1986-07-16 1993-05-06 Eniricerche Spa Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
IT1227907B (it) * 1988-12-23 1991-05-14 Eniricerche S P A Milano Sclav Procedimento per la sintesi di peptidi retro-inversi e nuovi intermediin tale procedimento

Also Published As

Publication number Publication date
IT1227907B (it) 1991-05-14
DE68913935T2 (de) 1994-07-07
CA2006560A1 (en) 1990-06-23
EP0375040B1 (en) 1994-03-16
ES2061956T3 (es) 1994-12-16
US5061811A (en) 1991-10-29
DE68913935D1 (de) 1994-04-21
ATE102949T1 (de) 1994-04-15
JPH02221294A (ja) 1990-09-04
US5116947A (en) 1992-05-26
EP0375040A2 (en) 1990-06-27
EP0375040A3 (en) 1991-07-03

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19931230