IT8820882A0 - NEUTRAL ENDOPEPTIDASE INHIBITORS. - Google Patents

NEUTRAL ENDOPEPTIDASE INHIBITORS.

Info

Publication number
IT8820882A0
IT8820882A0 IT8820882A IT2088288A IT8820882A0 IT 8820882 A0 IT8820882 A0 IT 8820882A0 IT 8820882 A IT8820882 A IT 8820882A IT 2088288 A IT2088288 A IT 2088288A IT 8820882 A0 IT8820882 A0 IT 8820882A0
Authority
IT
Italy
Prior art keywords
neutral endopeptidase
endopeptidase inhibitors
inhibitors
neutral
endopeptidase
Prior art date
Application number
IT8820882A
Other languages
Italian (it)
Other versions
IT1217799B (en
Inventor
Norma G Delaney
Eric M Gordon
Jack Deforrest
David W Cushman
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8820882A0 publication Critical patent/IT8820882A0/en
Application granted granted Critical
Publication of IT1217799B publication Critical patent/IT1217799B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT20882/88A 1987-06-08 1988-06-07 NEUTRAL ENDOPEPTIDASE INHIBITORS IT1217799B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5907287A 1987-06-08 1987-06-08

Publications (2)

Publication Number Publication Date
IT8820882A0 true IT8820882A0 (en) 1988-06-07
IT1217799B IT1217799B (en) 1990-03-30

Family

ID=22020675

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20882/88A IT1217799B (en) 1987-06-08 1988-06-07 NEUTRAL ENDOPEPTIDASE INHIBITORS

Country Status (6)

Country Link
US (1) US5496805A (en)
CA (1) CA1337400C (en)
DE (1) DE3819539A1 (en)
FR (1) FR2616070B1 (en)
GB (1) GB2207351B (en)
IT (1) IT1217799B (en)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
ZA902661B (en) * 1989-04-10 1991-01-30 Schering Corp Mercapto-acyl amino acids
JPH05501247A (en) * 1989-10-13 1993-03-11 シェリング・コーポレーション Carboxyalkyl dipeptide inhibitors of endopeptidases
JPH075530B2 (en) * 1989-11-21 1995-01-25 シェリング・コーポレーション Carboxyalkylcarbonyl amino acid endopeptidase inhibitor
US5075302A (en) * 1990-03-09 1991-12-24 Schering Corporation Mercaptoacyl aminolactam endopeptidase inhibitors
WO1992001468A1 (en) * 1990-07-25 1992-02-06 The Green Cross Corporation Endoserine converting enzyme inhibitor or vascular twitch remedy
US5173506A (en) * 1990-08-16 1992-12-22 Schering Corporation N-(mercaptoalkyl)ureas and carbamates
WO1992013564A1 (en) * 1991-02-06 1992-08-20 Schering Corporation Combination of an angiotensin ii antagonist or renin inhibitor with a neutral endopeptidase inhibitor
WO1992018159A1 (en) * 1991-04-16 1992-10-29 Schering Corporation Use of neutral endopeptidase inhibitors in the treatment of nephrotoxicity
US5294632A (en) * 1991-05-01 1994-03-15 Ciba-Geigy Corporation Phosphono/biaryl substituted dipetide derivatives
US5155100A (en) * 1991-05-01 1992-10-13 Ciba-Geigy Corporation Phosphono/biaryl substituted dipeptide derivatives
FR2679564A1 (en) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med NOVEL ACYLMERCAPTOALCANOLDIPEPTIDES, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM.
US5225401A (en) * 1991-08-12 1993-07-06 E. R. Squibb & Sons, Inc. Treatment of congestive heart failure
US5250522A (en) * 1992-10-09 1993-10-05 Ciba-Geigy Corporation Phosphono/biaryl substituted amino acid derivatives
FR2682952B1 (en) * 1991-10-25 1993-12-03 Institut Nal Sante Recherc Medic NOVEL N- (MERCAPTOACYL) AMINO-ACIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US5217996A (en) * 1992-01-22 1993-06-08 Ciba-Geigy Corporation Biaryl substituted 4-amino-butyric acid amides
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
AU3494093A (en) * 1993-01-22 1994-08-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) S-lipophilic aliphatic carbonyl {n-mercaptoacyl-(amino acid or peptide)} compounds as antihypertensive agents
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
US5508272A (en) * 1993-06-15 1996-04-16 Bristol-Myers Squibb Company Compounds containing a fused bicycle ring and processes therefor
FR2707089B1 (en) * 1993-06-30 1995-08-18 Adir New phosphonic acid derivatives, process for their preparation and pharmaceutical compositions containing them.
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam
US5616775A (en) * 1994-05-05 1997-04-01 Bristol-Myers Squibb Co. Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
US5508266A (en) * 1994-06-22 1996-04-16 Ciba-Geigy Corporation Gem-disubstituted amino acid derivatives
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
FR2745571B1 (en) * 1996-03-04 1998-06-19 Inst Nat Sante Rech Med NOVEL SULFUR DERIVATIVES COMPRISING AN AMIDE BINDING, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2745570B1 (en) * 1996-03-04 1998-06-19 Roussel Uclaf NOVEL SULFUR DERIVATIVES COMPRISING A RETROAMIDE BINDING, THEIR PREPARATION METHOD AND INTERMEDIATES, THEIR APPLICATION AS MEDICAMENTS, AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE19906310A1 (en) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Use of 3-(1-(2-aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido)-2,3,4,5-tetrahydro-2-oxo-1H-benz(b)azepine-1-acetic acid derivatives for treating hypertension
NL1015714C2 (en) * 2000-07-14 2002-01-15 Dsm Nv Process for crystallizing enantiomerically enriched 2-acetylthio-3-phenylpropanoic acid.
MX2011012627A (en) 2009-05-28 2011-12-14 Novartis Ag Substituted aminobutyric derivatives as neprilysin inhibitors.
ME01923B (en) 2009-05-28 2015-05-20 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
TR201808541T4 (en) 2013-02-14 2018-07-23 Novartis Ag Bisphenyl butanoic phosphonic acid derivatives substituted as nep (neutral endopeptidase) inhibitors.
MX2015010434A (en) 2013-02-14 2015-10-05 Novartis Ag Substituted bisphenyl butanoic acid derivatives as nep inhibitors with improved in vivo efficacy.
CN108117502A (en) * 2017-11-29 2018-06-05 四川大学 The preparation of a kind of 2- substitutions-(S)-(3- sulfydryl -2- methylpropionyls)-glycine derivative and purposes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053651A (en) * 1976-05-10 1977-10-11 E. R. Squibb & Sons, Inc. Compounds and method for alleviating angiotensin related hypertension
US4339600A (en) * 1976-05-10 1982-07-13 E. R. Squibb & Sons, Inc. Compounds for alleviating angiotensin related hypertension
US4105789A (en) * 1976-05-10 1978-08-08 E. R. Squibb & Sons, Inc. Carboxyalkylacylamino acids
US4217347A (en) * 1977-12-27 1980-08-12 E. R. Squibb & Sons, Inc. Method of treating hypertension and medicaments therefor
US4316896A (en) * 1978-09-07 1982-02-23 Merck & Co., Inc. Aminoacid derivatives as antihypertensives
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4235885A (en) * 1979-06-25 1980-11-25 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
FR2474829B1 (en) * 1980-02-01 1983-09-09 Agronomique Inst Nat Rech PROCESS FOR THE TREATMENT OF A CASEIN MATERIAL CONTAINING PHOSPHOCASEINATES OF MONOVALENT CATIONS OR DERIVATIVES THEREOF, PRODUCTS OBTAINED AND APPLICATIONS
JPS56145220A (en) * 1980-04-10 1981-11-11 Dainippon Pharmaceut Co Ltd Antihypertensive agent containing prolylamino acid derivative and diuretic agent as main constituent
FR2480747A1 (en) * 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
US4629787A (en) * 1980-08-18 1986-12-16 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4409146A (en) * 1980-10-06 1983-10-11 Merck & Co., Inc. Substituted caprolactam derivatives as antihypertensives
US4379146A (en) * 1981-02-17 1983-04-05 Merck & Co., Inc. Substituted phosphonamides as antihypertensives
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
US4587238A (en) * 1981-07-06 1986-05-06 Merck & Co., Inc. Substituted caprylolactam derivatives as anti-hypertensives
US4432972A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
EP0075896B1 (en) * 1981-09-25 1986-02-26 The Wellcome Foundation Limited Pharmaceutical amides, and preparation, formulations and use thereof
AU549310B2 (en) * 1981-09-25 1986-01-23 Wellcome Foundation Limited, The N- 2-dihydroxyphosphinyl -3- substituted phenyl propionyl -leucine
US4401677A (en) * 1981-10-09 1983-08-30 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
NZ206920A (en) * 1983-01-28 1986-10-08 Schering Corp Phosphorus-containing amide,urea or carbamate derivatives and pharmaceutical compositions
US4722810A (en) * 1984-08-16 1988-02-02 E. R. Squibb & Sons, Inc. Enkephalinase inhibitors
EP0136883B1 (en) * 1983-10-03 1987-11-25 E.R. Squibb & Sons, Inc. Enkephalinase inhibitors
US4508712A (en) * 1984-01-10 1985-04-02 Washington University Atrial peptide
DE3560829D1 (en) * 1984-04-02 1987-12-03 Squibb & Sons Inc ENKEPHALINASE INHIBITORS
JPS60243650A (en) * 1984-04-09 1985-12-03 イ−・アイ・デユポン・ド・ネモア−ス・アンド・コンパニ− Dye for direct positive
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
WO1986000066A1 (en) * 1984-06-08 1986-01-03 Ciba-Geigy Ag N-substituted butyramide derivatives
US4692455A (en) * 1985-01-25 1987-09-08 E. R. Squibb & Sons, Inc. Certain acyclic, alicyclic, aromatic or heterocyclic derivatives of 3-benzoylamino-2-oxo- butyl-amino-carbonyl-oxy-3-propanoic acids, esters thereof, pharmaceutical compositions containing same and their enkephalinase inhibiting properties
DE3532036A1 (en) * 1985-09-09 1987-03-26 Hoechst Ag PHARMACEUTICAL PREPARATION FOR TREATING HIGH PRESSURE
EP0225292A3 (en) * 1985-12-06 1988-11-30 Ciba-Geigy Ag Certain n-substituted butyramide derivatives
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
US4740499A (en) * 1986-07-28 1988-04-26 Monsanto Company Method of enhancing the bioactivity of atrial peptides
KR880007441A (en) * 1986-12-11 1988-08-27 알렌 제이.스피겔 Spiro-Substituted Glutaramide Diuretics

Also Published As

Publication number Publication date
DE3819539A1 (en) 1988-12-22
GB2207351A (en) 1989-02-01
CA1337400C (en) 1995-10-24
FR2616070B1 (en) 1994-07-01
IT1217799B (en) 1990-03-30
US5496805A (en) 1996-03-05
FR2616070A1 (en) 1988-12-09
GB8813372D0 (en) 1988-07-13
GB2207351B (en) 1991-09-18

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970628