IT8322815A1 - NEW PHARMACEUTICAL FORMULATIONS WITH ANTISEPTIC ACTIVITY - Google Patents
NEW PHARMACEUTICAL FORMULATIONS WITH ANTISEPTIC ACTIVITY Download PDFInfo
- Publication number
- IT8322815A1 IT8322815A1 IT1983A22815A IT2281583A IT8322815A1 IT 8322815 A1 IT8322815 A1 IT 8322815A1 IT 1983A22815 A IT1983A22815 A IT 1983A22815A IT 2281583 A IT2281583 A IT 2281583A IT 8322815 A1 IT8322815 A1 IT 8322815A1
- Authority
- IT
- Italy
- Prior art keywords
- pharmaceutical formulations
- merbromin
- powder
- lactose
- solid support
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 9
- 230000002421 anti-septic effect Effects 0.000 title claims description 3
- SQFDQLBYJKFDDO-UHFFFAOYSA-K merbromin Chemical compound [Na+].[Na+].C=12C=C(Br)C(=O)C=C2OC=2C([Hg]O)=C([O-])C(Br)=CC=2C=1C1=CC=CC=C1C([O-])=O SQFDQLBYJKFDDO-UHFFFAOYSA-K 0.000 claims description 18
- 229960002782 merbromin Drugs 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 11
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 229940008716 mercurochrome Drugs 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 239000001993 wax Substances 0.000 claims description 5
- 239000007921 spray Substances 0.000 claims description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000035874 Excoriation Diseases 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Description
DESCRIZIONE DELL ' INVENZIONE INDUSTRIALE DAL T I TOLO : "FORMULAZIONI FARMACEUTICHE AD ATTIVIT?' ANTISETTICA" DESCRIPTION OF THE INDUSTRIAL INVENTION FROM T I TOLO: "PHARMACEUTICAL FORMULATIONS WITH ACTIVITIES" ANTISEPTIC "
R I A S S U N T O SUMMARY
Si descrivono nuove formulazioni farmaceutiche topiche (spray, polvere aspersoria ecc. ) contenenti merbromina (mercurocromo) raicroincapsulata , atte alla disinfezione di ferite. We describe new topical pharmaceutical formulations (sprays, sprinkling powder, etc.) containing raicroencapsulated merbromin (mercurochrome), suitable for the disinfection of wounds.
DESCRIZIONE DELL'INVENZIONE DESCRIPTION OF THE INVENTION
La presente invenzione si riferisce a nuove formulazioni farmaceutiche atte alla disinfezione di ferite di varia natura, sia di origine chirurgica che traumatica. The present invention refers to new pharmaceutical formulations suitable for the disinfection of wounds of various kinds, both of surgical and traumatic origin.
Le propriet? disinfettanti delle soluzioni di merbromina (mercurocromo ) sono note da tempo. L'uso di queste soluzioni, in concentrazioni da 2 a 5% , ? comune in tutti i campi ove esistono necessit? di sterilizzazione superficiale. L'invenzione in oggetto si propone lo scopo di migliorare l'utilizzo del mercurocromo che, come noto, ha la ca ratteristica di colorare fortemente di rosso-arancione la parte disinfettata. The properties disinfectants of merbromin solutions (mercurochrome) have long been known. The use of these solutions, in concentrations from 2 to 5%,? common in all fields where there is a need? of surface sterilization. The object of the present invention is to improve the use of mercurochrome which, as known, has the characteristic of strongly coloring the disinfected part of red-orange.
Si ? ora trovato che sottoponendo la merbromina a un processo di microincapsulazione, si ottiene una polvere che, a contatto con il sangue o il siero che si trovano nella parte lesa della cute, si fissa e cede la merbromina contenuta. Questa cessione risulta proporzionale alla quantit? di liquido presente sulla cute. Oltre a ci? la polvere mie roincapsulata crea uno strato protettivo che risulta particolarmente utile nelle piccole abrasioni cutanee . Yup ? It has now been found that by subjecting merbromin to a microencapsulation process, a powder is obtained which, in contact with the blood or serum found in the injured part of the skin, fixes itself and releases the merbromin contained. This sale is proportional to the quantity? of liquid present on the skin. In addition to there? my roencapsulated powder creates a protective layer which is particularly useful in small skin abrasions.
Poich? nell'interno della ferita non esistono condizioni per il fissaggio della polvere (presenza di sangue, siero, ecc.) le parti circostanti, dopo l'applicazione dello spray, risultano facilmente detergibili con il sem plice spolveramento della stessa. Le formulazioni della presente invenzione consentono pertanto un trattamento molto pi? pratico rispetto alle soluzioni tradizionalmente usate, consentendo tra l'altro un'efficace disinfezione senza colorazioni accidentali di indumenti e quindi rendendo comoda l'applicazione anche in ambiente extraospe* daliero o domestico. Since? inside the wound there are no conditions for the fixing of the powder (presence of blood, serum, etc.) the surrounding parts, after applying the spray, are easily cleaned by simply dusting it. The formulations of the present invention therefore allow a much better treatment. practical compared to the solutions traditionally used, allowing, among other things, an effective disinfection without accidental dyes of clothing and therefore making it easy to apply even in an out-of-the-way or domestic environment.
Le formulazioni oggetto dell?invenzione sono preparate a partire da una soluzione di merbromina in metanolo che viene fatta adsorbire su di un idoneo supporto solido quale lattosio, saccarosio, amido, talco, ecc. La polvere cosi ottenuta viene quindi sottoposta a uno dei metodi noti per la microincapsulazione, impiegando ad esempio derivati della cellulosa, cere ecc. Le formulazioni oggetto dell?invenzione hanno tipicamente un titolo in merbromina compreso tra il 2 e il 5?. The formulations object of the invention are prepared starting from a solution of merbromin in methanol which is adsorbed on a suitable solid support such as lactose, sucrose, starch, talc, etc. The powder thus obtained is then subjected to one of the known methods for microencapsulation, using for example cellulose derivatives, waxes, etc. The formulations object of the invention typically have a merbromin titer between 2 and 5 ?.
Il seguente esempio, illustra in dettaglio la preparazione delle formulazioni oggetto dell?invenzione, ma non deve per que sto essere ritenuto limitativo. The following example illustrates in detail the preparation of the formulations object of the invention, but should not therefore be considered limiting.
ESEMPIO EXAMPLE
Metodo di preparazione Method of preparation
Si scioglie la merbromina in 0,7 litri di alcol metilico. Merbromin is dissolved in 0.7 liters of methyl alcohol.
(Soluzione A ). (Solution A).
La soluzione A ? aggiunta a 1 kg di lattosio F.U. miscelando il composto ottenuto sino a miscela omogenea (composto B). Solution A? added to 1 kg of lactose F.U. mixing the obtained compound until a homogeneous mixture (compound B).
Si secca completamente e si macina per ottenere una polvere con granuli di dimensioni comprese tra 50 e 100 micron. It is completely dried and ground to obtain a powder with granules ranging in size from 50 to 100 microns.
Microin capsulazione Microin capsulation
In 3 kg di cicloesano vengono sciolti 33 g di etilcellulosa e 33 g di cera polietilencarbossilica e a caldo, sotto agitazio ne,viene aggiunto il composto B. 33 g of ethylcellulose and 33 g of polyethylene carboxylic wax are dissolved in 3 kg of cyclohexane and compound B.
Si lascia raffreddare sempre sotto agitazione e si filtra. Il filtrato viene lavato per tre volte con cicloesano fresco. It is allowed to cool, always under stirring, and filtered. The filtrate is washed three times with fresh cyclohexane.
Si secca completamente a 60?C e si passa la polvere ottenu ta su vibrovaglio per ottenere microgranuli di dimensioni comprese tra 50 e 100 micron. It is completely dried at 60 ° C and the powder obtained is passed through a vibrating sieve to obtain microgranules with dimensions ranging from 50 to 100 microns.
La mieroincapsulaz ione cos? condotta porta ad ottenere una phase ratio di 30/1 rispetto alle dimensioni delle particelle. La polvere cos? ottenuta pu? essere impiegata come tale oppure essere dosata in opportuno contenitore spray impiegando veicoli convenzionali. Is myeroencapsulation like this? conducted leads to obtain a phase ratio of 30/1 with respect to the size of the particles. The dust so? obtained can? be used as such or be dosed in a suitable spray container using conventional vehicles.
Sulla polvere cos? ottenuta, si effettua la determinazione della velocit? di rilascio della merbromina in acqua. On the dust so? obtained, is the determination of the speed? release of merbromin into water.
In provette contenenti H^O si fa cadere una quantit? di circa 200 mg di mercurocromo microincapsulato ottenuto secondo l'esempio precedente. In tubes containing H ^ O a quantity is dropped of about 200 mg of microencapsulated mercurochrome obtained according to the previous example.
Dal contatto della polvere con l'acqua devono passare circa 6 secondi affinch? si possa notare il rilascio di merbromina nella provetta. From the contact of the powder with the water, about 6 seconds must pass so that? you can see the release of merbromin in the tube.
Nelle medesime condizioni si ha che la merbromina rilasciata Under the same conditions, merbromin is released
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22815/83A IT1194391B (en) | 1983-09-08 | 1983-09-08 | Antiseptic compsn. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT22815/83A IT1194391B (en) | 1983-09-08 | 1983-09-08 | Antiseptic compsn. |
Publications (3)
Publication Number | Publication Date |
---|---|
IT8322815A0 IT8322815A0 (en) | 1983-09-08 |
IT8322815A1 true IT8322815A1 (en) | 1985-03-08 |
IT1194391B IT1194391B (en) | 1988-09-22 |
Family
ID=11200752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT22815/83A IT1194391B (en) | 1983-09-08 | 1983-09-08 | Antiseptic compsn. |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1194391B (en) |
-
1983
- 1983-09-08 IT IT22815/83A patent/IT1194391B/en active
Also Published As
Publication number | Publication date |
---|---|
IT8322815A0 (en) | 1983-09-08 |
IT1194391B (en) | 1988-09-22 |
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