IT8322815A1 - NEW PHARMACEUTICAL FORMULATIONS WITH ANTISEPTIC ACTIVITY - Google Patents

NEW PHARMACEUTICAL FORMULATIONS WITH ANTISEPTIC ACTIVITY Download PDF

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Publication number
IT8322815A1
IT8322815A1 IT1983A22815A IT2281583A IT8322815A1 IT 8322815 A1 IT8322815 A1 IT 8322815A1 IT 1983A22815 A IT1983A22815 A IT 1983A22815A IT 2281583 A IT2281583 A IT 2281583A IT 8322815 A1 IT8322815 A1 IT 8322815A1
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IT
Italy
Prior art keywords
pharmaceutical formulations
merbromin
powder
lactose
solid support
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Application number
IT1983A22815A
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Italian (it)
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IT8322815A0 (en
IT1194391B (en
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Rossi Gianfranco
Pivoli Franco
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Priority to IT22815/83A priority Critical patent/IT1194391B/en
Publication of IT8322815A0 publication Critical patent/IT8322815A0/en
Publication of IT8322815A1 publication Critical patent/IT8322815A1/en
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Publication of IT1194391B publication Critical patent/IT1194391B/en

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Description

DESCRIZIONE DELL ' INVENZIONE INDUSTRIALE DAL T I TOLO : "FORMULAZIONI FARMACEUTICHE AD ATTIVIT?' ANTISETTICA" DESCRIPTION OF THE INDUSTRIAL INVENTION FROM T I TOLO: "PHARMACEUTICAL FORMULATIONS WITH ACTIVITIES" ANTISEPTIC "

R I A S S U N T O SUMMARY

Si descrivono nuove formulazioni farmaceutiche topiche (spray, polvere aspersoria ecc. ) contenenti merbromina (mercurocromo) raicroincapsulata , atte alla disinfezione di ferite. We describe new topical pharmaceutical formulations (sprays, sprinkling powder, etc.) containing raicroencapsulated merbromin (mercurochrome), suitable for the disinfection of wounds.

DESCRIZIONE DELL'INVENZIONE DESCRIPTION OF THE INVENTION

La presente invenzione si riferisce a nuove formulazioni farmaceutiche atte alla disinfezione di ferite di varia natura, sia di origine chirurgica che traumatica. The present invention refers to new pharmaceutical formulations suitable for the disinfection of wounds of various kinds, both of surgical and traumatic origin.

Le propriet? disinfettanti delle soluzioni di merbromina (mercurocromo ) sono note da tempo. L'uso di queste soluzioni, in concentrazioni da 2 a 5% , ? comune in tutti i campi ove esistono necessit? di sterilizzazione superficiale. L'invenzione in oggetto si propone lo scopo di migliorare l'utilizzo del mercurocromo che, come noto, ha la ca ratteristica di colorare fortemente di rosso-arancione la parte disinfettata. The properties disinfectants of merbromin solutions (mercurochrome) have long been known. The use of these solutions, in concentrations from 2 to 5%,? common in all fields where there is a need? of surface sterilization. The object of the present invention is to improve the use of mercurochrome which, as known, has the characteristic of strongly coloring the disinfected part of red-orange.

Si ? ora trovato che sottoponendo la merbromina a un processo di microincapsulazione, si ottiene una polvere che, a contatto con il sangue o il siero che si trovano nella parte lesa della cute, si fissa e cede la merbromina contenuta. Questa cessione risulta proporzionale alla quantit? di liquido presente sulla cute. Oltre a ci? la polvere mie roincapsulata crea uno strato protettivo che risulta particolarmente utile nelle piccole abrasioni cutanee . Yup ? It has now been found that by subjecting merbromin to a microencapsulation process, a powder is obtained which, in contact with the blood or serum found in the injured part of the skin, fixes itself and releases the merbromin contained. This sale is proportional to the quantity? of liquid present on the skin. In addition to there? my roencapsulated powder creates a protective layer which is particularly useful in small skin abrasions.

Poich? nell'interno della ferita non esistono condizioni per il fissaggio della polvere (presenza di sangue, siero, ecc.) le parti circostanti, dopo l'applicazione dello spray, risultano facilmente detergibili con il sem plice spolveramento della stessa. Le formulazioni della presente invenzione consentono pertanto un trattamento molto pi? pratico rispetto alle soluzioni tradizionalmente usate, consentendo tra l'altro un'efficace disinfezione senza colorazioni accidentali di indumenti e quindi rendendo comoda l'applicazione anche in ambiente extraospe* daliero o domestico. Since? inside the wound there are no conditions for the fixing of the powder (presence of blood, serum, etc.) the surrounding parts, after applying the spray, are easily cleaned by simply dusting it. The formulations of the present invention therefore allow a much better treatment. practical compared to the solutions traditionally used, allowing, among other things, an effective disinfection without accidental dyes of clothing and therefore making it easy to apply even in an out-of-the-way or domestic environment.

Le formulazioni oggetto dell?invenzione sono preparate a partire da una soluzione di merbromina in metanolo che viene fatta adsorbire su di un idoneo supporto solido quale lattosio, saccarosio, amido, talco, ecc. La polvere cosi ottenuta viene quindi sottoposta a uno dei metodi noti per la microincapsulazione, impiegando ad esempio derivati della cellulosa, cere ecc. Le formulazioni oggetto dell?invenzione hanno tipicamente un titolo in merbromina compreso tra il 2 e il 5?. The formulations object of the invention are prepared starting from a solution of merbromin in methanol which is adsorbed on a suitable solid support such as lactose, sucrose, starch, talc, etc. The powder thus obtained is then subjected to one of the known methods for microencapsulation, using for example cellulose derivatives, waxes, etc. The formulations object of the invention typically have a merbromin titer between 2 and 5 ?.

Il seguente esempio, illustra in dettaglio la preparazione delle formulazioni oggetto dell?invenzione, ma non deve per que sto essere ritenuto limitativo. The following example illustrates in detail the preparation of the formulations object of the invention, but should not therefore be considered limiting.

ESEMPIO EXAMPLE

Metodo di preparazione Method of preparation

Si scioglie la merbromina in 0,7 litri di alcol metilico. Merbromin is dissolved in 0.7 liters of methyl alcohol.

(Soluzione A ). (Solution A).

La soluzione A ? aggiunta a 1 kg di lattosio F.U. miscelando il composto ottenuto sino a miscela omogenea (composto B). Solution A? added to 1 kg of lactose F.U. mixing the obtained compound until a homogeneous mixture (compound B).

Si secca completamente e si macina per ottenere una polvere con granuli di dimensioni comprese tra 50 e 100 micron. It is completely dried and ground to obtain a powder with granules ranging in size from 50 to 100 microns.

Microin capsulazione Microin capsulation

In 3 kg di cicloesano vengono sciolti 33 g di etilcellulosa e 33 g di cera polietilencarbossilica e a caldo, sotto agitazio ne,viene aggiunto il composto B. 33 g of ethylcellulose and 33 g of polyethylene carboxylic wax are dissolved in 3 kg of cyclohexane and compound B.

Si lascia raffreddare sempre sotto agitazione e si filtra. Il filtrato viene lavato per tre volte con cicloesano fresco. It is allowed to cool, always under stirring, and filtered. The filtrate is washed three times with fresh cyclohexane.

Si secca completamente a 60?C e si passa la polvere ottenu ta su vibrovaglio per ottenere microgranuli di dimensioni comprese tra 50 e 100 micron. It is completely dried at 60 ° C and the powder obtained is passed through a vibrating sieve to obtain microgranules with dimensions ranging from 50 to 100 microns.

La mieroincapsulaz ione cos? condotta porta ad ottenere una phase ratio di 30/1 rispetto alle dimensioni delle particelle. La polvere cos? ottenuta pu? essere impiegata come tale oppure essere dosata in opportuno contenitore spray impiegando veicoli convenzionali. Is myeroencapsulation like this? conducted leads to obtain a phase ratio of 30/1 with respect to the size of the particles. The dust so? obtained can? be used as such or be dosed in a suitable spray container using conventional vehicles.

Sulla polvere cos? ottenuta, si effettua la determinazione della velocit? di rilascio della merbromina in acqua. On the dust so? obtained, is the determination of the speed? release of merbromin into water.

In provette contenenti H^O si fa cadere una quantit? di circa 200 mg di mercurocromo microincapsulato ottenuto secondo l'esempio precedente. In tubes containing H ^ O a quantity is dropped of about 200 mg of microencapsulated mercurochrome obtained according to the previous example.

Dal contatto della polvere con l'acqua devono passare circa 6 secondi affinch? si possa notare il rilascio di merbromina nella provetta. From the contact of the powder with the water, about 6 seconds must pass so that? you can see the release of merbromin in the tube.

Nelle medesime condizioni si ha che la merbromina rilasciata Under the same conditions, merbromin is released

Claims (8)

RIVENDICAZIONI 1. Formulazioni farmaceutiche topiche ad attivit? antisettica contenenti come principio attivo merbromina (mercurocromo) micro incapsulata . 1. Topical active pharmaceutical formulations? antiseptic containing micro encapsulated merbromin (mercurochrome) as the active ingredient. 2. ' Formulazioni farmaceutiche secondo la rivendicazione 1 contenenti merbromina in concentrazioni comprese tra il 2 e il 5?. 2. Pharmaceutical formulations according to claim 1 containing merbromin in concentrations ranging from 2 to 5 ?. 3. Formulazioni farmaceutiche secondo le rivendicazioni 1 e 2, sotto forma di spray o polvere aspersoria. 3. Pharmaceutical formulations according to claims 1 and 2, in the form of spray or sprinkling powder. 4. Formulazioni farmaceutiche secondo le rivendicazioni 1-3, contenenti come agenti micro.incapsulanti cere e deriva ti della cellulosa oltre a supporti solidi quali lattosio, saccarosio, amido, talco. 4. Pharmaceutical formulations according to claims 1-3, containing waxes and cellulose derivatives as microencapsulating agents as well as solid supports such as lactose, sucrose, starch, talc. 5. Formulazioni farmaceutiche secondo le rivendicazioni 1-4, contenenti etilcellulosa e cera polietilencarbossi lica come agenti microincapsulanti e lattosio come supporto soli_ do . 5. Pharmaceutical formulations according to claims 1-4, containing ethyl cellulose and polyethylene carboxylic wax as microencapsulating agents and lactose as solid support. 6 . Procedimento per la preparazione delle formulazioni delle rivendicazioni 1-5 caratterizzato dal fatto che una soluzione in alcol metilico di merbromina viene fatta adsorbire sul supporto solido e che la polvere cos? ottenuta viene microincapsulata con uno dei metodi noti. 6. Process for the preparation of the formulations of claims 1-5 characterized in that a solution of merbromin in methyl alcohol is made to adsorb on the solid support and that the powder is thus absorbed. obtained is microencapsulated with one of the known methods. 7. Procedimento secondo la rivendicazione 6 in cui il supporto solido ? lattosio. 7. Process according to claim 6 wherein the solid support? lactose. 8. Procedimento secondo la rivendicazione 6 in cui la microincapsulazione viene effettuata trattando' la polvere adsorbita in un solvente idrocarburico con cera polietilencarbossilica e con etilcellulosa . 8. Process according to claim 6 wherein the microencapsulation is carried out by treating the powder adsorbed in a hydrocarbon solvent with polyethylene carboxylic wax and with ethyl cellulose.
IT22815/83A 1983-09-08 1983-09-08 Antiseptic compsn. IT1194391B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT22815/83A IT1194391B (en) 1983-09-08 1983-09-08 Antiseptic compsn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22815/83A IT1194391B (en) 1983-09-08 1983-09-08 Antiseptic compsn.

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IT8322815A0 IT8322815A0 (en) 1983-09-08
IT8322815A1 true IT8322815A1 (en) 1985-03-08
IT1194391B IT1194391B (en) 1988-09-22

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IT22815/83A IT1194391B (en) 1983-09-08 1983-09-08 Antiseptic compsn.

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IT8322815A0 (en) 1983-09-08
IT1194391B (en) 1988-09-22

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