IT202200009872A1 - Processo di preparazione di Zanubrutinib in forma amorfa. - Google Patents
Processo di preparazione di Zanubrutinib in forma amorfa. Download PDFInfo
- Publication number
- IT202200009872A1 IT202200009872A1 IT102022000009872A IT202200009872A IT202200009872A1 IT 202200009872 A1 IT202200009872 A1 IT 202200009872A1 IT 102022000009872 A IT102022000009872 A IT 102022000009872A IT 202200009872 A IT202200009872 A IT 202200009872A IT 202200009872 A1 IT202200009872 A1 IT 202200009872A1
- Authority
- IT
- Italy
- Prior art keywords
- zanubrutinib
- preparation process
- amorphous form
- amorphous
- preparation
- Prior art date
Links
- RNOAOAWBMHREKO-QFIPXVFZSA-N (7S)-2-(4-phenoxyphenyl)-7-(1-prop-2-enoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C(C=C)(=O)N1CCC(CC1)[C@@H]1CCNC=2N1N=C(C=2C(=O)N)C1=CC=C(C=C1)OC1=CC=CC=C1 RNOAOAWBMHREKO-QFIPXVFZSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 229950007153 zanubrutinib Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102022000009872A IT202200009872A1 (it) | 2022-05-12 | 2022-05-12 | Processo di preparazione di Zanubrutinib in forma amorfa. |
| PCT/IB2023/054862 WO2023218389A1 (en) | 2022-05-12 | 2023-05-11 | Process for preparing zanubrutinib in amorphous form |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102022000009872A IT202200009872A1 (it) | 2022-05-12 | 2022-05-12 | Processo di preparazione di Zanubrutinib in forma amorfa. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT202200009872A1 true IT202200009872A1 (it) | 2023-11-12 |
Family
ID=83081506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102022000009872A IT202200009872A1 (it) | 2022-05-12 | 2022-05-12 | Processo di preparazione di Zanubrutinib in forma amorfa. |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | IT202200009872A1 (it) |
| WO (1) | WO2023218389A1 (it) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018033853A2 (en) * | 2016-08-16 | 2018-02-22 | Beigene, Ltd. | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| WO2018033135A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
| WO2021259732A1 (en) | 2020-06-24 | 2021-12-30 | Sandoz Ag | Multi-component compounds comprising zanubrutinib and a benzoic acid derivative |
-
2022
- 2022-05-12 IT IT102022000009872A patent/IT202200009872A1/it unknown
-
2023
- 2023-05-11 WO PCT/IB2023/054862 patent/WO2023218389A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018033853A2 (en) * | 2016-08-16 | 2018-02-22 | Beigene, Ltd. | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| WO2018033135A1 (en) | 2016-08-19 | 2018-02-22 | Beigene, Ltd. | Use of a combination comprising a btk inhibitor for treating cancers |
| WO2019108795A1 (en) | 2017-11-29 | 2019-06-06 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive b-cell lymphomas using a combination comprising btk inhibitors |
| WO2021259732A1 (en) | 2020-06-24 | 2021-12-30 | Sandoz Ag | Multi-component compounds comprising zanubrutinib and a benzoic acid derivative |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023218389A1 (en) | 2023-11-16 |
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