IT202200006287A1 - Molecole di acido nucleico funzionali per regolazione epigenetica - Google Patents

Molecole di acido nucleico funzionali per regolazione epigenetica Download PDF

Info

Publication number
IT202200006287A1
IT202200006287A1 IT102022000006287A IT202200006287A IT202200006287A1 IT 202200006287 A1 IT202200006287 A1 IT 202200006287A1 IT 102022000006287 A IT102022000006287 A IT 102022000006287A IT 202200006287 A IT202200006287 A IT 202200006287A IT 202200006287 A1 IT202200006287 A1 IT 202200006287A1
Authority
IT
Italy
Prior art keywords
nucleic acid
acid molecules
functional nucleic
epigenetic regulation
epigenetic
Prior art date
Application number
IT102022000006287A
Other languages
English (en)
Inventor
Angelo Serani
Valter Tucci
Original Assignee
Fondazione St Italiano Tecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fondazione St Italiano Tecnologia filed Critical Fondazione St Italiano Tecnologia
Priority to IT102022000006287A priority Critical patent/IT202200006287A1/it
Publication of IT202200006287A1 publication Critical patent/IT202200006287A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
IT102022000006287A 2022-03-30 2022-03-30 Molecole di acido nucleico funzionali per regolazione epigenetica IT202200006287A1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT102022000006287A IT202200006287A1 (it) 2022-03-30 2022-03-30 Molecole di acido nucleico funzionali per regolazione epigenetica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102022000006287A IT202200006287A1 (it) 2022-03-30 2022-03-30 Molecole di acido nucleico funzionali per regolazione epigenetica

Publications (1)

Publication Number Publication Date
IT202200006287A1 true IT202200006287A1 (it) 2023-09-30

Family

ID=82100769

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102022000006287A IT202200006287A1 (it) 2022-03-30 2022-03-30 Molecole di acido nucleico funzionali per regolazione epigenetica

Country Status (1)

Country Link
IT (1) IT202200006287A1 (it)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017040793A1 (en) * 2015-09-01 2017-03-09 Dana-Farber Cancer Institute Inc. Systems and methods for selection of grna targeting strands for cas9 localization
WO2018053037A1 (en) * 2016-09-13 2018-03-22 The Jackson Laboratory Targeted enhanced dna demethylation
WO2020178831A1 (en) * 2019-03-05 2020-09-10 Ramot At Tel-Aviv University Ltd. Plant dna methyltransferases and uses thereof
WO2021081135A2 (en) * 2019-10-21 2021-04-29 The Regents Of The University Of California Compositions and methods for editing of the cdkl5 gene

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017040793A1 (en) * 2015-09-01 2017-03-09 Dana-Farber Cancer Institute Inc. Systems and methods for selection of grna targeting strands for cas9 localization
WO2018053037A1 (en) * 2016-09-13 2018-03-22 The Jackson Laboratory Targeted enhanced dna demethylation
WO2020178831A1 (en) * 2019-03-05 2020-09-10 Ramot At Tel-Aviv University Ltd. Plant dna methyltransferases and uses thereof
WO2021081135A2 (en) * 2019-10-21 2021-04-29 The Regents Of The University Of California Compositions and methods for editing of the cdkl5 gene

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LAVENDER P ET AL: "CRISPR-based reagents to study the influence of the epigenome on gene expression", CLINICAL AND EXPERIMENTAL IMMUNOLOGY, WILEY-BLACKWELL PUBLISHING LTD, GB, vol. 194, no. 1, 11 September 2018 (2018-09-11), pages 9 - 16, XP071086127, ISSN: 0009-9104, DOI: 10.1111/CEI.13190 *
YONG LEI ET AL: "Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein", NATURE COMMUNICATIONS, vol. 8, 11 July 2017 (2017-07-11), pages 16026, XP055459752, DOI: 10.1038/ncomms16026 *

Similar Documents

Publication Publication Date Title
SG11202111878RA (en) Method of detecting target nucleic acid molecules
GB202307947D0 (en) Reagents for massively parallel nucleic acid sequencing
EP2601293A4 (en) CATENIN RNA INTERFERENCE-INHIBITING INHIBITION (CADHERIN-ASSOCIATED PROTEIN), EXPRESSION OF BETA-1 GENE (CTNNB1) USING SMALL INTERFERING NUCLEIC ACID (SIAN)
IT1401911B1 (it) Processo per la sintesi di acido 2,5-furandicarbossilico
IL290274A (en) Methods and reagents for nucleic acid sequencing and related applications
GB2581599B8 (en) Tagging nucleic acid molecules from single cells for phased sequencing
EP3775259A4 (en) NUCLEIC ACID MOLECULES SEQUENCING PROCESSES
EP4123021A4 (en) STRUCTURE OF AN ONCOLYTIC VIRUS WITH BISPECIFIC NUCLEIC ACID MOLECULE
IT201900025039A1 (it) Processo per purificare il bis(2-idrossietil)tereftalato.
IT202200006287A1 (it) Molecole di acido nucleico funzionali per regolazione epigenetica
IT202200006296A1 (it) Molecole di acido nucleico funzionali per regolazione epigenetica
EP4133081A4 (en) GROUPING OF HIGH-PLEX GUIDES FOR NUCLEIC ACID DETECTION
IL310281A (en) Optical systems for nucleic acid sequencing and methods thereof
GB202207795D0 (en) Functional nucleic acid molecule
GB202207796D0 (en) Functional nucleic acid molecule
GB202205423D0 (en) Functional nucleic acid molecule
EP4168574A4 (en) MULTIMODAL ANALYSIS OF CIRCULATIVE TUMOR NUCLEIC ACID MOLECULES
EP4107561A4 (en) HIGHLY MULTIPLEXED NUCLEIC ACID SEQUENCING SYSTEMS
EP3283501A4 (en) ST.VIOMETRIC ST REGULATION OF NUCLEIC ACID HYBRIDIZATION PROBES WITH AUXILIARY OLIGONUCLEOTIDE SPECIES
EP3953467A4 (en) DUPLEX-SPECIFIC NUCLEAR DEPLETION FOR PURIFICATION OF NUCLEIC ACID SAMPLES
GB202103955D0 (en) Functional nucleic acid molecules directed to cdnf
GB202403511D0 (en) Functional nucleic acid
GB202401412D0 (en) Functional nucleic acid
GB202401415D0 (en) Modified nucleic acid
GB202300886D0 (en) Compounds for nucleic acid cleavage