IT202200000614U1 - Preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-ß-glycyrrhetinic acid for skin lesions. - Google Patents
Preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-ß-glycyrrhetinic acid for skin lesions. Download PDFInfo
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- IT202200000614U1 IT202200000614U1 IT202022000000614U IT202200000614U IT202200000614U1 IT 202200000614 U1 IT202200000614 U1 IT 202200000614U1 IT 202022000000614 U IT202022000000614 U IT 202022000000614U IT 202200000614 U IT202200000614 U IT 202200000614U IT 202200000614 U1 IT202200000614 U1 IT 202200000614U1
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- quercetin
- oils
- plant extracts
- natural plant
- topical use
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- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 title claims description 44
- 230000000699 topical effect Effects 0.000 title claims description 24
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 title claims description 22
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 title claims description 22
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 title claims description 22
- 229960001285 quercetin Drugs 0.000 title claims description 22
- 235000005875 quercetin Nutrition 0.000 title claims description 22
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 title claims description 21
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 title claims description 21
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 title claims description 21
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 title claims description 21
- 239000005642 Oleic acid Substances 0.000 title claims description 21
- 229940048300 coco-caprylate Drugs 0.000 title claims description 21
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 title claims description 21
- 239000003921 oil Substances 0.000 title claims description 21
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 21
- 239000000419 plant extract Substances 0.000 title claims description 19
- -1 Coco Caprylate Substances 0.000 title claims description 18
- 229960002969 oleic acid Drugs 0.000 title claims description 18
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 title description 6
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 title description 5
- 231100000444 skin lesion Toxicity 0.000 title description 2
- 206010040882 skin lesion Diseases 0.000 title description 2
- 229960003720 enoxolone Drugs 0.000 claims description 21
- 208000025865 Ulcer Diseases 0.000 claims description 20
- 208000027418 Wounds and injury Diseases 0.000 claims description 20
- 231100000397 ulcer Toxicity 0.000 claims description 20
- 206010052428 Wound Diseases 0.000 claims description 16
- 230000001939 inductive effect Effects 0.000 claims description 5
- 238000007906 compression Methods 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 208000015181 infectious disease Diseases 0.000 claims description 3
- 230000001684 chronic effect Effects 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims 5
- 230000006378 damage Effects 0.000 claims 4
- 230000002792 vascular Effects 0.000 claims 4
- 238000002512 chemotherapy Methods 0.000 claims 3
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 210000004872 soft tissue Anatomy 0.000 claims 2
- 230000000472 traumatic effect Effects 0.000 claims 2
- 206010000370 Accident at home Diseases 0.000 claims 1
- 208000032984 Intraoperative Complications Diseases 0.000 claims 1
- 208000004210 Pressure Ulcer Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 230000008718 systemic inflammatory response Effects 0.000 claims 1
- 230000008736 traumatic injury Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 4
- 230000018109 developmental process Effects 0.000 description 3
- 229960000890 hydrocortisone Drugs 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000017423 tissue regeneration Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 102000004277 11-beta-hydroxysteroid dehydrogenases Human genes 0.000 description 1
- 108090000874 11-beta-hydroxysteroid dehydrogenases Proteins 0.000 description 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- 102100026148 Free fatty acid receptor 1 Human genes 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 101000912510 Homo sapiens Free fatty acid receptor 1 Proteins 0.000 description 1
- 208000002260 Keloid Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
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- 150000001298 alcohols Chemical group 0.000 description 1
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- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
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- 229960004544 cortisone Drugs 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
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- 150000002632 lipids Chemical class 0.000 description 1
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- 238000000034 method Methods 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
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- 235000021315 omega 9 monounsaturated fatty acids Nutrition 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
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- WNIFXKPDILJURQ-UHFFFAOYSA-N stearyl glycyrrhizinate Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=O)OCCCCCCCCCCCCCCCCCC)(C)CC5C4=CC(=O)C3C21C WNIFXKPDILJURQ-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Tipologia Ordinaria Ordinary Type
Titolo: Title:
Preparato per uso topico a base di oli ed estratti naturali vegetali comprendenti Coco caprilato, Acido Oleico, Quercetina e Acido 18-?-glicirretico per lesioni cutanee. Preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-?-glycyrrhetinic acid for skin lesions.
DESCRIZIONE DESCRIPTION
del brevetto d?uso dal titolo: of the usage patent entitled:
?Preparato per uso topico a base di oli ed estratti naturali vegetali comprendenti Coco caprilato, Acido Oleico, Quercetina e Acido 18-?-glicirretico? ?Preparation for topical use based on oils and natural plant extracts including Coco caprylate, Oleic Acid, Quercetin and 18-?-glycyrrhetinic acid?
La presente invenzione ? relativa ad un preparato per uso topico a base di oli ed estratti naturali vegetali comprendenti Coco caprilato, Acido Oleico, Quercetina e Acido 18-?-glicirretico per l?uso nel trattamento delle ulcere e delle ferite da qualsiasi natura localizzato in qualsiasi distretto. This invention? relating to a preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-?-glycyrrhetinic acid for use in the treatment of ulcers and wounds of any nature located in any district.
Le ulcere sono definite come perdita di sostanza della cute che coinvolgono i tessuti sottostanti e che sia associa a dolore e ad infezioni locali o sistemiche fino allo sviluppo di setticemia che possono produrre una riduzione della qualit? della vita, un incremento delle ospedalizzazioni fino alla morte dei pazienti. Ulcers are defined as loss of skin substance involving the underlying tissues and which is associated with pain and local or systemic infections up to the development of septicemia which can produce a reduction in the quality of the skin. of life, an increase in hospitalizations up to the death of patients.
Le strategie impiegate nella prevenzione o nel trattamento delle ulcere sono basate sulla compressione meccanica, sulla terapia non farmacologica e sull?utilizzo di farmaci capaci di indurre una rigenerazione tessutale e la riduzione del dolore comprendenti l?uso di paracetamolo e oppiacei. The strategies used in the prevention or treatment of ulcers are based on mechanical compression, non-pharmacological therapy and the use of drugs capable of inducing tissue regeneration and pain reduction including the use of paracetamol and opiates.
Alla luce di quanto sopra esposto risulta evidente l?esigenza di una nuova terapia per il trattamento topico di ulcere e ferite di qualsiasi natura capace di indurre una rapida guarigione delle stesse senza sviluppo di infezioni. In light of the above, the need for a new therapy for the topical treatment of ulcers and wounds of any nature capable of inducing rapid healing without the development of infections is evident.
Scopo della presente invenzione ? fornire un preparato per uso topico a base di oli ed estratti naturali vegetali comprendenti Acido Oleico, Quercetina, Acido 18-?glicirretico e coco caprilato nel trattamento topico delle ulcere e delle ferite da qualsiasi causa, come da rivendicazione 1, che garantisca una rapida efficacia clinica senza sviluppo di reazioni avverse avente, quindi, caratteristiche tali da superare i limiti che ancora influenzano i preparati topici utilizzati nel trattamento delle ulcere o delle ferite. Purpose of the present invention? provide a preparation for topical use based on oils and natural plant extracts including Oleic Acid, Quercetin, 18-glycyrrhetinic acid and coco caprylate in the topical treatment of ulcers and wounds from any cause, as per claim 1, which guarantees rapid effectiveness clinical without development of adverse reactions, therefore having characteristics such as to overcome the limits that still influence topical preparations used in the treatment of ulcers or wounds.
Secondo la presente invenzione, un preparato per uso topico a base di oli ed estratti naturali vegetali comprendenti Coco caprilato, Acido Oleico, Quercetina e Acido 18-?-glicirretico per l?uso topico nel trattamento delle ulcere e delle ferite da qualsiasi causa, come definito nella rivendicazione 1. According to the present invention, a preparation for topical use based on oils and natural plant extracts including coco caprylate, oleic acid, quercetin and 18-?-glycyrrhetinic acid for topical use in the treatment of ulcers and wounds from any cause, such as defined in claim 1.
Per una migliore comprensione della presente invenzione vengono ora riportate le caratteristiche delle singole sostanze utilizzate: For a better understanding of the present invention, the characteristics of the individual substances used are now reported:
1) Il coco caprilato ? un olio di derivazione vegetale e pi? precisamente un estere fra alcoli e acidi grassi saturi a media catena (C8-C18) derivato dal cocco. Ha un effetto "silicone-like", senza per? occludere i pori della pelle, permettendone invece la traspirazione. 1) Coco caprylate? a vegetable-derived oil and more? precisely an ester between alcohols and medium chain saturated fatty acids (C8-C18) derived from coconut. It has a "silicone-like" effect, without however? occlude the pores of the skin, allowing perspiration instead.
Esso risulta inoltre facilmente assorbibile e penetra rapidamente senza lasciare tracce di unto. Per tutti questi motivi questo prodotto risulta l'ideale per la veicolazione di sostanze attive liposolubili senza rinunciare ad una texture ricca. It is also easily absorbable and penetrates quickly without leaving traces of grease. For all these reasons this product is ideal for the delivery of fat-soluble active substances without giving up a rich texture.
Il coco caprilato ? un lipide estremamente versatile in quanto pu? essere utilizzato come fase grassa in tutte le formulazioni e la sua texture leggera e non invasiva, rende i prodotti in cui viene utilizzato molto performanti. Un?altra caratteristica decisamente importante ? la sua alta diffusibilit?; infatti, risulta facilmente assorbibile e penetra rapidamente. Per tutti questi motivi quest?olio risulta l'ideale per la veicolazione di sostanze attive liposolubili, specie nei prodotti da massaggio, per uno skinfeel molto gradevole che non lascia tracce di unto. Coco caprylate? an extremely versatile lipid as it can? be used as an oily phase in all formulations and its light and non-invasive texture makes the products in which it is used highly performing. Another decidedly important feature? its high diffusibility; in fact, it is easily absorbable and penetrates quickly. For all these reasons this oil is ideal for the conveyance of fat-soluble active substances, especially in massage products, for a very pleasant skinfeel that leaves no traces of grease.
Infine,? biodegradabile, sicuro e non irritante. In the end,? biodegradable, safe and non-irritating.
2) L? Acido Oleico: ? un grasso omega-9 ad azione antinfiammatoria. In particolare, l?olio d?oliva ? uno dei pi? ricchi di acido oleico (circa il 62%), il pi? abbondante tra gli acidi grassi monoinsaturi a lunga catena presenti nel nostro corpo, con grandi propriet? nutrienti ed emollienti per la pelle. Svolge inoltre una azione antinfiammatoria ed antiossidante capace di indurre una attivazione dei fibroblasti coinvolti nei processi di rigenerazione dei tessuti. 2) L? Oleic Acid: ? an omega-9 fat with anti-inflammatory action. In particular, olive oil is one of the most rich in oleic acid (about 62%), the most? abundant among the long-chain monounsaturated fatty acids present in our body, with great properties? nourishing and emollient for the skin. It also has an anti-inflammatory and antioxidant action capable of inducing an activation of the fibroblasts involved in tissue regeneration processes.
3) La quercetina: appartiene ad un gruppo delle sostanze polifenoliche conosciute come flavonoidi e nello specifico appartiene alla classe dei flavonoidi. L?utilizzo dell?estratto di quercetina ? stato ampiamente dimostrato in studi preclinici e clinici che hanno documentato come essa sia in grado di avere attivit? antinfiammatoria, antiossidante e di rigenerazione tessutale probabilmente legata alla sua azione sui recettori GPR40. 3) Quercetin: belongs to a group of polyphenolic substances known as flavonoids and specifically belongs to the class of flavonoids. The use of quercetin extract is has been widely demonstrated in preclinical and clinical studies which have documented how it is capable of having anti-inflammatory, antioxidant and tissue regeneration probably linked to its action on GPR40 receptors.
La quercetina esercita sulla pelle numerosi effetti benefici: antinfiammatoria, antiallergica, antivirale, immunomodulatoria e come scavenger dei radicali liberi prevenendo l?alterazione del tessuto connettivo e preservando quindi la sintesi di collagene ed elastina che rappresentano le proteine strutturali della pelle. Quercetin exerts numerous beneficial effects on the skin: anti-inflammatory, anti-allergic, antiviral, immunomodulatory and as a scavenger of free radicals, preventing the alteration of the connective tissue and therefore preserving the synthesis of collagen and elastin which represent the structural proteins of the skin.
4) Acido 18-?-glicirretico: chiamato anche enoxolone o acido glicirretinico, ? un acido organico triterpenico pentaciclico, derivato dalle beta-amirine, che viene estratto dalla pianta di liquirizia. Ha notevoli propriet? antinfiammatorie, cicatrizzanti e antisettica. Esso esercita un?azione simile a quella dell?idrocortisone topico, anzi in alcuni studi scientifici emerge che la sua attivit? supera quella del cortisone, soprattutto in casi cronici. Questo si spiega tramite la sua interazione con l?enzima 11 ?idrossisteroide-deidrogenasi tissutale che converte il cortisolo dalla forma attiva a quella inattiva. Mediante tale inibizione enzimatica, l?acido glicirretico prolunga la normale attivit? antiinfiammatoria del cortisolo dopo essere stato rilasciato in seguito a stimolo infiammatorio. Mediante tale meccanismo si ottiene un effett antinfiammatorio e di controllo della proliferazione cellulare evitando la formazione di cheloidi. 4) 18-?-glycyrrhetinic acid: also called enoxolone or glycyrrhetinic acid, ? a pentacyclic triterpenic organic acid, derived from beta-amyrins, which is extracted from the liquorice plant. Does it have notable properties? anti-inflammatory, healing and antiseptic. It exerts an action similar to that of topical hydrocortisone, indeed in some scientific studies it emerges that its activity exceeds that of cortisone, especially in chronic cases. This is explained by its interaction with the tissue 11 hydroxysteroid dehydrogenase enzyme which converts cortisol from the active to the inactive form. Through this enzymatic inhibition, glycyrrhetinic acid prolongs normal activity. anti-inflammatory action of cortisol after being released following an inflammatory stimulus. Through this mechanism, an anti-inflammatory and cellular proliferation control effect is obtained, avoiding the formation of keloids.
Secondo un aspetto dell?invenzione il dosaggio del preparato in crema o olio-gel prevede la totale copertura dell?area della lesione con apposizione di uno strato di alcuni millimetri (massimo 2). According to one aspect of the invention, the dosage of the cream or oil-gel preparation involves total coverage of the lesion area with the application of a layer of a few millimeters (maximum 2).
Claims (13)
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IT202022000000614U IT202200000614U1 (en) | 2022-02-17 | 2022-02-17 | Preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-ß-glycyrrhetinic acid for skin lesions. |
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IT202022000000614U IT202200000614U1 (en) | 2022-02-17 | 2022-02-17 | Preparation for topical use based on oils and natural plant extracts including Coco Caprylate, Oleic Acid, Quercetin and 18-ß-glycyrrhetinic acid for skin lesions. |
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