IT201900023079A1 - Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali - Google Patents

Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali

Info

Publication number
IT201900023079A1
IT201900023079A1 IT102019000023079A IT201900023079A IT201900023079A1 IT 201900023079 A1 IT201900023079 A1 IT 201900023079A1 IT 102019000023079 A IT102019000023079 A IT 102019000023079A IT 201900023079 A IT201900023079 A IT 201900023079A IT 201900023079 A1 IT201900023079 A1 IT 201900023079A1
Authority
IT
Italy
Prior art keywords
complexes
cancer
preparation
Prior art date
Application number
IT102019000023079A
Other languages
English (en)
Inventor
Fabiano Visentin
Thomas Scattolin
Enrica Bortolamiol
Flavio Rizzolio
Original Assignee
Univ Ca Foscari
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ca Foscari filed Critical Univ Ca Foscari
Priority to IT102019000023079A priority Critical patent/IT201900023079A1/it
Priority to EP20828523.9A priority patent/EP4069710B1/en
Priority to PCT/EP2020/084360 priority patent/WO2021110790A1/en
Publication of IT201900023079A1 publication Critical patent/IT201900023079A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/006—Palladium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102019000023079A 2019-12-05 2019-12-05 Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali IT201900023079A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT102019000023079A IT201900023079A1 (it) 2019-12-05 2019-12-05 Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali
EP20828523.9A EP4069710B1 (en) 2019-12-05 2020-12-03 Pd(i) complexes, process for their preparation and use thereof as antitumour agents
PCT/EP2020/084360 WO2021110790A1 (en) 2019-12-05 2020-12-03 Pd(i) complexes, process for their preparation and use thereof as antitumour agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000023079A IT201900023079A1 (it) 2019-12-05 2019-12-05 Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali

Publications (1)

Publication Number Publication Date
IT201900023079A1 true IT201900023079A1 (it) 2021-06-05

Family

ID=70154914

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000023079A IT201900023079A1 (it) 2019-12-05 2019-12-05 Complessi di pd(i), processo per la loro preparazione e loro impiego come antitumorali

Country Status (3)

Country Link
EP (1) EP4069710B1 (it)
IT (1) IT201900023079A1 (it)
WO (1) WO2021110790A1 (it)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120190873A1 (en) 2009-07-30 2012-07-26 Johnson Matthey Public Limited Company Process for the preparation of palladium (i) tri-tert-butylphosphine bromide dimer
US20140187803A1 (en) 2011-06-29 2014-07-03 Umicore Ag & Co. Kg Method for the Preparation of Palladium(I) Tri-Tert-Butylphosphine Bromide Dimer and Process for its Use in Isomerization Reactions
WO2018073559A1 (en) 2016-10-21 2018-04-26 Johnson Matthey Public Limited Company Process
US20180194789A1 (en) 2017-01-07 2018-07-12 Indian Institute Of Technology Bombay Anticancer property studies of chiral palladium n-heterocyclic carbene complexes and process for preparation thereof
CN108558952A (zh) 2018-05-22 2018-09-21 玉林师范学院 一种2-苯基吡啶双核钯(ii)配合物及其制备方法和应用
WO2019158978A1 (en) * 2018-02-16 2019-08-22 University Of Stellenbosch Binuclear palladacycles and their use in the treatment of cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120190873A1 (en) 2009-07-30 2012-07-26 Johnson Matthey Public Limited Company Process for the preparation of palladium (i) tri-tert-butylphosphine bromide dimer
US20140187803A1 (en) 2011-06-29 2014-07-03 Umicore Ag & Co. Kg Method for the Preparation of Palladium(I) Tri-Tert-Butylphosphine Bromide Dimer and Process for its Use in Isomerization Reactions
WO2018073559A1 (en) 2016-10-21 2018-04-26 Johnson Matthey Public Limited Company Process
US20180194789A1 (en) 2017-01-07 2018-07-12 Indian Institute Of Technology Bombay Anticancer property studies of chiral palladium n-heterocyclic carbene complexes and process for preparation thereof
WO2019158978A1 (en) * 2018-02-16 2019-08-22 University Of Stellenbosch Binuclear palladacycles and their use in the treatment of cancer
CN108558952A (zh) 2018-05-22 2018-09-21 玉林师范学院 一种2-苯基吡啶双核钯(ii)配合物及其制备方法和应用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FOOD AND DRUG ADMINISTRATION, 1978
HECKENROTH M ET AL: "Synthesis and structural analysis of palladium biscarbene complexes derived from bisimidazolium ligand precursors", INORGANICA CHIMICA ACTA, ELSEVIER BV, NL, vol. 359, no. 6, 10 April 2006 (2006-04-10), pages 1929 - 1938, XP028068846, ISSN: 0020-1693, [retrieved on 20060410], DOI: 10.1016/J.ICA.2005.10.045 *
HEMMERT CATHERINE ET AL: "Synthesis, structures, and antimalarial activities of some silver(I), gold(I) and gold(III) complexes involvingN-heterocyclic carbene ligands", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 60, 7 December 2012 (2012-12-07), pages 64 - 75, XP028983520, ISSN: 0223-5234, DOI: 10.1016/J.EJMECH.2012.11.038 *
L. CANOVESE, POLYHEDRON, vol. 20, 2001, pages 3171 - 3181
RUIHU WANG ET AL: "Syntheses and Characterization of Unsymmetric Dicationic Salts Incorporating Imidazolium and Triazolium Functionalities", INORGANIC CHEMISTRY, vol. 45, no. 16, 1 August 2006 (2006-08-01), EASTON, US, pages 6396 - 6403, XP055721746, ISSN: 0020-1669, DOI: 10.1021/ic060822i *
Y. A. WANNIARACHCHI ET AL.: "an unusually static, Sterically Hindered silver bis(n-heterocryclic carbene) complex and its use in transmetalation", ORGANOMETALLICS, vol. 23, 2004, pages 5881 - 5884

Also Published As

Publication number Publication date
EP4069710C0 (en) 2023-10-04
EP4069710A1 (en) 2022-10-12
WO2021110790A1 (en) 2021-06-10
EP4069710B1 (en) 2023-10-04

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